期刊
POLYMERS
卷 8, 期 2, 页码 -出版社
MDPI AG
DOI: 10.3390/polym8020036
关键词
chemotherapy; l-cystine; polypeptide nanogel; prostate cancer; reduction-responsiveness; smart drug delivery
资金
- National Natural Science Foundation of China [51303174, 51233004, 51390484, 51321062, 51473165, 51203153, 51273196, 21104076]
- Scientific Development Program of Jilin Province [20140520050JH, 20140309005GX, 20130206058GX]
Smart polymer nanogel-assisted drug delivery systems have attracted more and more attention in cancer chemotherapy because of their well-defined morphologies and pleiotropic functions in recent years. In this work, an l-cystine-crosslinked reduction-responsive polypeptide nanogel of methoxy poly(ethylene glycol)-poly(l-phenylalanine-co-l-cystine) (mPEG-P(LP-co-LC)) was employed as a smart excipient for RM-1 prostate cancer (PCa) chemotherapy. Doxorubicin (DOX), as a regular chemotherapy drug, was embedded in the nanogel. The loading nanogel marked as NG/DOX was shown to exhibit glutathione (GSH)-induced swelling and GSH-accelerated DOX release. Subsequently, NG/DOX showed efficient cellular uptake and proliferation inhibition. Furthermore, NG/DOX presented enhanced antitumor efficacy and security in an RM-1 PCa-grafted mouse model in vivo, indicating its great potential for clinical treatment.
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