☆ 3.9 Review

Harnessing stem cell and lineage reprogramming technology to treat cardiac fibrosis

CELL REGENERATION (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biochemistry & Molecular Biology

Recent Advances in Generation of In Vitro Cardiac Organoids

Makoto Sahara

Summary: Cardiac organoids are three-dimensional structures composed of multiple cardiac cells that mimic the native heart more effectively than conventional two-dimensional culture systems. They have a wide range of applications in cardiogenesis, cardiac disease modeling, drug screening, and regenerative medicine. This mini-review summarizes recent advances in cardiac organoid technologies, discussing formation methods, current limitations, and future perspectives.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Review Cell Biology

Preclinical Large Animal Porcine Models for Cardiac Regeneration and Its Clinical Translation: Role of hiPSC-Derived Cardiomyocytes

Divya Sridharan et al.

Summary: Myocardial infarction (MI) is caused by coronary artery blockage, leading to ischemia and necrosis of the left ventricular heart muscle. The replacement of dying cardiac tissue with scar tissue decreases myocardial contractility, affecting heart function. Human induced pluripotent stem cells (hiPSCs) offer potential for cardiac regeneration, but their clinical application is hindered by poor preclinical reproducibility. This review discusses various animal models, with a focus on the translatable porcine MI model, to understand factors affecting reproducibility and translatability.

CELLS (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Cardiac muscle patches containing four types of cardiac cells derived from human pluripotent stem cells improve recovery from cardiac injury in mice

Xi Lou et al.

Summary: The study demonstrates that human cardiac muscle patches containing three types of cardiac cells derived from human pluripotent stem cells significantly improved cardiac function, reduced infarct size, and promoted cardiac maturation in a pig model of myocardial infarction. The inclusion of cardiac fibroblasts in the cardiac patches enhanced the maturity and function of cardiac muscle cells. Transplantation of cardiac patches with cardiac fibroblasts resulted in better cardiac recovery and engraftment compared to patches without fibroblasts.

CARDIOVASCULAR RESEARCH (2023)

添加到收藏夹

Article Engineering, Biomedical

Cyclic strain has antifibrotic effects on the human cardiac fibroblast transcriptome in a human cardiac fibrosis-on-a-chip platform

Tom C. L. Bracco Gartner et al.

Summary: Cardiac fibroblasts in the ever-beating human heart remain quiescent due to the antifibrotic effect of cyclic strain conditions revealed by a novel platform for studying cardiac fibrosis-on-a-chip. This study provides insights into the mechanosensitive pathways and genes involved in the fibrogenic process, which can contribute to the development of new therapies against cardiac fibrosis.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2023)

添加到收藏夹

Article Cell Biology

Cooperative regulation of Zhx1 and hnRNPA1 drives the cardiac progenitor-specific transcriptional activation during cardiomyocyte differentiation

Yang Chen et al.

Summary: The zinc finger proteins (ZNFs) play a critical role in regulating cell fate transition. However, the specific regulatory mechanism of ZNFs in cardiomyocyte differentiation remains unclear. In this study, we found that the transiently expressed Zhx1 protein during cell fate transition from mesoderm to cardiac progenitors is essential for proper cardiomyocyte differentiation in mouse and human embryonic stem cells. Zhx1 interacts with hnRNPA1 to promote the specification of cardiac progenitors and co-activates the transcription of a wide range of genes. Further investigation showed that Zhx1 binds to hnRNPA1 through the amino acid residues (Thr111-His120) of the second Znf domain, contributing to the formation of cardiac progenitors. Our findings provide new insights into the role of Zhx1/hnRNPA1 interaction in gene transcription during cardiac progenitor specification and highlight the specificity of cell fate determination in cardiomyocyte differentiation.

CELL DEATH DISCOVERY (2023)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Transforming growth factor-β in myocardial disease

Nikolaos G. Frangogiannis

Summary: Transforming growth factor-beta (TGF beta) plays an important role in myocardial diseases, regulating the phenotype and function of cardiovascular cells, participating in cardiac repair and remodeling.

NATURE REVIEWS CARDIOLOGY (2022)

添加到收藏夹

Review Cell & Tissue Engineering

Progress in multicellular human cardiac organoids for clinical applications

Hyeonyu Kim et al.

Summary: Advances in self-organizing cardiac organoids have provided a powerful tool for studying human cardiac development, cardiovascular diseases, drug testing, and transplantation. This review highlights the recent progress on multicellular cardiac organoids and introduces key readouts and tools for assessing their clinical applications.

CELL STEM CELL (2022)

添加到收藏夹

Review Cell Biology

Direct cardiac reprogramming comes of age: Recent advance and remaining challenges

Yifang Xie et al.

Summary: The adult human heart has limited regenerative capacity. Direct cardiac reprogramming, which converts cardiac fibroblast into functional cardiomyocyte-like cells, holds great promise for heart regeneration. Significant progress has been made in improving reprogramming efficiency and understanding the underlying molecular mechanisms.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2022)

添加到收藏夹

Article Engineering, Biomedical

Reprogramming of fibroblasts into expandable cardiovascular progenitor cells via small molecules in xeno-free conditions

Jia Wang et al.

Summary: A combination of small molecules can generate a cell population with cardiovascular differentiation potential from fibroblasts. These chemically induced cardiovascular progenitor cells (ciCPCs) can self-renew and preserve their differentiation capacity in chemically defined and xeno-free conditions. Transplantation of ciCPCs into infarcted mouse hearts improves cardiac function. Expanded autologous cardiovascular cells have important applications in drug discovery, disease modeling, and cardiac cell therapy.

NATURE BIOMEDICAL ENGINEERING (2022)

添加到收藏夹

Article Biology

Computational profiling of hiPSC-derived heart organoids reveals chamber defects associated with NKX2-5 deficiency

Wei Feng et al.

Summary: The researchers developed a human cardiac organoid system and used single cell RNA sequencing and machine learning to study the genetic variant associated with Ebstein's Anomaly. They found that the system could generate chamber-specific organoids and successfully recapitulated the disease's atrialized ventricular defects.

COMMUNICATIONS BIOLOGY (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation

Gloria Garoffolo et al.

Summary: This study suggests that preventing molecular translation of mechanical cues in cardiac stromal cells can reduce the impact of cardiac maladaptive remodeling and have a positive effect on fibrosis.

CIRCULATION RESEARCH (2022)

添加到收藏夹

Article Medicine, General & Internal

Effect of MRI-Guided Fibrosis Ablation vs Conventional Catheter Ablation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation The DECAAF II Randomized Clinical Trial

Nassir F. Marrouche et al.

Summary: Among patients with persistent atrial fibrillation, MRI-guided fibrosis ablation in addition to PVI did not show significant reduction in atrial arrhythmia recurrence compared to PVI catheter ablation alone. The findings do not support the use of MRI-guided fibrosis ablation for the treatment of persistent AF.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

TBX20 Improves Contractility and Mitochondrial Function During Direct Human Cardiac Reprogramming

Yawen Tang et al.

Summary: The addition of TBX20 to the MGT133 reprogramming cocktail promotes cardiac reprogramming and enhances cardiac function in induced cardiomyocytes by activating genes associated with cardiac contractility and mitochondrial respiration.

CIRCULATION (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeting fibrosis, mechanisms and cilinical trials

Manyu Zhao et al.

Summary: Fibrosis is a common pathological process in which excessive extracellular matrix deposition occurs due to dysregulated wound and connective tissue repair response. This review provides an overview of the etiology and epidemiology of several fibrosis diseases, as well as discussing the abnormal cells and their interactions, signaling pathways, and therapeutic targets involved in fibrosis. It also highlights the potential of anti-fibrotic drugs in targeting these mechanisms. This review serves as a valuable reference for further research, drug development, and clinical trials in the field of fibrosis.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

添加到收藏夹

Article Cell & Tissue Engineering

Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids

Ana C. Silva et al.

Summary: This study demonstrates the successful generation of a human multilineage iPSC-derived organoid model that recapitulates cooperative cardiac and gut development, showing the importance of endoderm tissue in driving cardiac tissue features. This advancement allows for further examination of multi-tissue interactions during development, physiological maturation, and disease.

CELL STEM CELL (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Human iPSC-engineered cardiac tissue platform faithfully models important cardiac physiology

Willem J. de Lange et al.

Summary: This study provides a detailed assessment of engineered human cardiac tissue constructs (hiPSC-ECTs) formed by coculturing hiPSC-CMs and cardiac fibroblasts in a 3D fibrin matrix. The hiPSC-ECTs show improved physiological responsiveness, develop a t-tubular system, and exhibit calcium-handling and contractile kinetics similar to human myocardium. The study emphasizes the suitability of 3D-engineered human cardiac tissues as a model for studying cardiac function and provides data to aid in selecting the most appropriate configuration based on the research question.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner

Eva Querdel et al.

Summary: The transplantation of engineered heart tissue (EHT) patches resulted in partial remuscularization of the injured heart and improved left ventricular function in a dose-dependent manner in guinea pig and pig models. Human-scale patches were successfully transplanted onto pigs in a proof-of-principle study.

CIRCULATION (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Human heart-forming organoids recapitulate early heart and foregut development

Lika Drakhlis et al.

Summary: This study successfully generated three-dimensional heart-forming organoids that closely resemble early native heart anlagen, containing myocardial layer, endocardial-like cells, septum-transversum-like anlagen, and distinct anterior versus posterior foregut endoderm tissues. These organoids were used to study genetic defects in vitro and demonstrated a phenotype similar to cardiac malformations seen in transgenic mice with the knockout of NKX2.5 gene.

NATURE BIOTECHNOLOGY (2021)

添加到收藏夹

Article Engineering, Biomedical

Direct conversion of adult human fibroblasts into functional endothelial cells using defined factors

Jung-Kyu Han et al.

Summary: Direct conversion of aHDFs into functional ECs was achieved by delivering ER71, KLF2, and TAL1, along with two EMT inhibitors, followed by a second-stage conversion process, resulting in improved efficiency. The genetic and epigenetic profiles of the converted iECs resembled those of functional ECs.

BIOMATERIALS (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction

Meng Zhao et al.

Summary: The study demonstrated that the enhanced potency of CCND2(OE)CMs promoted myocyte proliferation in both grafts and recipient tissue in a large mammal acute myocardial infarction model. These results suggest that CCND2(OE)CMs transplantation may be a potential therapeutic strategy for the repair of infarcted hearts.

CIRCULATION (2021)

添加到收藏夹

Article Cell Biology

The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming

Glynnis A. Garry et al.

Summary: The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to increase accessibility to core cardiac transcription factors, facilitating direct cardiac reprogramming.

NATURE CELL BIOLOGY (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Cardiac fibrosis models using human induced pluripotent stem cell-derived cardiac tissues allow anti-fibrotic drug screening in vitro

Hiroko Iseoka et al.

Summary: The study screened potential anti-fibrotic drugs using human induced pluripotent stem cell-derived cardiomyocytes and non-cardiomyocytes, and validated their efficacy in a heart failure model, indicating the usefulness of the in vitro model for drug screening.

STEM CELL RESEARCH (2021)

添加到收藏夹

Review Cell & Tissue Engineering

Surfing the clinical trials of mesenchymal stem cell therapy in ischemic cardiomyopathy

Iman Razeghian-Jahromi et al.

Summary: Mesenchymal stem cell (MSC) therapy has shown positive outcomes in clinical trials for heart failure, including scar size reduction, reverse remodeling, and angiogenesis. However, there are still uncertainties regarding the optimal dose, route of administration, timing, and source of stem cells, which are limiting the routine use of MSC therapy in clinical practice.

STEM CELL RESEARCH & THERAPY (2021)

添加到收藏夹

Review Cell Biology

Endothelial-Myocardial Angiocrine Signaling in Heart Development

Hyeonyu Kim et al.

Summary: This review focuses on the multifunctional nature of vascular endothelial cells in the mammalian heart and their regulation of critical processes in heart development via unique angiocrine signaling pathways. Advancements in single-cell sequencing have accelerated the understanding of intercellular communication among functional cell types in the heart, highlighting the heterogeneous nature of cardiac endothelial cells and their contributions to various aspects of heart development.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Heart Organoids and Engineered Heart Tissues: Novel Tools for Modeling Human Cardiac Biology and Disease

Yonatan R. Lewis-Israeli et al.

Summary: Organoids are three-dimensional cell constructs that mimic organ properties and structure, and have been widely used to model various organs and disease conditions. However, the technology for generating and using heart organoids in cardiovascular research lags behind other organ types. Efforts are being made to overcome the challenges in creating heart organoids to advance cardiovascular studies and treatment of heart disorders.

BIOMOLECULES (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Thymosin β4 increases cardiac cell proliferation, cell engraftment, and the reparative potency of human induced-pluripotent stem cell-derived cardiomyocytes in a porcine model of acute myocardial infarction

Shi Hua Tan et al.

Summary: In a porcine model of myocardial infarction, co-treatment with Tb4-microspheres and hiPSC-CMs improved the engraftment and reparative potency of the transplanted hiPSC-CMs, induced vasculogenesis and proliferation of cardiomyocytes and endothelial cells, improved left ventricular systolic function, and reduced infarct size. HiPSC-CM implantation did not increase the incidence of ventricular arrhythmias and did not induce tumorigenesis in the immunosuppressed pigs.

THERANOSTICS (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Cardiac fibrosis

Nikolaos G. Frangogiannis

Summary: Myocardial fibrosis, characterized by the expansion of cardiac interstitium through deposition of extracellular matrix proteins, is a common pathophysiologic feature in various myocardial conditions. Activated fibroblasts and myofibroblasts play a central role in cardiac fibrosis, producing matrix proteins and triggering fibrogenic signalling cascades in response to stress. Immune cells, vascular cells, and cardiomyocytes can also contribute to fibrosis, while fibrotic changes may disrupt cardiac function and play a role in arrhythmogenesis.

CARDIOVASCULAR RESEARCH (2021)

添加到收藏夹

Review Biochemical Research Methods

Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature

Shun Zhang et al.

Summary: Human organoids, derived from pluripotent stem cells, replicate the structural and functional characteristics of in vivo organs. However, the lack of a functional vasculature leads to necrosis in the core region, highlighting the importance of incorporating vascular systems for the maturation and growth of organoids.

LAB ON A CHIP (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis

Francisco J. Rios et al.

CARDIOVASCULAR RESEARCH (2020)

添加到收藏夹

Review Health Care Sciences & Services

Efficacy and safety of recombinant human interleukin-11 in the treatment of acute leukaemia patients with chemotherapy-induced thrombocytopenia: A systematic review and metaanalysis

ZhiRong Liu et al.

JOURNAL OF EVALUATION IN CLINICAL PRACTICE (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics

David T. Paik et al.

PHARMACOLOGICAL REVIEWS (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Bioengineered 3D Models to Recapitulate Tissue Fibrosis

Marta Sacchi et al.

TRENDS IN BIOTECHNOLOGY (2020)

添加到收藏夹

Article Cell Biology

Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis

Qiang Wu et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹

Article Engineering, Biomedical

Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity

Dylan J. Richards et al.

NATURE BIOMEDICAL ENGINEERING (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Modeling Cardiac Disease Mechanisms Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Progress, Promises and Challenges

Elvira Immacolata Parrotta et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Multidisciplinary Sciences

In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix

Jiyoung Lee et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Chemistry, Medicinal

Stem Cell-Derived Exosomes Ameliorate Doxorubicin-Induced Muscle Toxicity through Counteracting Pyroptosis

Fatima Bianca A. Dessouki et al.

PHARMACEUTICALS (2020)

添加到收藏夹

Article Biochemical Research Methods

An Optimized Protocol for Human Direct Cardiac Reprogramming

Tiffany A. Garbutt et al.

STAR PROTOCOLS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling

Yimu Zhao et al.

CELL (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming

Naoto Muraoka et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Biochemical Research Methods

Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells

Mi-Ok Lee et al.

JOURNAL OF BIOLOGICAL ENGINEERING (2019)

添加到收藏夹

Article Multidisciplinary Sciences

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

Brian Leei Lin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Article Cell & Tissue Engineering

Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming

Yang Zhou et al.

CELL STEM CELL (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Generation of Quiescent Cardiac Fibroblasts From Human Induced Pluripotent Stem Cells for In Vitro Modeling of Cardiac Fibrosis

Had Zhang et al.

CIRCULATION RESEARCH (2019)

添加到收藏夹

Article Engineering, Biomedical

Cardiovascular disease models: A game changing paradigm in drug discovery and screening

Houman Savoji et al.

BIOMATERIALS (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Human Cardiac Organoids for Disease Modeling

Bramasta Nugraha et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2019)

添加到收藏夹

Article Engineering, Biomedical

Cardiac Tissue Chips (CTCs) for Modeling Cardiovascular Disease

Aaron J. Rogers et al.

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2019)

添加到收藏夹

Article Engineering, Biomedical

Cardiac Fibrotic Remodeling on a Chip with Dynamic Mechanical Stimulation

Ming Kong et al.

ADVANCED HEALTHCARE MATERIALS (2019)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Ca2+ Signaling in Cardiac Fibroblasts and Fibrosis-Associated Heart Diseases

Jianlin Feng et al.

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE (2019)

添加到收藏夹

Article Cell Biology

TGF-β1 Signaling and Tissue Fibrosis

Kevin K. Kim et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

添加到收藏夹

Article Cell & Tissue Engineering

Direct&IT In Vivo&IT Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction

Kazutaka Miyamoto et al.

CELL STEM CELL (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

New insights into TGF-β/Smad signaling in tissue fibrosis

He-He Hu et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2018)

添加到收藏夹

Article Cell Biology

A three-dimensional in vitro dynamic micro-tissue model of cardiac scar formation

Paola Occhetta et al.

INTEGRATIVE BIOLOGY (2018)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

Dynamics of fibroblast activation in the infarcted heart

Alexandra Le Bras

NATURE REVIEWS CARDIOLOGY (2018)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Human embryonic stem cell-derived cardiomyocytes restore function in infarcted hearts of non-human primates

Yen-Wen Liu et al.

NATURE BIOTECHNOLOGY (2018)

添加到收藏夹

Review Dermatology

Mechanical Forces in Cutaneous Wound Healing: Emerging Therapies to Minimize Scar Formation

Leandra A. Barnes et al.

ADVANCES IN WOUND CARE (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell-Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine

Ling Gao et al.

CIRCULATION (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cardiac fibrosis: new insights into the pathogenesis

Zhen-Guo Ma et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Human iPS cell-derived cardiac tissue sheets for functional restoration of infarcted porcine hearts

Masanosuke Ishigami et al.

PLOS ONE (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

Xing Fu et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Direct Reprogramming of Human Dermal Fibroblasts Into Endothelial Cells Using ER71/ETV2

Sangho Lee et al.

CIRCULATION RESEARCH (2017)

添加到收藏夹

Review Medicine, Research & Experimental

The extracellular matrix in myocardial injury, repair, and remodeling

Nikolaos G. Frangogiannis

JOURNAL OF CLINICAL INVESTIGATION (2017)

添加到收藏夹

Article Biochemical Research Methods

Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions

Xiaoping Bao et al.

NATURE PROTOCOLS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice

Fu-Li Xiang et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Cardiac spheroids as promising in vitro models to study the human heart microenvironment

Liudmila Polonchuk et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Review Cell Biology

Bioengineering Approaches to Mature Human Pluripotent Stem Cell-Derived Cardiomyocytes

Xuetao Sun et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2017)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Plasminogen Activator Inhibitor Type I Controls Cardiomyocyte Transforming Growth Factor-β and Cardiac Fibrosis

Panagiotis Flevaris et al.

CIRCULATION (2017)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

SOX17 Regulates Conversion of Human Fibroblasts Into Endothelial Cells and Erythroblasts by Dedifferentiation Into CD34+ Progenitor Cells

Lianghui Zhang et al.

CIRCULATION (2017)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Defining the Cardiac Fibroblast

Malina J. Ivey et al.

CIRCULATION JOURNAL (2016)

添加到收藏夹

Article Oncology

PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice

Radiosa Gallini et al.

EXPERIMENTAL CELL RESEARCH (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration

Dikshya Bastakoty et al.

FASEB JOURNAL (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Conversion of human fibroblasts into functional cardiomyocytes by small molecules

Nan Cao et al.

SCIENCE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

An approach to quantifying 3D responses of cells to extreme strain

Yuhui Li et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Developmental Biology

Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells

Dharini Iyer et al.

DEVELOPMENT (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Bone marrow-derived mesenchymal stromal cell treatment in patients with severe ischaemic heart failure: a randomized placebo-controlled trial (MSC-HF trial)

Anders Bruun Mathiasen et al.

EUROPEAN HEART JOURNAL (2015)

添加到收藏夹

Article Cell & Tissue Engineering

Development and Characterization of a Scaffold-Free 3D Spheroid Model of Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes

Philippe Beauchamp et al.

TISSUE ENGINEERING PART C-METHODS (2015)

添加到收藏夹

Review Biochemical Research Methods

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

Rasheena Edmondson et al.

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2014)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Interleukin-13 Deficiency Aggravates Healing and Remodeling in Male Mice After Experimental Myocardial Infarction

Ulrich Hofmann et al.

CIRCULATION-HEART FAILURE (2014)

添加到收藏夹

Article Medicine, Research & Experimental

TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice

Shaik O. Rahaman et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Human embryonic-stem-cell-derived cardiomyocytesregenerate non-humanprimate hearts

James J. H. Chong et al.

NATURE (2014)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Generation of the epicardial lineage from human pluripotent stem cells

Alec D. Witty et al.

NATURE BIOTECHNOLOGY (2014)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Cell therapy for cardiac repair-lessons from clinical trials

Atta Behfar et al.

NATURE REVIEWS CARDIOLOGY (2014)

添加到收藏夹

Review Multidisciplinary Sciences

Organogenesis in a dish: Modeling development and disease using organoid technologies

Madeline A. Lancaster et al.

SCIENCE (2014)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Making it stick: chasing the optimal stem cells for cardiac regeneration

Pearl Quijada et al.

EXPERT REVIEW OF CARDIOVASCULAR THERAPY (2014)

添加到收藏夹

Article Engineering, Biomedical

Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes

Donghui Zhang et al.

BIOMATERIALS (2013)

添加到收藏夹

Review Cell & Tissue Engineering

Stem Cell-Based Therapy for Ischemic Heart Disease

Lien-Cheng Hsiao et al.

CELL TRANSPLANTATION (2013)

添加到收藏夹

Article Chemistry, Medicinal

Transient Receptor Potential (TRP) Channels and Cardiac Fibrosis

Zhichao Yue et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2013)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro

George Kensah et al.

EUROPEAN HEART JOURNAL (2013)

添加到收藏夹

Article Biochemical Research Methods

Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes

Sara S. Nunes et al.

NATURE METHODS (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Induction of human cardiomyocyte-like cells from fibroblasts by defined factors

Rie Wada et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Design and formulation of functional pluripotent stem cell-derived cardiac microtissues

Nimalan Thavandiran et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

添加到收藏夹

Article Cell & Tissue Engineering

Direct Reprogramming of Human Fibroblasts toward a Cardiomyocyte-like State

Ji-Dong Fu et al.

STEM CELL REPORTS (2013)

添加到收藏夹

Review Dermatology

Integrin β1: A Mechanosignaling Sensor Essential for Connective Tissue Deposition by Fibroblasts

Andrew Leask

ADVANCES IN WOUND CARE (2013)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Transplantation and Tracking of Human-Induced Pluripotent Stem Cells in a Pig Model of Myocardial Infarction Assessment of Cell Survival, Engraftment, and Distribution by Hybrid Single Photon Emission Computed Tomography/Computed Tomography of Sodium Iodide Symporter Transgene Expression

Christian Templin et al.

CIRCULATION (2012)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes

Tilanthi M. Jayawardena et al.

CIRCULATION RESEARCH (2012)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Regulation of the Inflammatory Response in Cardiac Repair

Nikolaos G. Frangogiannis

CIRCULATION RESEARCH (2012)

添加到收藏夹

Article Medicine, General & Internal

Comparison of Allogeneic vs Autologous Bone Marrow-Derived Mesenchymal Stem Cells Delivered by Transendocardial Injection in Patients With Ischemic Cardiomyopathy The POSEIDON Randomized Trial

Joshua M. Hare et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2012)

添加到收藏夹

Article Multidisciplinary Sciences

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

Li Qian et al.

NATURE (2012)

添加到收藏夹

Article Multidisciplinary Sciences

2D and 3D-Organized Cardiac Cells Shows Differences in Cellular Morphology, Adhesion Junctions, Presence of Myofibrils and Protein Expression

Carolina Pontes Soares et al.

PLOS ONE (2012)

添加到收藏夹

Review Biochemical Research Methods

Primary Cells and Stem Cells in Drug Discovery: Emerging Tools for High-Throughput Screening

Richard Eglen et al.

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2011)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Growth of Engineered Human Myocardium With Mechanical Loading and Vascular Coculture

Nathaniel L. Tulloch et al.

CIRCULATION RESEARCH (2011)

添加到收藏夹

Article Cell Biology

Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition

Omonigho Aisagbonhi et al.

DISEASE MODELS & MECHANISMS (2011)

添加到收藏夹

Article Medicine, Research & Experimental

Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload

Norimichi Koitabashi et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

添加到收藏夹

Article Cell Biology

Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy

Jem A. Efe et al.

NATURE CELL BIOLOGY (2011)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Spironolactone Therapy is Associated with Reduced Ventricular Tachycardia Rate in Patients with Cardiomyopathy

Vassilis Dimas et al.

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Human Engineered Heart Tissue as a Versatile Tool in Basic Research and Preclinical Toxicology

Sebastian Schaaf et al.

PLOS ONE (2011)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Local angiotensin II aggravates cardiac remodeling in hypertension

Jiang Xu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

Masaki Ieda et al.

CELL (2010)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Intracoronary Administration of Cardiac Progenitor Cells Alleviates Left Ventricular Dysfunction in Rats With a 30-Day-Old Infarction

Xian-Liang Tang et al.

CIRCULATION (2010)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

TRPM7-Mediated Ca2+ Signals Confer Fibrogenesis in Human Atrial Fibrillation

Jianyang Du et al.

CIRCULATION RESEARCH (2010)

添加到收藏夹

Review Biophysics

The myofibroblast: Paradigm for a mechanically active cell

Boris Hinz

JOURNAL OF BIOMECHANICS (2010)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Diminished Cardiac Fibrosis in Heart Failure is Associated with Altered Ventricular Arrhythmia Phenotype

Jorge Massare et al.

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2010)

添加到收藏夹

Article Biochemical Research Methods

Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an in vitro model for studying human cardiac physiology and pathophysiology

Anke M. Smits et al.

NATURE PROTOCOLS (2009)

添加到收藏夹

Article Multidisciplinary Sciences

Induced pluripotent stem cell lines derived from human somatic cells

Junying Yu et al.

SCIENCE (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

Kazutoshi Takahashi et al.

CELL (2007)

添加到收藏夹

Article Anatomy & Morphology

Culture of HepG2 liver cells on three dimensional polystyrene scaffolds enhances cell structure and function during toxicological challenge

Maria Bokhari et al.

JOURNAL OF ANATOMY (2007)

添加到收藏夹

Review Physiology

Myocardial matrix remodeling and the matrix metalloproteinases: Influence on cardiac form and function

Francis G. Spinale

PHYSIOLOGICAL REVIEWS (2007)

添加到收藏夹

Review Medicine, Research & Experimental

ECM remodeling in hypertensive heart disease

Bradford C. Berk et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Kazutoshi Takahashi et al.

CELL (2006)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model

GV Silva et al.

CIRCULATION (2005)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Mechanical force regulation of myofibroblast differentiation in cardiac fibroblasts

J Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2003)

添加到收藏夹

Article Peripheral Vascular Disease

Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis

S Kurisu et al.

HYPERTENSION (2003)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Myocardial fibrosis in chronic aortic regurgitation - Molecular and cellular responses to volume overload

JS Borer et al.

CIRCULATION (2002)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Angiotensin II has multiple profibrotic effects in human cardiac fibroblasts

H Kawano et al.

CIRCULATION (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.