☆ 4.3 Review

NECTIN-4 targeted theranostics for urothelial cancer: getting ready for primetime?

EXPERT REVIEW OF ANTICANCER THERAPY (2023)

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Article Oncology

First-in-Human Study of the Radioligand 68Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma

Xiaojiang Duan et al.

Summary: This study developed a bicyclic peptide-based radiotracer Ga-68-N188 for targeting Nectin-4 and conducted preclinical and translational studies. The results demonstrated that Ga-68-N188 has high affinity and specific uptake for Nectin-4, and can quantitatively image the expression level of Nectin-4 in different organs. The findings of this study provide a companion diagnostic tool for treatments targeting Nectin-4.

CLINICAL CANCER RESEARCH (2023)

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Review Radiology, Nuclear Medicine & Medical Imaging

Long axial field of view (LAFOV) PET-CT: implementation in static and dynamic oncological studies

Antonia Dimitrakopoulou-Strauss et al.

Summary: Long axial field of view (LAFOV) PET-CT scanners have been recently developed and are already in clinical use in few centers worldwide, providing increased sensitivity for lesion detectability, reduced PET acquisition time and/or radiotracer dose, and improved attenuation correction approaches. However, challenges such as high purchase price, logistics issues, and the need for infrastructure in radiochemistry still need to be addressed. Overall, LAFOV PET-CT represents an important advancement in molecular imaging, with potential for dynamic imaging and improved oncological applications.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Potential and Most Relevant Applications of Total Body PET/CT Imaging

Abass Alavi et al.

Summary: The introduction of total body PET/CT instruments has brought about a new era in medical imaging. These instruments with higher sensitivity allow for whole-body imaging, accurate assessment of disease extent, improved detection of cancer and chemotherapy complications, and evaluation of systemic diseases and musculoskeletal disorders.

CLINICAL NUCLEAR MEDICINE (2022)

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Review Oncology

Immune Checkpoint Inhibitors as a Neoadjuvant/Adjuvant Treatment of Muscle-Invasive Bladder Cancer: A Systematic Review

Biagio Barone et al.

Summary: Bladder cancer is the ninth most common cancer worldwide. Immune checkpoint inhibitors have been used in neoadjuvant and adjuvant settings to improve the survival of bladder cancer patients. However, some patients do not respond to these drugs, and identifying eligible patients for this therapy is an ongoing effort. This review aims to summarize the latest evidence on the use of immune checkpoint inhibitors in the treatment of muscle-invasive bladder cancer.

CANCERS (2022)

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Editorial Material Engineering, Biomedical

Long axial field-of-view PET/CT devices: are we ready for the technological revolution?

Luca Filippi et al.

EXPERT REVIEW OF MEDICAL DEVICES (2022)

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Article Engineering, Biomedical

Digital PET/CT with 18F-FACBC in early castration-resistant prostate cancer: our preliminary results

Luca Filippi et al.

Summary: Digital PET/CT with F-18-FACBC was evaluated in patients with early castration-resistant prostate cancer, and it was found that F-18-FACBC dPET/CT can detect M1 metastasis in 33.3% of patients, significantly impacting clinical management.

EXPERT REVIEW OF MEDICAL DEVICES (2022)

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Review Biochemistry & Molecular Biology

Novel Therapeutic Opportunities in Neoadjuvant Setting in Urothelial Cancers: A New Horizon Opened by Molecular Classification and Immune Checkpoint Inhibitors

Maria Lucia Iacovino et al.

Summary: This review summarizes the application of neoadjuvant chemotherapy in muscle invasive bladder cancer (MIBC) and focuses on novel therapeutic strategies such as immunotherapy, considering the improved patient stratification and selection from the emerging molecular classification.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Pharmacology & Pharmacy

Nectin cell adhesion molecule-4 (NECTIN-4): A potential target for cancer therapy

Subhajit Chatterjee et al.

Summary: Nectin-4, an immunoglobulin-like protein mainly involved in cell-cell adhesion, is found to be overexpressed in various malignant tumors. Its overexpression is associated with aspects of tumor progression such as proliferation, metastasis, and poor prognosis.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Health Care Sciences & Services

Epidemiology and treatment patterns for locally advanced or metastatic urothelial carcinoma: a systematic literature review and gap analysis

Zsolt Hepp et al.

Summary: Current studies on the treatment patterns of locally advanced or metastatic urothelial carcinoma mainly come from the U.S., Japan, and the U.K., showing significant variations in the use of IO agents at different lines of therapy. A proportion of patients do not receive subsequent therapy after discontinuation of IO treatment.

JOURNAL OF MANAGED CARE & SPECIALTY PHARMACY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Theranostics: Leveraging Molecular Imaging and Therapy to Impact Patient Management and Secure the Future of Nuclear Medicine

Lilja B. Solnes et al.

JOURNAL OF NUCLEAR MEDICINE (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Prognostic value of neutrophil-to-lymphocyte ratio and its correlation with fluorine-18-fluorodeoxyglucose metabolic parameters in intrahepatic cholangiocarcinoma submitted to 90Y-radioembolization

Luca Filippi et al.

NUCLEAR MEDICINE COMMUNICATIONS (2020)

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Review Biochemistry & Molecular Biology

Theragnostic Aspects and Radioimmunotherapy in Pediatric Tumors

Andrea Cimini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Oncology

The emerging role of antibody-drug conjugates in urothelial carcinoma

Michael Lattanzi et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2020)

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Editorial Material Oncology

Targeted α-Therapy

Martin W. Brechbiel

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS (2020)

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Review Urology & Nephrology

Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends

Sebastien Antoni et al.

EUROPEAN UROLOGY (2017)

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Review Radiology, Nuclear Medicine & Medical Imaging

Clinical History of the Theranostic Radionuclide Approach to Neuroendocrine Tumors and Other Types of Cancer: Historical Review Based on an Interview of Eric P. Krenning by Rachel Levine

Rachel Levine et al.

JOURNAL OF NUCLEAR MEDICINE (2017)

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Article Oncology

Bladder cancer: ESMO Practice Guidelines for diagnosis, treatment and follow-up

J. Bellmunt et al.

ANNALS OF ONCOLOGY (2014)

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