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Management of chronic HBV-HDV patients chronic HBV-HDV infection: A review on new management options

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JOHN WILEY & SONS LTD
DOI: 10.1002/ueg2.12494

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Buleviritide; chronic HBV-HDV infection; hepatitis B virus; hepatitis D virus; interferon alpha; lonafarnib

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Hepatitis D virus is a chronic viral hepatitis with the poorest prognosis, and progress in its diagnosis and treatment has been scarce until recent years. The approval of bulevirtide has provided a glimmer of hope for patients with Chronic Hepatitis D, although important gaps still need to be addressed regarding its use in therapy and the epidemiology and diagnosis of the disease.
Hepatitis D virus was first described by Mario Rizzeto in 1977, and it is considered chronic viral hepatitis with the poorest prognosis. Despite its discovery almost 50 years ago, progress in its diagnosis and treatment has been scarce until recent years. The approval of bulevirtide has shed some light for patients with Chronic Hepatitis D, although important gaps regarding its use in therapy as well as about the epidemiology and diagnosis of the disease need to be addressed. image

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