Hematopoietic cell transplantation and cellular therapies in Switzerland. Evolution over 25 years. A report from the stem cell transplantation and cellular therapies working groups of the SBST 1997-2021

Article Immunology

Successful Induction of Specific Immunological Tolerance by Combined Kidney and Hematopoietic Stem Cell Transplantation in HLA-Identical Siblings

Thomas Fehr et al.

Summary: This study reports the first European clinical trial on kidney transplantation aiming to induce immunological tolerance through mixed lymphohematopoietic chimerism. The results demonstrate that combined kidney and hematopoietic stem cell transplantation from an HLA-matched sibling is a feasible and successful approach, while maintaining immune responsiveness to mRNA vaccines.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Cell Biology

Dynamics of T cell repertoire renewal following autologous hematopoietic stem cell transplantation in multiple sclerosis

Josefine Ruder et al.

Summary: Autologous hematopoietic stem cell transplantation (aHSCT) is a highly effective treatment for multiple sclerosis (MS), renewing adaptive immune cells. The dynamics of T cells after aHSCT were examined in this study. The results showed that naive T cells were barely detectable early after aHSCT, while effect or memory (EM) T cells quickly reconstituted. EM CD4(+) T cells early after aHSCT exhibited shorter telomeres and higher expression of senescence and exhaustion markers. The T cell receptor (TCR) repertoire overlap between early post-aHSCT EM CD4(+) T cells and pre-aHSCT declined over time, indicating the renewal of the T cell repertoire by nascent T cells. The reactivity of HLA-DR-associated EM CD4(+) T cells towards MS-related antigens decreased after aHSCT, while reactivity towards Epstein-Barr virus (EBV) increased.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Article Medicine, General & Internal