☆ 4.8 Review

Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia

EMBO JOURNAL (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Analytical

LC-MS-Based Targeted Metabolomics for FACS-Purified Rare Cells

Katharina Schoenberger et al.

Summary: A newly optimized protocol for targeted metabolomics on rare cell types is presented, which requires only 5000 cells per sample and can detect up to 80 metabolites. This method preserves cell-type-specific differences and ensures high data quality.

ANALYTICAL CHEMISTRY (2023)

添加到收藏夹

Review Hematology

HSC-derived fatty acid oxidation in steady-state and stressed hematopoiesis

Jayna J. Mistry et al.

Summary: Metabolism has a fundamental role in physiology and affects all cellular functions. The regulation of metabolism in hematopoiesis is dynamically controlled under steady-state and stress conditions. The role of fatty acid oxidation (FAO) in hematopoietic stem cells (HSCs) is discussed, including its involvement in steady-state hematopoiesis, HSCs under stress conditions, and the impact of FAO on emergency hematopoiesis.

EXPERIMENTAL HEMATOLOGY (2023)

添加到收藏夹

Article Cell & Tissue Engineering

The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow

Dachuan Zhang et al.

Summary: This study reveals that the microbiota regulates hematopoietic stem cells (HSCs) self-renewal and differentiation by modulating local iron availability in the bone marrow. Microbiota depletion enhances HSC self-renewal but compromises differentiation under stress conditions. The interplay between the microbiota, macrophages, and iron is essential for regulating critical HSC fate decisions.

CELL STEM CELL (2022)

添加到收藏夹

Article Cell & Tissue Engineering

Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity

Katharina Schoenberger et al.

Summary: This study investigates the complex regulatory networks that preserve stemness in hematopoietic stem cells and uncovers a non-classical retinoic acid signaling axis that controls their function. The findings highlight the importance of a single metabolite in controlling stem cell fate through epigenetic and transcriptional attributes.

CELL STEM CELL (2022)

添加到收藏夹

Article Oncology

Chromatin remodeling subunit BRM and valine regulate hematopoietic stem/progenitor cell function and self-renewal via intrinsic and extrinsic effects

Samisubbu R. Naidu et al.

Summary: Research has shown that the absence of Brm in mice results in increased numbers of HSCs and HPCs in the bone marrow, but decreased engraftment in secondary and tertiary transplants, indicating that BRM enhances HSC self-renewal. Valine, through regulating BRM expression in HPCs, influences the proliferation and differentiation of HSCs and HPCs.

LEUKEMIA (2022)

添加到收藏夹

Article Oncology

Small peptide targeting ANP32A as a novel strategy for acute myeloid leukemia therapy

Manman Wang et al.

Summary: Recent studies identified ANP32A as a novel biomarker of unfavorable outcome of leukemia, suggesting that targeting ANP32A may be a promising therapeutic strategy against AML. Disrupting ANP32A and H3 interaction with H3-binding peptide can impair the oncogenicity of ANP32A and potentially treat AML effectively.

TRANSLATIONAL ONCOLOGY (2022)

添加到收藏夹

Article Oncology

Article The proteogenomic subtypes of acute leukemia

Ashok Kumar Jayavelu et al.

Summary: This study conducted a comprehensive proteogenomic analysis of bone marrow biopsies from 252 uniformly treated AML patients to uncover the molecular pathophysiology of AML and provide insights for future diagnosis and treatment. The analysis identified five proteomic AML subtypes, with one subtype (Mito-AML) associated with poor prognosis and heightened response to the BCL2 inhibitor venetoclax.

CANCER CELL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration

Terumasa Umemoto et al.

Summary: By studying the mitochondrial metabolism and ATP citrate lyase (ACLY) in hematopoietic stem cells (HSCs), we have gained new insights into the regulation of HSCs during hematopoietic regeneration.

EMBO JOURNAL (2022)

添加到收藏夹

Article Oncology

TET3 promotes AML growth and epigenetically regulates glucose metabolism and leukemic stem cell associated pathways

Alex Jose Pulikkottil et al.

Summary: The overexpression of TET3 in AML patients plays an important role in regulating glucose metabolism in AML cells. Depletion of TET3 makes AML cells highly sensitive to the blockade of glycolysis and STAT5 signaling pathways, providing a potential therapeutic approach for targeting AML.

LEUKEMIA (2022)

添加到收藏夹

Article Oncology

JMJD1C-regulated lipid synthesis contributes to the maintenance of MLL-rearranged acute myeloid leukemia

Daoxin Qi et al.

Summary: In this study, we investigated the role of JMJD1C in MLLr AML and found that it regulates lipid synthesis-associated genes. We identified FABP5 as an interacting protein of JMJD1C and showed that FABP5 regulates JMJD1C expression. We also developed a small molecule inhibitor of JMJD1C, JDI-10, which represses MLLr AML cells and decreases expression of JMJD1C-regulated lipid synthesis genes. These findings highlight the importance of lipid synthesis in MLLr AML and suggest that targeting lipid synthesis may be a potential therapeutic strategy.

LEUKEMIA & LYMPHOMA (2022)

添加到收藏夹

Review Cell Biology

Metabolic regulation of somatic stem cells in vivo

Corbin E. Meacham et al.

Summary: The metabolism of somatic stem cells plays a crucial role in their long-term maintenance, activation, proliferation, and differentiation. Understanding the metabolic regulation in stem cells can lead to new opportunities in manipulating their functions, which can have applications in tissue regeneration and cancer prevention. Recent evidence suggests that stem cells have distinct metabolic characteristics compared to restricted progenitors and that metabolic changes influence tissue homeostasis and regeneration. Stem cell metabolism is influenced by the microenvironment and can interact with other cells in their niches.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate

Ruiqing Wang et al.

Summary: This study demonstrates that the gut microbiota is associated with AML progression. Dysbiosis of the gut microbiota induced by antibiotic treatment accelerates AML progression in mice, while fecal microbiota transplantation reverses this process. Decreased levels of butyrate, produced by the gut microbiota (especially Faecalibacterium), are found in the feces of AML patients. However, gavage with butyrate or Faecalibacterium postpones AML progression in mice. Additionally, the study reveals that AML mice have damaged intestinal barriers, leading to increased leakage of lipopolysaccharide (LPS) into the blood. The increased LPS exacerbates leukemia progression in vitro and in vivo. Butyrate can repair intestinal barrier damage and inhibit LPS absorption in AML mice.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Letter Oncology

Vitamin D activates FBP1 to block the Warburg effect and modulate blast metabolism in acute myeloid leukemia

Yi Xu et al.

Summary: This study demonstrates the successful use of vitamin D gene therapy to treat AML mouse models. The researchers found that 1,25VD3 treatment affected the expression of 17,757 genes, with a significant increase in fructose-bisphosphatase 1 (FBP1) expression. Additionally, 1,25VD3 was found to regulate various metabolic processes in AML. The results suggest that targeting FBP1 overexpression induced by 1,25VD3 could be a novel therapeutic approach to reduce energy production in AML blasts.

BIOMARKER RESEARCH (2022)

添加到收藏夹

Article Biology

Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia

Zhiqiang Wang et al.

Summary: SIRT1 plays an unexpected role in promoting aging of HSCs and age-dependent MPAL. Knockout of Sirt1 improves the function of aging HSCs and suppresses the development of MPAL.

COMMUNICATIONS BIOLOGY (2022)

添加到收藏夹

Article Hematology

Physioxia-induced downregulation of Tet2 in hematopoietic stem cells contributes to enhanced self-renewal

Arafat Aljoufi et al.

Summary: Hematopoietic stem cells (HSCs) show impaired recovery and self-renewal, as well as increased differentiation, when exposed to ambient air. The mechanism behind this distinction involves upregulation of HSC self-renewal genes, downregulation of genes involved in inflammatory pathways and HSC differentiation, and downregulation of the epigenetic modifier Tet2.

BLOOD (2022)

添加到收藏夹

Article Cell Biology

Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells

Yu Wei Zhang et al.

Summary: This study uses single-cell RNA sequencing to investigate the dormancy state of HSCs in human bone marrow and identifies the GPRC5C receptor and its signaling pathway with hyaluronic acid as important factors in maintaining dormancy.

NATURE CELL BIOLOGY (2022)

添加到收藏夹

Article Cell Biology

The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness

Geethu Emily Thomas et al.

Summary: The mitochondrial enzyme hexokinase 2 (HK2) localizes to the nucleus of leukaemic and normal haematopoietic stem cells, where it interacts with nuclear proteins to regulate chromatin accessibility. This nuclear localization and regulation are independent of the enzymatic activity of HK2. It influences stem cell properties, differentiation, and chemoresistance.

NATURE CELL BIOLOGY (2022)

添加到收藏夹

Article Hematology

Dietary methionine starvation impairs acute myeloid leukemia progression

Alan Cunningham et al.

Summary: Targeting altered tumor cell metabolism, specifically methionine depletion, can be an effective therapeutic approach for acute myeloid leukemia (AML). Methionine is primarily used for protein translation and histone methylation, and its depletion leads to various cellular damages, including reduced RNA levels and enhanced apoptosis. Dietary methionine starvation delays AML progression.

BLOOD (2022)

添加到收藏夹

Article Biochemical Research Methods

Targeted LC-MS/MS-based metabolomics and lipidomics on limited hematopoietic stem cell numbers

Katharina Schoenberger et al.

Summary: Metabolism plays a crucial role in regulating HSCs, but the technical challenges of analyzing metabolomes in limited HSC samples have been a hurdle. This study presents two targeted liquid chromatography-mass spectrometry approaches that allow the detection of metabolites after fluorescence-activated cell sorting, addressing the issue of limited sample amounts.

STAR PROTOCOLS (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Single-cell metabolic profiling of human cytotoxic T cells

Felix J. Hartmann et al.

Summary: This antibody-based method allows profiling of metabolic protein expression and regulation in single cells using mass spectrometry while characterizing cellular phenotype. The approach was validated using mass cytometry and applied to clinical samples, revealing tissue-restricted, metabolically repressed immune cells in human colorectal carcinoma. The combination with multiplexed ion beam imaging unveiled the spatial organization of metabolic programs in human tissues.

NATURE BIOTECHNOLOGY (2021)

添加到收藏夹

Review Genetics & Heredity

Epigenetic Regulators as the Gatekeepers of Hematopoiesis

Cecilia Pessoa Rodrigues et al.

Summary: Hematopoiesis is the process of deriving all blood cells from a single multipotent progenitor cell, hematopoietic stem cells, in both fetal and adult organisms. The correct execution of this process relies on the interaction between genetically encoded differentiation programs and various cell-intrinsic and cell-extrinsic factors. Recent studies have highlighted the significant contributions of epigenetic modifiers to HSC self-renewal and lineage specification.

TRENDS IN GENETICS (2021)

添加到收藏夹

Article Cell Biology

High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells

Sangmoo Jeong et al.

Summary: Leukemic cells exhibit a significant dependence on the de novo serine synthesis pathway (SSP) in fructose-rich conditions, and inhibition of SSP can reduce leukemia engraftment in mice in the presence of high fructose, highlighting the essential role of SSP in the metabolic plasticity of leukemic cells.

CELL METABOLISM (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Nociceptive nerves regulate haematopoietic stem cell mobilization

Xin Gao et al.

Summary: Nociceptive nerves play a role in enforcing HSC mobilization through CGRP secretion, collaborating with sympathetic nerves to maintain HSCs in the bone marrow. CGRP directly activates HSCs via the G alpha(s)/adenylyl cyclase/cAMP pathway, and consumption of capsaicin-containing food enhances HSC mobilization in mice.

NATURE (2021)

添加到收藏夹

Article Cell Biology

OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy

Koichi Murakami et al.

Summary: This study reveals the crucial role of O-GlcNAc transferase in hematopoietic stem cells, showing that its deficiency can lead to rapid loss of HSPCs and increased oxidative stress and apoptosis. Additionally, Ogt-deficient hematopoietic stem cells exhibit impaired mitochondrial quality due to decreased Pink1 levels, leading to defective mitophagy.

CELL REPORTS (2021)

添加到收藏夹

Article Biology

Metabolomic profiling of rare cell populations isolated by flow cytometry from tissues

Andrew W. DeVilbiss et al.

Summary: Little is known about the metabolic regulation of rare cell populations, but a new method involving hydrophilic liquid interaction chromatography and high-sensitivity orbitrap mass spectrometry detected 160 metabolites in 10,000 hematopoietic stem cells, revealing more glycolytic and lipid intermediates. Improved chromatographic separation, increased mass resolution, minimized ion suppression, and eliminated sample drying allowed for routine metabolomic analysis of rare cells from tissues.

ELIFE (2021)

添加到收藏夹

Article Oncology

Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition

Pu Zhang et al.

Summary: The study identified two histone deacetylases, HDAC8 and SIRT6, whose knockout conferred synthetic lethality with the NAMPT inhibitor KPT-9274 in AML. Combination therapy with HDAC8-specific inhibitor or class I HDAC inhibitor synergistically decreased AML cell survival in a dose-dependent manner, with promising in vivo efficacy compared to monotherapy. Genetic inhibition of SIRT6 potentiated the effect of KPT-9274 on DNA repair deficiencies, suggesting a rationale for a novel combination-based treatment for AML.

CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Article Immunology

Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response

Lauren S. Levine et al.

Summary: Memory T cells rely on oxidative phosphorylation, while short-lived effector T cells rely on glycolysis. The study revealed a distinct metabolic state in early-activated T cells characterized by maximal expression of glycolytic and oxidative metabolic proteins, which rapidly decreased after 5 days post-infection. This transient state was also observed in chimeric antigen receptor (CAR) T cells in lymphoma patients.

IMMUNITY (2021)

添加到收藏夹

Article Hematology

The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability

Zhaowei Tu et al.

Summary: The Chd8 gene encodes a chromatin remodeler essential for normal hematopoiesis, with its deficiency leading to severe anemia and instability of HSPCs. CHD8 maintains hematopoiesis by regulating ATM-P53-mediated survival of HSPCs.

BLOOD (2021)

添加到收藏夹

Review Hematology

Hematopoietic versus leukemic stem cell quiescence: Challenges and therapeutic opportunities

Eimear O'Reilly et al.

Summary: Hematopoietic stem cells (HSC) are responsible for producing mature blood cells, with most HSCs being in a state of quiescence and controlled by intrinsic and extrinsic mechanisms. In acute myeloid leukemia (AML), leukemic cells take over the hematopoietic bone marrow niche, acquiring a quiescent state and resistance to chemotherapy. Efforts to target driver mutations in AML are progressing, but addressing drug resistance in quiescent leukemic stem cells (LSCs) remains a challenge.

BLOOD REVIEWS (2021)

添加到收藏夹

Article Immunology

Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia

Lucille Stuani et al.

Summary: Mutations in IDH lead to enhanced mitochondrial oxidative metabolism in AML, involving increased electron transport chain activity and fatty acid oxidation. IDH1 mutant inhibitors reduce 2-HG levels and CEBPα methylation, but do not reverse fatty acid oxidation and OxPHOS. Targeting mitochondrial activities may improve anti-AML efficacy of IDH mutant inhibitors.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

New Advances in Tissue Metabolomics: A Review

Michelle Saoi et al.

Summary: Metabolomics plays a crucial role in clinical medicine by providing a hypothesis-generating approach for biomarker discovery using human biofluids, while tissue metabolomic studies offer insights into aberrant metabolism at the direct site of disease pathogenesis. Recent advancements in metabolomics have focused on ex vivo analysis, in situ imaging of tissue specimens, and introducing innovative clinical applications for improved cancer screening, diagnostic testing, and therapeutic interventions.

METABOLITES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

Xuan Sun et al.

Summary: Nicotinamide riboside treatment can restore metabolic capacity of hematopoietic stem cells through various ways and shift aged HSC function, metabolism, and molecular characteristics towards a youthful state.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Chemistry, Analytical

Multiomics Imaging Using High-Energy Water Gas Cluster Ion Beam Secondary Ion Mass Spectrometry [(H2O)n-GCIB-SIMS] of Frozen-Hydrated Cells and Tissue

Hua Tian et al.

Summary: Integration of multiomics at the single-cell level allows for clear dissection of phenotypic heterogeneity in different cellular states. Imaging mass spectrometry shows promise in measuring multiple biomolecules simultaneously within a cell. The use of (H2O)(n)-GCIB-SIMS as an analytical tool has been explored for multiomics assays, allowing for enhanced chemical sensitivity and reduced matrix effects in biological samples. High spatial resolution and cryogenic sample preparation have enabled the imaging of lipids and metabolites within cells, making integrated omics analysis feasible in the same sample. Additionally, (H2O)(n)-GCIB has shown potential for generating multiple charged peptides on protein standards, providing enhanced ionization for various biomolecules and enabling omics analysis using SIMS.

ANALYTICAL CHEMISTRY (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis

Amit Subedi et al.

Summary: The study identified that NAMPT inhibitors selectively kill LSCs in AML while sparing normal hematopoietic stem cells and found that SREBP signaling plays a key role in NAMPT inhibitor-induced apoptosis. The work demonstrates altered lipid homeostasis as a crucial factor in inducing apoptosis by NAMPT inhibition and highlights NAMPT inhibition as a promising therapeutic strategy for targeting LSCs in AML.

CELL STEM CELL (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism

Sandra Nitsch et al.

Summary: Post-translational modifications of histone proteins can alter chromatin architecture and gene expression. Cellular metabolites can affect histone acylations, linking cell metabolism with chromatin structure and cellular adaptation. However, technical challenges currently hinder a full understanding of the impact of these modifications on chromatin dynamics.

EMBO REPORTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells

Dong Chen et al.

Summary: The study revealed that mutant IDH2 in AML cells commonly has K413 acetylation, which negatively regulates its activity by attenuating dimerization and blocking substrate and cofactor binding. K413 acetylation of mitochondrial mIDH2 is achieved through a series of hierarchical phosphorylation events, optimizing the leukemogenic ability of mIDH2 in AML cells.

MOLECULAR CELL (2021)

添加到收藏夹

Article Biochemical Research Methods

SpaceM reveals metabolic states of single cells

Luca Rappez et al.

Summary: SpaceM is an open-source method for in situ single-cell metabolomics that can detect a large number of metabolites per hour and predict and validate the cell types and metabolic states. By simulating different stimuli, SpaceM reveals the coexistence of different cellular metabolic states and the mechanisms of balance disruption.

NATURE METHODS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

Ali Khateb et al.

Summary: Epigenetic changes play a role in AML tumorigenesis, with ubiquitin ligase RNF5 and its substrate RBBP4 influencing AML development by regulating transcription and affecting sensitivity to HDAC inhibitors. Inhibiting RNF5 can reduce AML cell growth and prolong survival in mouse models, highlighting a potential therapeutic target for stratifying patients for HDAC inhibitor treatment.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Oncology

SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Dongqing Yan et al.

Summary: SIRT5 is crucial for the survival and growth of AML cells, regardless of genotype, by controlling key metabolic pathways. Inhibiting SIRT5 activity is detrimental to AML cells but well tolerated by healthy hematopoietic cells, making it a potential therapeutic target for AML.

BLOOD CANCER DISCOVERY (2021)

添加到收藏夹

Article Oncology

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia

Melissa B. Pappalardi et al.

Summary: GSK3685032 is a potent first-in-class DNMT1-selective inhibitor that competes with the active-site loop of DNMT1 for penetration into hemi-methylated DNA. It induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition in vitro. Compared with decitabine, GSK3685032 shows improved in vivo tolerability and superior tumor regression and survival in preclinical AML models.

NATURE CANCER (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Bmi1 counteracts hematopoietic stem cell aging by repressing target genes and enforcing the stem cell gene signature

Eriko Nitta et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

添加到收藏夹

Article Oncology

Vitamin B6 Addiction in Acute Myeloid Leukemia

Chi-Chao Chen et al.

CANCER CELL (2020)

添加到收藏夹

Article Cell & Tissue Engineering

Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency

Raymond Liang et al.

CELL STEM CELL (2020)

添加到收藏夹

Article Cell & Tissue Engineering

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition

Ashwini Hinge et al.

CELL STEM CELL (2020)

添加到收藏夹

Review Multidisciplinary Sciences

Mitochondrial TCA cycle metabolites control physiology and disease

Inmaculada Martinez-Reyes et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Subcellular Mass Spectrometry Imaging and Absolute Quantitative Analysis across Organelles

Aurelien Thomen et al.

ACS NANO (2020)

添加到收藏夹

Article Cell Biology

Vitamin D Receptor Controls Cell Sternness in Acute Myeloid Leukemia and in Normal Bone Marrow

Etienne Paubelle et al.

CELL REPORTS (2020)

添加到收藏夹

Article Hematology

Mitochondrial carrier homolog 2 is necessary for AML survival

Dilshad H. Khan et al.

BLOOD (2020)

添加到收藏夹

Article Cell & Tissue Engineering

Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal

Rashim Pal Singh et al.

CELL STEM CELL (2020)

添加到收藏夹

Article Biology

Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells

Ana Filipa Domingues et al.

ELIFE (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Evaluation of phytoestrogens in inducing cell death mediated by decreasing Annexin A1 in Annexin A1-knockdown leukemia cells

Masyitah Hasan et al.

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

添加到收藏夹

Review Endocrinology & Metabolism

Compartmentalised acyl-CoA metabolism and roles in chromatin regulation

Sophie Trefely et al.

MOLECULAR METABOLISM (2020)

添加到收藏夹

Review Endocrinology & Metabolism

Two genomes, one cell: Mitochondrial-nuclear coordination via epigenetic pathways

Meike Wiese et al.

MOLECULAR METABOLISM (2020)

添加到收藏夹

Article Oncology

MAT2A as Key Regulator and Therapeutic Target in MLLr Leukemogenesis

Kathy-Ann Secker et al.

CANCERS (2020)

添加到收藏夹

Article Genetics & Heredity

DNA methylation disruption reshapes the hematopoietic differentiation landscape

Franco Izzo et al.

NATURE GENETICS (2020)

添加到收藏夹

Review Cell Biology

Hematopoietic Stem Cell Metabolism during Development and Aging

Ayako Nakamura-Ishizu et al.

DEVELOPMENTAL CELL (2020)

添加到收藏夹

Article Hematology

TET family dioxygenases and the TET activator vitamin C in immune responses and cancer

Xiaojing Yue et al.

BLOOD (2020)

添加到收藏夹

Article Hematology

Quantitative proteomics reveals specific metabolic features of acute myeloid leukemia stem cells

Simon Raffel et al.

BLOOD (2020)

添加到收藏夹

Article Hematology

Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171

Agatheeswaran Subramaniam et al.

BLOOD (2020)

添加到收藏夹

Article Cell Biology

Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle

Christine S. Kim et al.

CELL METABOLISM (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Glycogen accumulation, central carbon metabolism, and aging of hematopoietic stem and progenitor cells

Laura Poisa-Beiro et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Review Genetics & Heredity

The evolving metabolic landscape of chromatin biology and epigenetics

Ziwei Dai et al.

NATURE REVIEWS GENETICS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

High-fat diet intensifies MLL-AF9-induced acute myeloid leukemia through activation of the FLT3 signaling in mouse primitive hematopoietic cells

Francois Hermetet et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Review Oncology

Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches

Lei Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

添加到收藏夹

Review Cell & Tissue Engineering

Common Sources of Inflammation and Their Impact on Hematopoietic Stem Cell Biology

Daniel Hormaechea-Agulla et al.

CURRENT STEM CELL REPORTS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

ACLY is the novel signaling target of PIP2/PIP3 and Lyn in acute myeloid leukemia

Johnvesly Basappa et al.

HELIYON (2020)

添加到收藏夹

Article Cell & Tissue Engineering

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

Nicola Vannini et al.

CELL STEM CELL (2019)

添加到收藏夹

Article Oncology

Chromatin remodeling mediated by ARID1A is indispensable for normal hematopoiesis in mice

Lin Han et al.

LEUKEMIA (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Low expression of ACLY associates with favorable prognosis in acute myeloid leukemia

Jinghan Wang et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation

Evgenia V. Verovskaya et al.

TRENDS IN MOLECULAR MEDICINE (2019)

添加到收藏夹

Review Oncology

Rationale for Targeting Deregulated Metabolic Pathways as a Therapeutic Strategy in Acute Myeloid Leukemia

Nicolas Chapuis et al.

FRONTIERS IN ONCOLOGY (2019)

添加到收藏夹

Article Hematology

SIRT3 deacetylase activity confers chemoresistance in AML via regulation of mitochondrial oxidative phosphorylation

Jiao Ma et al.

BRITISH JOURNAL OF HAEMATOLOGY (2019)

添加到收藏夹

Article Oncology

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation

Zhimin Gu et al.

CANCER DISCOVERY (2019)

添加到收藏夹

Article Cell & Tissue Engineering

Control of Hematopoietic Stem and Progenitor Cell Function through Epigenetic Regulation of Energy Metabolism and Genome Integrity

Zhenhua Yang et al.

STEM CELL REPORTS (2019)

添加到收藏夹

Review Cell Biology

Metabolic Plasticity of Acute Myeloid Leukemia

Johanna Kreitz et al.

CELLS (2019)

添加到收藏夹

Article Cell & Tissue Engineering

Electron transport chain complex II sustains high mitochondrial membrane potential in hematopoietic stem and progenitor cells

Claudia Morganti et al.

STEM CELL RESEARCH (2019)

添加到收藏夹

Article Cell Biology

Perturbation of Methionine/S-adenosylmethionine Metabolism as a Novel Vulnerability in MLL Rearranged Leukemia

Aditya Barve et al.

CELLS (2019)

添加到收藏夹

Article Environmental Sciences

Genistein induces apoptosis in vitro and has antitumor activity against human leukemia HL-60 cancer cell xenograft growth in vivo

Yin-Chen Hsiao et al.

ENVIRONMENTAL TOXICOLOGY (2019)

添加到收藏夹

Article Hematology

AMP-activated protein kinase links acetyl-CoA homeostasis to BRD4 recruitment in acute myeloid leukemia

Yajian Jiang et al.

BLOOD (2019)

添加到收藏夹

Article Oncology

JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis

Jennifer R. Lynch et al.

LEUKEMIA (2019)

添加到收藏夹

Review Hematology

Epigenetic regulation of hematopoietic stem cell homeostasis

Penglei Jianga et al.

BLOOD SCIENCE (2019)

添加到收藏夹

Article Cell Biology

Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation

Yuan-Liang Zhang et al.

CELL RESEARCH (2018)

添加到收藏夹

Article Cell & Tissue Engineering

AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells

Shanshan Pei et al.

CELL STEM CELL (2018)

添加到收藏夹

Article Hematology

High fat diet-induced obesity exacerbates hematopoiesis deficiency and cytopenia caused by 5-fluorouracil via peroxisome proliferator-activated receptor γ

Yanhong Li et al.

EXPERIMENTAL HEMATOLOGY (2018)

添加到收藏夹

Article Hematology

Branched-chain amino acid depletion conditions bone marrow for hematopoietic stem cell transplantation avoiding amino acid imbalance-associated toxicity

Adam C. Wilkinson et al.

EXPERIMENTAL HEMATOLOGY (2018)

添加到收藏夹

Article Oncology

The chromatin remodeling subunit Baf200 promotes normal hematopoiesis and inhibits leukemogenesis

Lulu Liu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

添加到收藏夹

Article Oncology

ANP32A regulates histone H3 acetylation and promotes leukemogenesis

Xuejing Yang et al.

LEUKEMIA (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation

Sharanya Sivanand et al.

TRENDS IN BIOCHEMICAL SCIENCES (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism

Cunqi Ye et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width

Ziwei Dai et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Cell Biology

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo

Mira Jeong et al.

CELL REPORTS (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation

Oswaldo A. Lozoya et al.

PLOS BIOLOGY (2018)

添加到收藏夹

Article Cell & Tissue Engineering

The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells

Bowen Xu et al.

STEM CELL REPORTS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells

Juan I. Garaycoechea et al.

NATURE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline

Marco L. Hennrich et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Oncology

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

Courtney L. Jones et al.

CANCER CELL (2018)

添加到收藏夹

Article Hematology

Membrane-potential compensation reveals mitochondrial volume expansion during HSC commitment

Massimo Bonora et al.

EXPERIMENTAL HEMATOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Stable Isotope Labeling Highlights Enhanced Fatty Acid and Lipid Metabolism in Human Acute Myeloid Leukemia

Lucille Stuani et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

Daniel A. Pollyea et al.

NATURE MEDICINE (2018)

添加到收藏夹

Review Oncology

Revisiting the role of ABC transporters in multidrug-resistant cancer

Robert W. Robey et al.

NATURE REVIEWS CANCER (2018)

添加到收藏夹

Meeting Abstract Hematology

BCOR Regulates Cell Fate Transition, Myeloid Differentiation and Leukaemogenesis

Lev M. Kats et al.

BLOOD (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Regulation of Cellular Metabolism through Phase Separation of Enzymes

Manoel Prouteau et al.

BIOMOLECULES (2018)

添加到收藏夹

Article Immunology

Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells

Guoxiang Jin et al.

NATURE IMMUNOLOGY (2018)

添加到收藏夹

Article Biotechnology & Applied Microbiology

DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells

Tianpeng Gu et al.

GENOME BIOLOGY (2018)

添加到收藏夹

Review Chemistry, Analytical

Mass Spectrometry Imaging: A Review of Emerging Advancements and Future Insights

Amanda Rae Buchberger et al.

ANALYTICAL CHEMISTRY (2018)

添加到收藏夹

Article Oncology

Fatty acid-binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells

F. Yan et al.

LEUKEMIA (2017)

添加到收藏夹

Article Hematology

Lifelong dietary intervention does not affect hematopoietic stem cell function

Seka Lazare et al.

EXPERIMENTAL HEMATOLOGY (2017)

添加到收藏夹

Article Hematology

Dissecting the valine dependency of hematopoietic stem cell function

Adam Wilkinson et al.

EXPERIMENTAL HEMATOLOGY (2017)

添加到收藏夹

Article Hematology

MOZ and BMI1 act synergistically to maintain hematopoietic stem cells

Bilal N. Sheikh et al.

EXPERIMENTAL HEMATOLOGY (2017)

添加到收藏夹

Article Immunology

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions

Amelie V. Guitart et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase

Yugang Wang et al.

NATURE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Autophagy maintains the metabolism and function of young and old stem cells

Theodore T. Ho et al.

NATURE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

Ayuna Hattori et al.

NATURE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

Michalis Agathocleous et al.

NATURE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

Simon Raffel et al.

NATURE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

Philipp Mews et al.

NATURE (2017)

添加到收藏夹

Article Cell Biology

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

Elena Anso et al.

NATURE CELL BIOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

Elodie M. Kuntz et al.

NATURE MEDICINE (2017)

添加到收藏夹

Article Cell & Tissue Engineering

The ISWI ATPase Smarca5 (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells

Juraj Kokavec et al.

STEM CELLS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Characterization of histone acylations links chromatin modifications with metabolism

Johayra Simithy et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Cell & Tissue Engineering

Dye-Independent Methods Reveal Elevated Mitochondrial Mass in Hematopoietic Stem Cells

Mariana Justino de Almeida et al.

CELL STEM CELL (2017)

添加到收藏夹

Article Hematology

H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations

Bernhard Lehnertz et al.

BLOOD (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Luisa Cimmino et al.

CELL (2017)

添加到收藏夹

Article Cell & Tissue Engineering

Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration

Thomas H. Ambrosi et al.

CELL STEM CELL (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy

Nina Cabezas-Wallscheid et al.

CELL (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

From single cells to our planet-recent advances in using mass spectrometry for spatially resolved metabolomics

Daniel Petras et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2017)

添加到收藏夹

Article Hematology

MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells

Bilal N. Sheikh et al.

BLOOD (2016)

添加到收藏夹

Article Hematology

Adult hematopoietic stem cells lacking Hif-1α self-renew normally

Milica Vukovic et al.

BLOOD (2016)

添加到收藏夹

Article Oncology

Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential

Wen-Lian Chen et al.

CANCER CELL (2016)

添加到收藏夹

Article Oncology

Selected polyphenols potentiate the apoptotic efficacy of glycolytic inhibitors in human acute myeloid leukemia cell lines. Regulation by protein kinase activities

Elena de Blas et al.

CANCER CELL INTERNATIONAL (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause

Roberta Scognamiglio et al.

CELL (2016)

添加到收藏夹

Article Cell & Tissue Engineering

DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation

Matthias Farlik et al.

CELL STEM CELL (2016)

添加到收藏夹

Article Cell & Tissue Engineering

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

Haobin Ye et al.

CELL STEM CELL (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Butyrate regulates the expression of inflammatory and chemotactic cytokines in human acute leukemic cells during apoptosis

Stephanie R. Pulliam et al.

CYTOKINE (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Diet-induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow

Susan M. van den Berg et al.

FASEB JOURNAL (2016)

添加到收藏夹

Article Immunology

Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals

Catherine M. Sawai et al.

IMMUNITY (2016)

添加到收藏夹

Article Immunology

Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

Duozhuang Tang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Diverse Activities of Histone Acylations Connect Metabolism to Chromatin Function

Arnob Dutta et al.

MOLECULAR CELL (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential

Larry L. Luchsinger et al.

NATURE (2016)

添加到收藏夹

Review Cell Biology

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing

Navdeep S. Chandel et al.

NATURE CELL BIOLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance

Kyoko Ito et al.

SCIENCE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation

Yuki Taya et al.

SCIENCE (2016)

添加到收藏夹

Article Cell Biology

Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion

Jose Antonio Bejarano-Garcia et al.

CELL DEATH & DISEASE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity

Nicola Vannini et al.

NATURE COMMUNICATIONS (2016)

添加到收藏夹

Article Cell Biology

Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production

Mauricio Cortes et al.

CELL REPORTS (2016)

添加到收藏夹

Article Medicine, General & Internal

High Expression of CPT1A Predicts Adverse Outcomes: A Potential Therapeutic Target for Acute Myeloid Leukemia

Jinlong Shi et al.

EBIOMEDICINE (2016)

添加到收藏夹

Article Hematology

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Shrivani Sriskanthadevan et al.

BLOOD (2015)

添加到收藏夹

Article Cell Biology

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

Samantha J. Mentch et al.

CELL METABOLISM (2015)

添加到收藏夹

Review Cell & Tissue Engineering

Metabolic Reprogramming of Stem Cell Epigenetics

James G. Ryall et al.

CELL STEM CELL (2015)

添加到收藏夹

Article Cell & Tissue Engineering

AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow

Yusuke Saito et al.

CELL STEM CELL (2015)

添加到收藏夹

Review Cell & Tissue Engineering

Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease

Isabel Beerman et al.

CELL STEM CELL (2015)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Epigenetics and Metabolism

Samuel T. Keating et al.

CIRCULATION RESEARCH (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3

Pauline Rimmele et al.

EMBO REPORTS (2015)

添加到收藏夹

Article Endocrinology & Metabolism

Fish Oil-Rich Diet Promotes Hematopoiesis and Alters Hematopoietic Niche

Sheng Xia et al.

ENDOCRINOLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

Katrin Busch et al.

NATURE (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

Dagmar Walter et al.

NATURE (2015)

添加到收藏夹

Article Multidisciplinary Sciences

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

Mary Mohrin et al.

SCIENCE (2015)

添加到收藏夹

Article Cell & Tissue Engineering

Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells

Fernando Ugarte et al.

STEM CELL REPORTS (2015)

添加到收藏夹

Review Cell Biology

Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process

Antero Salminen et al.

AGEING RESEARCH REVIEWS (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Reactive Oxygen Species Regulate Hematopoietic Stem Cell Self-Renewal, Migration and Development, As Well As Their Bone Marrow Microenvironment

Aya Ludin et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

添加到收藏夹

Article Hematology

DNA damage response, redox status and hematopoiesis

Cary N. Weiss et al.

BLOOD CELLS MOLECULES AND DISEASES (2014)

添加到收藏夹

Article Oncology

The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers

David A. Russler-Germain et al.

CANCER CELL (2014)

添加到收藏夹

Article Oncology

Genistein Protects Hematopoietic Stem Cells against G-CSF-Induced DNA Damage

Liliana R. Souza et al.

CANCER PREVENTION RESEARCH (2014)

添加到收藏夹

Article Cell Biology

Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells

Nobuaki Shiraki et al.

CELL METABOLISM (2014)

添加到收藏夹

Article Cell & Tissue Engineering

Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells

Grant A. Challen et al.

CELL STEM CELL (2014)

添加到收藏夹

Article Cell & Tissue Engineering

Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

Chia-Wei Cheng et al.

CELL STEM CELL (2014)

添加到收藏夹

Article Hematology

Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis

Marinus R. Heideman et al.

HAEMATOLOGICA (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Haematopoietic stem cells require a highly regulated protein synthesis rate

Robert A. J. Signer et al.

NATURE (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Clonal dynamics of native haematopoiesis

Jianlong Sun et al.

NATURE (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Identification of Novel Molecular Markers for Prognosis Estimation of Acute Myeloid Leukemia: Over-Expression of PDCD7, FIS1 and Ang2 May Indicate Poor Prognosis in Pretreatment Patients with Acute Myeloid Leukemia

Yiming Tian et al.

PLOS ONE (2014)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Hypercholesterolemia Induces Oxidant Stress That Accelerates the Ageing of Hematopoietic Stem Cells

Guodong Tie et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2014)

添加到收藏夹

Article Endocrinology & Metabolism

Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells

Kanakadurga Singer et al.

MOLECULAR METABOLISM (2014)

添加到收藏夹

Review Cell Biology

Mitophagy in hematopoietic stem cells The case for exploration

Aashish Joshi et al.

AUTOPHAGY (2013)

添加到收藏夹

Article Hematology

Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells

Maria Lyngaas Torgersen et al.

BLOOD (2013)

添加到收藏夹

Article Hematology

Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance

Amelie V. Guitart et al.

BLOOD (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Influence of Metabolism on Epigenetics and Disease

William G. Kaelin et al.

CELL (2013)

添加到收藏夹

Article Cell Biology

Oxidized low-density lipoprotein induces hematopoietic stem cell senescence

Xian-Ping Zhang et al.

CELL BIOLOGY INTERNATIONAL (2013)

添加到收藏夹

Article Cell & Tissue Engineering

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

Keiyo Takubo et al.

CELL STEM CELL (2013)

添加到收藏夹

Article Cell & Tissue Engineering

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

Eleni D. Lagadinou et al.

CELL STEM CELL (2013)

添加到收藏夹

Article Hematology

Cord blood-derived CD34+ hematopoietic cells with low mitochondrial mass are enriched in hematopoietic repopulating stem cell function

Damia Romero-Moya et al.

HAEMATOLOGICA (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells

Shanshan Pei et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

FOXO3A directs a protective autophagy program in haematopoietic stem cells

Matthew R. Warr et al.

NATURE (2013)

添加到收藏夹

Article Medicine, General & Internal

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

Timothy J. Ley et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Curcumin Down-Regulates DNA Methyltransferase 1 and Plays an Anti-Leukemic Role in Acute Myeloid Leukemia

Jianhua Yu et al.

PLOS ONE (2013)

添加到收藏夹

Editorial Material Oncology

A Tale of Metabolites: The Cross-Talk between Chromatin and Energy Metabolism

Barbara Martinez-Pastor et al.

CANCER DISCOVERY (2013)

添加到收藏夹

Article Cell Biology

SIRT3 Reverses Aging-Associated Degeneration

Katharine Brown et al.

CELL REPORTS (2013)

添加到收藏夹

Article Physiology

Mitochondria and FOXO3: breath or die

Judith Hagenbuchner et al.

FRONTIERS IN PHYSIOLOGY (2013)

添加到收藏夹

Article Hematology

Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells

Fatih Kocabas et al.

BLOOD (2012)

添加到收藏夹

Article Cell & Tissue Engineering

Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation

Maria Carolina Florian et al.

CELL STEM CELL (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

β-N-Acetylglucosamine (O-GlcNAc) Is a Novel Regulator of Mitosis-specific Phosphorylations on Histone H3

Jerry J. Fong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

添加到收藏夹

Article Immunology

A role for GPx3 in activity of normal and leukemia stem cells

Olivier Herault et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

添加到收藏夹

Article Multidisciplinary Sciences

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

Sang-Min Jeon et al.

NATURE (2012)

添加到收藏夹

Article Genetics & Heredity

Dnmt3a is essential for hematopoietic stem cell differentiation

Grant A. Challen et al.

NATURE GENETICS (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Keisuke Ito et al.

NATURE MEDICINE (2012)

添加到收藏夹

Review Cell & Tissue Engineering

Concise Review: Multidimensional Regulation of the Hematopoietic Stem Cell State

Il-Hoan Oh et al.

STEM CELLS (2012)

添加到收藏夹

Article Oncology

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

Kelly Moran-Crusio et al.

CANCER CELL (2011)

添加到收藏夹

Review Cell & Tissue Engineering

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

Toshio Suda et al.

CELL STEM CELL (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

Yaohui Chen et al.

EMBO REPORTS (2011)

添加到收藏夹

Article Oncology

Hypoxia-inducible factor-1α protein expression is associated with poor survival in normal karyotype adult acute myeloid leukemia

George Deeb et al.

LEUKEMIA RESEARCH (2011)

添加到收藏夹

Review Cell Biology

Mechanisms of mitophagy

Richard J. Youle et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

Myunggon Ko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

添加到收藏夹

Article Oncology

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

Maria E. Figueroa et al.

CANCER CELL (2010)

添加到收藏夹

Article Oncology

DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

Maria E. Figueroa et al.

CANCER CELL (2010)

添加到收藏夹

Article Cell & Tissue Engineering

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

Tugba Simsek et al.

CELL STEM CELL (2010)

添加到收藏夹

Article Cell & Tissue Engineering

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

Keiyo Takubo et al.

CELL STEM CELL (2010)

添加到收藏夹

Article Multidisciplinary Sciences

β-N-acetylglucosamine (O-GlcNAc) is part of the histone code

Kaoru Sakabe et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

添加到收藏夹

Review Medicine, Research & Experimental

Oxygen homeostasis

Gregg L. Semenza

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2010)

添加到收藏夹

Article Cell & Tissue Engineering

DNA Methyltransferase 1 Is Essential for and Uniquely Regulates Hematopoietic Stem and Progenitor Cells

Jennifer J. Trowbridge et al.

CELL STEM CELL (2009)

添加到收藏夹

Article Genetics & Heredity

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction

Ann-Marie Broeske et al.

NATURE GENETICS (2009)

添加到收藏夹

Article Cell Biology

The role of the chromatin remodeler Mi-2β in hematopoietic stem cell self-renewal and multilineage differentiation

Toshimi Yoshida et al.

GENES & DEVELOPMENT (2008)

添加到收藏夹

Article Immunology

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

Chong Chen et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

添加到收藏夹

Article Plant Sciences

Antileukemic activity of genistein, a major isoflavone present in soy products

Noeel J. -M. Raynal et al.

JOURNAL OF NATURAL PRODUCTS (2008)

添加到收藏夹

Article Multidisciplinary Sciences

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

Boyi Gan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

添加到收藏夹

Article Cell & Tissue Engineering

The effect of bleeding on hematopoietic stem cell cycling and self-renewal

Samuel H. Cheshier et al.

STEM CELLS AND DEVELOPMENT (2007)

添加到收藏夹

Article Cell & Tissue Engineering

MII has a critical role in fetal and adult hematopoietic stem cell self-renewal

Kathryn A. McMahon et al.

CELL STEM CELL (2007)

添加到收藏夹

Article Cell & Tissue Engineering

Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors

Craig D. Jude et al.

CELL STEM CELL (2007)

添加到收藏夹

Review Cell & Tissue Engineering

FoxO transcription factors and stem cell homeostasis: Insights from the hematopoietic system

Zuzana Tothova et al.

CELL STEM CELL (2007)

添加到收藏夹

Article Cell & Tissue Engineering

Foxo3a is essential for maintenance of the hematopoietic stem cell pool

Kana Miyamoto et al.

CELL STEM CELL (2007)

添加到收藏夹

Article Multidisciplinary Sciences

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

Derrick J. Rossi et al.

NATURE (2007)

添加到收藏夹

Article Biology

Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival

Thomas A. Davis et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

Zuzana Tothova et al.

CELL (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Regulation of LSD1 histone demethylase activity by its associated factors

YJ Shi et al.

MOLECULAR CELL (2005)

添加到收藏夹

Review Microbiology

Effects of vitamin A supplementation on immune responses and correlation with clinical outcomes

E Villamor et al.

CLINICAL MICROBIOLOGY REVIEWS (2005)

添加到收藏夹

Article Immunology

Vitamin A deficiency in patients with common variable immunodeficiency

SS Kilic et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process

F Forneris et al.

FEBS LETTERS (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.