期刊
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
卷 15, 期 4, 页码 901-914出版社
SPRINGER
DOI: 10.3758/s13415-015-0369-0
关键词
Isolation rearing; Visuospatial priming; Negative priming; Amphetamine; Schizophrenia; Information processing; Rats
资金
- NIH [R01-MH104344, R01-MH059803, R01-MH042228, R21-MH091571]
- Veteran's Administration VISN 22 Mental Illness Research, Education, and Clinical Center
- Tourette's Syndrome Association
Negative visuospatial priming (NP) represents a quantifiable measure of inhibitory information processing that is disrupted in several neurodevelopmental and psychiatric disorders, including schizophrenia. We developed a novel rodent NP task to investigate mechanisms underlying NP and its role in various disorders, and to test potential therapeutics. In the present studies, we further characterized this novel paradigm by investigating whether NP is disrupted in rats reared in isolation, a developmental manipulation that produces a range of abnormalities in behavior, neurochemistry, and brain structure that mirror aspects of schizophrenia pathology. We also further explored the role of monoaminergic signaling in NP and the effects of isolation rearing by challenging both socially reared and isolation-reared rats with D-amphetamine during the NP task. Although fewer isolation-reared animals learned the complex NP task, those that learned exhibited unaffected NP compared with socially reared rats. Consistent with previous reports, D-amphetamine impaired NP and increased motor impulsivity in socially reared rats. In contrast, Damphetamine did not affect NP or motor impulsivity in isolation-reared rats. These data confirm a monoaminergic influence on NP behavior and indicate that rats reared in isolation have altered dopaminergic sensitivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据