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Chemistry, Multidisciplinary
Tianyi Wang et al.
Summary: Intracerebral hemorrhage (ICH) is a significant cause of morbidity and mortality worldwide, and surgery remains the most effective way to remove ICH. However, surgery brings potential risks such as brain tissue damage, post-operative infection, and difficulty in removing deep hematoma, which are the main problems in the surgical treatment of ICH.
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Chemistry, Multidisciplinary
Yanlin Feng et al.
Summary: Photoimmunotherapy is a novel targeted therapeutic strategy for highly malignant triple-negative breast cancer. However, its therapeutic effect is restricted by limited tissue penetration of light and complex immunosuppressive microenvironment. A new mace-like plasmonic Au-Pd heterostructures have been developed to enhance the outcomes of photoimmunotherapy. These structures exhibit strong photothermal and photodynamic effects, triggering immunogenic cell death and stimulating immune response. This study integrates nanotopology and plasmonic performance for the treatment of TNBC through immunotherapy.
Article
Chemistry, Multidisciplinary
Yilin Liu et al.
Summary: A user-friendly microemulsion method was developed to assemble multifunctional superparticles, enabling real-time imaging, magnetic targeting, and photodynamic therapy. The superparticles showed high tumor accumulation under magnetic targeting and demonstrated great potential in targeted cancer treatment.
Review
Chemistry, Multidisciplinary
Xukai Wang et al.
Summary: Osteomyelitis is a refractory disease in orthopedics caused by infection with pathogenic microorganisms. Antibacterial therapy, in addition to surgical debridement, is currently the main approach for treating osteomyelitis. However, traditional antibiotics are facing bacterial resistance, prompting the development of advanced antibacterial agents. This review discusses the main targets and mechanisms of antibacterial agents for osteomyelitis treatment, as well as their potential clinical applications.
Article
Multidisciplinary Sciences
Haodong Zhang et al.
Summary: Poly-beta-lysine with beta-homo-glycine substitution (beta Lys50HG50) shows potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and MRSA persister cells, with low cytotoxicity and no antimicrobial resistance. It has strong therapeutic potential in both local and systemic MRSA infections, suggesting a generalizable strategy for designing promising antibacterial polypeptides.
Review
Chemistry, Multidisciplinary
Yang Zhu et al.
Summary: Nanomaterials with enzyme-mimicking properties, known as nanozymes, have become an alternative to natural enzymes due to their advantages, such as stability, ease of preparation, and catalytic performance. Single atom nanozymes (SAzymes) have recently been developed, showing superior catalytic performance and selectivity, and have made progress in biomedical applications. This review systematically summarizes the recent advances in SAzyme preparation methods, catalytic mechanisms, and biomedical applications, and discusses their potential challenges and prospects for future development.
Article
Chemistry, Multidisciplinary
Yuqian Qiao et al.
Summary: Microwave (MV)-trigged dynamic therapy using MV-responsive materials shows promise for treating deep infection diseases, including life-threatening osteomyelitis, that are not effectively treated by antibiotics. Surface states of materials play a key role in the generation of free charges and the MV dynamic effects. A new MV responsive system, consisting of a 2D metal-organic framework (2D MOF) on oxidized carbon nanotube (CNT), is developed, which exhibits highly effective antimicrobial activity and eradicates Staphylococcus aureus infected rabbit tibia osteomyelitis under MV irradiation. This study represents a major advancement in antibiotic-free MV therapy for deep tissue bacterial infection.
Article
Materials Science, Multidisciplinary
Xiaojun Zeng et al.
Summary: In this work, a Mo2C/NiFe-NC networker with a hierarchical porous structure, 3D network skeleton, heterogeneous interface, abundant heteroatom doping, and magnetic NiFe alloy was constructed. The designed networker exhibited a reflection loss value of -51.56 dB at an ultrathin matching thickness of 1.4 mm and an effective absorption bandwidth of up to 3.7 GHz.
MATERIALS TODAY PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Zhiying Wang et al.
Summary: In this study, an antibacterial nanofiber membrane with enhanced photocatalytic activity is fabricated using a ferroelectric polarization strategy. The membrane exhibits excellent visible light absorption and photothermal conversion performance, and is capable of killing Staphylococcus aureus and Escherichia coli.
ADVANCED FIBER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yiwen Zhu et al.
Summary: The newly designed P alpha Gal(50)-b-PGRB(20) can effectively disperse biofilms and selectively kill MDR-P. aeruginosa within biofilms by binding to Lec A in the extracellular polymeric substances and on the P. aeruginosa membrane under low phototoxicity caused by broad-spectrum aPDT. It has bactericidal activities by damaging DNA, RNA, protein, and membrane, showing potential for better corneal recovery in MDR-P. aeruginosa biofilm infected keratitis model.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yueming Wu et al.
Summary: The PMMA@polymer, designed as a synthetic mimic of host defense peptide, shows potent activity against MRSA, superior therapeutic efficacy in vivo, and low toxicity, suggesting great potential as an effective treatment for MRSA-infected chronic osteomyelitis.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Kyungwha Chung et al.
Summary: Non-oxidized bare copper nanoparticles can be maintained in air by passivating their surfaces with excess electrons. This finding has the potential to enhance the practical use of metal nanoparticles.
NATURE NANOTECHNOLOGY
(2022)
Review
Microbiology
Elysia A. Masters et al.
Summary: This review explores the microbial pathogenesis, immunity, and clinical management of bone infections, highlighting osteomyelitis as a significant risk in orthopaedic surgery. It discusses the mechanisms of persistence and immune evasion in Staphylococcus aureus infection of the skeletal system, as well as features of other osteomyelitis-causing pathogens. The article also describes the clinical management of skeletal infection, including osteomyelitis classification and strategies for treating skeletal infections with emerging technologies.
NATURE REVIEWS MICROBIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Rui Lv et al.
Summary: The flower-like CuS/GO hybrids synthesized in this study exhibit superior antibacterial efficacy and biocompatibility, making them a promising material for daily applications such as water disinfection and wound sterilization.
Review
Materials Science, Multidisciplinary
Shun Duan et al.
Summary: The development of antimicrobial materials has evolved from ancient silver containers to modern synthesized chemicals, constantly improving and enhancing efficacy. With advances in materials science and engineering, multifunctional antimicrobial materials now have the ability to effectively combat infections and enhance the efficacy of medical devices.
PROGRESS IN MATERIALS SCIENCE
(2022)
Article
Multidisciplinary Sciences
Yuqian Qiao et al.
Summary: This study presents a method to effectively eliminate Gram-negative bacteria by creating nanopores in the outer membrane using microwave irradiation, allowing Garcinia nanoparticles to penetrate and kill the bacteria. The antibacterial efficiency of Garcinia nanoparticles against Escherichia coli can be significantly enhanced with microwave assistance. In addition, the combined use of Garcinia nanoparticles and microwaves has been shown to effectively treat mice with bacterial pneumonia.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
J. J. Aguilera-Correa et al.
Summary: This study proposes the use of bone-targeted mesoporous silica nanoparticles for the treatment of Staphylococcus aureus-caused osteomyelitis, providing synergistic therapeutic effects through multidrug delivery. The nanoparticles are engineered with a functional coating that can disaggregate bacterial biofilms, inhibit premature antibiotic release, and protect the intact bone. They effectively target bone tissue both in vitro and in vivo, demonstrating high biocompatibility and significant antibacterial effects.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Lihong Wu et al.
Summary: A frequency-tuning strategy using pressure variations is developed to achieve dynamic frequency regulation of microwave absorbing materials. The fabricated carbon nanocoils/carbon foam (CNCs/CF) can be tuned from S-band to Ku-band through adjusting compression strain. The method opens up new possibilities for the applications of dynamically frequency-tunable MAMs.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Thermodynamics
Peng Zhang et al.
Summary: This study proposes an efficient method initiated by microwave plasma discharging to decompose plastics into hydrogen and carbon nanotubes. The use of iron-based catalysts on activated carbons achieves the best catalytic activity.
ENERGY CONVERSION AND MANAGEMENT
(2022)
Article
Materials Science, Multidisciplinary
Peng-Fei Cai et al.
Summary: The daily life of people in the intelligent age is inseparable from electronic devices, but the presence of bacteria on touch screens poses a threat to users' health. By synthesizing a photocatalytic TiO2/Ag thin film, the growth of bacteria can be effectively inhibited, and the film also exhibits excellent biocompatibility. This research not only provides a more convenient choice for traditional antibacterial methods, but also has great potential for application in the field of billions of touch screens.
Article
Chemistry, Multidisciplinary
Liguo Jin et al.
Summary: This study reports a microwave-excited magnetic composite MoS2/Fe3O4 that effectively eradicates bacteria-infected osteomyelitis through thermal enhancement and ROS production. The excellent microwave absorption ability of MoS2/Fe3O4 is attributed to the synergy between MoS2 and Fe3O4 as well as multiple dielectric reflections and interfacial polarization.
Article
Chemistry, Physical
Wei Li et al.
Summary: The study found that the tip effect can exacerbate Li dendrite formation and reduce the cycle life and safety of lithium metal batteries, but by controlling the distribution of nano-tips, surface electric field can be regulated for uniform lithium deposition. The use of Ag nanoparticles and graphene aerogel in anode can mitigate inhomogeneous current distribution, improve lithium deposition, and demonstrate excellent electrochemical performance in full cell testing.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Review
Chemistry, Applied
Fenghua Tao et al.
Summary: Chitosan, a cationic polysaccharide extracted from chitin, has gained attention in bacterial inhibition and drug delivery. Local antibiotic delivery after surgical debridement using chitosan-based biomaterials is effective in overcoming antibiotic resistance and reducing systemic toxicity in the treatment of osteomyelitis. This review highlights recent advances and future perspectives in utilizing chitosan-based drug delivery systems for osteomyelitis treatment.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Multidisciplinary
Huipeng Lv et al.
Summary: The two-dimensional sandwiched FeNi@SnO2 design achieved an ultra-wide effective absorption bandwidth of 11.70 GHz with strong absorption of -49.1 dB at a thickness of 1.75 mm. This structure not only achieved superior electromagnetic wave absorption, but also provided a versatile strategy to integrate different loss mechanisms in the design of electromagnetic wave absorbers with extra-wide bandwidth.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Environmental
Ting Xu et al.
Summary: Bifunctional polysilsesquioxane/carbon nanotube magnetic composites were prepared and their adsorption capacities for Au(III) were systematically investigated. The results showed that the composites exhibited good adsorption performance and could be utilized for efficient recovery of Au(III) from waste water.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Shubin Wei et al.
Summary: In this study, a rapid and noninvasive therapeutic strategy was developed using Prussian blue as a microwave-responsive material to effectively treat bacteria-induced osteomyelitis. The released Fe2+ and Fe3+ from PB could easily penetrate bacterial membrane by microwave, react with H2O2 and GSH inside bacteria, leading to the final death of the bacteria due to the synergistic action of microwave, microwave thermal effect and Fe2+/Fe3+ induced Fenton reaction/GSH consumption. This study provides novel insight for designing remote and noninvasive antibacterial systems for treating deep bacteria-infected diseases.
Article
Chemistry, Multidisciplinary
Jieni Fu et al.
Summary: MW-responsive engineered pseudo-macrophages (M-Fe3O4/Au NPs) are able to clear Staphylococcus aureus infections, induce M2 polarization of macrophages, and enhance osteogenic differentiation of MSCs under MW irradiation. Fe3O4/Au NPs generate reactive oxygen species and heat under MW irradiation, promoting the production of ROS and reducing inflammatory cytokines secretion in MSCs. The engineered pseudo-macrophages show promise for treating bacterial infections and promoting osteogenic differentiation in deep tissues under MW irradiation.
ADVANCED MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Kylie M. Roux et al.
Summary: Osteomyelitis is a growing concern in modern healthcare due to antibiotic resistance, and current treatments are limited in their effectiveness and can lead to recurrence. Developing safer and more effective treatment options is necessary, and animal models are essential for testing treatment regimens. However, establishing a model that accurately reflects the clinical disease remains a challenge for scientists.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
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(2020)
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Yue Wang et al.
ADVANCED MATERIALS
(2020)
Review
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Kim Lewis
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L. Pasquina-Lemonche et al.
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Yuqian Qiao et al.
NATURE COMMUNICATIONS
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Han Xu et al.
ADVANCED MATERIALS
(2018)
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ADVANCED MATERIALS
(2018)
Review
Microbiology
Nicola Kavanagh et al.
CLINICAL MICROBIOLOGY REVIEWS
(2018)
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ADVANCED FUNCTIONAL MATERIALS
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Dalong Ni et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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Wenlong Wang et al.
IEEE TRANSACTIONS ON PLASMA SCIENCE
(2017)
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Kazem Majdzadeh-Ardakani et al.
PROGRESS IN MATERIALS SCIENCE
(2017)
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Yuli Zhou et al.
APPLIED THERMAL ENGINEERING
(2017)
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Qingtao Liu et al.
CHEMICAL ENGINEERING JOURNAL
(2017)
Review
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Xiaoqin Qian et al.
ADVANCED MATERIALS
(2016)
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Editorial Material
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Michael E. Olson et al.
CELL HOST & MICROBE
(2013)
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CELL HOST & MICROBE
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IM Gould et al.
JOURNAL OF APPLIED MICROBIOLOGY
(2002)
