4.4 Article

Female aging: when translational models don't translate

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Orthopedics

Uncovering the riddle of femininity in osteoarthritis: a systematic review and meta-analysis of menopausal animal models and mathematical modeling of estrogen treatment

G. Gilmer et al.

Summary: This study aims to summarize the current understanding of the effects of menopause on osteoarthritis (OA) in animal models and investigate the impact of dosage and timing of estrogen treatment on cartilage degeneration. The results show that post-menopausal animals have worse cartilage outcomes compared to non-menopausal animals, and early initiation and higher doses of estrogen treatment may improve cartilage health.

OSTEOARTHRITIS AND CARTILAGE (2023)

Article Multidisciplinary Sciences

Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity

Hirotaka Iijima et al.

Summary: Matrix stiffening is a key characteristic of aged tissues. In this study, the authors found that an aged (stiff) matrix causes epigenetic repression of the gene encoding alpha-Klotho, a longevity factor, leading to chondrocyte dysfunction, which is a major cause of osteoarthritis. Exposing aged chondrocytes to a soft matrix restores a more youthful phenotype and enhances cartilage integrity. These findings highlight the importance of age-related biophysical alterations in extracellular matrix and have implications for the broader field of aging research.

NATURE COMMUNICATIONS (2023)

Review Endocrinology & Metabolism

Sex-dependent variation in cartilage adaptation: from degeneration to regeneration

Jhanvee Patel et al.

Summary: Despite recognition of sex-based differences in cartilage biology, the implications for study design and treatment efficacy remain unclear. This paper summarizes current findings on sex-dependent variation in knee anatomy, sex hormones' effect on cartilage, and cartilaginous degeneration and regeneration, with a focus on stem cell therapies. The contribution of both stem cell donor and recipient sex to sex-related differences in treatment efficacy is highlighted. More research is needed to optimize strategies for cartilage regeneration, taking sex into account for more effective and personalized treatments.

BIOLOGY OF SEX DIFFERENCES (2023)

Review Biochemistry & Molecular Biology

Hallmarks of aging: An expanding universe

Carlos Lopez-Otin et al.

Summary: Aging is driven by hallmarks that manifest with age, accelerate aging when accentuated experimentally, and can be decelerated, stopped, or reversed with therapeutic interventions. The twelve proposed hallmarks of aging include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. These hallmarks are interconnected with each other and with the recently proposed hallmarks of health.
Article Multidisciplinary Sciences

Demographic and hormonal evidence for menopause in wild chimpanzees

Brian M. Wood et al.

SCIENCE (2023)

Article Biochemistry & Molecular Biology

Menopause—Biology, consequences, supportive care, and therapeutic options

Susan R. Davis et al.

Editorial Material Biochemistry & Molecular Biology

Do mammals have menopause?

Ivana Winkler et al.

Summary: Semantics and lack of data have hindered our understanding of menopause in non-human mammals. This study redefines menopause as the permanent cessation of ovulation and shows that it is widespread across mammalian orders.
Article Geriatrics & Gerontology

Is Sex as a Biological Variable Still Being Ignored in Preclinical Aging Research?

Colleen Carmody et al.

Summary: 《The Importance of Considering Sex Differences in Aging Research》. Five years after the introduction of the NIH mandate on considering sex as a biological variable, many NIA-funded studies are still not adhering to this requirement. This review examines the state of preclinical aging research in terms of sex differences and suggests strategies for improving adherence to the mandate. Considering sex as a biological variable and including both males and females in aging biology research is crucial for improving health outcomes for all.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2022)

Review Cell Biology

Molecular mechanisms of dietary restriction promoting health and longevity

Cara L. Green et al.

Summary: Dietary restriction with adequate nutrition is considered the gold standard for delaying ageing and extending healthspan and lifespan in various species, as it impacts key nutrient-sensing signalling pathways to promote healthy longevity.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Article Endocrinology & Metabolism

Management of menopause: a view towards prevention

Roger A. Lobo et al.

Summary: Menopause is a critical period for women to prevent metabolic and cardiovascular diseases. The use of hormone therapy in young postmenopausal women can improve quality of life and reduce mortality.

LANCET DIABETES & ENDOCRINOLOGY (2022)

Article Multidisciplinary Sciences

Mapping the effects of pregnancy on resting state brain activity, white matter microstructure, neural metabolite concentrations and grey matter architecture

Elseline Hoekzema et al.

Summary: This study investigated the effects of pregnancy on the human brain and found significant changes in neural architecture and neural network organization. These changes were associated with pregnancy hormones and maternal-fetal bonding, and may play a crucial role in the mother-infant relationship.

NATURE COMMUNICATIONS (2022)

Review Biochemistry & Molecular Biology

Cellular senescence and senolytics: the path to the clinic

Selim Chaib et al.

Summary: Cellular senescence has emerged as a promising therapeutic target for disorders across the lifespan; targeting persistent senescent cells causing tissue damage may delay, prevent, or alleviate multiple diseases.

NATURE MEDICINE (2022)

Article Obstetrics & Gynecology

The 2022 hormone therapy position statement of The North American Menopause Society

Stephanie S. Faubion et al.

Summary: The 2022 Hormone Therapy Position Statement of NAMS updates the previous statement and provides recommendations for the use of hormone therapy in menopausal women. Hormone therapy is effective in treating vasomotor symptoms and preventing bone loss, but its risks vary depending on individual factors. It is important to assess the benefits and risks on an individual basis and regularly reevaluate the need for continued therapy.

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY (2022)

Article Obstetrics & Gynecology

Reproductive aging and menopause-like transition in the menstruating spiny mouse (Acomys cahirinus)

Nadia Bellofiore et al.

Summary: This study is the first to demonstrate a natural and gradual menopausal transition in rodents. The findings suggest that spiny mice may be a more suitable perimenopausal model than current rodent models for studying the pathways involved in menopause.

HUMAN REPRODUCTION (2021)

Article Cell Biology

Sex omission and male bias are still widespread in cell experiments

Jun Yeob Kim et al.

Summary: Integrating sex as an important biological variable is crucial for enhancing the accuracy and reproducibility of cell-based studies. While there has been progress in reporting cell sex, sex omission and male bias are still common issues. Collaborative efforts are needed to boost the implementation of sex-considerate research in basic biomedical studies.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2021)

Review Cell Biology

How stem cells remember their past

Lars N. Royal et al.

Summary: Somatic stem cells play vital roles in tissue development, homeostasis, and repair. Recent research indicates that the previous biographical experiences of individual stem cells can influence their behavior and responses to external stimuli. Understanding the molecular mechanisms underlying how past experiences guide future cellular behavior is a key direction for future research.

CURRENT OPINION IN CELL BIOLOGY (2021)

Article Biology

The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function

Zachary Clemens et al.

Summary: Aging is associated with disrupted information flow and molecular mistakes accumulation. Statistical physics approach can estimate the disorderliness of aging muscle. Network entropy reaches inflection point at old age, leading to structural and functional alterations progressing into oldest-old age.
Review Cardiac & Cardiovascular Systems

Misdiagnosis of Heart Failure: A Systematic Review of the Literature

Chun Wai Wong et al.

Summary: Heart failure (HF) misdiagnosis is common, often mistaken for chronic obstructive pulmonary disease (COPD). Conditions such as anemia and chronic kidney disease may increase the likelihood of unrecognized left ventricular systolic dysfunction. In addition to COPD, obesity, old age, atrial fibrillation, and ischemic heart disease are also common factors in the misdiagnosis of HF.

JOURNAL OF CARDIAC FAILURE (2021)

Review Medicine, General & Internal

Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data

Matilde Tschon et al.

Summary: Gender differences have been noted in patients with OA, with women showing higher healthcare utilization, prevalence of OA, clinical pain and inflammation. More in-depth studies and mechanistic research are needed to analyze the impact of different genders on OA.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Public, Environmental & Occupational Health

Sex as a Biological Variable: A 5-Year Progress Report and Call to Action

Matthew E. Arnegard et al.

JOURNAL OF WOMENS HEALTH (2020)

Article Biochemistry & Molecular Biology

Differential impacts of charcoal-stripped fetal bovine serum on c-Myc among distinct subtypes of breast cancer cell lines

Zi-Rui Liang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Immunology

Microbiota Induced Changes in the Immune Response in Pregnant Mice

Marijke M. Faas et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Oncology

Association Between Breastfeeding and Ovarian Cancer Risk

Ana Babic et al.

JAMA ONCOLOGY (2020)

Article Endocrinology & Metabolism

Sex differences in pharmacokinetics predict adverse drug reactions in women

Irving Zucker et al.

BIOLOGY OF SEX DIFFERENCES (2020)

Article Medicine, Research & Experimental

Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice

R. N. Lippert et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Cell Biology

A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease

Emily J. Davis et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Editorial Material Cell Biology

Female XX sex chromosomes increase survival and extend lifespan in aging mice

Emily J. Davis et al.

AGING CELL (2019)

Letter Orthopedics

Concerns on modeling postmenopausal osteoporosis on young female rats

Pavlos Lelovas et al.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2019)

Article Peripheral Vascular Disease

Breastfeeding and Maternal Hypertension

Sangshin Park et al.

AMERICAN JOURNAL OF HYPERTENSION (2018)

Article Neurosciences

Differences Between Women and Men in Incidence Rates of Dementia and Alzheimer's Disease

Christopher R. Beam et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Editorial Material Endocrinology & Metabolism

Breastfeeding reduces risk of type 2 diabetes mellitus

Alan Morris

NATURE REVIEWS ENDOCRINOLOGY (2018)

Review Geriatrics & Gerontology

Sexual dimorphism in predisposition to Alzheimer's disease

Daniel W. Fisher et al.

NEUROBIOLOGY OF AGING (2018)

Review Biochemistry & Molecular Biology

Considering sex as a biological variable in preclinical research

Leah R. Miller et al.

FASEB JOURNAL (2017)

Review Immunology

Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology

David Masopust et al.

JOURNAL OF IMMUNOLOGY (2017)

Article Obstetrics & Gynecology

The 2017 hormone therapy position statement of The North American Menopause Society

JoAnn V. Pinkerton et al.

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY (2017)

Article Geriatrics & Gerontology

Sex Differences in the Cognitive and Hippocampal Effects of Streptozotocin in an Animal Model of Sporadic AD

Jian Bao et al.

FRONTIERS IN AGING NEUROSCIENCE (2017)

Review Medicine, General & Internal

Long-Term Effects of Pregnancy Complications on Maternal Health: A Review

Ran Neiger

JOURNAL OF CLINICAL MEDICINE (2017)

Article Obstetrics & Gynecology

First evidence of a menstruating rodent: the spiny mouse (Acomys cahirinus)

Nadia Bellofiore et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2017)

Article Public, Environmental & Occupational Health

A global assessment of the gender gap in self-reported health with survey data from 59 countries

Ties Boerma et al.

BMC PUBLIC HEALTH (2016)

Article Public, Environmental & Occupational Health

Perimenopause: From Research to Practice

Nanette Santoro

JOURNAL OF WOMENS HEALTH (2016)

Review Medicine, Research & Experimental

Men and mice: Relating their ages

Sulagna Dutta et al.

LIFE SCIENCES (2016)

Review Geriatrics & Gerontology

Modeling menopause: The utility of rodents in translational behavioral endocrinology research

Stephanie V. Koebele et al.

MATURITAS (2016)

Review Pathology

Comparative histopathology of the estrous or menstrual cycle in laboratory animals

Junko Sato et al.

JOURNAL OF TOXICOLOGIC PATHOLOGY (2016)

Article Cell Biology

The rejuvenating effect of pregnancy on muscle regeneration

Tal Falick Michaeli et al.

AGING CELL (2015)

Article Public, Environmental & Occupational Health

Twenty years and still counting: including women as participants and studying sex and gender in biomedical research

Carolyn M. Mazure et al.

BMC WOMENS HEALTH (2015)

Article Agriculture, Dairy & Animal Science

Animal Models of Aging Research: Implications for Human Aging and Age-Related Diseases

Sarah J. Mitchell et al.

ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 3 (2015)

Review Cell Biology

Do you know the sex of your cells?

Kalpit Shah et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2014)

Article Multidisciplinary Sciences

Genomic responses in mouse models poorly mimic human inflammatory diseases

Junhee Seok et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Chemistry, Applied

Development of an in vitro model of menopause using primary human dermal fibroblasts

N. Remoue et al.

INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (2013)

Article Geriatrics & Gerontology

Menopause occurs late in life in the captive chimpanzee (Pan troglodytes)

James G. Herndon et al.

Article Multidisciplinary Sciences

Skin shedding and tissue regeneration in African spiny mice (Acomys)

Ashley W. Seifert et al.

NATURE (2012)

Article Obstetrics & Gynecology

Executive summary of the Stages of Reproductive Aging Workshop+10: addressing the unfinished agenda of staging reproductive aging

Sioban D. Harlow et al.

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY (2012)

Article Andrology

4-vinylcyclohexene diepoxide: a model chemical for ovotoxicity

Connie J. Kappeler et al.

SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE (2012)

Article Multidisciplinary Sciences

Performing Vaginal Lavage, Crystal Violet Staining, and Vaginal Cytological Evaluation for Mouse Estrous Cycle Staging Identification

Ashleigh C. McLean et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2012)

Article Public, Environmental & Occupational Health

Gender differences in health: results from SHARE, ELSA and HRS

Eileen M. Crimmins et al.

EUROPEAN JOURNAL OF PUBLIC HEALTH (2011)

Review Endocrinology & Metabolism

Cooperation of sex chromosomal genes and endocrine influences for hypothalamic sexual differentiation

Gregor Majdic et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2011)

Review Genetics & Heredity

Epigenetic regulation of autosomal gene expression by sex chromosomes

Patrick J. Wijchers et al.

TRENDS IN GENETICS (2011)

Review Endocrinology & Metabolism

What does the four core genotypes mouse model tell us about sex differences in the brain and other tissues?

Arthur P. Arnold et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2009)

Article Public, Environmental & Occupational Health

Gender Differences in the Association Between Morbidity and Mortality Among Middle-Aged Men and Women

Archana Singh-Manoux et al.

AMERICAN JOURNAL OF PUBLIC HEALTH (2008)

Review Reproductive Biology

Menopause in nonhuman primates?

Margaret L. Walker et al.

BIOLOGY OF REPRODUCTION (2008)

Article Endocrinology & Metabolism

Comparison of skeletal effects of ovariectomy versus chemically induced ovarian failure in mice

Laura E. Wright et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2008)

Review Pharmacology & Pharmacy

Gender differences in drug responses

Flavia Franconi et al.

PHARMACOLOGICAL RESEARCH (2007)