期刊
JOURNAL OF APPLIED POLYMER SCIENCE
卷 140, 期 44, 页码 -出版社
WILEY
DOI: 10.1002/app.54614
关键词
chitosan; micelles; pH responsive; redox responsive; tumor targeting
In this study, a polymer with tumor targeting function and dual redox/pH sensitivity was designed and synthesized. The polymer can self-assemble to form micelles and solubilize paclitaxel, exhibiting excellent tumor growth inhibition efficacy and low systemic toxicity.
In this study, a polymer with tumor targeting function and dual redox/pH sensitivity is designed and synthesized by integrating chitosan (CS), Poloxamer 407 (P407), cholesterol (CHO), folic acid (FA), and disulfide bonds into one molecule (P407-CS(FA)-SS-CHO). The polymer can self-assemble in water to form micelles and solubilize paclitaxel (PTX). The mean particle size of PTX-loaded P407-CS(FA)-SS-CHO micelles is 133nm. In vitro drug release study demonstrates the acid and glutathione (GSH) triggered PTX release behavior of the micelles. In vitro and in vivo experiments demonstrate the excellent tumor growth inhibition efficacy and low systemic toxicity of the PTX-loaded micelles. The P407-CS(FA)-SS-CHO micelles will be potential intelligent drug carriers for PTX delivery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据