☆ 4.5 Review

Management of chronic HBV-HDV patients chronic HBV-HDV infection: A review on new management options

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Gastroenterology & Hepatology

Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries

Homie A. Razavi et al.

Summary: Hepatitis D virus (HDV) coinfection with hepatitis B increases the risk of liver cancer, cirrhosis, and death compared to hepatitis B monoinfection. Accurate estimates of HDV prevalence are needed to effectively identify coinfected individuals. Implementing double reflex testing, including anti-HDV testing and HDV RNA testing, is the most effective method to generate estimates and identify undiagnosed individuals. This strategy is feasible and requires a relatively low number of tests.

JOURNAL OF HEPATOLOGY (2023)

添加到收藏夹

Article Gastroenterology & Hepatology

A 3-year course of bulevirtide monotherapy may cure HDV infection in patients with cirrhosis

Maria Paola Anolli et al.

Summary: Bulevirtide has received conditional approval from the EMA for treating chronic hepatitis delta, but the optimal duration of therapy remains unknown. In this study, a patient with compensated cirrhosis and esophageal varices achieved hepatitis delta cure after 3 years of bulevirtide monotherapy. Virological and biochemical responses were maintained during the 72-week off-therapy follow-up, and significant improvements were observed in liver biopsy results.

JOURNAL OF HEPATOLOGY (2023)

添加到收藏夹

Article Gastroenterology & Hepatology

Treating hepatitis D with bulevirtide-Real-world experience from 114 patients

Christopher Dietz-Fricke et al.

Summary: This study reported the safety and efficacy of bulevirtide in the treatment of chronic hepatitis D in a real-world setting in Germany. Among the 114 patients included, 87 cases showed virologic response and only a small proportion did not respond after 24 weeks of treatment. The treatment was well tolerated and showed signs of improvement in liver inflammation.

JHEP REPORTS (2023)

添加到收藏夹

Article Gastroenterology & Hepatology

Long-term follow-up of patients discontinuing bulevirtide treatment upon long-term HDV-RNA suppression

Mathias Jachs et al.

JHEP Reports (2023)

添加到收藏夹

Article Gastroenterology & Hepatology

A phase 2 dose-finding study of lonafarnib and ritonavir with or without interferon alpha for chronic delta hepatitis

Cihan Yurdaydin et al.

Summary: The study found that the combination of lonafarnib and ritonavir for the treatment of patients infected with HDV achieved good safety and efficacy at the end of 24 weeks. Patients in the all-oral LNF 50 mg bid + RTV and combination LNF + RTV + PEG-IFN alpha treatment groups reached the primary efficacy endpoint at the end of treatment. In addition, several patients in the combination treatment group experienced well-tolerated alanine aminotransferase increases after treatment.

HEPATOLOGY (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Response-guided long-term treatment of chronic hepatitis D patients with bulevirtide-Results of A real world Study

Mathias Jachs et al.

Summary: Bulevirtide effectively decreases HDV-RNA and ALT levels by blocking the uptake of hepatitis D virus into hepatocytes. The study explores the efficacy and duration of BLV treatment, and proposes a response-guided treatment approach.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Bulevirtide monotherapy for 48 weeks in patients with HDV-related compensated cirrhosis and clinically significant portal hypertension

Elisabetta Degasperi et al.

Summary: A 48-week course of BLV 2 mg/day monotherapy is safe and effective for patients with HDV-related compensated cirrhosis and CSPH.

JOURNAL OF HEPATOLOGY (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Implementation of anti-HDV reflex testing among HBsAg-positive individuals increases testing for hepatitis D

Adriana Palom et al.

Summary: Implementation of reflex anti-HDV testing in HBsAg-positive individuals significantly increases the diagnosis rate of chronic hepatitis D infection. A large percentage of HBsAg-positive individuals had not undergone anti-HDV testing before reflex testing was established.

JHEP REPORTS (2022)

添加到收藏夹

Review Gastroenterology & Hepatology

The changing context of hepatitis D

Mario Rizzetto et al.

Summary: The global epidemiology of hepatitis D is changing with the widespread implementation of hepatitis B vaccination. In high-income countries, the epidemiology of chronic hepatitis D is dual, with distinct characteristics observed in endemic countries. Despite recent progress, therapeutic management of HDV remains unsatisfactory.

JOURNAL OF HEPATOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

The hepatitis D virus in Italy. A vanishing infection, not yet a vanished disease

Gian Paolo Caviglia et al.

Summary: Although HDV infection is disappearing in Italy, it still has a medical impact on liver transplantation due to the presence of residual cases among native Italian patients. The study found that a significant proportion of native Italians with HDV infection had cirrhosis, and a majority remained HDV viremic even after follow-up. Hepatitis D played a disproportionate role in liver transplants compared to its minor prevalence in HBsAg-positive liver disorders in Italy.

JOURNAL OF ADVANCED RESEARCH (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Persistent Control of Hepatitis B Virus and Hepatitis Delta Virus Infection Following REP 2139-Ca and Pegylated Interferon Therapy in Chronic Hepatitis B Virus/Hepatitis Delta Virus Coinfection

Michel Bazinet et al.

Summary: REP 2139-Ca + pegIFN combination treatment shows high efficacy in patients with HBV/HDV coinfection without long-term safety issues. HDV functional cure, HBV virologic control/functional cure, and HBsAg seroconversion achieved during therapy are durable over 3.5 years of follow-up.

HEPATOLOGY COMMUNICATIONS (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Long-term clinical outcomes in patients with chronic hepatitis delta: the role of persistent viraemia

Adriana Palom et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2020)

添加到收藏夹

Article Immunology

Estimating the Global Prevalence, Disease Progression, and Clinical Outcome of Hepatitis Delta Virus Infection

Zhijiang Miao et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Long-Term Study of Hepatitis Delta Virus Infection at Secondary Care Centers: The Impact of Viremia on Liver-Related Outcomes

Habiba Kamal et al.

HEPATOLOGY (2020)

添加到收藏夹

Review Gastroenterology & Hepatology

The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis

Alexander J. Stockdale et al.

JOURNAL OF HEPATOLOGY (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Origin, HDV genotype and persistent viremia determine outcome and treatment response in patients with chronic hepatitis delta

Dominique Roulot et al.

JOURNAL OF HEPATOLOGY (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

48 weeks of high dose (10 mg) bulevirtide as monotherapy or with peginterferon alfa-2a in patients with chronic HBV/HDV co-infection

Heiner Wedemeyer et al.

JOURNAL OF HEPATOLOGY (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Treating chronic hepatitis delta: The need for surrogate markers of treatment efficacy

Cihan Yurdaydin et al.

JOURNAL OF HEPATOLOGY (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

Optimizing lonafarnib treatment for the management of chronic delta hepatitis: The LOWR HDV-1 study

Cihan Yurdaydin et al.

HEPATOLOGY (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance

Norah A. Terrault et al.

HEPATOLOGY (2018)

添加到收藏夹

Article Immunology

Interferon Treatment Duration in Patients With Chronic Delta Hepatitis and its Effect on the Natural Course of the Disease

Cihan Yurdaydin et al.

JOURNAL OF INFECTIOUS DISEASES (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

Antiviral Treatment and Liver- Related Complications in Hepatitis Delta

Anika Wranke et al.

HEPATOLOGY (2017)

添加到收藏夹

Article Gastroenterology & Hepatology

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

JOURNAL OF HEPATOLOGY (2017)

添加到收藏夹

Article Gastroenterology & Hepatology

Treatment of chronic hepatitis D with the entry inhibitor myrcludex B: First results of a phase Ib/IIa study

Pavel Bogomolov et al.

JOURNAL OF HEPATOLOGY (2016)

添加到收藏夹

Article Gastroenterology & Hepatology

Late HDV RNA Relapse After Peginterferon Alpha-Based Therapy of Chronic Hepatitis Delta

Benjamin Heidrich et al.

HEPATOLOGY (2014)

添加到收藏夹

Article Gastroenterology & Hepatology

Outcome of chronic hepatitis delta in Italy: A long-term cohort study

G.A. Niro et al.

DIGESTIVE AND LIVER DISEASE (2009)

添加到收藏夹

Article Gastroenterology & Hepatology

A 28-Year Study of the Course of Hepatitis Δ Infection: A Risk Factor for Cirrhosis and Hepatocellular Carcinoma

Raffaella Romeo et al.

GASTROENTEROLOGY (2009)

添加到收藏夹

Article Gastroenterology & Hepatology

Long-term benefit of interferon a therapy of chronic hepatitis D: Regression of advanced hepatic fibrosis

P Farci et al.

GASTROENTEROLOGY (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.