期刊
POLYMERS
卷 8, 期 5, 页码 -出版社
MDPI AG
DOI: 10.3390/polym8050181
关键词
protein; graphene oxide; singlet oxygen generation; co-assembly; photodynamic therapy
资金
- National Natural Science Foundation of China [21522307, 21473208, 91434103, 51403214]
- Talent Fund of the Recruitment Program of Global Youth Experts
- CAS [2016VTA042]
- Chinese Academy of Sciences (CAS)
- Natural Science Foundation of China [21473153]
- Science Foundation for the Excellent Youth Scholars from Universities and Colleges of Hebei Province [YQ2013026]
- Support Program for the Top Young Talents of Hebei Province
- Post-graduate's Innovation Fund Project of Hebei Province [2016SJBS009]
- China Postdoctoral Science Foundation [2015M580214]
- Scientific and Technological Research and Development Program of Qinhuangdao City [201502A006]
The inactivation of photosensitizers before they reach the targeted tissues can be an important factor, which limits the efficacy of photodynamic therapy (PDT). Here, we developed co-assembled nanohybrids of graphene oxide (GO) and albumin/photosensitizer that have a potential for protecting the photosensitizers from the environment and releasing them in targeted sites, allowing for an enhanced PDT. The nanohybrids were prepared by loading the pre-assembled nanoparticles of chlorin e6 (Ce6) and bovine serum albumin (BSA) on GO via non-covalent interactions. The protection to Ce6 is evident from the inhibited fluorescence and singlet oxygen generation activities of Ce6-BSA-GO nanohybrids. Importantly, compared to free Ce6 and Ce6 directly loaded by GO (Ce6-GO), Ce6-BSA-GO nanohybrids showed enhanced cellular uptake and in vitro release of Ce6, leading to an improved PDT efficiency. These results indicate that the smart photosensitizer delivery system constructed by co-assembly of GO and albumin is promising to improve the stability, biocompatibility, and efficiency of PDT.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据