期刊
CELLS
卷 12, 期 23, 页码 -出版社
MDPI
DOI: 10.3390/cells12232673
关键词
adult muscle stem cells; muscle regeneration; small GTPase proteins; muscle damage; muscle hypertrophy; muscle cell fusion
类别
This study demonstrates the vital role of RhoA in regulating skeletal muscle satellite cell fusion and the importance of its presence for efficient skeletal muscle homeostasis restoration.
Satellite cells (SCs) are adult muscle stem cells that are mobilized when muscle homeostasis is perturbed. Here we show that RhoA in SCs is indispensable to have correct muscle regeneration and hypertrophy. In particular, the absence of RhoA in SCs prevents a correct SC fusion both to other RhoA-deleted SCs (regeneration context) and to growing control myofibers (hypertrophy context). We demonstrated that RhoA is dispensable for SCs proliferation and differentiation; however, RhoA-deleted SCs have an inefficient movement even if their cytoskeleton assembly is not altered. Proliferative myoblast and differentiated myotubes without RhoA display a decreased expression of Chordin, suggesting a crosstalk between these genes for myoblast fusion regulation. These findings demonstrate the importance of RhoA in SC fusion regulation and its requirement to achieve an efficient skeletal muscle homeostasis restoration.
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