期刊
INDUSTRIAL CROPS AND PRODUCTS
卷 207, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.indcrop.2023.117766
关键词
Surface molecularly imprinted membrane; Stimuli-responsiveness; Psoralen; Recognition mechanism
In this study, an intelligent solvent-responsive surface molecularly imprinted membrane (SR-SMIMs) was developed for the separation and recovery of Psoralen (PSO). The membrane demonstrated remarkable adsorption capacity in methanol and efficient desorption. The recognition mechanism of SR-SMIMs was identified to be a synergistic effect of hydrogen bonding, 7C-7C stacking, and Van der Waals forces. The method showed promising potential for specific separation of target compounds from complex natural plant extracts.
Psoralen (PSO), a natural product in Ficus carica L., exhibits remarkable pharmacological activity and clinical efficacy. However, achieving selective recognition and effective recovery in PSO separation process remains a challenge. In this study, an intelligent solvent-responsive surface molecularly imprinted membranes (SR-SMIMs) with switchable adsorption/desorption behavior was developed and applied to separate PSO. Cellulose membranes were modified with chitosan and polydopamine in sequence, followed by the construction of a surface molecularly imprinting layer using bi-functional monomers (AM and 4-VPBA) and solvent-responsive crosslinking agent (TEGDMA). The TEGDMA drives the swelling or shrinking of polymer chains, resulting in a switch in the adsorption/desorption behavior of SR-SMIMs. Hence, SR-SMIMs exhibited remarkable adsorption capacity of 40.69 mg center dot g-1 towards PSO in 25% methanol and can be efficiently desorbed with satisfactory efficiency in methanol. The molecular simulation and NMR analysis demonstrated that the recognition mechanism of SRSMIMs was a synergistic effect of hydrogen bonding, 7C-7C stacking and Van der Waals forces. Furthermore, the SR-SMIMs were effectively employed for the separation of PSO from Ficus carica L. leaves, exhibiting an impressive adsorption capacity of 20.51 mg center dot g-1 and a high elution recovery rate of 92.54%. This efficient and sustainable SR-SMIMs possessed promising potential for specific separation of target compound from complex natural plants extracts.
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