期刊
MATERIALS TODAY ADVANCES
卷 20, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.mtadv.2023.100437
关键词
Mycoplasma infection; Sandwich-DNA hybridization; Plasmonic nano-amplifier; Early diagnosis; Electrochemical biosensor
Mycoplasma contamination in cell/tissue cultures can significantly affect cell characteristics and drug reactions without obvious changes in morphology or growth rates. A newly developed electrochemical screening system offers rapid, accurate, and convenient detection of Mycoplasma at low concentrations.
Mycoplasma contamination in cell/tissue cultures significantly affects cell characteristics, susceptibility to infectious pathogens, and drug reactions without obvious morphological changes and noticeable changes in cell growth rates. Although the technology for screening mycoplasma is essential, conventional technologies have limitations in the selection of a quick and easy manner. Here, we introduce an innovative screening system for mycoplasma based on electrochemical methods. In the electrochemical screening, a newly designed electrode, consisting of a sandwich-DNA hybridization for high selectivity and a nano-amplifier to improve the sensitivity, has implemented a realistic screening system by presenting detection capability at extremely low (ng/mu L) levels and detection potential in real samples. Therefore, this system offers rapid screening, data accuracy, temporal effectiveness, and affordable-and-portable installation, enabling timely elimination of Mycoplasma contamination and facilitating progress in biomedical and pharmaceutical research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据