期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 -, 期 -, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/aac.01009-23
关键词
gram-negative bacteria; siderophores; Pseudomonas aeruginosa; cefiderocol
This study reports a clinical case of cefiderocol-resistant P. aeruginosa and identifies mutations not previously reported, suggesting potential novel pathways to cefiderocol resistance.
Cefiderocol is a siderophore cephalosporin designed to target multi-drug-resistant Gram-negative bacteria. Previously, the emergence of cefiderocol non-susceptibility has been associated with mutations in the chromosomal cephalosporinase (PDC) along with mutations in the PirA and PiuA/D TonB-dependent receptor pathways. Here, we report a clinical case of cefiderocol-resistant P. aeruginosa that emerged in a patient during treatment. This resistance was associated with mutations not previously reported, suggesting potential novel pathways to cefiderocol resistance.
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