☆ 4.7 Review

A comprehensive review of silk-fibroin hydrogels for cell and drug delivery applications in tissue engineering and regenerative medicine

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2023)

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Article Engineering, Biomedical

The mechanical behavior of silk-fibroin reinforced alginate hydrogel biocomposites-Toward functional tissue biomimetics

Adi Aharonov et al.

Summary: In this study, we developed a biomimetic silk-based biocomposite laminate using natural silk and fibroin fibers embedded in an alginate hydrogel matrix. By conducting unidirectional tensile tests with different fiber volume fractions and orientations, we investigated the mechanical behavior of these laminates. The results demonstrate the potential of fibroin fiber-reinforced biocomposites to replicate the mechanics of human soft tissues.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2023)

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Article Nanoscience & Nanotechnology

Original nanomedjournal.com Novel fabrication of bioengineered injectable chitosan hydrogel loaded with conductive nanoparticles to improve therapeutic potential of mesenchymal stem cells in functional recovery after ischemic myocardial infarction

Zheng Wu et al.

Summary: Researchers investigated the co-culture of modified mesenchymal stem cells with Au@Ch-SF macro-hydrogel and H9C2 cells for tissue regeneration and cardiac function recovery. The results showed that Au@Ch-SF macro-hydrogel promoted cardiomyocyte fiber restoration without toxicity. Co-culture of mesenchymal stem cells may be effective in treating myocardial injury.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2023)

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Article Engineering, Biomedical

Construction of adhesive and bioactive silk fibroin hydrogel for treatment of spinal cord injury

Yuanshan Liu et al.

Summary: Spinal cord injury often leads to severe and permanent disabilities. Tissue engineering with biocompatible hydrogels has shown promise for SCI repair, but achieving stable contact with transected nerve stumps and promoting neural regeneration remains a challenge.

ACTA BIOMATERIALIA (2023)

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Review Chemistry, Multidisciplinary

Silk Fibroin as Sustainable Advanced Material: Material Properties and Characteristics, Processing, and Applications

Ander Reizabal et al.

Summary: In this review, the molecular structure, original properties, available modifications, and processing methods of silk fibroin are presented, providing a wide overview for custom structural and functional variations.

ADVANCED FUNCTIONAL MATERIALS (2023)

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Article Chemistry, Applied

Magnetic chitosan-silk fibroin hydrogel/graphene oxide nanobiocomposite for biological and hyperthermia applications

Reza Eivazzadeh-Keihan et al.

Summary: This study successfully prepared a biocompatible magnetic nanobiocomposite with high structural uniformity, thermal stability, biocompatibility, and stability in an aqueous solution. Various analysis methods were used to evaluate the characteristics of the composite material, and the results showed excellent performance in magnetic fluid hyperthermia process.

CARBOHYDRATE POLYMERS (2023)

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Article Biophysics

Injectable methacrylated gelatin/thiolated pectin hydrogels carrying melatonin/tideglusib-loaded core/shell PMMA/silk fibroin electrospun fibers for vital pulp regeneration

Deniz Atila et al.

Summary: Injectable hydrogels have potential in dental pulp regeneration due to their ability to fill non-uniform voids. In this study, gelatin methacrylate/thiolated pectin hydrogels carrying electrospun core/shell fibers were designed for vital pulp regeneration. The release of melatonin and Tideglusib from the fibers induced stem cell proliferation and odontoblastic differentiation. This hydrogel system holds promise for pulp tissue regeneration.

COLLOIDS AND SURFACES B-BIOINTERFACES (2023)

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Review Chemistry, Multidisciplinary

From Mesoscopic Functionalization of Silk Fibroin to Smart Fiber Devices for Textile Electronics and Photonics

Ronghui Wu et al.

Summary: The silk fibers from Bombyx mori show great potential for applications in smart textiles, such as fiber sensors, actuators, optical fibers, and energy harvesters. By reconstructing/functionalizing silk fibroin at a mesoscopic scale, it is possible to create smart fiber devices with functions like sensors, actuators, optical fibers, and energy harvesters. Spinning technologies, such as wet spinning, dry spinning, microfluidic spinning, electrospinning, and direct writing, can be used to self-assemble silk fibroin solutions into regenerated fiber devices.

ADVANCED SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Silk fibroin based interpenetrating network hydrogel for corneal stromal regeneration

Promita Bhattacharjee et al.

Summary: There is a need to develop tissue engineering methods to address the shortage of donor corneas for transplantation. A novel approach using free-radical polymerization to fabricate three-dimensional hydrogels for corneal stromal tissue regeneration was investigated. The hydrogels showed rapid gelation, good porosity, enhanced cellular adhesion and proliferation, and no cytotoxicity. This study provides an initial step towards developing clinically applicable ocular implants.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biotechnology & Applied Microbiology

Etanercept embedded silk fibroin/pullulan hydrogel enhance cartilage repair in bone marrow stimulation

Xiongbo Song et al.

Summary: The study demonstrates that the embedding of Ept in hydrogel can enhance the therapeutic efficacy of BMS, promoting cartilage repair through regulating catabolic and anabolic dynamics in adjacent chondrocytes and enhancing BMSCs chondrogenesis.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications

Mostafa Ghafori Gorab et al.

Summary: In this study, an efficient nanobiocomposite based on graphene oxide, carboxymethylcellulose hydrogel, silk fibroin, and Fe3O4 nanoparticles was synthesized and evaluated for its performance in hyperthermia applications. The nanobiocomposite showed low toxicity against normal cells and potential for destroying cancer cells.

NANOSCALE ADVANCES (2022)

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Article Engineering, Biomedical

Cytoprotection of Human Progenitor and Stem Cells through Encapsulation in Alginate Templated, Dual Crosslinked Silk and Silk-Gelatin Composite Hydrogel Microbeads

Onur Hasturk et al.

Summary: The susceptibility of mammalian cells to harsh processing conditions limits their use in cell transplantation and tissue engineering. In this study, a method for fabricating Alg templated silk and silk/gelatin composite hydrogel microspheres using centrifugation-based droplet processing is demonstrated. The composite microspheres show improved structural stability and mechanical properties compared to ionically crosslinked Alg microspheres. Human mesenchymal stem and neural progenitor cells can be successfully encapsulated in these composite microspheres and protected from environmental factors.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Engineering, Biomedical

Conductive Hydrogel Conduits with Growth Factor Gradients for Peripheral Nerve Repair in Diabetics with Non-Suture Tape

Yuting Cai et al.

Summary: This study develops a graphene-based nerve guidance conduit for diabetic patients with peripheral nerve injury. The conduit incorporates a natural double network hydrogel and a neurotrophic concentration gradient, providing good biocompatibility and sustained growth factor release. The graphene mesh improves the toughness and conductivity of the conduit, promoting regeneration.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Efficient Regulation of the Behaviors of Silk Fibroin Hydrogel via Enzyme-Catalyzed Coupling of Hyaluronic Acid

Lin Wang et al.

Summary: The study demonstrates the enhancement of structural stability and flexibility of silk fibroin (SF) hydrogel through the synthesis of a composite double-network hydrogel. The swelling ratio, mechanical property, drug loading, and release behaviors of the hydrogel can be controlled by various methods, offering potential for applications in drug delivery systems.

LANGMUIR (2021)

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Review Biotechnology & Applied Microbiology

In Situ 3D Printing: Opportunities with Silk Inks

Francesca Agostinacchio et al.

Summary: In situ 3D printing is an emerging technique designed for patient-specific needs and performed directly in the patient's tissues in the operating room. Silk fibroin inks are emerging as a viable option due to their diverse range of formulations, aqueous processability, robust and tunable mechanical properties, and self-assembly via biophysical adsorption.

TRENDS IN BIOTECHNOLOGY (2021)

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Article Biochemical Research Methods

3D bioprinted silk fibroin hydrogels for tissue engineering

Soon Hee Kim et al.

Summary: The development of biocompatible and precisely printable bioink addresses the growing demand for three-dimensional bioprinting applications in tissue engineering. The versatile bioink, with high mechanical stability and biocompatibility, can be broadly used in nerve tissue engineering and wound healing, among other applications.

NATURE PROTOCOLS (2021)

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Article Chemistry, Multidisciplinary

Conductive In Situ Reduced Graphene Oxide-Silk Fibroin Bionanocomposites

Parushuram Nilogal et al.

Summary: This research paper describes the fabrication of bionanocomposites based on silk fibroin and reduced graphene oxide. The nanocomposites were characterized using various techniques such as UV-visible spectroscopy, X-ray diffraction, and scanning electron microscopy. The results showed that the addition of rGO increased the electrical conductivity of the SF biopolymer, demonstrating improved conductive behavior of the bionanocomposites.

ACS OMEGA (2021)

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Article Biochemistry & Molecular Biology

3D Printable Soy/Silk Hybrid Hydrogels for Tissue Engineering Applications

Pramod Dorishetty et al.

Summary: The development of protein-based 3D printable hydrogel systems with tunable structure and properties is crucial in biomedical applications. Hybrid hydrogels co-cross-linked between globular soy protein isolate (SPI) and fibrous silk fibroin (SF) were successfully 3D printed for the first time, showing tunable mechanical properties and increased printing accuracy with higher SF content. The fabricated hybrid hydrogels exhibited larger micropores and good cell attachment and proliferation, demonstrating their potential for tissue engineering applications.

BIOMACROMOLECULES (2021)

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Article Biophysics

Silk fibroin hydrogel/dexamethasone sodium phosphate loaded chitosan nanoparticles as a potential drug delivery system

Mohammad Akrami-Hasan-Kohal et al.

Summary: The study developed a sustained release formulation using dexamethasone sodium phosphate-loaded chitosan nanoparticles embedded in silk fibroin hydrogel. The scanning electron microscopy showed the prepared drug delivery system had a properly interconnected porous structure, indicating potential for drug delivery applications.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Polymer Science

Silk fibroin/chitosan hydrogel with antibacterial, hemostatic and sustained drug-release activities

Zhangpeng Xu et al.

Summary: A multifunctional hydrogel with antibacterial, hemostatic and sustained drug-release activities was prepared by chemically crosslinking silk fibroin (SF) and chitosan (CS) biomacromolecules. The synthesized hydrogel exhibited higher swelling and faster in vitro degradation rates under acidic conditions, along with enhanced mechanical properties. In vitro studies confirmed the hydrogel's good bacteriostatic and hemostatic properties, as well as its non-toxicity towards human skin fibroblasts.

POLYMER INTERNATIONAL (2021)

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Review Materials Science, Biomaterials

Functional silk fibroin hydrogels: preparation, properties and applications

Haiyan Zheng et al.

Summary: Traditional silk protein hydrogels have limitations in terms of structure and functionality, but the development of functional silk protein hydrogels presents opportunities to overcome these limitations, attracting attention from scholars worldwide.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Materials Science, Biomaterials

Optimization of hyaluronic acid-tyramine/silk-fibroin composite hydrogels for cartilage tissue engineering and delivery of anti-inflammatory and anabolic drugs

Reihane Ziadlou et al.

Summary: This study aimed to formulate injectable hydrogels for drug delivery and cartilage tissue engineering by combining hyaluronic acid-tyramine (HA-Tyr) with regenerated silk-fibroin (SF) solutions. The HA20/SF80 hydrogel showed superior chondrogenic effects and mechanical properties for cartilage tissue engineering applications, making it a promising biomaterial for osteoarthritis treatment.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Paper & Wood

3D printed hydrogels with oxidized cellulose nanofibers and silk fibroin for the proliferation of lung epithelial stem cells

Li Huang et al.

Summary: A novel biomaterial ink composed of regenerated silk fibroin and TEMPO-oxidized bacterial cellulose nanofibrils has been developed for 3D printing lung tissue scaffolds. The addition of OBC nanofibrils increased ink viscosity and improved scaffold shape fidelity, with optimal printing parameters identified as 0.3 bar printing pressure, 45 mm/s printing speed, and 410 μm nozzle diameter. OBC nanofibrils were aligned along print lines, guiding the orientation of lung epithelial stem cells and maintaining their proliferation ability and epithelial phenotype after 7 days of culture.

CELLULOSE (2021)

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Article Cell & Tissue Engineering

Phospholipid-induced silk fibroin hydrogels and their potential as cell carriers for tissue regeneration

Chavee Laomeephol et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2020)

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Article Cell Biology

3D printing with silk: considerations and applications

Megan K. DeBari et al.

CONNECTIVE TISSUE RESEARCH (2020)

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Article Engineering, Biomedical

Enzymatically crosslinked silk and silk-gelatin hydrogels with tunable gelation kinetics, mechanical properties and bioactivity for cell culture and encapsulation

Onur Hasturk et al.

BIOMATERIALS (2020)

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Article Engineering, Biomedical

Characterization of silk-hyaluronic acid composite hydrogels towards vitreous humor substitutes

Nicole R. Raia et al.

BIOMATERIALS (2020)

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Article Engineering, Biomedical

Dual growth factor delivery using PLGA nanoparticles in silk fibroin/PEGDMA hydrogels for articular cartilage tissue engineering

Milad Fathi-Achachelouei et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2020)

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Article Nanoscience & Nanotechnology

Photo-Electro Active Nanocomposite Silk Hydrogel for Spatiotemporal Controlled Release of Chemotherapeutics: An In Vivo Approach toward Suppressing Solid Tumor Growth

Ankit Gangrade et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Biochemistry & Molecular Biology

3D Extracellular Matrix Mimics: Fundamental Concepts and Role of Materials Chemistry to Influence Stem Cell Fate

Julien Nicolas et al.

BIOMACROMOLECULES (2020)

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Article Chemistry, Multidisciplinary

Tunable Biomimetic Hydrogels from Silk Fibroin and Nanocellulose

Pramod Dorishetty et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2020)

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Article Materials Science, Biomaterials

Injectable, Thixotropic, and Multiresponsive Silk Fibroin Hydrogel for Localized and Synergistic Tumor Therapy

Shuangquan Gou et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Materials Science, Biomaterials

Flexible Water-Absorbing Silk-Fibroin Biomaterial Sponges with Unique Pore Structure for Tissue Engineering

Jian Liu et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Chemistry, Multidisciplinary

From Molecular Reconstruction of Mesoscopic Functional Conductive Silk Fibrous Materials to Remote Respiration Monitoring

Liyun Ma et al.

SMALL (2020)

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Article Biochemical Research Methods

3D Bioprinting of Bone Marrow Mesenchymal Stem Cell-Laden Silk Fibroin Double Network Scaffolds for Cartilage Tissue Repair

Tianyu Ni et al.

BIOCONJUGATE CHEMISTRY (2020)

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Article Materials Science, Biomaterials

Modulation of Neuronal Cell Affinity on PEDOT-PSS Nonwoven Silk Scaffolds for Neural Tissue Engineering

Adrian Magaz et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Nanoscience & Nanotechnology

Injectable Silk Fibroin-Based Hydrogel for Sustained Insulin Delivery in Diabetic Rats

Biswanath Maity et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Medicine, Research & Experimental

Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing

Qing Yao et al.

THERANOSTICS (2020)

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Article Chemistry, Physical

Application of injectable silk fibroin/graphene oxide hydrogel combined with bone marrow mesenchymal stem cells in bone tissue engineering

Lu Wang et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2020)

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Article Nanoscience & Nanotechnology

Investigation on the Structure and Mechanical Properties of Highly Tunable Elastomeric Silk Fibroin Hydrogels Cross-Linked by γ-Ray Radiation

Nier Wu et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Ophthalmology

Clinical Outcomes of Silk versus Nylon Sutures for Suturing of Conjunctival Autograft in Pterygium Surgery

Hossein Jamali et al.

MIDDLE EAST AFRICAN JOURNAL OF OPHTHALMOLOGY (2020)

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Article Materials Science, Biomaterials

Injectable Carbon Nanotube Impregnated Silk Based Multifunctional Hydrogel for Localized Targeted and On-Demand Anticancer Drug Delivery

Ankit Gangrade et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

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Article Multidisciplinary Sciences

Evaluation of Neurosecretome from Mesenchymal Stem Cells Encapsulated in Silk Fibroin Hydrogels

Yolanda Martin-Martin et al.

SCIENTIFIC REPORTS (2019)

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Article Materials Science, Biomaterials

Smart Microneedle Fabricated with Silk Fibroin Combined Semi interpenetrating Network Hydrogel for Glucose-Responsive Insulin Delivery

Siyuan Chen et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

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Article Engineering, Biomedical

Genipin-crosslinked polyvinyl alcohol/silk fibroin/nano-hydroxyapatite hydrogel for fabrication of artificial cornea scaffolds-a novel approach to corneal tissue engineering

Haohao Zhou et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2019)

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Review Chemistry, Multidisciplinary

Hierarchical Structure of Silk Materials Versus Mechanical Performance and Mesoscopic Engineering Principles

Wu Qiu et al.

SMALL (2019)

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Article Polymer Science

An Environmentally Sensitive Silk Fibroin/Chitosan Hydrogel and Its Drug Release Behaviors

Zhangpeng Xu et al.

POLYMERS (2019)

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Article Materials Science, Multidisciplinary

Silk fibroin coaxial bead-on-string fiber materials and their drug release behaviors in different pH

Huanjie Xi et al.

JOURNAL OF MATERIALS SCIENCE (2019)

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Article Chemistry, Multidisciplinary

An injectable silk fibroin nanofiber hydrogel hybrid system for tumor upconversion luminescence imaging and photothermal therapy

Wei He et al.

NEW JOURNAL OF CHEMISTRY (2019)

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Article Engineering, Biomedical

Evaluation of a series of silk fibroin protein-based nonwoven mats for use as an anti-adhesion patch for wound management in robotic surgery

Yu-Chi Wang et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2018)

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Article Engineering, Biomedical

Silk fibroin/collagen protein hybrid cell-encapsulating hydrogels with tunable gelation and improved physical and biological properties

Jennifer O. Buitrago et al.

ACTA BIOMATERIALIA (2018)

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Review Chemistry, Multidisciplinary

Biomedical Applications of Recombinant Silk-Based Materials

Tamara Bernadette Aigner et al.

ADVANCED MATERIALS (2018)

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Article Pharmacology & Pharmacy

Iontophoresis-stimulated silk fibroin films as a peptide delivery system for wound healing

Camila Nunes Lemos et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018)

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Article Biochemistry & Molecular Biology

Enzymatically crosslinked and mechanically tunable silk fibroin/pullulan hydrogels for mesenchymal stem cells delivery

Tao Li et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Biochemistry & Molecular Biology

Injectable silk fibroin hydrogels functionalized with microspheres as adult stem cells-carrier systems

Matteo Ciocci et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Materials Science, Biomaterials

Fabrication of micro/nanoporous collagen/dECM/silk-fibroin biocomposite scaffolds using a low temperature 3D printing process for bone tissue regeneration

Hyeongjin Lee et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Article Multidisciplinary Sciences

Rapidly responsive silk fibroin hydrogels as an artificial matrix for the programmed tumor cells death

Viviana P. Ribeiro et al.

PLOS ONE (2018)

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Article Materials Science, Biomaterials

3D Printing of Silk Particle-Reinforced Chitosan Hydrogel Structures and Their Properties

Jun Zhang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Materials Science, Biomaterials

3D Printing of Silk Particle-Reinforced Chitosan Hydrogel Structures and Their Properties

Jun Zhang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Chemistry, Physical

Silk fibroin-based hydrogels as a protective matrix for stabilization of enzymes against pH denaturation

Yueying Han et al.

MOLECULAR CATALYSIS (2018)

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Article Biochemistry & Molecular Biology

Avidin Adsorption to Silk Fibroin Films as a Facile Method for Functionalization

Alycia Abbott et al.

BIOMACROMOLECULES (2018)

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Article Polymer Science

Characterization of silk hydrogel formed with hydrolyzed silk fibroin-methacrylate via photopolymerization

H. H. Kim et al.

POLYMER (2018)

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Review Cell & Tissue Engineering

Advances in Regenerative Medicine and Tissue Engineering: Innovation and Transformation of Medicine

Kevin Dzobo et al.

STEM CELLS INTERNATIONAL (2018)

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Review Pharmacology & Pharmacy

Reverse-engineered silk hydrogels for cell and drug delivery

F. Philipp Seib

THERAPEUTIC DELIVERY (2018)

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Article Cell & Tissue Engineering

A silk-based encapsulation platform for pancreatic islet transplantation improves islet function in vivo

Diana C. Hamilton et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)

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Article Materials Science, Biomaterials

Inkjet Bioprinting of 3D Silk Fibroin Cellular Constructs Using Sacrificial Alginate

Ashley M. Compaan et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2017)

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Article Materials Science, Biomaterials

Inkjet Bioprinting of 3D Silk Fibroin Cellular Constructs Using Sacrificial Alginate

Ashley M. Compaan et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2017)

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Article Multidisciplinary Sciences

Increased stem cells delivered using a silk gel/scaffold complex for enhanced bone regeneration

Xun Ding et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

Synthetic smart gel provides glucose-responsive insulin delivery in diabetic mice

Akira Matsumoto et al.

SCIENCE ADVANCES (2017)

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Article Engineering, Biomedical

An injectable particle-hydrogel hybrid system for glucose-regulatory insulin delivery

Fuli Zhao et al.

ACTA BIOMATERIALIA (2017)

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Article Engineering, Biomedical

Enzymatically crosslinked silk-hyaluronic acid hydrogels

Nicole R. Raia et al.

BIOMATERIALS (2017)

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Article Nanoscience & Nanotechnology

Injectable and pH-Responsive Silk Nanofiber Hydrogels for Sustained Anticancer Drug Delivery

Hongchun Wu et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Review Engineering, Biomedical

Silk protein-based hydrogels: Promising advanced materials for biomedical applications

Sonia Kapoor et al.

ACTA BIOMATERIALIA (2016)

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Article Engineering, Biomedical

Human mesenchymal stem cells cultured on silk hydrogels with variable stiffness and growth factor differentiate into mature smooth muscle cell phenotype

Michael Floren et al.

ACTA BIOMATERIALIA (2016)

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Review Engineering, Biomedical

Extracellular matrix-based biomaterial scaffolds and the host response

Joseph M. Aamodt et al.

BIOMATERIALS (2016)

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Article Engineering, Biomedical

Rheological, mechanical and degradable properties of injectable chitosan/silk fibroin/hydroxyapatite/glycerophosphate hydrogels

Jingjing Wu et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2016)

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Article Chemistry, Multidisciplinary

In situ formation of silk-gelatin hybrid hydrogels for affinity-based growth factor sequestration and release

John C. Bragg et al.

RSC ADVANCES (2016)

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Article Nanoscience & Nanotechnology

Silk Hydrogels of Tunable Structure and Viscoelastic Properties Using Different Chronological Orders of Genipin and Physical Cross-Linking

Winston H. Elliott et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

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Article Engineering, Biomedical

Bioprintable, cell-laden silk fibroin-gelatin hydrogel supporting multilineage differentiation of stem cells for fabrication of three-dimensional tissue constructs

Sanskrita Das et al.

ACTA BIOMATERIALIA (2015)

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Article Chemistry, Multidisciplinary

Inkjet Printing of Regenerated Silk Fibroin: From Printable Forms to Printable Functions

Hu Tao et al.

ADVANCED MATERIALS (2015)

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Article Chemistry, Analytical

A comparative study of graphene-hydrogel hybrid bionanocomposites for biosensing

S. L. Burrs et al.

ANALYST (2015)

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Article Pharmacology & Pharmacy

Fabrication and characterization of silk fibroin-coated liposomes for ocular drug delivery

Yixuan Dong et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

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Article Pharmacology & Pharmacy

Silk hydrogels for sustained ocular delivery of anti-vascular endothelial growth factor (anti-VEGF) therapeutics

Michael L. Lovett et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

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Article Engineering, Biomedical

Fabrication and characterization of polyacrylamide/silk fibroin hydrogels for peripheral nerve regeneration

Guicai Li et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2015)

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Article Multidisciplinary Sciences

Self-assembled hydrogels utilizing polymer-nanoparticle interactions

Eric A. Appel et al.

NATURE COMMUNICATIONS (2015)

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Article Biotechnology & Applied Microbiology

Tissue engineering and regenerative medicine: semantic considerations for an evolving paradigm

Ravi Katari et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2015)

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Review Chemistry, Multidisciplinary

Silk-based biomaterials for sustained drug delivery

Tuna Yucel et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Review Biochemical Research Methods

The advances and perspectives of recombinant protein production in the silk gland of silkworm Bombyx mori

Hanfu Xu

TRANSGENIC RESEARCH (2014)

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Editorial Material Microbiology

Recombinant protein expression in microbial systems

German L. Rosano et al.

FRONTIERS IN MICROBIOLOGY (2014)

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Article Materials Science, Biomaterials

Facile and rapid ruthenium mediated photo-crosslinking of Bombyx mori silk fibroin

Jasmin L. Whittaker et al.

JOURNAL OF MATERIALS CHEMISTRY B (2014)

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Article Chemistry, Multidisciplinary

Antibiotic-Releasing Silk Biomaterials for Infection Prevention and Treatment

Eleanor M. Pritchard et al.

ADVANCED FUNCTIONAL MATERIALS (2013)

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Article Biochemistry & Molecular Biology

Silk Fibroin/Hyaluronic Acid 3D Matrices for Cartilage Tissue Engineering

Cristina Foss et al.

BIOMACROMOLECULES (2013)

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Article Biochemistry & Molecular Biology

Tuning Chemical and Physical Cross-Links in Silk Electrogels for Morphological Analysis and Mechanical Reinforcement

Yinan Lin et al.

BIOMACROMOLECULES (2013)

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Article Engineering, Biomedical

The influence of specific binding of collagen-silk chimeras to silk biomaterials on hMSC behavior

Bo An et al.

BIOMATERIALS (2013)

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Article Chemistry, Physical

Physical hydrogels composed of polyampholytes demonstrate high toughness and viscoelasticity

Tao Lin Sun et al.

NATURE MATERIALS (2013)

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Article Biochemistry & Molecular Biology

Biocompatible and Biodegradable Dual-Drug Release System Based on Silk Hydrogel Containing Silk Nanoparticles

Keiji Numata et al.

BIOMACROMOLECULES (2012)

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Article Engineering, Biomedical

Enhanced function of pancreatic islets co-encapsulated with ECM proteins and mesenchymal stromal cells in a silk hydrogel

Nicolynn E. Davis et al.

BIOMATERIALS (2012)

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Article Biochemistry & Molecular Biology

Balanced electrostatic blending approach - An alternative to chemical crosslinking of Thai silk fibroin/gelatin scaffold

Panida Jetbumpenkul et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2012)

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Article Pharmacology & Pharmacy

Comparison of silk-elastinlike protein polymer hydrogel and poloxamer in matrix-mediated gene delivery

Robert Price et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

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Article Biotechnology & Applied Microbiology

Ultrasonication and Genipin Cross-Linking to Prepare Novel Silk Fibroin-Gelatin Composite Hydrogel

Wenqian Xiao et al.

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS (2012)

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Article Engineering, Biomedical

Silk fibroin electrogelation mechanisms

Qiang Lu et al.

ACTA BIOMATERIALIA (2011)

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Article Biochemistry & Molecular Biology

Design and Production of a Chimeric Resilin-, Elastin-, and Collagen-Like Engineered Polypeptide

Angelo Bracalello et al.

BIOMACROMOLECULES (2011)

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Article Engineering, Biomedical

Lyophilized silk fibroin hydrogels for the sustained local delivery of therapeutic monoclonal antibodies

Nicholas Guziewicz et al.

BIOMATERIALS (2011)

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Article Engineering, Biomedical

The use of injectable sonication-induced silk hydrogel for VEGF165 and BMP-2 delivery for elevation of the maxillary sinus floor

Wenjie Zhang et al.

BIOMATERIALS (2011)

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Review Chemistry, Multidisciplinary

Silk fibroin as a vehicle for drug delivery applications

Esther Wenk et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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Article Materials Science, Multidisciplinary

Biomaterials & scaffolds for tissue engineering

Fergal J. O'Brien

MATERIALS TODAY (2011)

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Article Biotechnology & Applied Microbiology

Biocompatible Materials from Regenerated Silk for Tissue Engineering and Medicinal Therapy

A. S. Kon'kov et al.

APPLIED BIOCHEMISTRY AND MICROBIOLOGY (2010)

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Article Materials Science, Textiles

Silk Grafting with Chitosan and Crosslinking Agents

Franco Ferrero et al.

FIBERS AND POLYMERS (2010)

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Review Pharmacology & Pharmacy

Protein aggregation-Pathways and influencing factors

Wei Wang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

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Article Engineering, Biomedical

Silk hydrogel for cartilage tissue engineering

Pen-Hsiu Grace Chao et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2010)

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Article Engineering, Biomedical

Silk fibroin/polyacrylamide Semi-interpenetrating network hydrogels for controlled drug release

Biman B. Mandal et al.

BIOMATERIALS (2009)

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Article Biophysics

Vortex-Induced Injectable Silk Fibroin Hydrogels

Tuna Yucel et al.

BIOPHYSICAL JOURNAL (2009)

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Article Biotechnology & Applied Microbiology

Hydrogels as Extracellular Matrix Mimics for 3D Cell Culture

Mark W. Tibbitt et al.

BIOTECHNOLOGY AND BIOENGINEERING (2009)

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Article Chemistry, Multidisciplinary

Two distinct beta-sheet fibrils from silk protein

Zuguang Gong et al.

CHEMICAL COMMUNICATIONS (2009)

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Article Chemistry, Medicinal

Preparation and evaluation of gel formulations for oral sustained delivery to dysphagic patients

Shozo Miyazaki et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2009)

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Article Pharmacology & Pharmacy

Silk fibroin/gelatin multilayered films as a model system for controlled drug release

Biman B. Mandal et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2009)

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Article Chemistry, Multidisciplinary

Silk-elastinlike recombinant polymers for gene therapy of head and neck cancer: From molecular definition to controlled gene expression

Joshua Gustafson et al.

JOURNAL OF CONTROLLED RELEASE (2009)

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Review Pharmacology & Pharmacy

Engineering cartilage tissue

Cindy Chung et al.

ADVANCED DRUG DELIVERY REVIEWS (2008)

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Article Biochemistry & Molecular Biology

Biodegradable materials based on silk fibroin and keratin

Andreia Vasconcelos et al.

BIOMACROMOLECULES (2008)

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Article Engineering, Biomedical

Functionalized injectable hydrogels for controlled insulin delivery

Dai P. Huynh et al.

BIOMATERIALS (2008)

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Article Engineering, Biomedical

Modification of silk fibroin using diazonium coupling chemistry and the effects on hMSC proliferation and differentiation

Amanda R. Murphy et al.

BIOMATERIALS (2008)

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Article Engineering, Biomedical

Sonication-induced gelation of silk fibroin for cell encapsulation

Xiaoqin Wang et al.

BIOMATERIALS (2008)

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Review Pharmacology & Pharmacy

Mathematical modeling of drug delivery

J. Siepmann et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)

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Article Anatomy & Morphology

Tissue engineering: strategies, stem cells and scaffolds

Daniel Howard et al.

JOURNAL OF ANATOMY (2008)

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Article Engineering, Biomedical

Fibroin/collagen hybrid hydrogels with crosslinking method: Preparation, properties, and cytocompatibility

Qiang Lv et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2008)

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Review Polymer Science

Silk as a biomaterial

Charu Vepari et al.

PROGRESS IN POLYMER SCIENCE (2007)

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Article Chemistry, Multidisciplinary

Adenoviral gene delivery to solid tumors by recombinant silk-elastinlike protein polymers

A. Hatefi et al.

PHARMACEUTICAL RESEARCH (2007)

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Article Biophysics

Protein secondary structure and orientation in silk as revealed by Raman spectromicroscopy

Thierry Lefevre et al.

BIOPHYSICAL JOURNAL (2007)

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Article Biophysics

Design of superior spider silk: From nanostructure to mechanical properties

Ning Du et al.

BIOPHYSICAL JOURNAL (2006)

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Article Polymer Science

Ultrasound in polymer chemistry: Revival of an established technique

Jos M. J. Paulusse et al.

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY (2006)

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Article Polymer Science

Preparation of non-woven mats from all-aqueous silk fibroin solution with electrospinning method

Chen Chen et al.

POLYMER (2006)

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Article Biotechnology & Applied Microbiology

Biocompatible fibroin blended films with recombinant human-like collagen for hepatic tissue engineering

K Hu et al.

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS (2006)

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Article Materials Science, Multidisciplinary

The intersection of biology and materials science

GM Whitesides et al.

MRS BULLETIN (2006)

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Article Engineering, Biomedical

Structural and mechanical characteristics of silk fibroin and chitosan blend scaffolds for tissue regeneration

AS Gobin et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2005)

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Article Engineering, Biomedical

De novo engineering of reticular connective tissue in vivo by silk fibroin nonwoven materials

I Dal Pra et al.

BIOMATERIALS (2005)

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Article Polymer Science

Regeneration of Bombyx mori silk by electrospinning.: Part 3:: characterization of electrospun nonwoven mat

J Ayutsede et al.

POLYMER (2005)

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Article Biochemistry & Molecular Biology

Structure and properties of silk hydrogels

UJ Kim et al.

BIOMACROMOLECULES (2004)

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Article Engineering, Biomedical

Growth of human cells on a non-woven silk fibroin net: a potential for use in tissue engineering

RE Unger et al.

BIOMATERIALS (2004)

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Article Chemistry, Multidisciplinary

In vitro and in vivo evaluation of recombinant silk-elastinlike hydrogels for cancer gene therapy

Z Megeed et al.

JOURNAL OF CONTROLLED RELEASE (2004)

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Article Polymer Science

Silk fibroin/chitosan conjugate crosslinked by tyrosinase

GD Kang et al.

MACROMOLECULAR RESEARCH (2004)

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Article Biochemistry & Molecular Biology

Preparation of semi-interpenetrating polymer networks composed of silk fibroin and poloxamer macromer

MK Yoo et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2004)

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Article Engineering, Biomedical

Bone morphogenetic protein-2 decorated silk fibroin films induce osteogenic differentiation of human bone marrow stromal cells

V Karageorgiou et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2004)

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Article Chemistry, Multidisciplinary

Dissolution and regeneration of Bombyx mori Silk fibroin using ionic liquids

DM Phillips et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)

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Article Biochemical Research Methods

Introduction to protein crystallization

A McPherson

METHODS (2004)

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Article Biochemistry & Molecular Biology

Optical spectroscopy to investigate the structure of regenerated Bombyx mori silk fibroin in solution

YH Yang et al.

BIOMACROMOLECULES (2004)

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Article Materials Science, Multidisciplinary

Benefit and risk in tissue engineering

David Williams

MATERIALS TODAY (2004)

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Article Engineering, Biomedical

Fibroin hydrogels for biomedical applications: preparation, characterization and in vitro cell culture studies

A Motta et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2004)

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Article Biochemistry & Molecular Biology

Porous 3-D scaffolds from regenerated silk fibroin

R Nazarov et al.

BIOMACROMOLECULES (2004)

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Review Pharmacology & Pharmacy

Genetically engineered silk-elastinlike protein polymers for controlled drug delivery

Z Megeed et al.

ADVANCED DRUG DELIVERY REVIEWS (2002)

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Article Polymer Science

Physical properties of silk fibroin/chitosan blend films

H Kweon et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2001)

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Review Multidisciplinary Sciences

Liquid crystalline spinning of spider silk

F Vollrath et al.

NATURE (2001)

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Review Chemistry, Multidisciplinary

Growth factor delivery for tissue engineering

JE Babensee et al.

PHARMACEUTICAL RESEARCH (2000)

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