期刊
ADVANCED HEALTHCARE MATERIALS
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202303838
关键词
bioengineering; endometrium; extracellular matrix hydrogel; organoids
The endometrium plays a vital role in fertility and understanding its physiology is crucial for improving reproductive healthcare. This study presents a hybrid endometrial-derived hydrogel that shows promising potential as a biomaterial for regenerative treatments in reproductive medicine. The hydrogel provides excellent support for hEO culture, enhances hEO differentiation efficiency, and demonstrates in vivo compatibility and stability.
The endometrium plays a vital role in fertility, providing a receptive environment for embryo implantation and development. Understanding the endometrial physiology is essential for developing new strategies to improve reproductive healthcare. Human endometrial organoids (hEOs) are emerging as powerful models for translational research and personalized medicine. However, most hEOs are cultured in a 3D microenvironment that significantly differs from the human endometrium, limiting their applicability in bioengineering. This study presents a hybrid endometrial-derived hydrogel that combines the rigidity of PuraMatrix (PM) with the natural scaffold components and interactions of a porcine decellularized endometrial extracellular matrix (EndoECM) hydrogel. This hydrogel provides outstanding support for hEO culture, enhances hEO differentiation efficiency due to its biochemical similarity with the native tissue, exhibits superior in vivo stability, and demonstrates xenogeneic biocompatibility in mice over a 2-week period. Taken together, these attributes position this hybrid endometrial-derived hydrogel as a promising biomaterial for regenerative treatments in reproductive medicine. This work presents a novel hybrid endometrial-derived hydrogel that combines the rheological properties of PM with the biochemical cues of porcine EndoECM hydrogel. This hydrogel not only provides a suitable support for hEO culture and differentiation, but also exhibits in vivo compatibility and stability, presenting it as a promising biomaterial for regenerative treatments in reproductive medicine.image
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据