期刊
ACTA CHIMICA SLOVENICA
卷 70, 期 3, 页码 353-360出版社
SLOVENSKO KEMIJSKO DRUSTVO
DOI: 10.17344/acsi.2023.8253
关键词
Schiff base; Copper complex; Cobalt complex; Crystal structure; Urease inhibition
Three copper and cobalt complexes were synthesized and characterized. They showed inhibition activity towards Jack bean urease.
Three copper(II) and cobalt(III) complexes, [CuL(dca)](n) (1), [CuL(N-3)](n) (2) and [CoL(N-3)(2)(DMF)] (3), where L is the monoanionic form of the Schiff base (((2-(pyrrolidin-1-yl)ethyl)imino)methyl)naphthalen-2-ol (HL), and dca is dicyanamide, have been prepared and characterized by elemental analyses, IR and UV-Vis spectroscopy, as well as single crystal X-ray diffraction. The Cu atoms in complexes 1 and 2 are in square pyramidal coordination, and the Co atom in complex 3 is in octahedral one. Complexes 1 and 2 inhibit the Jack bean urease with IC50 values of 0.25 +/- 0.14 and 0.32 +/- 0.15 mu mol L-1, respectively. Complex 3 show weak activity on Jack bean urease with percentage inhibition of 37%.
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