☆ 4.5 Review

Non-coding RNAs involved in fibroblast-like synoviocyte functioning in arthritis rheumatoid: From pathogenesis to therapy

CYTOKINE (2024)

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Article Cell Biology

Circ_0088194 Regulates Proliferation, Migration, Apoptosis, and Inflammation by miR-30a-3p/ADAM10 Axis in Rheumatoid Arthritis Fibroblastic Synovial Cells

Lei Feng et al.

Summary: This study investigated the role of the circ_0088194/miR-30a-3p/ADAM10 axis in rheumatoid arthritis (RA). The results showed that circ_0088194 promoted the proliferation, migration, and inflammatory response of RA-fibroblast-like synoviocytes (RA-FLSs) by regulating the expression of miR-30a-3p and ADAM10.

INFLAMMATION (2023)

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Article Immunology

LncRNA OIP5-AS1/miR-410-3p/Wnt7b axis promotes the proliferation of rheumatoid arthritis fibroblast-like synoviocytes via regulating the Wnt/β-catenin pathway

Yuan Sun et al.

Summary: This study investigated the role of lncRNA OIP5-AS1 in the pathogenesis of rheumatoid arthritis (RA). The results showed that lncRNA OIP5-AS1 promotes the activation of the Wnt/beta-catenin signaling pathway by regulating the miR-410-3p/Wnt7b signaling axis, thereby participating in the occurrence and development of RA.

AUTOIMMUNITY (2023)

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Article Biochemistry & Molecular Biology

Circ_0004712 Silencing Suppresses the Aggressive Changes of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Targeting miR-633/TRAF6 Axis

Shihui Zhang et al.

Summary: This study found that circular RNA_0004712 (circ_0004712) is up-regulated in rheumatoid arthritis (RA) and plays a role in RA progression by regulating the miR-633/TRAF6/NF-kappa B signaling pathway. Silencing circ_0004712 suppressed the viability, proliferation, migration, and inflammation of RA fibroblast-like synoviocytes (RA-FLSs) and promoted apoptosis. Circ_0004712 was shown to interact with miR-633 and TRAF6, providing new targets for the treatment of RA.

BIOCHEMICAL GENETICS (2023)

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Article Immunology

Hsa_circ_0007707 participates in PDE3B-mediated apoptosis inhibition and inflammation promotion in fibroblast-like synoviocytes

Yanhua Zuo et al.

Summary: Synovial samples from RA patients and normal controls were used to isolate FLSs. Increased expression of circ_0007707 was observed in synovial samples from RA patients and FLS-RA cells. Circ_0007707 silencing inhibited cell proliferation, induced cell apoptosis, and decreased cell inflammatory response in FLS-RA cells. Mechanistically, circ_0007707 mediated cell apoptosis and inflammatory response in FLS-RA cells through the miR-27b-3p/PDE3B axis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

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Article Rheumatology

Astragalosides inhibit proliferation of fibroblast-like synoviocytes in experimental arthritis by modulating LncRNA S56464.1/miR-152-3p/Wnt1 signaling axis

Xiaoya Cui et al.

Summary: This study found that astragalosides, the primary medicinal ingredient of Astragalus membranaceus, have a therapeutic effect on rheumatoid arthritis by inhibiting fibroblast-like synoviocyte proliferation through modulating the LncRNA S56464.1/miR-152-3p/Wnt1 signaling axis, providing a new approach for the treatment of rheumatoid arthritis.

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2023)

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Article Cell Biology

MiR-326 regulates cell proliferation and apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis

Yiou Wang et al.

Summary: The dysregulation of miR-326 is involved in the development of RA. Upregulation of miR-326 can inhibit proliferation and induce apoptosis in RA-FLS. The lncRNA-EWSAT1/miR-326 axis may serve as a potential therapeutic target for RA.

HUMAN CELL (2023)

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Article Orthopedics

Circ_0000479 promotes proliferation, invasion, migration and inflammation and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes via miR-766/FKBP5 axis

Peng Zhao et al.

Summary: This study found that circ_0000479 is upregulated in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs) and its knockdown can suppress the pathogenic properties of RA-FLSs. It was discovered that circ_0000479 binds to miR-766 to promote RA progression via FKBP5.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2023)

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Article Orthopedics

Circ_0002984 promotes proliferation, migration and inflammatory cytokine secretion and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes by inducing PCSK6 through miR-543

Jian-zuo Lu et al.

Summary: In this study, it was found that circular RNA circ_0002984 promoted the proliferation, migration, and inflammatory response of rheumatoid arthritis fibroblast-like synoviocytes by binding to miR-543 to induce PCSK6 production, while inhibiting apoptosis. This provides a potential target for rheumatoid arthritis therapy.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2023)

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Review Medicine, Research & Experimental

Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance

Chunjie Huang et al.

Summary: Cancer is a complex disease with diverse factors. DNA methylation and dysregulation of non-coding RNAs play critical roles in cancer progression. Understanding the interplay between DNMT3B and ncRNAs provides insights into tumorigenesis and potential therapeutic interventions.

JOURNAL OF TRANSLATIONAL MEDICINE (2023)

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Article Food Science & Technology

Sodium Propionate Relieves LPS-Induced Inflammation by Suppressing the NF-κB and MAPK Signaling Pathways in Rumen Epithelial Cells of Holstein Cows

Chenxu Zhao et al.

Summary: Subacute ruminal acidosis (SARA) is a common disease in intensive dairy farming, where the rumen environment acidifies, causing the release of lipopolysaccharide (LPS) from gram-negative bacteria. LPS can lead to rumentitis and other complications. This study investigates the anti-inflammatory effects of sodium propionate (SP) in reducing LPS-induced inflammation in rumen epithelial cells (RECs) and the underlying mechanism.

TOXINS (2023)

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Article Biochemistry & Molecular Biology

MiRNA-6089 inhibits rheumatoid arthritis fibroblast-like synoviocytes proliferation and induces apoptosis by targeting CCR4

Suxian Lin et al.

Summary: This study highlights the importance of miR-6089 in regulating rheumatoid arthritis (RA)-fibroblast-like synoviocytes (FLSs). Up-regulation of miR-6089 inhibits cell proliferation and promotes apoptosis in RA-FLSs. CCR4 is identified as a direct target of miR-6089 and its expression is increased in the synovial tissues of RA. Overexpression of CCR4 effectively reverses the effects of miR-6089 on proliferation and apoptosis in RA-FLSs.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

The effects of 1,25(OH)2D3 treatment on immune responses and intracellular metabolic pathways of bone marrow-derived dendritic cells from lean and obese mice

Da Hye Cho et al.

Summary: Vitamin D affects the differentiation, maturation, and activation of dendritic cells, while obesity is associated with metabolic changes in immune cells. This study investigates the effects of vitamin D and obesity on immune responses and markers related to immunometabolism of bone marrow-derived dendritic cells.

IUBMB LIFE (2022)

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Review Immunology

Genetics of rheumatoid arthritis

Leonid Padyukov

Summary: Rheumatoid arthritis is an inflammatory autoimmune disease with significant genetic associations and variations. Current research focuses on immune receptor binding, T cell activation, and cell signaling mechanisms. More than 150 candidate loci have been identified, with further discoveries expected in the future.

SEMINARS IN IMMUNOPATHOLOGY (2022)

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Article Orthopedics

Circ_0001947 promotes cell proliferation, invasion, migration and inflammation and inhibits apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes through miR-671-5p/STAT3 axis

Yang Yang et al.

Summary: In this study, the researchers found that circ_0001947 contributes to the development of RA-FLS by elevating STAT3 through absorbing miR-671-5p.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2022)

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Article Orthopedics

miR-653-5p suppresses the viability and migration of fibroblast-like synoviocytes by targeting FGF2 and inactivation of the Wnt/beta-catenin pathway

Peilong Dong et al.

Summary: This study revealed that miR-653-5p inhibits the viability and metastasis of HFLS-RA cells by targeting FGF2 and repressing the Wnt/beta-Catenin pathway.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2022)

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Review Biotechnology & Applied Microbiology

Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective

Cristina Quispe et al.

Summary: Research shows that nanocurcumin has anti-diabetic activity by reducing hyperglycemia through complex pharmacological mechanisms. Therefore, nanocurcumin may be a potential agent in the pharmacotherapeutic management of patients with diabetes.

BIOMED RESEARCH INTERNATIONAL (2022)

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Article Biotechnology & Applied Microbiology

LncRNA OSER1-AS1 regulates the inflammation and apoptosis of rheumatoid arthritis fibroblast like synoviocytes via regulating miR-1298-5p/E2F1 axis

Qiang Fu et al.

Summary: This study reveals that the expression level of LncRNA OSER1-AS1 is significantly decreased in rheumatoid arthritis (RA) patients and may serve as a potential diagnostic marker. The overexpression of OSER1-AS1 inhibits the inflammatory response in RA through its interaction with miR-1298-5p and E2F1.

BIOENGINEERED (2022)

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Article Biotechnology & Applied Microbiology

Long non-coding RNA TSPEAR Antisense RNA 2 is downregulated in rheumatoid arthritis and inhibits the apoptosis of fibroblast-like synoviocytes by downregulating microRNA-212-3p (miR-212-3p)

Zhifen Lv et al.

Summary: TSPEAR-AS2 is downregulated in rheumatoid arthritis (RA) and its overexpression can decrease the apoptosis of RA synovial fibroblasts by downregulating miR-212-3p.

BIOENGINEERED (2022)

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Article Biotechnology & Applied Microbiology

Long non-coding RNA cancer susceptibility candidate 2 regulates the function of human fibroblast-like synoviocytes via the microRNA-18a-5p/B-cell translocation gene 3 signaling axis in rheumatoid arthritis

Zhiqin Ye et al.

Summary: RA patients showed downregulation of lncRNA CASC2 and upregulation of miR-18a-5p. Overexpression of lncRNA CASC2 alleviated RA through the miR-18a-5p/BTG3 signaling axis, suggesting its potential as a therapeutic option for RA.

BIOENGINEERED (2022)

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Article Immunology

Sodium propionate improves rheumatoid arthritis by inhibiting survivin mediated proliferation of fibroblast like synoviocytes by promoting miR-140-5p

Sha Ma et al.

Summary: This study aimed to investigate whether propionate alleviates rheumatoid arthritis (RA) through the miR-140-5p/survivin pathway. The results showed that propionate promotes the expression of miR-140-5p and alleviates RA by inhibiting Survivin expression and the proliferation and impairment of RA-FLSs cells.

AUTOIMMUNITY (2022)

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Article Immunology

MiR-361-5p promotes proliferation and inhibits apoptosis of fibroblast-like synoviocytes via targeting ZBTB10 in rheumatoid arthritis

Aixian Zhang et al.

Summary: The study showed that miR-361-5p is upregulated in RA tissues and cultured RA-FLS cells. Inhibiting miR-361-5p can suppress proliferation, induce cell cycle arrest in G1/G0 phase, increase apoptosis, and reduce inflammatory factors secretion by RA-FLS cells. ZBTB10 is a direct target of miR-361-5p and its overexpression can reverse the effects of miR-361-5p in RA-FLS.

AUTOIMMUNITY (2022)

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Article Immunology

Circ_0088036 facilitates the proliferation and inflammation and inhibits the apoptosis of fibroblast-like synoviocytes through targeting miR-326/FZD4 axis in rheumatoid arthritis

Xueli Geng et al.

Summary: The study investigates the role of circ_0088036 in the progression of rheumatoid arthritis (RA) by targeting the miR-326/FZD4 signaling pathway in synovial lining layer tissues and RA-fibroblast-like synoviocytes (RA-FLSs). The findings suggest that circ_0088036 contributes to TNF-alpha-induced RA progression by interfering with miR-326 and upregulating FZD4.

AUTOIMMUNITY (2022)

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Article Immunology

Long non-coding RNA Xist contribution in systemic lupus erythematosus and rheumatoid arthritis

Chloe Bost et al.

Summary: Growing evidence suggests that the long non-coding RNA Xist expressed in female cells plays a significant role in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Xist controls transcription and sequesters miRNAs, leading to alterations in key inflammatory and proliferative pathways.

CLINICAL IMMUNOLOGY (2022)

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Article Immunology

Circ_0003972 Promotes the Proliferation and Inflammation of Fibroblast-like Synovial Cells in Rheumatoid Arthritis through Regulation of the miR-654-5p/FZD4 Axis

Juan Li et al.

Summary: The study revealed that circ_0003972 was highly expressed in RA patients and HFLS-RA cells, and its knockdown inhibited proliferation and inflammation while promoting apoptosis in TNF alpha-induced HFLS-RA cells. MiR-654-5p was downregulated in RA patients and HFLS-RA cells, and could be sponged by circ_0003972. Furthermore, FZD4, targeted by miR-654-5p and positively regulated by circ_0003972, reversed the effects of miR-654-5p on proliferation, inflammation, and apoptosis in TNF alpha-induced HFLS-RA cells.

IMMUNOLOGICAL INVESTIGATIONS (2022)

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Article Cell Biology

Circular RNA circ_0008360 Inhibits the Proliferation, Migration, and Inflammation and Promotes Apoptosis of Fibroblast-Like Synoviocytes by Regulating miR-135b-5p/HDAC4 Axis in Rheumatoid Arthritis

Jinying Hao et al.

Summary: It has been found that circRNA circ_0008360 is downregulated in rheumatoid arthritis and acts to inhibit the proliferation, migration, and inflammation of RA-FLSs while promoting apoptosis by regulating miR-135b-5p and HDAC4. This provides a potential new target for the treatment of rheumatoid arthritis.

INFLAMMATION (2022)

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Article Integrative & Complementary Medicine

Total Saponins of Radix Clematis Regulate Fibroblast-Like Synoviocyte Proliferation in Rheumatoid Arthritis via the LncRNA OIP5-AS1/MiR-410-3p/Wnt7b Signaling Pathway

Lingyu Pan et al.

Summary: This study found that total saponins of Radix clematidis (TSC) can inhibit the proliferation of rheumatoid arthritis (RA) synovial cells, and exert therapeutic effects by regulating the lncRNA OIP5-AS1/miR-410-3p/Wnt7b signaling pathway and the Wnt signaling pathway.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Immunology

Triptolide inhibits cell growth and inflammatory response of fibroblast-like synoviocytes by modulating hsa-circ-0003353/microRNA-31-5p/CDK1 axis in rheumatoid arthritis

Jian-ting Wen et al.

Summary: This study demonstrated that Triptolide (TPL) has therapeutic effects on rheumatoid arthritis (RA) by repressing cell growth and inflammatory response of RA fibroblast-like synoviocytes (RAFLSs). The ceRNA axis of hsa-circ-0003353 (circ0003353), miR-31-5p, and CDK1 is identified as a potential biomarker for RA patients who respond to TPL treatment.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

Health Benefits of Quercetin in Age-Related Diseases

Deepika et al.

Summary: Polyphenols, including the widely occurring quercetin, are a group of plant compounds with antioxidant properties that protect against aging and various age-related diseases. Quercetin, present in abundant quantities in nature and particularly in onions, possesses antioxidant, anti-inflammatory, anti-carcinogenic, and anti-diabetic properties. It can easily cross the blood-brain barrier and has shown potential as a curative agent in neurodegeneration, diabetes, cancer, and inflammation. Further studies and formulations of quercetin could explore its potential in treating other age-associated diseases.

MOLECULES (2022)

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Review Cardiac & Cardiovascular Systems

Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease

Donato Santovito et al.

Summary: In this Review, the authors discuss the functional relevance of non-canonical features of microRNAs in cardiovascular homeostasis and pathophysiology, including atypical microRNA biogenesis and localization, RISC heterogeneity, and non-conventional regulatory functions. They highlight the importance of uncovering these non-conventional properties for translational research in cardiovascular disease.

NATURE REVIEWS CARDIOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Curcumin relieved the rheumatoid arthritis progression via modulating the linc00052/miR-126-5p/PIAS2 axis

Jianwei Xiao et al.

Summary: Curcumin protects against arthritis by regulating the inc00052/miR-126-5p/PIAS2 axis through the JAK2/STAT3 signaling pathway.

BIOENGINEERED (2022)

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Article Immunology

Knockdown of circ_0025908 inhibits proliferation, migration, invasion, and inflammation while stimulates apoptosis in fibroblast-like synoviocytes by regulating miR-650-dependent SCUBE2

Ronghua Wang et al.

Summary: This study investigated the effects of circ_0025908 on rheumatoid arthritis (RA) and found that inhibition of circ_0025908 can suppress the dysfunction of synovial cells in RA patients by targeting the miR-650/SCUBE2 axis.

AUTOIMMUNITY (2022)

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Article Immunology

CircPTTG1IP knockdown suppresses rheumatoid arthritis progression by targeting miR-431-5p/FSTL1 axis

Chenhui Yang et al.

Summary: The study suggests that circPTTG1IP plays a key role in the pathology of RA and suppresses the progression of RA through regulating the miR-431-5p/FSTL1 signaling cascade.

TRANSPLANT IMMUNOLOGY (2022)

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Review Urology & Nephrology

MicroRNAs in kidney injury and disease

Nassim Mahtal et al.

Summary: MicroRNAs (miRNAs) play important roles in the development of kidney diseases, including acute kidney injury, chronic kidney disease, and allograft injury. Dysregulation of miRNAs is involved in the pathophysiology of these conditions. miRNAs can serve as biomarkers for graft function and kidney disease development, and targeting specific miRNAs may be a promising therapeutic strategy.

NATURE REVIEWS NEPHROLOGY (2022)

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Article Immunology

Circ_0088036 mediated progression and inflammation in fibroblast-like synoviocytes of rheumatoid arthritis by miR-1263/REL-activated NF-?B pathway

Xiaoyuan Wang et al.

Summary: This study reveals the important role of circ_0088036/miR-1263/REL/NF-kappa B pathway in the functional development of HFLS-RA cells, indicating a novel molecular network in the progression of RA in vitro.

TRANSPLANT IMMUNOLOGY (2022)

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Article Integrative & Complementary Medicine

Umbelliferone Inhibits Migration, Invasion and Inflammation of Rheumatoid Arthritis Fibroblast-Like Synoviocytes and Relieves Adjuvant-Induced Arthritis in Rats by Blockade of Wnt/β-Catenin Signaling Pathway

Li Cai et al.

Summary: In this study, umbelliferone (UMB) was found to inhibit migration, invasion, and inflammation of rheumatoid arthritis fibroblast-like synoviocytes (FLS), and alleviate joint damage and synovial inflammation in adjuvant-induced arthritis (AIA) rats by blocking the Wnt/β-catenin signaling pathway.

AMERICAN JOURNAL OF CHINESE MEDICINE (2022)

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Article Immunology

LncRNA HOTAIR inhibits the progression of fibroblast-like synoviocytes by sponging miRNA-106b-Sp in rheumatoid arthritis

Hongxia Qiu et al.

Summary: In this study, we investigated the effects of lncRNA HOTAIR on the pathological behavior of HFLSs in RA. We found that lncRNA HOTAIR influenced cell growth, migration, invasion, and apoptosis in HFLSs through the miR-106b-5p/Smad7 axis.

AUTOIMMUNITY (2022)

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Review Medicine, General & Internal

Advances in Circular RNA and Its Applications

Xian Zhao et al.

Summary: In this review, we summarized the characteristics, mechanisms, and biogenesis of circular RNA (circRNA), as well as its regulatory role in disease onset and progression. CircRNA can function mainly as miRNA sponges to regulate gene expression and protein transportation. It has great application prospects but also significant challenges.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Innate immunity drives pathogenesis of rheumatoid arthritis

Maria Edilova et al.

Summary: Rheumatoid arthritis is an autoimmune disease affecting about 1% of the population, with genetic and environmental factors playing key roles in its pathogenesis. While early studies focused on lymphocytes, recent research has highlighted the critical involvement of innate immune cells in the onset and progression of RA. Therapeutic approaches targeting different inflammatory pathways and immune cells, including the emerging roles of innate lymphoid cells and inflammasomes, are being explored for the treatment of RA.

BIOMEDICAL JOURNAL (2021)

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Article Immunology

LncRNA GAS5 alleviates rheumatoid arthritis through regulating miR-222-3p/Sirt1 signalling axis

Zhou Yang et al.

Summary: This study found that GAS5 expression was downregulated in serum samples from RA patients and in RA-FLSs. Overexpression of GAS5 or inhibition of miR-222-3p inhibited the activity of RA-FLSs by repressing proliferation and inflammation, and promoting apoptosis. GAS5 indirectly regulates Sirt1 expression by binding miR-222-3p, and Sirt1 overexpression restored the anti-RA activity of GAS5 under miR-222-3p mimic.

AUTOIMMUNITY (2021)

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Article Immunology

MiR-30a-3p ameliorates oxidative stress in rheumatoid arthritis synovial fibroblasts via activation of Nrf2-ARE signaling pathway

Xiaolong Lv et al.

Summary: The research demonstrated that downregulation of miR-30a-3p in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) has negative effects, while overexpression of miR-30a-3p can reverse these effects, activating the Nrf2 signaling pathway by targeting Keap1 and cul3 to protect cells from oxidative stress.

IMMUNOLOGY LETTERS (2021)

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Article Cell Biology

miR-34a in extracellular vesicles from bone marrow mesenchymal stem cells reduces rheumatoid arthritis inflammation via the cyclin I/ATM/ATR/p53 axis

Huaiguo Wu et al.

Summary: The study demonstrated that miR-34a contained in BM-MSC-derived Evs could reduce RA inflammation by inhibiting the cyclin I/ATM/ATR/p53 signaling pathway.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Cell Biology

Gene regulation by long non-coding RNAs and its biological functions

Luisa Statello et al.

Summary: Recent studies have shed new light on the biogenesis and functions of long non-coding RNAs (lncRNAs), showcasing their diverse roles in gene regulation and signaling pathways, particularly in the contexts of neuronal disorders, immune responses, and cancer. The discovery of unique biogenesis pathways and subcellular localizations of lncRNAs has opened up potential therapeutic avenues for targeting lncRNAs in various biological and pathophysiological conditions.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

LncRNA EWSAT1 Promotes Colorectal Cancer Progression Through Sponging miR-326 to Modulate FBXL20 Expression

Jing Liu et al.

Summary: The study revealed that EWSAT1 was highly expressed in CRC and promoted CRC progression by targeting the miR-326/FBXL20 pathway. This finding may offer a novel therapeutic target for CRC treatment.

ONCOTARGETS AND THERAPY (2021)

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Article Cell Biology

LncRNA NEAT1 regulates the proliferation and production of the inflammatory cytokines in rheumatoid arthritis fibroblast-like synoviocytes by targeting miR-204-5p

Jianwei Xiao et al.

Summary: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by erosive arthritis, which can lead to joint dysfunction and malformations. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play important roles in RA, with lncRNA NEAT1 identified as a potential diagnostic and therapeutic target in this disease. The study found that NEAT1 was up-regulated in RA patients' synovial tissue and TNF-alpha treated RA-FLSs, suggesting its potential as a therapeutic target for RA patients.

HUMAN CELL (2021)

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Article Medical Laboratory Technology

Long non-coding RNA NEAT1 and its targets (microRNA-21 and microRNA-125a) in rheumatoid arthritis: Altered expression and potential to monitor disease activity and treatment outcome

Junfeng Yang et al.

Summary: In patients with rheumatoid arthritis, elevated lnc-NEAT1 and decreased miR-21 and miR-125a are associated with inflammation and disease activity, and decreased lnc-NEAT1 is correlated with better treatment outcomes. Thus, lnc-NEAT1 may serve as a potential biomarker for monitoring disease activity and treatment outcomes in rheumatoid arthritis.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

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Article Oncology

miR-101-3p negatively regulates inflammation in systemic lupus erythematosus via MAPK1 targeting and inhibition of the NF-κB pathway

Xiaoying Zhao et al.

Summary: miR-101-3p is downregulated in SLE PBMCs and negatively regulates IL-10 and IFN-γ expression by targeting MAPK1. Overexpression of miR-101-3p attenuates the inflammatory response in SLE PBMCs by inhibiting MAPK1 expression and blocking the NF-κB pathway. These findings reveal a novel regulatory mechanism in SLE inflammation and suggest a new direction for the development of SLE treatments.

MOLECULAR MEDICINE REPORTS (2021)

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Article Medicine, Research & Experimental

MicroRNA-23a-5p regulates cell proliferation, migration and inflammation of TNF-α-stimulated human fibroblast-like MH7A synoviocytes by targeting TLR4 in rheumatoid arthritis

Xiao Bao et al.

Summary: The expression of miR-23a-5p was significantly downregulated in the plasma of patients with RA and MH7A cells. Overexpression of miR-23a-5p inhibited TNF-α-induced cell proliferation, migration, and inflammatory factor production, while reversing decreases in cell apoptosis. MiR-23a-5p targeted TLR4 to inhibit the TLR4/NF-κB signaling pathway in TNF-α-treated MH7A cells.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Gastroenterology & Hepatology

Circular RNA circAFF2 accelerates gastric cancer development by activating miR-6894-5p and regulating ANTXR 1 expression

Xuefeng Bu et al.

Summary: The study revealed that circAFF2 is overexpressed in gastric cancer cells and plays a crucial role in gastric cancer development; acting as a sponge for miR-6984-5p to elevate ANTXR 1 expression and promote tumor cell migration and invasion; in vivo experiments demonstrated that silencing circAFF2 could delay tumor growth.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2021)

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Article Orthopedics

Mesenchymal stem cell-originated exosomal lncRNA HAND2-AS1 impairs rheumatoid arthritis fibroblast-like synoviocyte activation through miR-143-3p/TNFAIP3/NF-κB pathway

Yuhua Su et al.

Summary: The study discovered that in rheumatoid arthritis, HAND2-AS1 expression is regulated by miR-143-3p and TNFAIP3, and may play a suppressive role in RA progression through exosome-mediated intercellular transfer of long non-coding RNA.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2021)

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Article Orthopedics

Circ-AFF2/miR-650/CNP axis promotes proliferation, inflammatory response, migration, and invasion of rheumatoid arthritis synovial fibroblasts

Wei Qu et al.

Summary: The study demonstrated that circ-AFF2 promotes the proliferation, inflammatory response, migration, and invasion of RAFLSs by modulating the miR-650/CNP axis.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2021)

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Article Cell Biology

Circ-SIRT1 inhibits cardiac hypertrophy via activating SIRT1 to promote autophagy

Weichen Wang et al.

Summary: Studies have shown that circ-SIRT1 restrains cardiac hypertrophy by activating SIRT1 to promote autophagy, suggesting circ-SIRT1 as a promising target for alleviating CH.

CELL DEATH & DISEASE (2021)

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Article Oncology

Single-nucleotide polymorphism rs4142441 and MYC co-modulated long non-coding RNA OSER1-AS1 suppresses non-small cell lung cancer by sequestering ELAVL1

Weijia Xie et al.

Summary: The study identified a lncRNA called OSER1-AS1, which exhibited tumor-suppressive functions in lung cancer by inhibiting tumor growth and metastasis. It may serve as a potential therapeutic target and prognostic marker.

CANCER SCIENCE (2021)

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Article Biotechnology & Applied Microbiology

MicroRNA-4423-3p inhibits proliferation of fibroblast-like synoviocytes by targeting matrix metalloproteinase 13 in rheumatoid arthritis

Weihong Xu et al.

Summary: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with increasing incidence globally. The study revealed that miR-4423-3p is downregulated in RA patients and targets MMP13 to inhibit cell proliferation, migration, and invasion while promoting apoptosis in HFLS-RA cells.

BIOENGINEERED (2021)

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Article Pathology

Circ_AFF2 facilitates proliferation and inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-375/TAB2 axis

Liqiang Zhi et al.

Summary: circ_AFF2 is upregulated in rheumatoid arthritis and modulates cell cycle, proliferation, apoptosis, and inflammatory response by interacting with miR-375, ultimately promoting RA progression through the miR-375/TAB2 axis. Circ_AFF2 may serve as a potential biomarker for the diagnosis and treatment of RA.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2021)

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Review Immunology

Fibroblast-like synoviocytes in rheumatoid arthritis: Surface markers and phenotypes

Zewen Wu et al.

Summary: Fibroblast-like synoviocytes (FLS) play a crucial role in the pathophysiology of rheumatoid arthritis (RA) and have become the main focus of research. Advances in technology, such as high-throughput sequencing, have made it possible to identify different FLS subsets, allowing for a detailed study of RA pathogenesis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Medicine, Research & Experimental

Astragaloside regulates lncRNA LOC100912373 and the miR-17-5p/PDK1 axis to inhibit the proliferation of fibroblast-like synoviocytes in rats with rheumatoid arthritis

Hui Jiang et al.

Summary: The study demonstrates that astragaloside inhibits fibroblast-like synoviocytes proliferation by regulating the expression of lncRNA LOC100912373 and the miR-17-5p/PDK1 axis.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Role of miRNA-19a in Cancer Diagnosis and Poor Prognosis

Alessio Ardizzone et al.

Summary: Cancer is a multifactorial disease with high mortality often linked to late diagnosis. The discovery of miRNAs has been crucial for cancer research, with miR-19a playing a key role in tumor growth, invasion, and prognosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Immunology

LncRNA FOXD2-AS1 promotes cell proliferation and invasion of fibroblast-like synoviocytes by regulation of miR-331-3p/PIAS3 pathway in rheumatoid arthritis

Qirui Zhao et al.

Summary: This study revealed that the long non-coding RNA FOXD2-AS1 promotes the progression of RA by regulating the miR-331-3p/PIAS3 pathway. FOXD2-AS1 could be a potential therapeutic target in the joints of RA patients.

AUTOIMMUNITY (2021)

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Article Immunology

LncRNA XIST is involved in rheumatoid arthritis fibroblast-like synoviocytes by sponging miR-126-3p via the NF-κB pathway

Wei Liu et al.

Summary: The study investigated the role of long non-coding RNA XIST in the development of rheumatoid arthritis (RA), showing that down-regulation of XIST can inhibit synovial fibroblast proliferation by regulating the expression levels of miR-126-3p/NF-kappa B, thereby inhibiting the occurrence and progression of RA.

AUTOIMMUNITY (2021)

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Article Immunology

Circ-Sirt1 inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes

Suhua Zhang et al.

Summary: The study revealed that circ-Sirt1 inhibits cell proliferation and induces apoptosis in MH7A cells, reduces levels of inflammatory factors, enhances expression of anti-inflammatory proteins, and plays a crucial role in inflammatory signal pathways.

AUTOIMMUNITY (2021)

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Review Medicine, Research & Experimental

A minor review of microRNA-338 exploring the insights of its function in tumorigenesis

Qian Yi et al.

Summary: MicroRNAs play critical roles in various biological processes; miRNA-338 is identified to participate in the progression of several cancers; the functions and underlying mechanisms of miRNA-338 in tumor progression remain unclear.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Immunology

Recent advances on signaling pathways and their inhibitors in rheumatoid arthritis

Shuang Liu et al.

Summary: Rheumatoid arthritis is characterized by systemic synovitis and joint destruction due to imbalances in pro-inflammatory and anti-inflammatory cytokines. Understanding the signaling pathways and inhibitors is crucial for the development of therapeutic targets and new drugs for RA.

CLINICAL IMMUNOLOGY (2021)

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Article Cell Biology

miR-483-3p Promotes IL-33 Production from Fibroblast-Like Synoviocytes by Regulating ERK Signaling in Rheumatoid Arthritis

Kailin Zhang et al.

Summary: The study found that miR-483-3p promotes the expression of IL-33 in RA fibroblast-like synoviocytes by regulating the ERK signaling pathway, which suggests miR-483-3p may be a potential effective target for rheumatoid arthritis treatment.

INFLAMMATION (2021)

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Review Biochemistry & Molecular Biology

The Interaction between microRNAs and the Wnt/β-Catenin Signaling Pathway in Osteoarthritis

Xiaobin Shang et al.

Summary: Osteoarthritis is a chronic disease that lacks disease-modifying treatment, with the Wnt/beta-catenin pathway playing a key role in its pathophysiology. Both excessive stimulation and suppression of this pathway can contribute to the development of OA. MicroRNAs have been found to regulate various cellular processes in different diseases, offering potential insights for the development of miRNA-based therapeutics for OA.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Rheumatology

Downregulation of miR-98-5p expression induces interleukin-6 expression in rheumatoid fibroblast-like synoviocytes

Shujun Wang et al.

Summary: The study investigated the regulation of IL-6 expression by miR-98-5p in rheumatoid fibroblast-like synoviocytes. Results showed that miR-98-5p negatively regulated IL-6 expression and could be a potential clinical approach in treating rheumatoid arthritis.

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2021)

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Article Medical Laboratory Technology

Influences of the lncRNA TUG1-miRNA-34a-5p network on fibroblast-like synoviocytes (FLSs) dysfunction in rheumatoid arthritis through targeting the lactate dehydrogenase A (LDHA)

Mei Zhang et al.

Summary: This study revealed the critical roles and molecular mechanisms of TUG1 in regulating the glucose metabolism and apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis (RA) via modulation of the miR-34a-5p-LDHA pathway. Silencing TUG1 suppressed FLSs-RA invasion, migration, glucose metabolism, and increased apoptosis, indicating that TUG1 plays a key role in the development of RA.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

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Article Chemistry, Medicinal

Triptolide promotes the apoptosis and attenuates the inflammation of fibroblast-like synoviocytes in rheumatoid arthritis by down-regulating lncRNA ENST00000619282

Jianting Wen et al.

Summary: The study suggests that TPL may promote apoptosis and reduce inflammation in RA by downregulating ENST00000619282, showing its potential as an anti-RA treatment.

PHYTOTHERAPY RESEARCH (2021)

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Article Cell Biology

Fibroblast-like synoviocytes: Role in synovial fibrosis associated with osteoarthritis

Anca Maglaviceanu et al.

Summary: This review discusses the activation of fibroblast-like synoviocytes and their role in driving fibrotic responses in osteoarthritis, as well as the impact of myofibroblast-like cells on the structure of the synovial membrane.

WOUND REPAIR AND REGENERATION (2021)

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Article Medicine, Research & Experimental

ZFAS1 knockdown inhibits ?broblast-like synoviocyte proliferation, migration, invasion and inflammation, and promotes apoptosis via miR-3926/FSTL1 in rheumatoid arthritis

Qiang Wang et al.

Summary: In rheumatoid arthritis (RA), ZFAS1 and FSTL1 are upregulated while miR-3926 is downregulated. ZFAS1 knockdown inhibits proliferation, migration, invasion, and inflammatory cytokine production in RA-FLS and induces apoptosis. ZFAS1 acts as a sponge for miR-3926 to abolish its effects, and FSTL1 is a direct target of miR-3926 in regulating RA-FLS progression.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Orthopedics

CircMAPK9 promotes the progression of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-140-3p/PPM1A axis

Zhihuan Luo et al.

Summary: The study found that circMAPK9 and PPM1A were upregulated and miR-140-3p was downregulated in RA patients and RA-FLSs. Silencing circMAPK9 suppressed cell proliferation, migration, invasion, inflammatory response, and promoted apoptosis in RA-FLSs. CircMAPK9 could regulate PPM1A expression by sponging miR-140-3p, offering a new mechanism for understanding RA development and potential treatment with circMAPK9.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2021)

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Article Health Care Sciences & Services

Silencing of LncRNA-PVT1 ameliorates lipopolysaccharide-induced inflammation in THP-1-derived macrophages via inhibition of the p38 MAPK signaling pathway

Shengcai Zheng et al.

Summary: The study demonstrated that lncRNA-PVT1 plays a crucial role in the inflammatory response of sepsis through the p38 MAPK signaling pathway, and it can regulate its own expression through a positive feedback loop, providing a potential therapeutic target for LPS-induced inflammation.

ANNALS OF PALLIATIVE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

circ-PTTG1IP/miR-671-5p/TLR4 axis regulates proliferation, migration, invasion and inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis

Lifeng Chen et al.

Summary: The circular RNA circ-PTTG1IP is overexpressed in rheumatoid arthritis patients and fibroblast-like synoviocytes, and its knockdown leads to suppression of cell proliferation, migration, invasion, and inflammatory response in RA-FLSs by regulating the miR-671-5p/TLR4 axis.

GENERAL PHYSIOLOGY AND BIOPHYSICS (2021)

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Article Biochemistry & Molecular Biology

MicroRNA-101-3p inhibits fibroblast-like synoviocyte proliferation and inflammation in rheumatoid arthritis by targeting PTGS2

Qiaofeng Wei et al.

BIOSCIENCE REPORTS (2020)

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Article Biochemistry & Molecular Biology

FOXM1/LINC00152 feedback loop regulates proliferation and apoptosis in rheumatoid arthritis fibroblast-like synoviocytes via Wnt/β-catenin signaling pathway

Wenlong Wang et al.

BIOSCIENCE REPORTS (2020)

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Review Immunology

An overview of autoantibodies in rheumatoid arthritis

Myrthe A. M. van Delft et al.

JOURNAL OF AUTOIMMUNITY (2020)

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Review Cell Biology

The functions and targets of miR-212 as a potential biomarker of cancer diagnosis and therapy

Wenjun Chen et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Biochemistry & Molecular Biology

RNA-seq reveals he circular RNA and miRNA expression profile of peripheral blood mononuclear cells in patients with rheumatoid arthritis

Jianting Wen et al.

BIOSCIENCE REPORTS (2020)

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Article Environmental Sciences

MiR-20a inhibits the progression of human arthritis fibroblast-like synoviocytes and inflammatory factor expression by targeting ADAM10

Zikang Xie et al.

ENVIRONMENTAL TOXICOLOGY (2020)

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Article Immunology

Quercetin suppresses migration and invasion by targeting miR-146a/GATA6 axis in fibroblast-like synoviocytes of rheumatoid arthritis

Jinying Zhao et al.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2020)

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Article Cell Biology

Long Non-coding RNA THRIL Mediates Cell Growth and Inflammatory Response of Fibroblast-Like Synoviocytes by Activating PI3K/AKT Signals in Rheumatoid Arthritis

Yongjian Liang et al.

INFLAMMATION (2020)

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Article Medicine, Research & Experimental

Effects of synbiotic supplementation on gut microbiome, serum level of TNF-α, and expression of microRNA-126 and microRNA-146a in patients with type 2 diabetes mellitus: study protocol for a double-blind controlled randomized clinical trial

Fahime Zeinali et al.

TRIALS (2020)

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Article Pharmacology & Pharmacy

Tanshinone IIA Suppresses Proliferation and Inflammatory Cytokine Production of Synovial Fibroblasts from Rheumatoid Arthritis Patients Induced by TNF-α and Attenuates the Inflammatory Response in AIA Mice

Hongyan Du et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Physiology

Exosomal MicroRNA-320a Derived From Mesenchymal Stem Cells Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Activation by Suppressing CXCL9 Expression

Qing Meng et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Cell Biology

MicroRNA-15a/16/SOX5 axis promotes migration, invasion and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes

Hua Wei et al.

AGING-US (2020)

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Article Immunology

MicroRNA-340-5p suppressed rheumatoid arthritis synovial fibroblast proliferation and induces apoptotic cell number by targeting signal transducers and activators of transcription 3

Shibin Zhang et al.

AUTOIMMUNITY (2020)

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Article Biochemistry & Molecular Biology

Lnc RNA ZFAS1 regulates the proliferation, apoptosis, inflammatory response and autophagy of fibroblast-like synoviocytes via miR-2682-5p/ADAMTS9 axis in rheumatoid arthritis

Shanshan Yang et al.

BIOSCIENCE REPORTS (2020)

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Review Oncology

Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review)

Stella Baliou et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2020)

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Article Rheumatology

MiR-1193 represses the proliferation and induces the apoptosis of interleukin-1β-treated fibroblast-like synoviocytes via targeting JAK3

Bo Liu et al.

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2020)

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Article Cell Biology

Soluble CD14 Induces Pro-inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-Like Synovial Cells via Toll-Like Receptor 4

Yoshihide Ichise et al.

CELLS (2020)

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Article Medicine, General & Internal

Deficient Expression of DGCR8 in Human Testis is Related to Spermatogenesis Dysfunction, Especially in Meiosis I

Emad Babakhanzadeh et al.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2020)

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Article Immunology

Icariin alleviates rheumatoid arthritis via regulating miR-223-3p/NLRP3 signalling axis

Zhi-Ming Wu et al.

AUTOIMMUNITY (2020)

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Article Medicine, Research & Experimental

miR-483-3p promotes cell proliferation and suppresses apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by targeting IGF-1

YueJiao Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

Hsa_circ_0088036 promotes the proliferation and migration of fibroblast-like synoviocytes by sponging miR-140-3p and upregulating SIRT 1 expression in rheumatoid arthritis

Shuping Zhong et al.

MOLECULAR IMMUNOLOGY (2020)

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Article Cell Biology

Long non-coding RNA PVT1 can regulate the proliferation and inflammatory responses of rheumatoid arthritis fibroblast-like synoviocytes by targeting microRNA-145-5p

Jiajun Tang et al.

HUMAN CELL (2020)

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Article Immunology

LncRNA NEAT1 Targets Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via the miR-410-3p/YY1 Axis

Yuejiao Wang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Rheumatology

miR-431-5p regulates cell proliferation and apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis by targeting XIAP

Yuejiao Wang et al.

ARTHRITIS RESEARCH & THERAPY (2020)

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Article Cell & Tissue Engineering

Linc02381 Exacerbates Rheumatoid Arthritis Through Adsorbing miR-590-5p and Activating the Mitogen-Activated Protein Kinase Signaling Pathway in Rheumatoid arthritis-fibroblast-like synoviocytes

Jing Wang et al.

CELL TRANSPLANTATION (2020)

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Review Immunology

NF-κB signaling in rheumatoid arthritis with focus on fibroblast-like synoviocytes

Leila Nejatbakhsh Samimi et al.

AUTOIMMUNITY HIGHLIGHTS (2020)

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Article Biochemistry & Molecular Biology

MicroRNA-19a-3p promotes rheumatoid arthritis fibroblast-like synoviocytes via targeting SOCS3

Yiyue Chen et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Review Pathology

Oncogenicity of lncRNA FOXD2-AS1 and its molecular mechanisms in human cancers

Qiuhui Hu et al.

PATHOLOGY RESEARCH AND PRACTICE (2019)

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Article Biochemistry & Molecular Biology

MiRNA-506 inhibits rheumatoid arthritis fibroblast-like synoviocytes proliferation and induces apoptosis by targetting TLR4

Dan Li et al.

BIOSCIENCE REPORTS (2019)

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Article Biochemistry & Molecular Biology

miR-124a inhibits the proliferation and inflammation in rheumatoid arthritis fibroblast-like synoviocytes via targeting PIK3/NF-κB pathway

BiLing Yang et al.

CELL BIOCHEMISTRY AND FUNCTION (2019)

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Review Biochemistry & Molecular Biology

LncRNA HOTAIR in Tumor Microenvironment: What Role?

Gerardo Botti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Immunology

Site-specific absence of microfibrillar-associated protein 4 (MFAP4) from the internal elastic membrane of arterioles in the rheumatoid arthritis synovial membrane: an immunohistochemical study in patients with advanced rheumatoid arthritis versus osteoarthritis

Anne Friesgaard Christensen et al.

APMIS (2019)

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Article Biochemistry & Molecular Biology

MiR-26a-5p enhances cells proliferation, invasion, and apoptosis resistance of fibroblast-like synoviocytes in rheumatoid arthritis by regulating PTEN/PI3K/AKT pathway

Zhengping Huang et al.

BIOSCIENCE REPORTS (2019)

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Article Genetics & Heredity

Down-regulation of microRNA-98 promoted apoptosis of TNF-α stimulated human fibroblast-like synoviocytes via up-regulating IL-10

Zhizhou Li et al.

GENE (2019)

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Review Immunology

Paeonol: pharmacological effects and mechanisms of action

Liang Zhang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Article Multidisciplinary Sciences

(5R)-5-Hydroxytriptolide (LLDT-8) induces substantial epigenetic mediated immune response network changes in fibroblast-like synoviocytes from rheumatoid arthritis patients

Shicheng Guo et al.

SCIENTIFIC REPORTS (2019)

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Review Immunology

Regulation of Immune Responses and Chronic Inflammation by Fibroblast-Like Synoviocytes

Hiroyuki Yoshitomi

FRONTIERS IN IMMUNOLOGY (2019)

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Review Oncology

MicroRNA-361: A Multifaceted Player Regulating Tumor Aggressiveness and Tumor Microenvironment Formation

Daozhi Xu et al.

CANCERS (2019)

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Article Medicine, Research & Experimental

miR-410-3p regulates proliferation and apoptosis of fibroblast-like synoviocytes by targeting YY1 in rheumatoid arthritis

YueJiao Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Biotechnology & Applied Microbiology

MicroRNA-21-5p are involved in apoptosis and invasion of fibroblast-like synoviocytes through PTEN/PI3K/AKT signal

Xin Yan et al.

CYTOTECHNOLOGY (2019)

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Article Medicine, General & Internal

Upregulation of miR-27b Facilitates Apoptosis of TNF-α-Stimulated Fibroblast-Like Synoviocytes

Shangwen Lei et al.

YONSEI MEDICAL JOURNAL (2019)

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Review Medicine, General & Internal

LncRNA: An all-rounder in rheumatoid arthritis

Junyu Liang et al.

JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE (2019)

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Article Rheumatology

Hypoxia-induced miR-191-C/EBPβ signaling regulates cell proliferation and apoptosis of fibroblast-like synoviocytes from patients with rheumatoid arthritis

Shanshan Yu et al.

ARTHRITIS RESEARCH & THERAPY (2019)

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Article Cell Biology

Piperlongumine inhibits the proliferation, migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis

Siqi Xu et al.

INFLAMMATION RESEARCH (2018)

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Article Cell Biology

LncRNA ZFAS1 promotes cell migration and invasion of fibroblast-like synoviocytes by suppression of miR-27a in rheumatoid arthritis

Yang Ye et al.

HUMAN CELL (2018)

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Article Immunology

Kaempferol inhibits the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes by blocking activation of the MAPK pathway

Dongmei Pan et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2018)

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Article

MicroRNA-146a suppresses rheumatoid arthritis fibroblast-like synoviocytes proliferation and inflammatory responses by inhibiting the TLR4/NF-kB signaling

Wei Liu et al.

Oncotarget (2018)

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Review Oncology

The Glucose-Regulated MiR-483-3p Influences Key Signaling Pathways in Cancer

Felice Pepe et al.

CANCERS (2018)

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Article Biochemistry & Molecular Biology

Tanshinone IIA promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by up-regulating lncRNA GAS5

Guoqing Li et al.

BIOSCIENCE REPORTS (2018)

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Article Cell Biology

miR-338-5p Regulates the Viability, Proliferation, Apoptosis and Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Targeting NFAT5

Ting Guo et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Article Biochemistry & Molecular Biology

MiR-199a-3p inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes via suppressing retinoblastoma 1

Yufan Wangyang et al.

BIOSCIENCE REPORTS (2018)

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Article Biology

MiR-92a inhibits fibroblast-like synoviocyte proliferation and migration in rheumatoid arthritis by targeting AKT2

Fang-Yuan Yu et al.

JOURNAL OF BIOSCIENCES (2018)

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Article Chemistry, Medicinal

miR-708-5p promotes fibroblast-like synoviocytes' cell apoptosis and ameliorates rheumatoid arthritis by the inhibition of Wnt3a/β-caten n pathway

Jie Wu et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2018)

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Review Biochemistry & Molecular Biology

MiR-137: an important player in neural development and neoplastic transformation

E. Mahmoudi et al.

MOLECULAR PSYCHIATRY (2017)

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Article Cell Biology

Paeonol protects against TNF-α-induced proliferation and cytokine release of rheumatoid arthritis fibroblast-like synoviocytes by upregulating FOXO3 through inhibition of miR-155 expression

Ning Liu et al.

INFLAMMATION RESEARCH (2017)

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Article Cell Biology

MicroRNA-192 suppresses cell proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes by downregulating caveolin 1

Supin Li et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2017)

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Review Oncology

Promising therapeutic role of miR-27b in tumor

Li Ding et al.

TUMOR BIOLOGY (2017)

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Article Cell Biology

Effect of 1,25-(OH)2D3 on Proliferation of Fibroblast-Like Synoviocytes and Expressions of Pro-Inflammatory Cytokines through Regulating MicroRNA-22 in a Rat Model of Rheumatoid Arthritis

Ping Fan et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)

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Article Medicine, Research & Experimental

MiR-650 inhibits proliferation, migration and invasion of rheumatoid arthritis synovial fibroblasts by targeting AKT2

Xiaoyan Xu et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

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Article Medicine, Research & Experimental

Quercetin promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1

Fang Pan et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

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Article Cell Biology

Icariin Prevents Cartilage and Bone Degradation in Experimental Models of Arthritis

Chen Chao Wei et al.

MEDIATORS OF INFLAMMATION (2016)

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Article Biochemistry & Molecular Biology

MicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis

Dong-liang Shi et al.

MOLECULES AND CELLS (2016)

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Article Orthopedics

Navigated 2-level posterior lumbar fusion: a 5-cm-incision procedure

Yu Wang et al.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2016)

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Article Oncology

Downregulation of microRNA-221 decreases migration and invasion in fibroblast-like synoviocytes in rheumatoid arthritis

Shuzhong Yang et al.

MOLECULAR MEDICINE REPORTS (2015)

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Article Integrative & Complementary Medicine

Antioxidant activities of saponins extracted from Radix Trichosanthis: an in vivo and in vitro evaluation

Ying Chen et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014)

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Article Multidisciplinary Sciences

Protease Inhibitors from Marine Actinobacteria as a Potential Source for Antimalarial Compound

L. Karthik et al.

PLOS ONE (2014)

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Review Genetics & Heredity

rniR-191: an emerging player in disease biology

Neha Nagpal et al.

FRONTIERS IN GENETICS (2014)

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Article Rheumatology

MiR-20a regulates ASK1 expression and TLR4-dependent cytokine release in rheumatoid fibroblast-like synoviocytes

Lucas Philippe et al.

ANNALS OF THE RHEUMATIC DISEASES (2013)

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Review Rheumatology

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

Nunzio Bottini et al.

NATURE REVIEWS RHEUMATOLOGY (2013)

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Article Rheumatology

Expression of beta-catenin in rheumatoid arthritis fibroblast-like synoviocytes

C. Y. Xiao et al.

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2011)

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Article Immunology

Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes

T Inoue et al.

JOURNAL OF IMMUNOLOGY (2005)

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