☆ 4.8 Review

Enzyme-mimetic antioxidant nanomaterials for ROS scavenging: Design, classification, and biological applications

COORDINATION CHEMISTRY REVIEWS (2024)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Multidisciplinary Sciences

Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme

Wenhui Gao et al.

Summary: We report a carbon dot (C-dot) superoxide dismutase (SOD) nanozyme with a catalytic activity comparable to that of natural enzymes. The SOD-like activity of C-dot nanozyme relies on specific chemical modifications and conjugated carbonyl groups for binding and electron transfer. Furthermore, the C-dot SOD nanozymes exhibit intrinsic targeting ability to oxidation-damaged cells and effectively protect neuron cells in the ischemic stroke mouse model.

NATURE COMMUNICATIONS (2023)

添加到收藏夹

Review Materials Science, Biomaterials

Glutathione peroxidase-like nanozymes: mechanism, classification, and bioapplication

Yifan Lai et al.

Summary: GPx-like nanozymes, which catalytically reduce H2O2/organic hydroperoxides to H2O/alcohols, have attracted significant attention due to their powerful antioxidant properties. They find broad applications in cytoprotection, anti-inflammation, neuroprotection, tumor therapy, and anti-aging. This review aims to summarize recent advances on GPx-like nanozymes, including their mechanism, classification, and bioapplication, while also discussing future prospects for their design and application.

BIOMATERIALS SCIENCE (2023)

添加到收藏夹

Review Chemistry, Multidisciplinary

Molecular insights of nanozymes from design to catalytic mechanism

Yuan Xu et al.

Summary: Nanozymes have emerged as cost-effective alternatives to natural enzymes and have gained increasing interest. To fully exploit their potential, rational structural engineering and explicit catalytic mechanisms at the molecular scale are required. Impressive progress has been made in mimicking the characteristics of natural enzymes, including the construction of metal active sites, binding pockets, scaffolds, and delicate allosteric regulation. This review introduces the state-of-the-art synthesis strategies and summarizes the general overview of the nanozyme mechanism, with a focus on adsorbed intermediates and descriptors that predict nanozyme activity. The emerging activity assessment methodology that illustrates the relationship between electrochemical oxygen reduction and enzymatic oxygen reduction is discussed, along with future opportunities and challenges to encourage further research in the field of nanozymes.

SCIENCE CHINA-CHEMISTRY (2023)

添加到收藏夹

Article Chemistry, Physical

Pyrolysis-free and universal synthesis of metal-NC single-atom nanozymes with dual catalytic sites for cytoprotection

Shuhan Chen et al.

Summary: Metal-nitrogen-doped carbon single-atom nanozymes have potential to replace natural enzymes for ROS-related diseases treatment. However, developing a pyrolysis-free and universal synthesis of these nanozymes with robust enzyme-mimicking activity remains challenging. In this study, a promising cytoprotective agent (Fe-NC SAzymes) with multiple enzyme-mimicking activities was successfully fabricated using a one-pot solvothermal method. The Fe-NC SAzymes showed enhanced catalytic performance and excellent biocompatibility, demonstrating outstanding cytoprotective performance.

CARBON (2023)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Carbon-based nanozymes: Design, catalytic mechanism, and bioapplication

Yun Sun et al.

Summary: Carbon-based nanomaterials with enzyme-like activity show great potential in biomedical applications. They have abundant active sites, excellent stability, and good biological safety. The unique optical, thermal, and acoustic properties of carbon-based nanozymes provide a multifunctional platform. This review discusses their recent research progress, challenges, and perspectives.

COORDINATION CHEMISTRY REVIEWS (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Nanoassemblies Derived from Natural Flavonoid Compounds as New Antioxidant Oral Preparations for Targeted Inflammatory Bowel Disease Therapy

Nan Tang et al.

Summary: The gastrointestinal tract, possessing the largest surface area of mucosa in the body, is susceptible to inflammatory damage caused by various external exposures, leading to inflammatory bowel disease (IBD). Excessive reactive oxygen species (ROS) can cause mucosal injury and amplify the inflammatory and immune response. Therefore, antioxidant therapy is considered as a potential strategy against IBDs. In this study, novel dihydromyricetin-based nanoassemblies with excellent antioxidant activities and high dispersion in the GI tract were developed for targeted IBD treatment.

ADVANCED FUNCTIONAL MATERIALS (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Multifunctional PtCuTe Nanosheets with Strong ROS Scavenging and ROS-Independent Antibacterial Properties Promote Diabetic Wound Healing

Yaru Guo et al.

Summary: A new class of multifunctional PtCuTe nanosheets with strong ROS scavenging and ROS-independent antibacterial properties is reported. It promotes endothelial tip cell formation, enhances vascular tube formation, stimulates macrophage polarization toward M2 phenotype, and improves fibroblast mobility, remarkably superior to the traditional PtCu nanoenzyme. Consequently, PtCuTe application accelerates diabetic wound healing at a rate not reported before.

ADVANCED MATERIALS (2023)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Bioinspired polydopamine nanoparticles as efficient antioxidative and anti-inflammatory enhancers against UV-induced skin damage

Jia Zhang et al.

Summary: In this study, novel sunscreen products based on melanin-inspired PDA nanoparticles were designed and prepared, showing superior effects in protecting against photodamage and photoaging. The mechanism of action of the sunscreen was also investigated, providing new insights for the development of sun protection products.

JOURNAL OF NANOBIOTECHNOLOGY (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bioactive Nanoenzyme Reverses Oxidative Damage and Endoplasmic Reticulum Stress in Neurons under Ischemic Stroke

Guanning Huang et al.

Summary: This study designed a translational antioxidative agent, HSA-Mn3O4, which effectively inhibits nervous system damage caused by ischemic stroke reperfusion, demonstrating neuroprotective capacity mainly by inhibiting apoptosis and endoplasmic reticulum stress to prevent brain tissue damage.

ACS NANO (2022)

添加到收藏夹

Article Nutrition & Dietetics

The Composition and Anti-Aging Activities of Polyphenol Extract from Phyllanthus emblica L. Fruit

Min Wu et al.

Summary: In this study, polyphenols were extracted from Phyllanthus emblica L. fruit and their antioxidant and anti-aging abilities were determined. The polyphenols exhibited strong antioxidant capacities and anti-cholinesterase abilities, and showed a protective effect against the aging process in a Caenorhabditis elegans model.

NUTRIENTS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bioceramic Scaffolds with Antioxidative Functions for ROS Scavenging and Osteochondral Regeneration

Cuijun Deng et al.

Summary: The developed bioscaffold integrating antioxidant and mechanical properties shows great potential for osteochondral regeneration in osteoarthritis. It protects chondrocytes, promotes their proliferation and maturation, as well as accelerates the osteogenic differentiation of bone marrow mesenchymal stem cells.

ADVANCED SCIENCE (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Therapeutic Hydrogel Patch to Treat Atopic Dermatitis by Regulating Oxidative Stress

Ye Eun Kim et al.

Summary: Atopic dermatitis (AD) is a chronic inflammatory disease associated with immune imbalances in the skin. High oxidative stress is implicated in AD pathogenesis. A therapeutic hydrogel patch embedded with ROS-scavenging nanoparticles shows promising results in reducing oxidative stress and improving AD symptoms in mouse models.

NANO LETTERS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Construction of a two-dimensional artificial antioxidase for nanocatalytic rheumatoid arthritis treatment

Bowen Yang et al.

Summary: The study constructs a two-dimensional metal-organic framework nanosheet catalyst that mimics the coordination environments of natural enzymes, and demonstrates its anti-inflammatory and anti-arthritic effects.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Engineering, Biomedical

A multi-target theranostic nano-composite against Alzheimer's disease fabricated by conjugating carbon dots and triple-functionalized human serum albumin

Wenjuan Wang et al.

Summary: This study developed a multifunctional theranostic nano-composite, HSA-BFP@CDs, for the diagnosis and treatment of Alzheimer's disease (AD). It demonstrated efficient detection of Aβ plaques and inhibition of Aβ aggregation, as well as scavenging of reactive oxygen species (ROS). The multifunctionality of HSA-BFP@CDs was further confirmed in an AD model, showing its potential for AD diagnosis and treatment.

ACTA BIOMATERIALIA (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Edge-Site Engineering of Defective Fe-N4 Nanozymes with Boosted Catalase-Like Performance for Retinal Vasculopathies

Ruofei Zhang et al.

Summary: This study rationally designed an iron-based nanozyme with excellent catalytic performance and demonstrated its potential therapeutic effects on retinal vasculopathies by scavenging ROS and alleviating oxidative stress. The nanozyme showed promising catalase-like activity and provided a new approach for refining nanozymes through engineering the defect environment and geometric structure around metal sites.

ADVANCED MATERIALS (2022)

添加到收藏夹

Article Engineering, Environmental

All-in-one: Harnessing multifunctional injectable natural hydrogels for ordered therapy of bacteria-infected diabetic wounds

Xiaoliang Qi et al.

Summary: An all-in-one hydrogel (QOP) has been developed to treat diabetic wounds. QOP can achieve rapid hemostasis, neutralize inflammatory cytokines, eliminate bacteria, regulate oxidation state, promote cell adhesion and migration, and facilitate angiogenesis. The QOP dressing can be fully absorbed by the organism after achieving the desired therapeutic effects.

CHEMICAL ENGINEERING JOURNAL (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ultrasmall Ruthenium Nanoparticles with Boosted Antioxidant Activity Upregulate Regulatory T Cells for Highly Efficient Liver Injury Therapy

Fan Xia et al.

Summary: This study introduces a size regulation strategy to enhance the antioxidant enzyme-like activities of RuNPs, showing promising potential for the treatment of oxidative stress-associated diseases.

SMALL (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Catalase-Like Nanozymes: Classification, Catalytic Mechanisms, and Their Applications

Deting Xu et al.

Summary: The field of nanozymes has witnessed rapid development, and CAT-like nanozymes in particular, as crucial regulators of reactive oxygen species, have attracted extensive research interest. Compared to other nanozymes, CAT-like nanozymes possess unique properties and find wide applications in fields such as tumor therapy and disease treatment. Therefore, a systematic discussion on CAT-like nanozymes is of great significance.

SMALL (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma

Shaofang Zhang et al.

Summary: The authors developed single-atom nanozymes of RhN4, VN4, and Fe-Cu-N-6 with higher catalytic activities than natural enzymes, and demonstrated the recyclability of Rh/VN4 and the scalp healing properties in bioactive sutures.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Review Anatomy & Morphology

Deconvoluting the Complexity of Reactive Oxygen Species (ROS) in Neurodegenerative Diseases

Yuxin Zhou et al.

Summary: This review focuses on summarizing the consequences of reactive oxygen species (ROS) in neurodegenerative diseases (NDs) and provides examples of key signaling pathways and relevant drugs in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease. The findings shed new light on the role of ROS-related pathways in the therapeutic development of neurodegenerative diseases.

FRONTIERS IN NEUROANATOMY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Living Macrophage-Delivered Tetrapod PdH Nanoenzyme for Targeted Atherosclerosis Management by ROS Scavenging, Hydrogen Anti-inflammation, and Autophagy Activation

Li Ding et al.

Summary: A distinct tetrapod needle-like PdH nanozyme was designed and engineered for efficient atherosclerosis treatment. This nanozyme scavenges reactive oxygen species (ROS), reduces inflammation, and activates autophagy. Both in vitro and in vivo results demonstrated the synergistic effects of antioxidation, anti-inflammatory response, and autophagy activation in alleviating atherosclerosis development. This study highlights the importance of engineering nanomedicines with multiple therapeutic functions and topology-induced biological effects for effective atherosclerosis management and therapy.

ACS NANO (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Catalase-Mimetic Artificial Biocatalysts with Ru Catalytic Centers for ROS Elimination and Stem-Cell Protection

Yimin Sun et al.

Summary: It is important to explore high-efficiency ROS-elimination materials for combating oxidative stress in various diseases, especially in stem-cell-based biotherapeutics. This study reports an innovative concept of designing ROS-elimination artificial biocatalysts with Ru catalytic centers, which mimic the Fe-N active centers of natural catalase. The results show that the artificial biocatalysts with Ru cluster centers have exceptional ROS-elimination activity and can provide efficient protection for stem cells in high ROS level conditions.

ADVANCED MATERIALS (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Multifunctional mesoporous silica-cerium oxide nanozymes facilitate miR129 delivery for high-quality healing of radiation-induced skin injury

Daijun Zhou et al.

Summary: Radiation-induced skin injury is a significant challenge in clinical treatments. This study developed a multiple radioresistance strategy using nanocomposites and miR129 to enhance therapeutic efficacy and promote wound healing.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

添加到收藏夹

Article Nanoscience & Nanotechnology

Designof MonovalentCerium-BasedMetalOrganicFrameworksasBioinspiredSuperoxideDismutaseMimicsfor IonizingRadiationProtection br

Ya Liu et al.

Summary: This study presents the design of two cerium-based metal organic frameworks, CeIIIBTC and CeIVBTC, which mimic the function of superoxide dismutase (SOD) and can effectively scavenge reactive oxygen species (ROS) and provide ionizing radiation protection. The CeIVBTC nanozymes show stronger SOD-like activity compared to CeIIIBTC, effectively scavenging ROS, improving cell viability, and enhancing the survival rate of irradiated mice.

ACS APPLIED MATERIALS & INTERFACES (2022)

添加到收藏夹

Article Materials Science, Biomaterials

Increasing the antioxidant capacity of ceria nanoparticles with catechol-grafted poly(ethylene glycol)

Yue Hu et al.

Summary: The use of reactive polymeric surface coatings can increase the cerium(iii) content of ceria nanoparticles, making them remarkable antioxidants. The length and architecture of the coating polymer can be tailored to enhance the antioxidant capacity of the nanoparticles.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

添加到收藏夹

Article Materials Science, Biomaterials

In vitro study of polydopamine nanoparticles as protective antioxidant agents in fibroblasts derived from ARSACS patients

Matteo Battaglini et al.

Summary: This study evaluated the effects of polydopamine nanoparticles (PDNPs) on human fibroblasts derived from patients with autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) in terms of antioxidant properties and protein expression. The results showed that PDNPs can partially counteract ROS-induced damages in ARSACS patient-derived fibroblasts.

BIOMATERIALS SCIENCE (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ligand-Dependent Activity Engineering of Glutathione Peroxidase-Mimicking MIL-47(V) Metal-Organic Framework Nanozyme for Therapy

Jiangjiexing Wu et al.

Summary: A ligand engineering strategy was developed to modulate the GPx-mimicking activity of a metal-organic framework (MOF) nanozyme, resulting in the rational regulation of the GPx-mimicking activities of MIL-47(V)-X MOFs. Among them, MIL-47(V)-NH2 demonstrated excellent antioxidation ability, effectively alleviating inflammatory responses in both ear injury and colitis models. This study proves the feasibility of designing high-performance GPx-mimicking nanozymes and highlights the importance of structure-activity relationships in directing in vivo therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Cerium Vanadate Nanozyme with Specific Superoxide Dismutase Activity Regulates Mitochondrial Function and ATP Synthesis in Neuronal Cells

Namrata Singh et al.

Summary: The study demonstrates that CeVO4 nanozyme can substitute the function of SOD1 and SOD2 in neuronal cells even when the natural enzymes are down-regulated. The nanozyme prevents mitochondrial damage by regulating superoxide levels and restores physiological levels of anti-apoptotic proteins. Additionally, it effectively prevents mitochondrial depolarization and improves cellular ATP levels under oxidative stress.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Review Behavioral Sciences

The glutathione system in Parkinson's disease and its progression

Geir Bjorklund et al.

Summary: Redox dysfunctions and neuro-oxidative stress play a major role in the pathophysiology and progression of Parkinson's disease (PD). Lowered GSH metabolism and a low GSH/GSSG ratio following oxidative stress are associated with mitochondrial dysfunctions and neuroinflammatory processes accompanying PD. Antioxidant approaches may have therapeutic efficacy in treating PD and its progression by neutralizing reactive oxygen species.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

A Functionalized Octahedral Palladium Nanozyme as a Radical Scavenger for Ameliorating Alzheimer's Disease

Zhi Jia et al.

Summary: The study demonstrates that the borneol-modified octahedral palladium nanozyme platform can efficiently reduce ROS and Ca2+ contents, protect mitochondria, and improve learning and memory functions in AD mice.

ACS APPLIED MATERIALS & INTERFACES (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Biomimetic Design of Mitochondria-Targeted Hybrid Nanozymes as Superoxide Scavengers

Yue Zhang et al.

Summary: Integrating protein reconstruction technology and nanotechnology, an artificial hybrid nanozyme with superoxide dismutase and catalase-like activities was developed to target mitochondria and demonstrate protective effects in mitochondrial oxidative injury and heart function recovery. This innovative approach highlights the potential of enzyme mimics in regenerative medicine for alleviating oxidative damage.

ADVANCED MATERIALS (2021)

添加到收藏夹

Review Cell Biology

Novel target for treating Alzheimer's Diseases: Crosstalk between the Nrf2 pathway and autophagy

Weiwei Zhang et al.

Summary: The Nrf2 pathway and autophagy are important intracellular defense systems in mammals, with p62 acting as a connector between the two through a positive feedback loop to enhance cellular protection. Studies have shown that the p62-activated noncanonical Nrf2 pathway is a significant marker of neurodegenerative diseases.

AGEING RESEARCH REVIEWS (2021)

添加到收藏夹

Article Biochemical Research Methods

Ligand-Modulated Catalytic Selectivity of Ag Clusterzyme for Relieving Multiorgan Injury via Inhabiting Acute Oxidative Stress

Meili Guo et al.

Summary: The study developed atomic precision Ag-25 clusterzymes which can modulate catalytic activity and selectivity by adjusting doping elements and ligands. The experiments showed potential applications of these clusterzymes in radiation protection and recovery in nanomedicine.

BIOCONJUGATE CHEMISTRY (2021)

添加到收藏夹

Article Engineering, Biomedical

Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Boyi Niu et al.

Summary: Glutathione (GSH) plays a crucial role in cellular antioxidative system, particularly in cancer cells, where a high level of GSH is essential for scavenging ROS and detoxifying xenobiotics. Depletion of GSH has been shown to enhance the efficacy of various therapies such as ROS-based therapy, ferroptosis, and chemotherapy. This review comprehensively discusses the importance of GSH depletion in cancer therapy and various strategies employed to achieve it.

BIOMATERIALS (2021)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Nanozymes: Activity origin, catalytic mechanism, and biological application

Wenping Yang et al.

Summary: Nanozymes have significant advantages over natural enzymes and have been widely used in various fields due to their low cost, high stability, controllable activity, and reusability. This review comprehensively analyzes the source of nanozyme catalytic activities, discusses their catalytic mechanism and multiple enzyme-like activities, and reviews biological applications based on RONS regulation. The current challenges and future research directions of nanozymes are also presented.

COORDINATION CHEMISTRY REVIEWS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Enhanced Multiple Enzymelike Activity of PtPdCu Trimetallic Nanostructures for Detection of Fe2+ and Evaluation of Antioxidant Capability

Yuanyang Mao et al.

Summary: Metallic nanozymes, such as PtPdCu trimetallic nanoalloys, exhibit enhanced enzymelike activities compared to bimetallic nanoalloys and commercial Pt/C due to the synergistic effect between heteroatoms and the exposure of more active surfaces. The incorporation of Cu into Pt and Pd to form a trimetallic structure not only changes the electronic structure but also improves the enzymelike catalytic activity. PtPdCu TNAs show applications in selective detection of Fe2+ in oral supplements and evaluation of the antioxidant capacity of natural antioxidants and tea extracts through ferroxidase-like and peroxidase-like activities.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Thermal Atomization of Platinum Nanoparticles into Single Atoms: An Effective Strategy for Engineering High-Performance Nanozymes

Yuanjun Chen et al.

Summary: A novel and efficient strategy was reported to access high-performance nanozymes by atomizing platinum nanoparticles into single atoms, leading to dramatically enhanced enzymatic performance. The engineered single-atom Pt nanozyme exhibited remarkable catalytic activity and kinetics, far exceeding traditional Pt nanoparticle nanozymes.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Engineering, Environmental

Dual cross-linked organic-inorganic hybrid hydrogels accelerate diabetic skin wound healing

Yuna Qian et al.

Summary: Limited treatment options are available for chronic non-self-healing diabetic wounds characterized by bacterial infection and hypoxic microenvironment. A multifunctional organic-inorganic hybrid hydrogel, SF/Hb/Ga, was developed to address these challenges. This hybrid hydrogel demonstrated antibacterial properties, promoted cell proliferation, and accelerated tissue repair phases, leading to complete healing of infected diabetic wounds in vivo within 15 days.

CHEMICAL ENGINEERING JOURNAL (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Novel Cascade Nanoreactor Integrating Two-Dimensional Pd-Ru Nanozyme, Uricase and Red Blood Cell Membrane for Highly Efficient Hyperuricemia Treatment

Jiang Ming et al.

Summary: Nanozyme-based cascade reactions are shown to be an effective strategy for disease treatment, with the designed Pd-Ru/Uricase@RBC nanoreactor demonstrating good stability, long circulation half-life, and the ability to effectively degrade uric acid to treat hyperuricemia. The integration of high-efficiency enzymatic activity, long circulation capability, and good biocompatibility make it a promising alternative for clinical treatment of hyperuricemia.

SMALL (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Biocatalytic and Antioxidant Nanostructures for ROS Scavenging and Biotherapeutics

Liyun Wang et al.

Summary: ROS significantly affect human physiological activities and lead to chronic diseases in inflammatory tissues. Many antioxidant molecules and enzymes have limitations, but biocatalytic or antioxidant nanostructures show promising ROS scavenging capabilities. This review summarizes recent advancements in engineering these nanostructures for ROS scavenging, including principles, methods, efficiencies, and applications.

ADVANCED FUNCTIONAL MATERIALS (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavenging

Yao Qi et al.

Summary: The study involved the development of nanoparticles loaded hydrogel to neutralize detrimental factors and promote diabetic wound healing. The cerium-doped zeolite nanoparticles eliminated mitochondrial ROS and neutralized inflammatory factors, remodeling the wound's anti-inflammatory microenvironment and enhancing angiogenesis. The thermoreversible hydrogel showed strong haemostatic and bactericidal properties, offering a promising multi-targeted therapy for diabetic wound healing.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Nanozymes for regulation of reactive oxygen species and disease therapy

Yujie Dai et al.

Summary: Nanozymes possess high catalytic activity and stability, making them advantageous in generating or eliminating reactive oxygen species (ROS) for potential applications in disease therapy. Researchers are exploring catalytic mechanisms and strategies to design nanozyme-based platforms for cancer therapy, pathogen infection, neurodegenerative diseases, and more. Challenges and future opportunities for the development and application of nanozymes are also being discussed.

CHINESE CHEMICAL LETTERS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Advances in oxidase-mimicking nanozymes: Classification, activity regulation and biomedical applications

Yu Chong et al.

Summary: This article introduces the classification, catalytic mechanisms, and methods for regulating the activity of oxidase-mimicking nanozymes, discusses their potential applications in the biomedical field, and also points out the research opportunities and challenges in this area.

NANO TODAY (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Antioxidant and anti-aging carbon quantum dots using tannic acid

Min Hyeong Son et al.

Summary: The study developed T-CQDs with antioxidant and anti-aging properties, exhibiting excellent free radical scavenging ability and inhibitory activity against skin aging-related enzymes. Moreover, they effectively suppressed UV-induced reactive oxygen species generation, showing great potential for applications in the cosmetic and nanomedicine fields.

NANOTECHNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases

Wei Feng et al.

Summary: Materials with enzymatic-like activities, such as 2D vanadium carbide MXene nanozymes, show promise in treating inflammatory and neurodegenerative diseases mediated by reactive oxygen species.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Platinum-Copper Bimetallic Colloid Nanoparticle Cluster Nanozymes with Multiple Enzyme-like Activities for Scavenging Reactive Oxygen Species

Yan Liu et al.

Summary: The study successfully prepared polyvinylpyrrolidone-platinum-copper nanoparticle clusters with multiple enzymatic activities using a simple chemical coreduction method. These clusters showed efficient antioxidant enzyme-like activities and ability to eliminate reactive oxygen species. The doping of copper not only reduced platinum usage but also improved catalytic efficiency and versatility.

LANGMUIR (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Cu,Zn Dopants Boost Electron Transfer of Carbon Dots for Antioxidation

Sheng Xue et al.

Summary: Enzyme-mimicking nanomaterials for antioxidative therapy show promise in treating various diseases by scavenging excessive ROS. The biocompatible CuZn-CDs exhibit catalase and superoxide dismutase activities, protecting cardiomyocytes from ROS-induced damage and reducing heart ischemia-reperfusion injury. Their rapid renal clearance and low toxicity suggest high biocompatibility for clinical applications.

SMALL (2021)

添加到收藏夹

Article Engineering, Biomedical

Nanozyme with Robust Catalase Activity by Multiple Mechanisms and Its Application for Hypoxic Tumor Treatment

Chongchong Wang et al.

Summary: Utilizing TiO2-modified Pd NS to enhance catalytic activity can lead to the creation of nanomotors with synergistic effects of photodynamic therapy and photothermal therapy.

ADVANCED HEALTHCARE MATERIALS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Single-atom engineering of metal-organic frameworks toward healthcare

Dongdong Wang et al.

Summary: Single-atomic nanocatalysts/nanozymes (SACs/SAEs) are a research frontier due to their high atom-utilization efficiency and well-defined localized structure. Metal-organic frameworks (MOFs) are promising host materials for constructing SACs/SAEs, with the potential for MOF-derived SACs/SAEs through pyrolysis. The recent advances of MOF-based SACs/SAEs in enzymatic healthcare applications, such as cancer treatment and biosensing, offer great opportunities for next-generation biosafe SACs/SAEs.

CHEM (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation

Ya Guan et al.

Summary: The study developed a sustained oxygenation system using oxygen-release microspheres and a reactive oxygen species (ROS)-scavenging hydrogel to promote diabetic wound healing. The sustained release of oxygen enhanced cell survival and migration, angiogenic growth factor expression, angiogenesis, and decreased proinflammatory cytokine expression in diabetic wounds, leading to a significant increase in wound closure rate.

SCIENCE ADVANCES (2021)

添加到收藏夹

Correction Materials Science, Biomaterials

Poly(acrylic acid)-mediated synthesis of cerium oxide nanoparticles with variable oxidation states and their effect on regulating the intracellular ROS level (vol 9, pg 7386, 2021)

Xiaohui Ju et al.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Poly(tannic acid) nanocoating based surface modification for construction of multifunctional composite CeO2NZs to enhance cell proliferation and antioxidative viability of preosteoblasts

Shuoshuo Yang et al.

Summary: Ceria (CeO2) based materials with multiple antioxidative properties were constructed by surface modification with nanoscale poly(tannic acid) coatings, showing stronger SOD-like activity and higher free radical scavenging rate, making them suitable for protecting cells under oxidative stress.

NANOSCALE (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Nanozymes Inspired by Natural Enzymes

Ruofei Zhang et al.

Summary: Nanozymes, nanomaterials with enzyme-like activities, have attracted significant attention in recent years as potential substitutes and competitors for natural enzymes. The key focus in this field is on creating nanozymes with catalytic performance comparable to or surpassing that of natural enzymes. By employing a bioinspired strategy, researchers have successfully synthesized high-activity nanozymes that show similar catalytic activities to natural enzymes, establishing a new hot topic in nanozyme research.

ACCOUNTS OF MATERIALS RESEARCH (2021)

添加到收藏夹

Review Materials Science, Biomaterials

Superoxide dismutase nanozymes: an emerging star for anti-oxidation

Hanqing Zhao et al.

Summary: Superoxide dismutases (SODs) play a crucial role in combating damage from reactive oxygen species in oxidative stress-related diseases. Nanozymes, as substitutes for SODs, offer better stability and cost-effectiveness.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

Meng Zhao et al.

Summary: Reducing mtROS levels attenuated renal dysfunction, mitochondrial damage, and inflammation in IRI-AKI mice. The loss of TFAM can impact mtDNA maintenance, mitochondrial energy metabolism, and cytokine release. Insights into the role of mtROS and TFAM in IRI-AKI provide potential therapeutic targets for renal repair.

THERANOSTICS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

When Nanozymes Meet Single-Atom Catalysis

Lei Jiao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

An Enzyme-Mimicking Single-Atom Catalyst as an Efficient Multiple Reactive Oxygen and Nitrogen Species Scavenger for Sepsis Management

Fangfang Cao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Article Cell Biology

ROS and diseases: role in metabolism and energy supply

Shenshu Yang et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2020)

添加到收藏夹

Review Nutrition & Dietetics

Vitamin D and Endothelial Function

Do-Houn Kim et al.

NUTRIENTS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Selenium-Doped Carbon Quantum Dots Act as Broad-Spectrum Antioxidants for Acute Kidney Injury Management

Zachary T. Rosenkrans et al.

ADVANCED SCIENCE (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Metal-Organic Framework Derived Nanozymes in Biomedicine

Dongdong Wang et al.

ACCOUNTS OF CHEMICAL RESEARCH (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Epitaxially Strained CeO2/Mn3O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection

Sang Ihn Han et al.

ADVANCED MATERIALS (2020)

添加到收藏夹

Review Critical Care Medicine

Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis

C. Fleischmann-Struzek et al.

INTENSIVE CARE MEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

Yufeng Liu et al.

SCIENCE ADVANCES (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

An Orally Administered CeO2@Montmorillonite Nanozyme Targets Inflammation for Inflammatory Bowel Disease Therapy

Shengwc. Zhao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

添加到收藏夹

Review Medicine, Research & Experimental

Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols

Mohammad Yunus Ansari et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Single-atom nanozymes: A rising star for biosensing and biomedicine

Xianlong Zhang et al.

COORDINATION CHEMISTRY REVIEWS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

The role of Nrf2 in acute kidney injury: Novel molecular mechanisms and therapeutic approaches

Wei Wei et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bile acid-based dual-functional prodrug nanoparticles for bone regeneration through hydrogen peroxide scavenging and osteogenic differentiation of mesenchymal stem cells

Yoshie Arai et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Biomimetic polysaccharide-cloaked lipidic nanovesicles/microassemblies for improving the enzymatic activity and prolonging the action time for hyperuricemia treatment

Lan Yang et al.

NANOSCALE (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

Yanyan Huang et al.

CHEMICAL REVIEWS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Promoting Angiogenesis in Oxidative Diabetic Wound Microenvironment Using a Nanozyme-Reinforced Self-Protecting Hydrogel

Haibin Wu et al.

ACS CENTRAL SCIENCE (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Melanin-Based Natural Antioxidant Defense Nanosystem for Theranostic Application in Acute Kidney Injury

Tuanwei Sun et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

添加到收藏夹

Review Cell & Tissue Engineering

Understanding the multifaceted mechanisms of diabetic wound healing and therapeutic application of stem cells conditioned medium in the healing process

Lai Woon Fui et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Recent Advances in Nanozyme Research

Hui Wang et al.

ADVANCED MATERIALS (2019)

添加到收藏夹

Review Medicine, General & Internal

Antioxidant Therapies for Neuroprotection-A Review

Raluca Ioana Teleanu et al.

JOURNAL OF CLINICAL MEDICINE (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Chiral Molecule-mediated Porous CuxO Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson's Disease

Changlong Hao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

ROS and the DNA damage response in cancer

Upadhyayula Sai Srinivas et al.

REDOX BIOLOGY (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)

Jiangjiexing Wu et al.

CHEMICAL SOCIETY REVIEWS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

A single-atom Fe-N4 catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection

Wenjie Ma et al.

CHEMICAL COMMUNICATIONS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Molecularly imprinted nanozymes with faster catalytic activity and better specificity

Zijie Zhang et al.

NANOSCALE (2019)

添加到收藏夹

Article Chemistry, Physical

Selenium-functionalized metal-organic frameworks as enzyme mimics

Weiqiang Zhou et al.

NANO RESEARCH (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Simultaneous Blood-Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles

Qunqun Bao et al.

ACS NANO (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ceria Nanoparticle Systems for Selective Scavenging of Mitochondrial, Intracellular, and Extracellular Reactive Oxygen Species in Parkinson's Disease

Hyek Jin Kwon et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Nanoisozymes: Crystal-Facet-Dependent Enzyme-Mimetic Activity of V2O5 Nanomaterials

Sourav Ghosh et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Manganese-Based Nanozymes: Multienzyme Redox Activity and Effect on the Nitric Oxide Produced by Endothelial Nitric Oxide Synthase

Namrata Singh et al.

CHEMISTRY-A EUROPEAN JOURNAL (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Selenium-Based Nanozyme as Biomimetic Antioxidant Machinery

Yanyan Huang et al.

CHEMISTRY-A EUROPEAN JOURNAL (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

The enzyme-like catalytic activity of cerium oxide nanoparticles and its dependency on Ce3+ surface area concentration

V. Baldim et al.

NANOSCALE (2018)

添加到收藏夹

Review Cell Biology

ROS signalling in the biology of cancer

Jennifer N. Moloney et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

ROS scavenging Mn3O4 nanozymes for in vivo anti-inflammation

Jia Yao et al.

CHEMICAL SCIENCE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy

Kelong Fan et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Enhanced catalysis of ultrasmall Au-MoS2 clusters against reactive oxygen species for radiation protection

Peixian Bian et al.

SCIENCE BULLETIN (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Targeted Therapy of Atherosclerosis by a Broad-Spectrum Reactive Oxygen Species Scavenging Nanoparticle with Intrinsic Anti-inflammatory Activity

Yuquan Wang et al.

ACS NANO (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease

Tae-In Kam et al.

SCIENCE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice

Dalong Ni et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery

Chun-Yan Shen et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Oxidative DNA damage & repair: An introduction

Jean Cadet et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

添加到收藏夹

Review Oncology

Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemia

Hubert Hackl et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

添加到收藏夹

Review Chemistry, Physical

Surface modification of nanozymes

Biwu Liu et al.

NANO RESEARCH (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Glycine-functionalized copper(II) hydroxide nanoparticles with high intrinsic superoxide dismutase activity

Karsten Korschelt et al.

NANOSCALE (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Light-Mediated Reversible Modulation of ROS Level in Living Cells by Using an Activity-Controllable Nanozyme

Faming Wang et al.

SMALL (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Redox Modulatory Mn3O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model

Namrata Singh et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

添加到收藏夹

Review Peripheral Vascular Disease

Oxidative Stress in Atherosclerosis

Ajoe John Kattoor et al.

CURRENT ATHEROSCLEROSIS REPORTS (2017)

添加到收藏夹

Article Nanoscience & Nanotechnology

Fibrous Nanozyme Dressings with Catalase-Like Activity for H2O2 Reduction To Promote Wound Healing

Minghan Hu et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Catalase, a remarkable enzyme: targeting the oldest antioxidant enzyme to find a new cancer treatment approach

Christophe Glorieux et al.

BIOLOGICAL CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ceria-Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment

Min Soh et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Selenium-Doped Carbon Quantum Dots for Free-Radical Scavenging

Feng Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

添加到收藏夹

Article Nanoscience & Nanotechnology

Selenium-Functionalized Graphene Oxide That Can Modulate the Balance of Reactive Oxygen Species

Jiahao Xia et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

添加到收藏夹

Review Genetics & Heredity

DNA repair and damage pathways in breast cancer development and therapy

Maryam Majidinia et al.

DNA REPAIR (2017)

添加到收藏夹

Article Nanoscience & Nanotechnology

Graphene Oxide Quantum Dots as Novel Nanozymes for Alcohol Intoxication

Anqi Sun et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis

Ulrich Foerstermann et al.

CIRCULATION RESEARCH (2017)

添加到收藏夹

Article Gastroenterology & Hepatology

The First European Evidence-based Consensus on Extra-intestinal Manifestations in Inflammatory Bowel Disease

Marcus Harbord et al.

JOURNAL OF CROHNS & COLITIS (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Highly Catalytic Nanodots with Renal Clearance for Radiation Protection

Xiao-Dong Zhang et al.

ACS NANO (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage

Cuicui Ge et al.

ACS NANO (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer's Disease

Hyek Jin Kwon et al.

ACS NANO (2016)

添加到收藏夹

Article Cell Biology

Skin aging and oxidative stress: Equol's anti-aging effects via biochemical and molecular mechanisms

Edwin D. Lephart

AGEING RESEARCH REVIEWS (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Self-Assembly of Multi-nanozymes to Mimic an Intracellular Antioxidant Defense System

Yanyan Huang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

添加到收藏夹

Article Engineering, Biomedical

Ceria/POMs hybrid nanoparticles as a mimicking metallopeptidase for treatment of neurotoxicity of amyloid-β peptide

Yijia Guan et al.

BIOMATERIALS (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Disturbed hypoxic responses as a pathogenic mechanism of diabetic foot ulcers

Sergiu-Bogdan Catrina et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2016)

添加到收藏夹

Review Immunology

The immune system's role in sepsis progression, resolution, and long-term outcome

Matthew J. Delano et al.

IMMUNOLOGICAL REVIEWS (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers

Wei Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

添加到收藏夹

Article Chemistry, Physical

Polyoxometalate-based nanozyme: Design of a multifunctional enzyme for multi-faceted treatment of Alzheimer's disease

Nan Gao et al.

NANO RESEARCH (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Tailoring Enzyme-Like Activities of Gold Nanoclusters by Polymeric Tertiary Amines for Protecting Neurons Against Oxidative Stress

Ching-Ping Liu et al.

SMALL (2016)

添加到收藏夹

Review Pharmacology & Pharmacy

Targeting Oxidative Stress in Central Nervous System Disorders

Manisha Patel

TRENDS IN PHARMACOLOGICAL SCIENCES (2016)

添加到收藏夹

Article Materials Science, Biomaterials

Controlling the surface chemistry of cerium oxide nanoparticles for biological applications

Ankur Gupta et al.

JOURNAL OF MATERIALS CHEMISTRY B (2016)

添加到收藏夹

Article Nanoscience & Nanotechnology

Nanosomal Microassemblies for Highly Efficient and Safe Delivery of Therapeutic Enzymes

Huarong Xiong et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

添加到收藏夹

Article Nanoscience & Nanotechnology

Dual-Enzyme Characteristics of Polyvinylpyrrolidone-Capped Iridium Nanoparticles and Their Cellular Protective Effect against H2O2-Induced Oxidative Damage

Hua Su et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

添加到收藏夹

Editorial Material Chemistry, Multidisciplinary

Small Organoselenium Compounds: More than just Glutathione Peroxidase Mimics

Thomas Wirth

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Deciphering a Nanocarbon-Based Artificial Peroxidase: Chemical Identification of the Catalytically Active and Substrate-Binding Sites on Graphene Quantum Dots

Hanjun Sun et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

添加到收藏夹

Review Cell & Tissue Engineering

Nanomaterials and bone regeneration

Tao Gong et al.

BONE RESEARCH (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Reactive Oxygen Species in Inflammation and Tissue Injury

Manish Mittal et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

添加到收藏夹

Review Chemistry, Multidisciplinary

Superoxide Dismutases and Superoxide Reductases

Yuewei Sheng et al.

CHEMICAL REVIEWS (2014)

添加到收藏夹

Review Physiology

MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) AND ROS-INDUCED ROS RELEASE

Dmitry B. Zorov et al.

PHYSIOLOGICAL REVIEWS (2014)

添加到收藏夹

Article Multidisciplinary Sciences

An antioxidant nanozyme that uncovers the cytoprotective potential of vanadia nanowires

Amit A. Vernekar et al.

NATURE COMMUNICATIONS (2014)

添加到收藏夹

Review Nutrition & Dietetics

Resources and Biological Activities of Natural Polyphenols

An-Na Li et al.

NUTRIENTS (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Antioxidant Properties of Cerium Oxide Nanocrystals as a Function of Nanocrystal Diameter and Surface Coating

Seung Soo Lee et al.

ACS NANO (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Glutathione peroxidases

Regina Brigelius-Flohe et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Flavonoids as Antioxidants and Developmental Regulators: Relative Significance in Plants and Humans

Cecilia Brunetti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Cerium oxide caged metal chelator: anti-aggregation and anti-oxidation integrated H2O2-responsive controlled drug release for potential Alzheimer's disease treatment

Meng Li et al.

CHEMICAL SCIENCE (2013)

添加到收藏夹

Article Engineering, Biomedical

Nanoceria-Triggered Synergetic Drug Release Based on CeO2-Capped Mesoporous Silica Host-Guest Interactions and Switchable Enzymatic Activity and Cellular Effects of CeO2

Can Xu et al.

ADVANCED HEALTHCARE MATERIALS (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Dual Enzyme-like Activities of Iron Oxide Nanoparticles and Their Implication for Diminishing Cytotoxicity

Zhongwen Chen et al.

ACS NANO (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ceria Nanoparticles that can Protect against Ischemic Stroke

Chi Kyung Kim et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

Apoferritin-CeO2 nano-truffle that has excellent artificial redox enzyme activity

Xiangyou Liu et al.

CHEMICAL COMMUNICATIONS (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

The Vital Role of Buffer Anions in the Antioxidant Activity of CeO2 Nanoparticles

Ying Xue et al.

CHEMISTRY-A EUROPEAN JOURNAL (2012)

添加到收藏夹

Review Infectious Diseases

Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes

Greg S. Martin

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2012)

添加到收藏夹

Article Engineering, Biomedical

The reversal of cisplatin-induced nephrotoxicity by selenium nanoparticles functionalized with 11-mercapto-1-undecanol by inhibition of ROS-mediated apoptosis

Yinghua Li et al.

BIOMATERIALS (2011)

添加到收藏夹

Review Medicine, General & Internal

Bone regeneration: current concepts and future directions

Rozalia Dimitriou et al.

BMC MEDICINE (2011)

添加到收藏夹

Review Endocrinology & Metabolism

Neuro-oxidative-nitrosative stress in sepsis

Ronan M. G. Berg et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2011)

添加到收藏夹

Article Rheumatology

Contemporary epidemiology of gout in the UK general population

Lucia Cea Soriano et al.

ARTHRITIS RESEARCH & THERAPY (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Hedgehog Signaling and Osteogenic Differentiation in Multipotent Bone Marrow Stromal Cells Are Inhibited by Oxidative Stress

Woo-Kyun Kim et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2010)

添加到收藏夹

Article Chemistry, Multidisciplinary

Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles

Atul Asati et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

添加到收藏夹

Review Chemistry, Multidisciplinary

Alzheimer's Disease: From Pathology to Therapeutic Approaches

Roland Jakob-Roetne et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

添加到收藏夹

Article Mathematics, Applied

A geometrically nonlinear finite element model of nanomaterials with consideration of surface effects

Hui She et al.

FINITE ELEMENTS IN ANALYSIS AND DESIGN (2009)

添加到收藏夹

Review Pathology

Oxidative stress in ulcerative colitis-associated carcinogenesis

A. Roessner et al.

PATHOLOGY RESEARCH AND PRACTICE (2008)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis of biocompatible dextran-coated nanoceria with pH-dependent antioxidant properties

J. Manuel Perez et al.

SMALL (2008)

添加到收藏夹

Review Cell Biology

ROS as signalling molecules:: mechanisms that generate specificity in ROS homeostasis

Benoit D'Autreaux et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting β-catenin from T cell factor- to Forkhead box O-mediated transcription

Maria Almeida et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

添加到收藏夹

Article Biochemical Research Methods

A macrophage-nanozyme delivery system for Parkinson's disease

Elena V. Batrakova et al.

BIOCONJUGATE CHEMISTRY (2007)

添加到收藏夹

Article Chemistry, Multidisciplinary

Superoxide dismutase mimetic properties exhibited by vacancy engineered ceria nanoparticles

Cassandra Korsvik et al.

CHEMICAL COMMUNICATIONS (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mitochondrial ROS-induced ROS release: An update and review

Dmitry B. Zorov et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2006)

添加到收藏夹

Review Neurosciences

Expanding insights of mitochondrial dysfunction in Parkinson's disease

PM Abou-Sleiman et al.

NATURE REVIEWS NEUROSCIENCE (2006)

添加到收藏夹

Review Medicine, General & Internal

Pathogenesis of gout

HK Choi et al.

ANNALS OF INTERNAL MEDICINE (2005)

添加到收藏夹

Review Pharmacology & Pharmacy

ROS stress in cancer cells and therapeutic implications

H Pelicano et al.

DRUG RESISTANCE UPDATES (2004)

添加到收藏夹

Review Multidisciplinary Sciences

Pathways towards and away from Alzheimer's disease

MP Mattson

NATURE (2004)

添加到收藏夹

Review Physiology

Role of oxidative modifications in atherosclerosis

R Stocker et al.

PHYSIOLOGICAL REVIEWS (2004)

添加到收藏夹

Review Biochemistry & Molecular Biology

Superefficient enzymes

ME Stroppolo et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2001)

添加到收藏夹

Review Endocrinology & Metabolism

Management of hyperglycemic crises in patients with diabetes

AE Kitabchi et al.

DIABETES CARE (2001)

添加到收藏夹

Article Biochemistry & Molecular Biology

Role of reactive oxygen species (ROS) in apoptosis induction

HU Simon et al.

APOPTOSIS (2000)

添加到收藏夹

Review Medicine, General & Internal

Science, medicine, and the future - Stem cell transplantation

AL Lennard et al.

BRITISH MEDICAL JOURNAL (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.