What matters in aging is signaling for responsiveness

Biological responsiveness refers to the capacity of living organisms to adapt to changes in both their internal and external environments through physiological and behavioral mechanisms. One of the prominent aspects of aging is the decline in this responsiveness, which can lead to a deterioration in the processes required for maintenance, survival, and growth. The vital link between physiological responsiveness and the essential life processes lies within the signaling systems. To devise effective strategies for controlling the aging process, a comprehensive re-evaluation of this connecting loop is imperative. This review aims to explore the impact of aging on signaling systems responsible for responsiveness and intro-duce a novel perspective on intervening in the aging process by restoring the compromised responsiveness. These innovative mechanistic approaches for modulating altered responsiveness hold the potential to illuminate the development of action plans aimed at controlling the aging process and treating age-related disorders.(c) 2023 Elsevier Inc. All rights reserved.

Automated summary

Biological responsiveness refers to the ability of living organisms to adapt to changes and declines with aging. Understanding the impact of aging on signaling systems and restoring compromised responsiveness can help develop strategies for controlling aging process and treating age-related disorders.