Loss of Autophagy Disrupts Stemness of Ameloblast-Lineage Cells in Aging

Article Dentistry, Oral Surgery & Medicine

Ift88 regulates enamel formation via involving Shh signaling

Takehisa Kudo et al.

Summary: The present study suggests that the function of primary cilia, mediated by Ift88, is critical for the secretory stage of amelogenesis, involving the Shh signaling pathway.

ORAL DISEASES (2023)

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Article Biochemistry & Molecular Biology

Role and regulation of autophagy in cancer

Ravichandran Rakesh et al.

Summary: Autophagy is a significant mechanism related to cellular stress, metabolism, and cancer, but its role in cancer is still not well understood. Autophagy involves modifications of various proteins and pathways and is influenced by the interaction between tumor cells and their microenvironment.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2022)

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Article Physiology

Energy metabolic shift contributes to the phenotype modulation of maturation stage ameloblasts

Haruno Arai et al.

Summary: The energy metabolism differences between ruffle-ended ameloblasts (RA) and smooth-ended ameloblasts (SA) affect the enamel mineralization process in teeth, providing new insights into the biological significance of enamel mineralization and the pathogenesis of enamel hypomineralization.

FRONTIERS IN PHYSIOLOGY (2022)

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Review Cell Biology

Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators

Laura Gomez-Virgilio et al.

Summary: Autophagy is a fundamental cellular process that plays a critical role in maintaining cell homeostasis. It functions as a survival mechanism under stress conditions, providing metabolic precursors to support cell function. Autophagy is essential for maintaining neuronal homeostasis, differentiation, and development, and dysregulation of this process is implicated in various human diseases.

CELLS (2022)

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Review Medicine, Research & Experimental

Emerging roles of ATG7 in human health and disease

Jack J. Collier et al.

Summary: ATG proteins are essential for macroautophagy and play important roles beyond autophagic elimination. Dysfunction of ATG7 is associated with diseases, but the mechanisms of how it contributes to these diseases remain unclear. Further research on the relationship between ATG7 dysfunction and diseases will help develop therapies for disorders involving ATG7 deficiency and impaired autophagy.

EMBO MOLECULAR MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Autophagy in tooth: Physiology, disease and therapeutic implication

Shengyan Yang et al.

Summary: Autophagy is a conserved cellular process that plays important roles in maintaining homeostasis and integrity of the dentin-pulp complex, as well as in the pathogenesis of dental diseases. It is also involved in tooth development and aging.

CELL BIOCHEMISTRY AND FUNCTION (2021)

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Review Cell Biology

Selective Autophagy in Hyperglycemia-Induced Microvascular and Macrovascular Diseases

Leena P. Bharath et al.

Summary: Dysregulation of autophagy plays a key role in the onset and progression of many metabolic diseases, including diabetes. Inability to upregulate autophagy or excessive autophagy can be detrimental to health. Autophagy is crucial for the development of vascular complications in diabetic patients.

CELLS (2021)

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Review Cell Biology

Autophagy in healthy aging and disease

Yahyah Aman et al.

Summary: This Review discusses the recent research on the mechanisms and roles of autophagy in health, aging, and disease, and how drugs modulating autophagy process could be used to suppress age-associated diseases. It examines emerging features of autophagy and proposes the potential links to aging and disease progression. The review also highlights the importance of understanding the interplay between autophagy and age-related pathologies for the development of clinical applications promoting long-term health.

NATURE AGING (2021)

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Article Cell Biology