4.6 Article

Increased histone acetylation is the signature of repressed state on the genes transcribed by RNA polymerase III

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Glucose starvation induces a switch in the histone acetylome for activation of gluconeogenic and fat metabolism genes

Wen-Chuan Hsieh et al.

Summary: Acetyl-CoA is a key intermediate that plays a critical role in coordinating gene expression with metabolic state. High levels of acetyl-CoA activate genes involved in cell growth or tumorigenesis through histone acetylation, but the role of histone acetylation under low levels of acetyl-CoA is not well understood. In a yeast starvation model, we observed a significant shift in the global occupancy of histone acetylation following carbon starvation. Histone acetylation marks relocate from growth-promoting genes to genes involved in gluconeogenesis and fat metabolism. This reallocation is mediated by the histone deacetylase Rpd3p and the acetyltransferase Gcn5p.

MOLECULAR CELL (2022)

Article Genetics & Heredity

Structural Features of the Nucleosomal DNA Modulate the Functional Binding of a Transcription Factor and Productive Transcription

Vinesh Vinayachandran et al.

Summary: This study found that the small non-histone protein Nhp6 in budding yeast specifically influences the transcription of the SNR6 gene. The absence of Nhp6 or disruption of the T-7 sequence leads to downstream initiation of transcription. Additionally, the relative rotational orientation of the promoter elements in nucleosomal DNA and Nhp6 regulate the transcription of the SNR6 gene with precision.

FRONTIERS IN GENETICS (2022)

Article Biochemistry & Molecular Biology

Deacetylation of H4 lysine16 affects acetylation of lysine residues in histone H3 and H4 and promotes transcription of constitutive genes

Anagh Ray et al.

Summary: The study highlights the importance of lysine acetylation in maintaining chromatin structure and function, specifically focusing on the role of H4K16 acetylation in regulating the expression of constitutive genes. Deacetylation of H4K16 is associated with hypoacetylation of H4K12 and H3K9, along with hyperacetylation of H3K56, creating a chromatin landscape conducive for transcription of constitutive genes.

EPIGENETICS (2021)

Article Biochemistry & Molecular Biology

Transcription-dependent enrichment of the yeast FACT complex influences nucleosome dynamics on the RNA polymerase III-transcribed genes

Ashutosh Shukla et al.

Summary: The FACT complex plays a role in regulating gene expression by influencing nucleosomal organization and controlling terminator-dependent Pol III transcription. Under different stress conditions, FACT shows differential enrichment patterns and gene-specific dynamics, offering a novel stress-sensing mechanism for transcription regulation.
Review Biochemistry & Molecular Biology

The nuclear and cytoplasmic activities of RNA polymerase III, and an evolving transcriptome for surveillance

Alan C. Kessler et al.

Summary: Pol III, the most complex eukaryotic RNA polymerase, has a unique termination-associated recycling process that enables highly efficient RNA synthesis. In addition to promoter-dependent transcription, Pol III also provides unconventional functions such as RNA synthesis from DNA ends and signaling molecule synthesis.

NUCLEIC ACIDS RESEARCH (2021)

Article Oncology

Histone H3 lysine 27 acetylation profile undergoes two global shifts in undernourished children and suggests altered one-carbon metabolism

Kristyna Kupkova et al.

Summary: This study explores how epigenetic changes in children's DNA can impact their growth and development, leading to stunting. Results show that children at risk of stunting exhibit elevated levels of H3K27ac, related to immune system activation, while overt stunting is associated with reduced H3K27ac levels, indicating metabolic changes and downregulation of immune pathways. The findings suggest that alterations in one-carbon metabolism may play a role in the development of stunting in children.

CLINICAL EPIGENETICS (2021)

Article Multidisciplinary Sciences

Yeast PAF1 complex counters the pol III accumulation and replication stress on the tRNA genes

Pratibha Bhalla et al.

SCIENTIFIC REPORTS (2019)

Review Biochemistry & Molecular Biology

Signaling to and from the RNA Polymerase III Transcription and Processing Machinery

Ian M. Willis et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)

Article Biochemistry & Molecular Biology

High-Resolution Chromatin Dynamics during a Yeast Stress Response

Assaf Weiner et al.

MOLECULAR CELL (2015)

Article Biochemistry & Molecular Biology

The Rpd3 Core Complex Is a Chromatin Stabilization Module

Xiao-Fen Chen et al.

CURRENT BIOLOGY (2012)

Review Microbiology

Nucleosome Positioning in Saccharomyces cerevisiae

An Jansen et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2011)

Article Biochemistry & Molecular Biology

Yeast H2A.Z, FACT complex and RSC regulate transcription of tRNA gene through differential dynamics of flanking nucleosomes

Sahasransu Mahapatra et al.

NUCLEIC ACIDS RESEARCH (2011)

Review Oncology

Cancer biology and NuRD: a multifaceted chromatin remodelling complex

Anne Y. Lai et al.

NATURE REVIEWS CANCER (2011)

Article Biochemistry & Molecular Biology

Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes

Artem Barski et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors

Andrew J. Oler et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Genomic binding profiles of functionally distinct RNA polymerase III transcription complexes in human cells

Zarmik Moqtaderi et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

HAT-HDAC interplay modulates global histone H3K14 acetylation in gene-coding regions during stress

Anna Johnsson et al.

EMBO REPORTS (2009)

Review Genetics & Heredity

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Michael Haberland et al.

NATURE REVIEWS GENETICS (2009)

Article Biochemistry & Molecular Biology

Regulation of RNA polymerase III transcription by Maf1 in mammalian cells

Sarah J. Goodfellow et al.

JOURNAL OF MOLECULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Chromatin structure and expression of a gene transcribed by RNA polymerase III are independent of H2A.Z deposition

Aneeshkumar Gopalakrishnan Arimbasseri et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Review Biotechnology & Applied Microbiology

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

Aleksey G. Kazantsev et al.

NATURE REVIEWS DRUG DISCOVERY (2008)

Review Genetics & Heredity

The expanding RNA polymerase III transcriptome

Giorgio Dieci et al.

TRENDS IN GENETICS (2007)

Article Biochemistry & Molecular Biology

Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms

Helder Ferreira et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Maf1 is involved in coupling carbon metabolism to RNA polymerase III transcription

Malgorzata Ciesla et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases

Sandra S. Johnson et al.

MOLECULAR CELL (2007)

Article Biochemistry & Molecular Biology

Requirement of Nhp6 proteins for transcription of a subset of tRNA genes and heterochromatin barrier function in Saccharomyces cerevisiae

Priscilla Braglia et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Review Biochemistry & Molecular Biology

Chromatin modifications and their function

Tony Kouzarides

Review Biochemistry & Molecular Biology

The role of chromatin during transcription

Bing Li et al.

Article Biochemistry & Molecular Biology

Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions

Chhabi K. Govind et al.

MOLECULAR CELL (2007)

Article Biotechnology & Applied Microbiology

Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug

Paul A. Marks et al.

NATURE BIOTECHNOLOGY (2007)

Review Biochemistry & Molecular Biology

Functions of Site-Specific Histone Acetylation and Deacetylation

Mona D. Shahbazian et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2007)

Article Biochemistry & Molecular Biology

RSC exploits histone acetylation to abrogate the nucleosomal block to RNA polymerase II elongation

Michael Carey et al.

MOLECULAR CELL (2006)

Review Neurosciences

Histone deacetylase inhibitors as therapeutics for polyglutamine disorders

Rachel Butler et al.

NATURE REVIEWS NEUROSCIENCE (2006)

Article Biochemistry & Molecular Biology

Rsc4 connects the chromatin remodeler RSC to RNA polymerases

Julie Soutourina et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Nhp6 is a transcriptional initiation fidelity factor for RNA polymerase III transcription in vitro and in vivo

GA Kassavetis et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

A role for Gcn5-mediated global histone acetylation in transcriptional regulation

RM Imoberdorf et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Multidisciplinary Sciences

Histone H4-K16 acetylation controls chromatin structure and protein interactions

M Shogren-Knaak et al.

SCIENCE (2006)

Review Pharmacology & Pharmacy

Keynote review: Chromation control and cancer-drug discovery: realizing the promise

AG Inche et al.

DRUG DISCOVERY TODAY (2006)

Article Biochemistry & Molecular Biology

A subcomplex of RNA polymerase III subunits involved in transcription termination and reinitiation

E Landrieux et al.

EMBO JOURNAL (2006)

Article Biochemistry & Molecular Biology

Single-nucleosome mapping of histone modifications in S-cerevisiae

CL Liu et al.

PLOS BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Histone H4 HDAC activity is necessary for expression of the PU.1 gene

RN Laribee et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2005)

Article Biochemistry & Molecular Biology

Genome-wide map of nucleosorne acetylation and methylation in yeast

DK Pokholok et al.

Review Biochemistry & Molecular Biology

Hyperacetylated chromatin domains: Lessons from heterochromatin

M Bulger

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes

AJ Bannister et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Mapping global histone acetylation patterns to gene expression

SK Kurdistani et al.

Review Biochemistry & Molecular Biology

Transcriptional elongation by RNA polymerase II and histone methylation

M Gerber et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Tip60 is a co-repressor for STAT3

H Xiao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcription

R Upadhya et al.

MOLECULAR CELL (2002)

Article Multidisciplinary Sciences

Requirement of Hos2 histone deacetylase for gene activity in yeast

A Wang et al.

SCIENCE (2002)

Review Cell Biology

Recruitment of RNA polymerase III to its target promoters

L Schramm et al.

GENES & DEVELOPMENT (2002)

Article Biochemistry & Molecular Biology

Role of the Ada2 and Ada3 transcriptional coactivators in histone acetylation

R Balasubramanian et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Immunology

Loss of PU.1 expression following inhibition of histone deacetylases

RN Laribee et al.

JOURNAL OF IMMUNOLOGY (2001)

Article Biochemistry & Molecular Biology

Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiae

K Pluta et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN

T Formosa et al.

EMBO JOURNAL (2001)

Review Biochemistry & Molecular Biology

The RNA polymerase III transcription apparatus

EP Geiduschek et al.

JOURNAL OF MOLECULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

High-mobility-group proteins NHP6A and NHP6B participate in activation of the RNA polymerase IIISNR6 gene

S Lopez et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

Nhp6, an HMG1 protein, functions in SNR6 transcription by RNA polymerase III in S-cerevisiae

M Kruppa et al.

MOLECULAR CELL (2001)

Article Multidisciplinary Sciences

Genomewide studies of histone deacetylase function in yeast

BE Bernstein et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Multidisciplinary Sciences

Global histone acetylation and deacetylation in yeast

M Vogelauer et al.

NATURE (2000)

Article Biochemistry & Molecular Biology

Inhibition of TATA-binding protein function by SAGA subunits Spt3 and Spt8 at Gcn4-activated promoters

R Belotserkovskaya et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)