A unique corrole-based metal-organic polymer for synergistic phototherapy

Nanoscale metal-organic polymers (MOPs) have demonstrated great performance in photodynamic therapy (PDT) and photothermal therapy (PTT) in recent years. However, incorporating synergistic PDT and PTT treatments into a single nanoagent normally requires a multistep production method. Corrole, a derivative of the porphyrin family, exhibits promising applications in phototherapy. Nevertheless, very few corrole-based organic polymer materials have been reported in the field of phototherapy. Herein, we present the successful synthesis of a unique corrole-based MOP (PFCC-Hf) assembled by the coordination of the corrolic dicarboxylate ligand PFCC with Hf using a simple solvothermal method. Interestingly, compared to the 40% cancer cell inhibition exhibited by DBP-Hf PDT, PFCC-Hf demonstrated superior synergistic PDT and PTT efficacies with 89% apoptosis of A375 cells in the in vitro anticancer study. This work highlights the potential of corrole-based metal-organic polymers for use in efficient phototherapy treatments. Corrole-based nanoscale metal-organic polymers (MOPs) have demonstrated great potentials in photodynamic therapy (PDT) and photothermal therapy (PTT).

Automated summary

Nanoscale metal-organic polymers (MOPs) based on corrole have shown great potential in photodynamic therapy (PDT) and photothermal therapy (PTT). In this study, a unique corrole-based MOP (PFCC-Hf) was successfully synthesized using a simple solvothermal method. The PFCC-Hf demonstrated superior synergistic PDT and PTT efficacies compared to traditional PDT treatment, with a high apoptosis rate of A375 cells in vitro. This work highlights the potential of corrole-based MOPs for efficient phototherapy treatments.