期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1113/JP285572
关键词
cardiac output; fetus; FGR; hypoxia; IUGR; magnetic resonance imaging; metabolism; mitochondria
Babies born with fetal growth restriction (FGR) have a higher risk of developing cardiometabolic diseases. FGR reduces substrate supply to the fetus, which affects cardiac growth, metabolism, and function. A study using a sheep model of placental restriction found that FGR decreases glucose and fatty acid transporters, as well as mitochondrial numbers and electron transport chain complexes in the fetal heart.
Babies born with fetal growth restriction (FGR) are at higher risk of developing cardiometabolic diseases across the life course. The reduction in substrate supply to the developing fetus that causes FGR not only alters cardiac growth and structure but may have deleterious effects on metabolism and function. Using a sheep model of placental restriction to induce FGR, we investigated key cardiac metabolic and functional markers that may be altered in FGR. We also employed phase-contrast magnetic resonance imaging MRI to assess left ventricular cardiac output (LVCO) as a measure of cardiac function. We hypothesized that signalling molecules involved in cardiac fatty acid utilisation and contractility would be impaired by FGR and that this would have a negative impact on LVCO in the late gestation fetus. Key glucose (GLUT4 protein) and fatty acid (FATP, CD36 gene expression) substrate transporters were significantly reduced in the hearts of FGR fetuses. We also found reduced mitochondrial numbers as well as abundance of electron transport chain complexes (complexes II and IV). These data suggest that FGR diminishes metabolic and mitochondrial capacity in the fetal heart; however, alterations were not correlated with fetal LVCO. Overall, these data show that FGR alters fetal cardiac metabolism in late gestation. If sustained ex utero, this altered metabolic profile may contribute to poor cardiac outcomes in FGR-born individuals after birth.
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