期刊
EMBO JOURNAL
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.15252/embj.2022112348
关键词
acute myeloid leukemia; epigenetics; hematopoietic stem cells; leukemia stem cells; metabolism
Significant progress has been made in understanding the relationship between cellular metabolism and epigenetic regulation in hematopoietic stem cells. Environmental factors, dietary habits, and hematological diseases can alter the metabolism and epigenetic features of HSCs. Understanding these mechanisms can lead to the discovery of new therapeutic targets for eliminating leukemia stem cells while preserving healthy HSCs.
During the last decades, remarkable progress has been made in further understanding the complex molecular regulatory networks that maintain hematopoietic stem cell (HSC) function. Cellular and organismal metabolisms have been shown to directly instruct epigenetic alterations, and thereby dictate stem cell fate, in the bone marrow. Epigenetic regulatory enzymes are dependent on the availability of metabolites to facilitate DNA- and histone-modifying reactions. The metabolic and epigenetic features of HSCs and their downstream progenitors can be significantly altered by environmental perturbations, dietary habits, and hematological diseases. Therefore, understanding metabolic and epigenetic mechanisms that regulate healthy HSCs can contribute to the discovery of novel metabolic therapeutic targets that specifically eliminate leukemia stem cells while sparing healthy HSCs. Here, we provide an in-depth review of the metabolic and epigenetic interplay regulating hematopoietic stem cell fate. We discuss the influence of metabolic stress stimuli, as well as alterations occurring during leukemic development. Additionally, we highlight recent therapeutic advancements toward eradicating acute myeloid leukemia cells by intervening in metabolic and epigenetic pathways. The complex interdependencies between cellular metabolism and epigenetic control of gene expression in blood stem cells and hematopoietic malignancies are summarised in this review.dagger image
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