4.7 Article

The response time paradox in functional magnetic resonance imaging analyses

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Summary: Magnetic resonance imaging (MRI) has greatly advanced our understanding of the human brain, but similar progress has not been made in mental health research. By analyzing three large neuroimaging datasets, researchers found that brain-wide association studies (BWAS) had smaller effect sizes than previously thought, leading to underpowered studies, inflated effect sizes, and replication failures. As sample sizes increased, replication rates improved and effect size inflation decreased. Functional MRI, cognitive tests, and multivariate methods showed more robust effects in BWAS. Smaller than expected brain-phenotype associations and population subsample variability explain the widespread replication failures in BWAS. Reproducibility in BWAS requires samples with thousands of individuals.

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