☆ 4.8 Article

Near-Infrared Fluorescent Switch-On Probe for Guanine-Quadruplex Imaging with Extremely Large Stokes Shift

ANALYTICAL CHEMISTRY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

A red light-triggered chemical tool for sequence-specific alkylation of G-quadruplex and I-motif DNA

Enrico Cadoni et al.

Summary: The importance of non-canonical DNA structures such as G-quadruplexes (G4) and intercalating-motifs (iMs) in cellular processes has been demonstrated. Developing tools for specific targeting of these structures is crucial. This study presents a simple methodology for sequence-specific targeting of G4 and iM DNA structures using a multi-component system.

NUCLEIC ACIDS RESEARCH (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Engineering fluorescent protein chromophores with an internal reference for high-fidelity ratiometric G4 imaging in living cells

Jiao-Na Han et al.

Summary: The NHCouI dual-emission chromophore is a G4-responsive probe with a red emission signal that specifically responds to parallel G4s and a green emission signal that acts as an internal reference signal. It can self-calibrate the signal and avoid viscosity disturbances during G4 imaging in living cells.

CHEMICAL SCIENCE (2023)

添加到收藏夹

Article Chemistry, Analytical

Dual-Color Fluorescence Switch-On Probe for Imaging G-Quadruplex and Double-Stranded DNA in Living Cells

Takashi Sakamoto et al.

Summary: A tripodal quinone-cyanine dye QCy(MeBT)(3) with one donor and three acceptors was synthesized and demonstrated to exhibit significantly enhanced fluorescence emissions in G4 DNA and double-stranded DNA structures. Docking simulations and viscosity change experiments revealed the reason behind the dual-fluorescence response. Fluorescence microscopy imaging experiments showed the potential of this dye to image G4 DNA and double-stranded DNA in the cell nucleus using near-infrared and red fluorescence emissions, and it could also be used to visualize pyridostatin-induced G4 formation in living cells using near-infrared fluorescence.

ANALYTICAL CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Analytical

Visualization of Deep Tissue G-quadruplexes with a Novel Large Stokes-Shifted Red Fluorescent Benzothiazole Derivative

Xu Lu et al.

Summary: This study established a G4 probe design strategy and developed ThT-NA, a red fluorescent benzothiazole derivative for detecting and imaging G4 structures in living cells and tissue samples. ThT-NA shows excellent photophysical properties and can reveal the distribution of RNA G4 in cells and differentiate the cell cycle by monitoring changes in RNA G4 folding.

ANALYTICAL CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Structural Basis of Pyridostatin and Its Derivatives Specifically Binding to G-Quadruplexes

Liu-Yi Liu et al.

Summary: This study reveals the structural basis for the specific recognition of G-quadruplex (G4) by pyridostatin (PDS) and its derivatives. The results demonstrate that the rigid aromatic rings of PDS linked by flexible amide bonds match adaptively with G-tetrad planes, enhancing p-p stacking and achieving specific recognition of G4s. The aliphatic amine side chains of PDS adjust conformation to interact with the phosphate backbone via hydrogen bonding and electrostatic interactions, increasing affinity for G4s.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Bioinspired large Stokes shift small molecular dyes for biomedical fluorescence imaging

Hao Chen et al.

Summary: In this study, a series of small molecular dyes SODs with long Stokes shift and NIR emissions were designed and synthesized, with the most promising SOD9-TPP being developed for various medical applications.

SCIENCE ADVANCES (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Tripodal Quinone-cyanine Fluorescent Dye as a Tool for Analyzing Structural Dynamics of DNA Guanine-quadruplex

Takashi Sakamoto et al.

CHEMISTRY LETTERS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy

Peter A. Summers et al.

Summary: The study demonstrates a method for identifying G-quadruplexes (G4s) within nuclei of live and fixed cells using a fluorescent probe combined with fluorescence lifetime imaging microscopy. This method allows for the study of interactions between G4s and non-fluorescent small molecules, as well as the exploration of G4 stability mechanisms in live cells.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Development of Near-Infrared Nucleic Acid Mimics of Fluorescent Proteins for In Vivo Imaging of Viral RNA with Turn-On Fluorescence

Jiaheng Zhang et al.

Summary: By structurally modulating GFP-like chromophores using a specific molecular configuration, researchers have created novel fluorogenic derivatives with infrared-shifted spectra. These derivatives can be fluorescently elicited by interacting with G-quadruplex structures, leading to the creation of FP mimics with tunable emission in the near-infrared region.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Near-Infrared Small Molecule as a Specific Fluorescent Probe for Ultrasensitive Recognition of Antiparallel Human Telomere G-Quadruplexes

Ming Jin et al.

Summary: The newly designed probe TOVJ shows high sensitivity and selectivity for G4s, especially antiparallel G4s. It has low detection limits for antiparallel human telomere G4s, making it an effective fluorescence sensor for this purpose. Live-cell imaging results demonstrate that TOVJ can enter live cells and localize in the mitochondria.

ACS APPLIED MATERIALS & INTERFACES (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Single-molecule visualization of DNA G-quadruplex formation in live cells

Marco Di Antonio et al.

NATURE CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC

Kai-Bo Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

A fluorescent dye with large Stokes shift and high stability: synthesis and application to live cell imaging

Zheng Gao et al.

RSC ADVANCES (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Thioflavin T as a fluorescence light-up probe for G4 formation

Amandine Renaud de la Faverie et al.

NUCLEIC ACIDS RESEARCH (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

An Orange Fluorescent Protein with a Large Stokes Shift for Single-Excitation Multicolor FCCS and FRET Imaging

Daria M. Shcherbakova et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

High Stokes Shift Anilido-Pyridine Boron Difluoride Dyes

Juan F. Araneda et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Evidence of genome-wide G4 DNA-mediated gene expression in human cancer cells

Anjali Verma et al.

NUCLEIC ACIDS RESEARCH (2009)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.