☆ 4.7 Review

Marine polysaccharides, proteins, lipids, and silica for drug delivery systems: A review

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Chemistry, Multidisciplinary

Preparation, Characterization, and Environmental Safety Assessment of Dithiocarbazate Loaded Mesoporous Silica Nanoparticles

Thacilla Menezes et al.

Summary: The main goal of this study was to design and evaluate the success of loading 3-methyl-5-phenyl-pyrazoline-1-(S-benzyldithiocarbazate) (DTC) into mesoporous silica nanoparticles (MSiNPs) by measuring its physicochemical properties and assessing the environmental safety of the new formulation using different aquatic organisms. The results showed that DTC, MSiNP, and MSiNP-DTC had low toxicity against aquatic organisms, but loading DTC slightly increased toxicity. Therefore, it is crucial to assess the impact of MSiNPs on the safety of the new formulation.

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Article Pharmacology & Pharmacy

Evaluating the Skin Interactions and Permeation of Alginate/Fucoidan Hydrogels Per Se and Associated with Different Essential Oils

Ana Isabel Barbosa et al.

Summary: In this study, menthol, L-linalool, bergamot oil, and beta-pinene were incorporated in alginate/fucoidan hydrogels to evaluate their skin permeation enhancement profile and assess their influence on the skin organization. The study highlights the effect of the composition in the design of formulations for topical or transdermal delivery systems.

PHARMACEUTICS (2023)

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Article Biochemistry & Molecular Biology

Reconstructed membrane vesicles from the microalga Dunaliella as a potential drug delivery system

Maja Levak Zorinc et al.

Summary: The aim of this study was to characterize reconstructed membrane vesicles obtained from microalgae in terms of their morphology, properties, composition, and ability to transport a model drug. The reconstructed vesicles had a non-uniform distribution of spherical surface structures that could be associated with surface coat proteins, as well as pore-like structures that could contribute to permeability. The vesicles were soft, hydrophilic, rich in proteins, and derived from the cytoplasm and chloroplasts. They were found to be permeable to calcein, impermeable to FITC-ovalbumin, and semipermeable to FITC-concanavalin A, suggesting potential as drug carriers.

BIOELECTROCHEMISTRY (2023)

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Article Environmental Sciences

Regenerative marine waste towards CaCO3 nanoformulation for Alzheimer?s therapy

Prakashkumar Nallasamy et al.

Summary: Alzheimer's disorder (AD) is a neurodegenerative disease with limited therapeutic options. In this study, a neuroprotective CaCO3 nanoformulation (CA@CaCO3 NFs) was developed by encapsulating the drug citronellyl acetate within CaCO3 nanoparticles. The CA@CaCO3 NFs showed enhanced antioxidant and AChE inhibitory activities, as well as the ability to attenuate and disaggregate beta-amyloid peptide (Aβ) plaques, a major risk factor for AD. Overall, this study suggests that CaCO3 nanoformulations have promising potential as a drug delivery system for the treatment of neurodegenerative and CNS-related disorders.

ENVIRONMENTAL RESEARCH (2023)

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Article Chemistry, Applied

Nanoencapsulation enhances the bioavailability of fucoxanthin in microalga Phaeodactylum tricornutum extract

Song Yi Koo et al.

Summary: Nanoencapsulation significantly improves the bioavailability of fucoxanthin in microalgae. Both types of nanoparticles show controlled release of fucoxanthin and enhance its permeability and absorption in cells and plasma.

FOOD CHEMISTRY (2023)

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Article Nanoscience & Nanotechnology

High-Performance Smart Hydrogels with Redox-Responsive Properties Inspired by Scallop Byssus

Pingping Xu et al.

Summary: A novel protein, Sbp9, derived from scallop byssus, has been found to form a smart hydrogel with desirable properties in the biomedical field. The hydrogel showed tunable gelation time, mechanical properties, nonswelling abilities, and good biocompatibility, making it suitable for applications in tissue engineering and drug release.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

iRGD Tumor-Penetrating Peptide-Modified Nano-Delivery System Based on a Marine Sulfated Polysaccharide for Enhanced Anti-Tumor Efficiency Against Breast Cancer

Bowei Chen et al.

Summary: A novel nano-delivery system based on a marine sulfated polysaccharide was developed, which effectively enhanced tumor targeting and cellular internalization of JQ1 and ORI. The combination of JQ1 and ORI showed synergistic antitumor activities against breast cancer.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Pharmacology & Pharmacy

Envisaging marine diatom Thalassiosira weissflogii as a SMART drug delivery system for insoluble drugs

Abhishek Saxena et al.

Summary: This study utilized naturally occurring diatoms frustules as a drug delivery system and successfully loaded curcumin onto the frustules. The research found that drug release was faster in physiological conditions compared to acidic conditions, and the frustules had good adsorption capacity. Experimental results further characterized the frustules' properties and drug release mechanism. The curcumin-loaded frustules were non-toxic to normal cells but showed toxicity against cancer cells, and exhibited broad-spectrum antibacterial activity. These findings demonstrate that diatoms can be a promising tool for drug delivery applications.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Microneedle Array Patch Made of Kangfuxin/Chitosan/Fucoidan Complex Enables Full-Thickness Wound Healing

Xixi Yu et al.

Summary: The use of a multifunctional microneedle array patch made from a blend of kangfuxin, chitosan, and fucoidan has shown great potential for accelerating full-thickness wound healing. This patch is not only antibacterial and cytocompatible, but also significantly improves epithelial thickness and collagen deposition, promoting wound healing in rats. With its versatile properties, this patch holds promise as a dressing for full-thickness wound healing.

FRONTIERS IN CHEMISTRY (2022)

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Article Pharmacology & Pharmacy

NGIWY-Amide: A Bioinspired Ultrashort Self-Assembled Peptide Gelator for Local Drug Delivery Applications

Nikoleta F. Theodoroula et al.

Summary: The NGIWY-amide pentapeptide derived from sea cucumber can self-assemble into a stiff hydrogel with a high content of beta-sheet structures, forming filamentous fibers with a helical-twisted morphology. It serves as a versatile vector for delivering hydrophobic and hydrophilic compounds of different molecular weights. In addition, the peptide demonstrates cytocompatibility and potential applications in cell growth, drug delivery, and 3D bioprinting tissue engineering.

PHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Enhanced Anticancer Activity of Nedaplatin Loaded onto Copper Nanoparticles Synthesized Using Red Algae

Nada Mostafa Aboeita et al.

Summary: This study optimized the ultrasound-assisted extraction technique to extract a highly antioxidant extract from red algae. The extract was then used for the synthesis of copper nanoparticles, which were loaded with nedaplatin to enhance its anticancer effect.

PHARMACEUTICS (2022)

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Review Multidisciplinary Sciences

Liposome-polymer complex for drug delivery system and vaccine stabilization

Sriwidodo et al.

Summary: Liposome complexes, formed through complexation with polymers, can enhance stability and enable targeted delivery and controlled release. The properties of the complex are influenced by the type of polymer, crosslinker, interaction, and bond involved.

HELIYON (2022)

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Article Materials Science, Ceramics

Preparation and characterization of pure natural hydroxyapatite derived from seashells for controlled drug delivery

Serap Ayaz Seyhan et al.

Summary: In this study, a poly (vinyl alcohol) containing Rifampicin-loaded Orange Spiny Oyster Seashell hydroxyapatite composite was synthesized using an in situ ultrasound-assisted method. The samples were analyzed using various techniques and the drug release behavior was evaluated. The results showed sustained drug release from the composite material in vitro.

JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY (2022)

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Review Pharmacology & Pharmacy

Different Methods and Formulations of Drugs and Vaccines for Nasal Administration

Junhu Tai et al.

Summary: Nasal drug delivery has advantages over other routes, but also has limitations. This review provides an overview of nasal anatomy and mucosal environment, explores methods to enhance absorption and improve delivery, and discusses future prospects.

PHARMACEUTICS (2022)

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Article Biochemistry & Molecular Biology

Antiherpetic Activity of Carrageenan Complex with Echinochrome A and Its Liposomal Form

Natalia V. V. Krylova et al.

Summary: This study investigated the antiherpetic activity of complexes of kappa- and sigma-carrageenans with echinochrome A, as well as their liposomal forms, showing promising results in inhibiting HSV-1 infection. The liposomal form of the sigma-CRG/Ech complex demonstrated three times higher virus-inhibiting activity compared to the complex itself, indicating potential for the development of effective antiherpetic drugs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Pharmaceutical Development of Nanostructured Vesicular Hydrogel Formulations of Rifampicin for Wound Healing

Chantal M. Wallenwein et al.

Summary: Two nanostructured hydrogel formulations of rifampicin were developed to address the treatment of chronic wounds. A freeze-drying method was used to protect rifampicin from degradation, and it was found that one formulation had an increase in vesicle size. The HPMC hydrogel formulation remained stable over 6 months of storage.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Fabrication of ulvan-based ionically cross-linked 3D-biocomposite: synthesis and characterization

Tejal K. Gajaria et al.

Nanotechnology for Environmental Engineering (2022)

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Article Biochemistry & Molecular Biology

Crab (Charybdis natator) exoskeleton derived chitosan nanoparticles for the in vivo delivery of poorly water-soluble drug: Ibuprofen

Akshad Balde et al.

Summary: This study aims to extract chitosan from crab exoskeleton and develop ibuprofen encapsulated chitosan nanoparticles. It demonstrates the potential and efficacy of the chitosan-based nano-carrier system in drug delivery through in vitro and in vivo experiments.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Chitosan-CaP microflowers and metronidazole loaded calcium alginate sponges with enhanced antibacterial, hemostatic and osteogenic properties for the prevention of dry socket after tooth removal

Mingzhe Yan et al.

Summary: In this study, bio-multifunctional sponge materials with antibacterial, hemostatic, and osteogenic properties were developed for the prevention of dry sockets after tooth removal. The sponge showed excellent antimicrobial effects, promoted cellular osteogenesis, and demonstrated potential for wound management.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Engineering, Biomedical

Fucoidan-based hydrogels particles as versatile carriers for diabetes treatment strategies

Lara L. Reys et al.

Summary: There is a lack of efficient therapies for diabetes mellitus. This study developed a versatile carrier using fucoidan (Fu) to control insulin release and support the viability of pancreatic beta cells.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2022)

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Article Chemistry, Multidisciplinary

Characterization and in vitro release kinetics of chitosan based biocomposites from Scotch Bonnets

Dilek Bilgic Alkaya et al.

JOURNAL OF THE INDIAN CHEMICAL SOCIETY (2022)

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Review Biology

Microalgae-Based Biorefineries: Challenges and Future Trends to Produce Carbohydrate Enriched Biomass, High-Added Value Products and Bioactive Compounds

Eugenia J. Olguin et al.

Summary: This review discusses the challenges and future trends of microalgae-based biorefineries, emphasizing the multi-product approach and the use of wastewater to improve cost-effectiveness. It also explores the therapeutic properties of microalgae-bioactive compounds and the application of circular economy strategies.

BIOLOGY-BASEL (2022)

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Review Pharmacology & Pharmacy

An Extensive Review on Hydrogels in Pharmaceutical Drug Delivery Applications

Subashini Rajaram et al.

Summary: In recent years, pharmaceutical companies have been focusing on designing new pharmaceutical dosage forms. Hydrogels, with their distinct characteristics and structures, have shown great potential in the fields of medicine, therapy, and diagnosis. Due to their resemblance to biological tissue, hydrogels can be used as drug delivery vehicles and have a wide range of applications in various medical fields.

INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION (2022)

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Article Biochemistry & Molecular Biology

Multifunctional nanoparticles based on marine polysaccharides for apremilast delivery to inflammatory macrophages: Preparation, targeting ability, and uptake mechanism*

Samah Shabana et al.

Summary: This study reports on the development of functionalized nanoparticles with enhanced accumulation at inflamed sites, reduced toxicity to healthy tissue, and improved pharmacokinetics. These nanoparticles have a controlled release, targeting abilities, and in-situ imaging properties, making them suitable for oral drug delivery to treat inflammatory bowel disease.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Review Chemistry, Multidisciplinary

An update on dual targeting strategy for cancer treatment

Yasamin Davatgaran Taghipour et al.

Summary: The lack of efficient strategies for targeted delivery and accumulation of therapeutic cargoes in the tumor microenvironment (TME) is a key issue in the treatment of solid tumors. This review focuses on dual targeting approaches, which combine biological strategies and physicochemical responsive smart delivery strategies, to increase the accumulation of nanoparticles within the TME and improve targeting efficiency towards cancer cells. The efficiency and rationale behind the choice of ligands for dual targeting strategies are critically reviewed. New approaches for smart drug delivery, including TME-specific responsive linkers and camouflaged nanoparticles, are also discussed.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Biochemistry & Molecular Biology

Assessment of Binary Agarose-Carbopol Buccal Gels for Mucoadhesive Drug Delivery: Ex Vivo and In Vivo Characterization

Muhammad Ali Syed et al.

Summary: This study evaluates the mucoadhesive potential of AG binary dispersions with Carbopol 934P as gel preparations. The results show that the mucoadhesive properties of AG are concentration dependent and can be improved by the addition of CP. The optimized formulation (F9) exhibits the highest mucoadhesive strength and swelling index.

MOLECULES (2022)

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Article Polymer Science

Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release

Veronika Mikusova et al.

Summary: Polysaccharides are attractive gelling agents in pharmacy due to their safety, biocompatibility, biodegradability, relatively easy way of preparation, and low price. They have potential to be used for designing new drug delivery systems for controlled drug release. In this study, rheological and texture properties as well as the in vitro release of model drug ibuprofen (IBU) with 11 polysaccharide-based hydrogels were investigated. The in vitro release of IBU significantly differed between different types of hydrogels due to the different interactions and viscosity within the groups.

GELS (2022)

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Article Biochemistry & Molecular Biology

Development and Optimization of Chitosan Nanoparticle-Based Intranasal Vaccine Carrier

Xiaoyi Gao et al.

Summary: This study modified chitosan nanoparticles with mannose and applied them to intranasal vaccine delivery. The results showed that mannose-modified chitosan nanoparticles enhanced antigen absorption and improved the immune response in mice. This research provides a promising method for further study of chitosan nanoparticle modification.

MOLECULES (2022)

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Review Biochemical Research Methods

Smart Nanocarriers for the Delivery of Nucleic Acid-Based Therapeutics: A Comprehensive Review

Thiruganesh Ramasamy et al.

Summary: Nucleic acid-based therapies hold promise for treating systemic disorders, but face challenges such as rapid degradation and poor cellular uptake. Utilizing advanced smart nanocarriers can help overcome these barriers and improve the clinical effectiveness of nucleic acid-based therapies.

BIOTECHNOLOGY JOURNAL (2021)

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Article Engineering, Environmental

Sponge-derived natural bioactive glass microspheres with self-assembled surface channel arrays opening into a hollow core for bone tissue and controlled drug release applications

Murat Kaya et al.

Summary: Naturally-assembled porous bioactive silica microspheres with open channels and hollow structures were discovered in this study. These spheres exhibited bioactivity, non-cytotoxicity, osteogenic ability, as well as excellent drug release capabilities. They show promising potential for applications in bone tissue engineering and drug delivery.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Inorganic & Nuclear

Facile Synthesis and Characterization of Quercetin-Loaded Alginate Nanoparticles for Enhanced In Vitro Anticancer Effect Against Human Leukemic Cancer U937 Cells

Sureshkumar Selvaraj et al.

Summary: This study aimed to synthesize alginate nanoparticles for the delivery of the bioactive compound quercetin, showing good drug entrapment efficiency and sustained release kinetics. The nanoparticles demonstrated antioxidant activity and enhanced anticancer efficacy on leukemia cells, making this a promising application for drug encapsulation in nanomedicine.

JOURNAL OF CLUSTER SCIENCE (2021)

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Article Pharmacology & Pharmacy

Lipids from algal biomass provide new (nonlamellar) nanovectors with high carrier potentiality for natural antioxidants

Ilaria Clemente et al.

Summary: This study examines new nanosystems built with lipids extracted from the marine microalga Nannochloropsis sp and their use as carriers for lipophilic antioxidants. Results show that cargo molecules play an active role in driving the interactions which characterize the overall structure of the aggregates.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

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Article Biochemistry & Molecular Biology

Development of delivery system based on marine chitosan: Encapsulation and release kinetic study of antioxidant peptides from chitosan microparticle

Rim Nasri et al.

Summary: This study aimed to encapsulate goby fish protein hydrolysate with antioxidant activity into microparticles using ionic gelation process. The loaded microparticles showed improved encapsulation efficiency and reduced particle size with increasing GPH concentration. Additionally, the encapsulated biopeptides exhibited enhanced thermal stability and followed a diffusion-controlled mechanism for release kinetics, leading to improved antioxidant activity compared to unloaded microparticles.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biotechnology & Applied Microbiology

Polyhydroxyalkanoate nanoparticles produced by marine bacteria cultivated on cost effective Mediterranean algal hydrolysate media

Fady Abd El-malek et al.

Summary: This study utilized different algae species as substrates for high-efficiency PHA production by Halomonas sp. By using Corallina mediterranea hydrolysates, isolates capable of producing high percentages of PHA were identified. The PHB nanoparticles exhibited promising drug delivery and antibacterial properties, presenting new applications in pharmaceutical fields.

JOURNAL OF BIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Ultrashort Peptide Bioinks Support Automated Printing of Large-Scale Constructs Assuring Long-Term Survival of Printed Tissue Constructs

Hepi H. Susapto et al.

Summary: By utilizing rationally designed ultrashort peptide bioinks, this study overcomes limitations in current bioprinting procedures and demonstrates the potential for automated complex tissue fabrication with stable large-scale constructs and long-term cell survival.

NANO LETTERS (2021)

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Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Food Science & Technology

Recent developments in valorisation of bioactive ingredients in discard/seafood processing by-products

Fatih Ozogul et al.

Summary: Seafood processing waste and by-products are rich in bioactive compounds with potential applications across various industries. Current research focuses on nutritional and functional properties, with future studies needed on bioavailability, yield, extraction methods, legislation, and safety issues.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2021)

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Article Materials Science, Biomaterials

In Vitro and in Vivo Analyses of the Effects of Source, Length, and Charge on the Cytotoxicity and Immunocompatibility of Cellulose Nanocrystals

Adam M. Weiss et al.

Summary: Cellulose nanocrystals (CNCs) are a sustainable nanomaterial that has been widely used in biomedical research. This study focused on exploring the effects of different sources, lengths, and charges of CNCs on cytotoxicity and immune response. The experiments showed that charged CNCs with specific surface functionalizations were biologically inert, supporting their potential use in future biological studies.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Review Chemistry, Physical

Polymer-Based Nanosystems-A Versatile Delivery Approach

Adelina-Gabriela Niculescu et al.

Summary: Polymer-based nanoparticles customized for size, morphology, and surface properties are gaining attention for drug, biomolecule, and gene delivery. They protect payloads from degradation and sustain controlled drug release, reducing clearance and increasing stability, solubility, and optimal concentration at target sites, especially in vaccine development.

MATERIALS (2021)

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Review Pharmacology & Pharmacy

An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers

Yining Xu et al.

Summary: This article reviews the importance of oral administration in drug delivery, discusses different preclinical models along with their advantages and disadvantages, as well as how to address the limitations of the models. The article emphasizes the increasing demand for sophisticated preclinical models with higher predictive capacity for orally delivered drugs.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Pharmacology & Pharmacy

A Review on Drug Delivery System for Tumor Therapy

Guoxiang Liu et al.

Summary: In recent years, the development of nanomaterials has led to a new field of cancer therapy focusing on drug delivery systems. These systems, such as drug nanoparticles, offer advantages like easy preparation, high efficiency, low toxicity, and active tumor targeting. Research in this area provides a theoretical basis for the future clinical application of personalized cancer nanomedicine.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Pharmacology & Pharmacy

Hydroxyapatite Nanoparticles in Drug Delivery: Physicochemistry and Applications

Sofia Lara-Ochoa et al.

Summary: Hydroxyapatite is the gold standard in the biomedical field due to its composition and similarity to human bone, with properties that can be tailored through different synthesis techniques and compounds. However, the correlation with biological response is still uncertain, necessitating a focus on the most desirable properties for an appropriate biological response.

PHARMACEUTICS (2021)

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Article Engineering, Chemical

Marine Biopolymers: Applications in Food Packaging

Niaz Mahmud et al.

Summary: Marine sources are increasingly being recognized for their potential in producing biopolymers with biocompatibility, biodegradability, and non-toxicity features, which can benefit the development of eco-friendly food packaging materials. Studies have explored the extraction, isolation, and potential applications of marine biopolymers in sustainable packaging solutions, presenting promising opportunities for reducing the use of traditional plastic packaging and achieving significant environmental and economic advantages.

PROCESSES (2021)

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Article Chemistry, Physical

A facile one-pot synthesis of microgels and nanogels of laminarin for biomedical applications

Mehmet Can et al.

Summary: Laminarin (LAM), a marine polysaccharide with various bioactivities, shows great potential in biomedical applications. A facile method was developed to prepare poly(laminarin) (p(LAM)) particles, which exhibited excellent blood compatibility and chemical modifiability. The synthesized p(LAM) particles hold promise as natural alternative surrogates in drug delivery and other biomedical applications.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Review Biochemistry & Molecular Biology

Seaweed Polysaccharide Based Products and Materials: An Assessment on Their Production from a Sustainability Point of View

Nishith A. Chudasama et al.

Summary: Polysaccharides are one of the oldest biopolymers on Earth and play a crucial role in the survival of animals and plants. Among polysaccharides, seaweed polysaccharides are preferred in many applications due to their distinct properties, and chemical modification can impart new functionalities. Sustainable extraction of seaweed polysaccharides using ionic solvent systems and the potential for efficient extraction and functionalization are discussed in this review.

MOLECULES (2021)

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Article Multidisciplinary Sciences

Peptide-based scaffolds for the culture and maintenance of primary human hepatocytes

Douglas MacPherson et al.

Summary: A nanofibrous hydrogel was developed as a 3D scaffold for culturing and maintaining primary human hepatocytes, showing superior performance to Matrigel in cytochrome P450 functional assays. This biomimetic microenvironment may provide insights for future implantable scaffolds for liver tissue regeneration in patients with liver disease.

SCIENTIFIC REPORTS (2021)

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Review Engineering, Biomedical

The evolution of commercial drug delivery technologies

Ava M. Vargason et al.

Summary: This review article discusses how challenges in delivering small molecules, nucleic acids, peptides, proteins, and cells have led to the development of commercial products and are now guiding the delivery of live-cell therapeutics. Drug delivery technologies have enabled the development of pharmaceutical products that enhance therapeutic delivery, minimize off-target effects, and improve patient compliance. Three drug delivery paradigms have been developed to aid in the successful delivery of small molecules and macromolecules, contributing to the initial clinical success of each therapeutic class.

NATURE BIOMEDICAL ENGINEERING (2021)

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Article Cell Biology

Nanoalgosomes: Introducing extracellular vesicles produced by microalgae

Giorgia Adamo et al.

Summary: The study of extracellular vesicles (EVs) for cellular, inter-organismal and cross kingdom communication has high expectations for various bio-technological applications. Microalgae are sustainable and renewable sources of bioactive compounds with sectoral applications in health supplements, cosmetic products, and food ingredients. The newly discovered subtype of EVs derived from microalgae, nanoalgosomes, has shown potential for efficient uptake by mammalian cell lines, demonstrating the cross kingdom communication capabilities of EVs.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Review Pharmacology & Pharmacy

Methotrexate Toxicity: Molecular Mechanisms and Management

Riyadh S. Almalki et al.

Summary: Methotrexate is commonly used in cancer chemotherapy and rheumatic disorders treatment, with major side effects being pulmonary and hepatotoxicity. Other toxicities are relatively rare but should still be managed carefully.

JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL (2021)

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Review Pharmacology & Pharmacy

Liposome composition in drug delivery design, synthesis, characterization, and clinical application

Danielle E. Large et al.

Summary: Liposomal drug delivery is a highly adaptable therapeutic platform for treating a wide range of diseases. The molecular diversity in liposome composition enables drug delivery with unique physiological functions, such as pH response and reduced systemic toxicity.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Medicine, Research & Experimental

Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities

Marta Guedes et al.

Summary: The study utilized sardine roe as a lipidic source to develop liposomes, showing potential as therapeutically active delivery devices with antioxidative and anti-inflammatory effects. These fishroesomes were non-toxic to certain cells, making them unique bioactive drug carriers for treating inflammatory diseases.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Polymer Science

Synthetic Biopolymers and Their Composites: Advantages and Limitations-An Overview

Asanda Mtibe et al.

Summary: In recent years, there has been a shift towards developing environmentally friendly polymers to reduce the impact of plastic leakage on ecosystems. Biopolymers have the potential to alleviate plastic pollution, but their utilization is influenced by various factors. This review discusses the potential and limitations of synthetic biopolymers and their composites in the context of environmentally friendly materials for a sustainable future.

MACROMOLECULAR RAPID COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

Preparation of magnetic methotrexate nanocarrier coated with extracted hydroxyapatite of sea urchin (Echinometra mathaei)

Ali Rajabiyan et al.

Summary: The study introduced a new polymer-coated magnetic nanocarrier using iron oxide nanoparticles and nanohydroxyapatite extracted from Sea urchin for Methotrexate delivery. The nanoparticles were successfully prepared through co-precipitation and hydrothermal methods with stabilization and optimization. The magnetic nanocarrier demonstrated good potential for guiding Methotrexate drug therapy in cancer chemotherapy.

MAIN GROUP CHEMISTRY (2021)

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Article Materials Science, Biomaterials

Fabrication of carbon and silver nanomaterials incorporated hydroxyapatite nanocomposites: Enhanced biological and mechanical performances for biomedical applications

Satheesh Kumar Balu et al.

Summary: Hydroxyapatite is widely used in biomedical applications due to its excellent biocompatibility and bioactivity. In this study, HAp nanocomposites derived from cuttlefish bones were fabricated by incorporating carbon nanomaterials and silver nanoparticles. The addition of carbon nanomaterials improved the physicochemical properties of the nanocomposites and showed better biocompatibility and mechanical properties.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Chemistry, Multidisciplinary

Protein-Based Nanohydrogels for Bioactive Delivery

Subhash Chander et al.

Summary: Hydrogels are polymer materials with a unique network structure capable of absorbing water and biological fluids. Nanohydrogels, composed of diverse synthetic or natural polymers, possess high biocompatibility and metabolic degradability. Protein nanohydrogels, with various preparation methods and broad applications in medicine, offer potential in diverse disciplines.

FRONTIERS IN CHEMISTRY (2021)

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Review Food Science & Technology

Bioactive Compounds of Nutraceutical Value from Fishery and Aquaculture Discards

Mirko Mutalipassi et al.

Summary: Seafood by-products, often discarded as wastes, can actually provide bioactive molecules with potential applications in functional foods and biotechnology. These by-products not only hold untapped protein sources but also supply valuable compounds that can be used in the production of high-value nutraceuticals, contributing to a more sustainable circular economy.

FOODS (2021)

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Article Biochemistry & Molecular Biology

Falkenbergia rufolanosa polysaccharide - Poly(vinyl alcohol) composite films: A promising wound healing agent against dermal laser burns in rats

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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ENVIRONMENTAL CHEMISTRY LETTERS (2020)

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Preparation of Calcipotriol Emulsion Using Bacterial Exopolysaccharides as Emulsifier for Percutaneous Treatment of Psoriasis Vulgaris

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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2020)

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Preparation and optimization of chitosan nanoparticles from discarded squilla (Carinosquilla multicarinata) shells for the delivery of anti-inflammatory drug: Diclofenac

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Novel Biodegradable Laminarin Microparticles for Biomedical Applications

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Conception and characterization of a multi-sensitive composite chitosan-red marine alga-polysaccharide hydrogels for insulin controlled-release

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Sardine Roe as a Source of Lipids To Produce Liposomes

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Responsive laminarin-boronic acid self-healing hydrogels for biomedical applications

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Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies

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Engineering Smart Targeting Nanovesicles and Their Combination with Hydrogels for Controlled Drug Delivery

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Antisolvent precipitative immobilization of micro and nanostructured griseofulvin on laboratory cultured diatom frustules for enhanced aqueous dissolution

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Therapeutic Effect of Calcipotriol Pickering Nanoemulsions Prepared by Exopolysaccharides Produced by Bacillus halotolerans FYS Strain on Psoriasis

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Fishery Wastes as a Yet Undiscovered Treasure from the Sea: Biomolecules Sources, Extraction Methods and Valorization

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Progress in Modern Marine Biomaterials Research

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Design and Characterization of Sodium Alginate and Poly(vinyl) Alcohol Hydrogels for Enhanced Skin Delivery of Quercetin

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Ultrashort Cell-Penetrating Peptides for Enhanced Sonophoresis-Mediated Transdermal Transport

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Development of methotrexate loaded fucoidan/chitosan nanoparticles with anti-inflammatory potential and enhanced skin permeation

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Preparation and Evaluation of Release Formulation of γ-Oryzanol/Algae Oil Self-Emulsified with Alginate Beads

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Hydrogels and Their Applications in Targeted Drug Delivery

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MOLECULES (2019)

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Application of a cyanobacterial extracellular polymeric substance in the microencapsulation of vitamin B12

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POWDER TECHNOLOGY (2019)

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Natural biodegradable polymers based nano-formulations for drug delivery: A review

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Design of Astaxanthin-Loaded Core-Shell Nanoparticles Consisting of Chitosan Oligosaccharides and Poly(lactic-co-glycolic acid): Enhancement of Water Solubility, Stability, and Bioavailability

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Marine Spongia collagens: Protein characterization and evaluation of hydrogel films

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Nanogels Derived from Fish Gelatin: Application to Drug Delivery System

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MARINE DRUGS (2019)

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Dual-layered pH-sensitive alginate/chitosan/kappa-carrageenan microbeads for colon-targeted release of 5-fluorouracil

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Epirubicin-loaded marine carrageenan oligosaccharide capped gold nanoparticle system for pH-triggered anticancer drug release

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RESEARCH SYNTHESIS METHODS (2019)

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A pH-sensitive nanotherapeutic system based on a marine sulfated polysaccharide for the treatment of metastatic breast cancer through combining chemotherapy and COX-2 inhibition

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In-situ synthesis of acylated sodium alginate-g-(tetrahydrofuran5-b-polyisobutylene) terpolymer/Ag-NPs nanocomposites

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Ulvan, a bioactive marine sulphated polysaccharide as a key constituent of hybrid biomaterials: A review

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Supramolecular Self-Assembly To Control Structural and Biological Properties of Multicomponent Hydrogels

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Protein-Mimicking Functions of Nano-Size Monoamido Amino Acids Derived from Polysaccharides of Marine Origin

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EUROPEAN POLYMER JOURNAL (2019)

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Glycol Chitosan-Docosahexaenoic Acid Liposomes for Drug Delivery: Synergistic Effect of Doxorubicin-Rapamycin in Drug-Resistant Breast Cancer

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Locust bean gum and sodium alginate based interpenetrating polymeric network microbeads encapsulating Capecitabine: Improved pharmacokinetics, cytotoxicity &in vivo antitumor activity

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Physical stimuli-responsive vesicles in drug delivery: Beyond liposomes and polymersomes

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Graphene oxide enhanced polyacrylamide-alginate aerogels catalysts

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Microcarriers Based on Glycosaminoglycan-Like Marine Exopolysaccharide for TGF-β1 Long-Term Protection

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Isorhamnetin encapsulation into biogenic silica from Cyclotella sp. using a microfluidic device for drug delivery applications

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Preparation of aroma microcapsules with sodium alginate and tetradecylallyldimethylammonium bromide (TADAB) and its potential applications in cosmetics

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POLYMERS FOR ADVANCED TECHNOLOGIES (2018)

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Biotemplated Synthesis and Characterization of Mesoporous Nitric Oxide-Releasing Diatomaceous Earth Silica Particles

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Encapsulation, protection, and delivery of bioactive proteins and peptides using nanoparticle and microparticle systems: A review

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Thermoresponsive behavior of sodium alginate grafted with poly(N-isopropylacrylamide) in aqueous media

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Marine sulfated polysaccharides as versatile polyelectrolytes for the development of drug delivery nanoplatforms: Complexation of ulvan with lysozyme

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Modified in vitro release of the chronobiotic hormone melatonin from matrix tablets based on the marine sulfated polysaccharide ulvan

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A Hydrogel-Film Casting to Fabricate Platelet-Reinforced Polymer Composite Films Exhibiting Superior Mechanical Properties

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Porous Inorganic Carriers Based on Silica, Calcium Carbonate and Calcium Phosphate for Controlled/Modulated Drug Delivery: Fresh Outlook and Future Perspectives

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PHARMACEUTICS (2018)

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Controlled drug delivery vehicles for cancer treatment and their performance

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Tumor Targeting Synergistic Drug Delivery by Self-Assembled Hybrid Nanovesicles to Overcome Drug Resistance

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PHARMACEUTICAL RESEARCH (2017)

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Review Biotechnology & Applied Microbiology

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ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2017)

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

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pH-Controlled drug delivery with hybrid aerogel of chitosan, carboxymethyl cellulose and graphene oxide as the carrier

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

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Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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pH-sensitive polymeric micelles for targeted delivery to inflamed joints

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Smart chemistry-based nanosized drug delivery systems for systemic applications: A comprehensive review

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JOURNAL OF CONTROLLED RELEASE (2017)

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Synthetic biology approaches for the production of plant metabolites in unicellular organisms

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Natural collagenic skeleton of marine sponges in pharmaceutics: Innovative biomaterial for topical drug delivery

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MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Cell-Penetrating Peptides: Design Strategies beyond Primary Structure and Amphipathicity

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MOLECULES (2017)

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Marine Biopolymer-Based Nanomaterials as a Novel Platform for Theranostic Applications

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POLYMER REVIEWS (2017)

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Recent trends in smart and flexible three-dimensional cross-linked polymers: synthesis of chitosan-ZnO nanocomposite hydrogels for insulin drug delivery

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MEDCHEMCOMM (2017)

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Synthesis and characterization of a multi-sensitive polysaccharide hydrogel for drug delivery

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Polymeric Hydrogels as Technology Platform for Drug Delivery Applications

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GELS (2017)

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Hydrogels for Biomedical Applications: Cellulose, Chitosan, and Protein/Peptide Derivatives

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GELS (2017)

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Hyper-cell-permeable micelles as a drug delivery carrier for effective cancer therapy

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BIOMATERIALS (2017)

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Extracellular vesicles for drug delivery

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ADVANCED DRUG DELIVERY REVIEWS (2016)

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Assembly of HE800 exopolysaccharide produced by a deep-sea hydrothermal bacterium into microgels for protein delivery applications

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Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

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JOURNAL OF CONTROLLED RELEASE (2016)

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Review Chemistry, Medicinal

Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications

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MARINE DRUGS (2016)

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Fucoidan Hydrogels Photo-Cross-Linked with Visible Radiation As Matrices for Cell Culture

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Fucoidan Hydrogels Photo-Cross-Linked with Visible Radiation As Matrices for Cell Culture

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ACS BIOMATERIALS SCIENCE & ENGINEERING (2016)

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Review Nanoscience & Nanotechnology

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NATURE REVIEWS MATERIALS (2016)

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Improved stability and biocompatibility of nanostructured silicon drug carrier for intravenous administration

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ACTA BIOMATERIALIA (2015)

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Article Biochemistry & Molecular Biology

Effects of Chitin Whiskers on Physical Properties and Osteoblast Culture of Alginate Based Nanocomposite Hydrogels

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BIOMACROMOLECULES (2015)

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Controlled drug release from pharmaceutical nanocarriers

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CHEMICAL ENGINEERING SCIENCE (2015)

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Formation and characterization of filled hydrogel beads based on calcium alginate: Factors influencing nanoemulsion retention and release

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FOOD HYDROCOLLOIDS (2015)

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Review Chemistry, Medicinal

Marine Structure Derived Calcium Phosphate-Polymer Biocomposites for Local Antibiotic Delivery

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MARINE DRUGS (2015)

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Chitosan and Kappa-Carrageenan Vaginal Acyclovir Formulations for Prevention of Genital Herpes. In Vitro and Ex Vivo Evaluation

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MARINE DRUGS (2015)

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Review Chemistry, Medicinal

The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms

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MARINE DRUGS (2015)

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Principles of nanoparticle design for overcoming biological barriers to drug delivery

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NATURE BIOTECHNOLOGY (2015)

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Chemically Modified Diatoms Biosilica for Bone Cell Growth with Combined Drug-Delivery and Antioxidant Properties

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Fabrication of stimulus-responsive diatom biosilica microcapsules for antibiotic drug delivery

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Article Biotechnology & Applied Microbiology

Biocompatible polyhydroxybutyrate (PHB) production by marine Vibrio azureus BTKB33 under submerged fermentation

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Adsorption of CI Natural Red 4 onto Spongin Skeleton of Marine Demosponge

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MATERIALS (2015)

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Layer-by-layer assembly of liposomal nanoparticles with PEGylated polyelectrolytes enhances systemic delivery of multiple anticancer drugs

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ACTA BIOMATERIALIA (2014)

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Article Chemistry, Applied

Layer-by-layer coated lipid-polymer hybrid nanoparticles designed for use in anticancer drug delivery

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Natural nanoporous silica frustules from marine diatom as a biocarrier for drug delivery

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JOURNAL OF POROUS MATERIALS (2014)

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Characterizations and microsphere formulation of polysaccharide from the marine clam (Mactra veneriformis)

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CARBOHYDRATE POLYMERS (2013)

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Article Engineering, Biomedical

Surface-functionalized diatom microcapsules for drug delivery of water-insoluble drugs

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Synthesis and characterization of poly(acrylic acid)-g-sodium alginate hydrogel initiated by gamma irradiation for controlled release of chlortetracycline HCl

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Article Biotechnology & Applied Microbiology

Biosynthesis and Characterization of Silver Nanoparticles Using Freshly Extracted Sodium Alginate from the Seaweed Padina tetrastromatica of Gulf of Mannar, India

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CURRENT NANOSCIENCE (2012)

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Isolation and characterization of drug delivering potential of type-I collagen from eel fish Evenchelys macrura

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Exploring a new jellyfish collagen in the production of microparticles for protein delivery

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Bio-templated synthesis of mesoporous bioactive glass with a hierarchical pore structure

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MATERIALS LETTERS (2012)

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Active Targeting to Osteosarcoma Cells and Apoptotic Cell Death Induction by the Novel Lectin Eucheuma serra Agglutinin Isolated from a Marine Red Alga

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Review Chemistry, Medicinal

Marine Polysaccharides: A Source of Bioactive Molecules for Cell Therapy and Tissue Engineering

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MARINE DRUGS (2011)

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Drug delivery systems: Advanced technologies potentially applicable in personalized treatments

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Chitosan-NAC Nanoparticles as a Vehicle for Nasal Absorption Enhancement of Insulin

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Article Chemistry, Multidisciplinary

Preparation and characterization of protein loaded microspheres based on a hydroxylated aliphatic polyester, poly (lactic-co-hydroxymethyl glycolic acid)

A. H. Ghassemi et al.

JOURNAL OF CONTROLLED RELEASE (2009)

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Article Engineering, Biomedical

Gentamicin-loaded bioresorbable films for prevention of bacterial infections associated with orthopedic implants

Moran Aviv et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2007)

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Review Pharmacology & Pharmacy

Endocytic mechanisms for targeted drug delivery

Lisa A. Bareford et al.

ADVANCED DRUG DELIVERY REVIEWS (2007)

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Review Polymer Science

Block copolymer vesicles - using concepts from polymer chemistry to mimic biomembranes

K Kita-Tokarczyk et al.

POLYMER (2005)

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Article Optics

Diatoms as living photonic crystals

T Fuhrmann et al.

APPLIED PHYSICS B-LASERS AND OPTICS (2004)

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Article Chemistry, Physical

Porous calcium carbonate microparticles as templates for encapsulation of bioactive compounds

GB Sukhorukov et al.

JOURNAL OF MATERIALS CHEMISTRY (2004)

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