期刊
PROTEIN & CELL
卷 7, 期 8, 页码 548-561出版社
SPRINGEROPEN
DOI: 10.1007/s13238-016-0288-z
关键词
TAZ; the Hippo pathway; cancer
类别
资金
- National Basic Research Program (973 Program) [2015CB910401]
- National Natural Science Foundation of China [81430057, 81225016]
- Youth Science and Technology Leading Talent by MOST
- Shanghai Outstanding Academic Leader [13XD1400600]
TAZ, a transcriptional coactivator with PDZ-binding motif, is encoded by WWTR1 gene (WW domain containing transcription regulator 1). TAZ is tightly regulated in the hippo pathway-dependent and -independent manner in response to a wide range of extracellular and intrinsic signals, including cell density, cell polarity, F-actin related mechanical stress, ligands of G protein-coupled receptors (GPCRs), cellular energy status, hypoxia and osmotic stress. Besides its role in normal tissue development, TAZ plays critical roles in cell proliferation, differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition (EMT), and stemness in multiple human cancers. We discuss here the regulators and regulation of TAZ. We also highlight the tumorigenic roles of TAZ and its potential therapeutic impact in human cancers.
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