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Review
Biochemistry & Molecular Biology
Sachin Bhaladhare et al.
Summary: The development of nanotechnology has had a significant impact on biomedical and pharmaceutical fields, particularly in the design and formulation of stimuli-responsive nano-drug delivery systems. These systems, known as smart drug delivery systems, are able to respond to various external and internal stimuli and deliver drugs to targeted sites in a controlled manner. They offer improved patient compliance, treatment efficiency, and reduced side effects on healthy tissue. Polymeric nanogels with stimuli-responsive characteristics have shown great potential in biomedical, tissue engineering, and pharmaceutical applications due to their small size, biocompatibility, stimuli-triggered drug deliverability, high payload capacity, and tailored functionality.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Ebru Altuntas et al.
Summary: Nanogels made from natural and synthetic polymers have attracted significant interest due to their increased surface area, swelling, active substance-loading capacity, and flexibility. The customized design and application of these micro/nano carriers, which are non-toxic, biocompatible, and biodegradable, make them highly feasible for various biomedical applications, including drug delivery, tissue engineering, and bioimaging. This review outlines the methodologies of nanogel design and application, and discusses the recent advancements in nanogel biomedical applications, particularly in drug and biomolecule delivery.
Article
Chemistry, Multidisciplinary
Shameer Pillarisetti et al.
Summary: We report a multi-stimulus responsive alginate nanogel that responds to changes in pH and redox potential in the tumor microenvironment. Combined with chemotherapy and photodynamic therapy (PDT), this nanogel enhances the therapeutic effect in breast cancer and melanoma by releasing a hydrophobic photosensitizer and a cytotoxic agent.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Hao Cai et al.
Summary: This study presents a smart drug-delivery system, LD-DOX/Ce6, based on LDBCs. LD-DOX/Ce6 can specifically release DOX and Ce6 in the tumor microenvironment, resulting in a synergistic chemo-photodynamic antitumor efficacy.
ADVANCED MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Yang Liping et al.
Summary: This study reports the synthesis of a GSH-responsive polymer that exhibits anti-cancer effects, high drug loading capacity, and the ability to overcome multidrug resistance. The polymer is capable of self-assembling into nanoparticles for efficient drug delivery. In vitro and in vivo experiments demonstrate the potential of this system for cancer treatment.
Article
Pharmacology & Pharmacy
Xianbin Ma et al.
Summary: The combination of chemotherapy and immunotherapy shows great potential in inhibiting tumor growth and improving the immunosuppressive tumor microenvironment. However, drug bioavailability limits the therapeutic effectiveness. In this study, a bioresponsive doxorubicin-based nanogel was developed for tumor-specific co-delivery of drugs. The nanogel exhibited stability, selective drug release, and prolonged survival time. It induced powerful antitumor immune response and damaged glucose metabolism in glycolysis and the tricarboxylic acid cycle. This nanogel provides a potential strategy to overcome the limitations of immunotherapy and offers a paradigm for immunomodulatory nanomedicines.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Engineering, Biomedical
Daquan Wang et al.
Summary: Researchers have proposed a new strategy for developing nanoplatforms based on metal-coordinated-polyprodrugs. These nanoplatforms have shown efficient drug delivery, contrast medium release, and tumor growth inhibition in response to tumor microenvironment conditions. The in vitro and in vivo investigations suggest that these nanoplatforms have good magnetic resonance imaging ability and high safety.
ACTA BIOMATERIALIA
(2022)
Article
Agriculture, Multidisciplinary
Yuan Zhu et al.
Summary: The study developed ASTA-PEG-g-CS nanoparticles to enhance the bioavailability of astaxanthin, a FDAI with antioxidant and antidiabetic functions. The nanoparticles were spherical with a particle size below 200 nm and showed rapid release of encapsulated astaxanthin in in vitro studies. In vivo and in vitro studies demonstrated that ASTA-PEG-g-CS nanoparticles significantly improved the oral bioavailability of astaxanthin, making it a promising carrier for encapsulating hydrophobic ingredients in food products.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Chemistry, Multidisciplinary
Lihua Du et al.
Summary: Immunotherapy has great potential for tumor therapy, but the immunosuppressive tumor microenvironment limits its effectiveness. A multifunctional nanoplatform combining drug delivery and medical imaging can overcome the immunosuppressive microenvironment and improve tumor treatment efficiency.
Article
Multidisciplinary Sciences
Tomasz Walski et al.
Summary: The study demonstrates the potential of photobiomodulation in the red/near-infrared spectral range for its anti-inflammatory and cytoprotective effects. In an in vitro setting using porcine blood samples, the study shows that NIR exposure can inhibit platelet activation and reduce hemolysis.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Patrick M. Glassman et al.
Summary: Engineering drug delivery systems that prolong pharmacokinetics has been a pursuit for nearly 50 years. Coating nanoparticles with polymers, specifically polyethylene glycol (PEGylation), is the gold standard for improving pharmacokinetics, and has been used in clinically viable products. This study uses erythrocytes, the longest circulating and most abundant component of blood, to enhance the pharmacokinetics of liposomes. In vitro tests show that antibody-mediated coupling of liposomes to erythrocytes does not adversely affect the carrier cells. In vivo experiments in mice show that erythrocyte targeting liposomes improve blood concentration over time compared to PEGylated liposomes. The results suggest that targeting erythrocytes is a viable strategy for improving liposome pharmacokinetics.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Qiu-Yi Duan et al.
Summary: A dual-responsive nanogel platform is constructed in this study, which possesses excellent drug loading and intracellular delivery capabilities. The nanogel can degrade and release drugs when encountering hyaluronidase or glutathione, and it can also deliver proteins without hinderance from serum proteins and maintain enzymatic activities. Furthermore, the nanogel can co-deliver different cargoes for combination therapy.
Article
Chemistry, Multidisciplinary
Yue-Qing Wang et al.
Summary: The coating of nanoparticles with natural red blood cell membrane (RBCm) has been found to prolong the blood circulation time of nanoparticles, thereby enhancing the therapeutic effect of hepatocellular carcinoma (HCC). Through comparative experiments, researchers found that nanoparticles with RBCm coating exhibited significantly better anti-HCC effects in vivo compared to regular nanoparticles. This study contributes to the future design and development of more effective drug delivery systems for HCC.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Yifan Cai et al.
Summary: This review provides a systemic analysis of the in vivo and subcellular fate of polymeric micelles (PMs), discussing their circulation stability, biodistribution, internalization, and degradation in cells. The findings contribute to the understanding of the mechanisms of PMs and facilitate their clinical translation.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Amaal Abdulraqeb Ali et al.
Summary: Hybrid nanogels are emerging as novel and multifunctional cancer therapeutic strategies, with the potential to possess cytotoxic effects, carry drugs/enzymes, improve imaging, and target tumor cells. Despite their promising abilities, their clinical application is limited and further research is needed. Factors affecting their future include lack of hemocompatibility studies, toxicological evaluations, and information on tumor heterogeneity and interaction with physiological fluids.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biochemistry & Molecular Biology
Giuseppina Ioele et al.
Summary: Despite the remarkable progress in anticancer research, there are still challenges in terms of high toxicity and stability of the approved drugs. Therefore, developing tissue-specific targeted drug formulations and improving stability are crucial. Prodrug development and the use of nanocarriers have shown promise in enhancing solubility, pharmacokinetics, cellular absorption, and stability of anticancer drugs.
Article
Nanoscience & Nanotechnology
Yi Sun et al.
Summary: This study reports the development and application of microsystems based on microshockwave delivery of drugs. By spraying drugs onto mucous membranes in curved or zigzag areas, endoluminal diseases can be effectively treated while minimizing side effects.
MICROSYSTEMS & NANOENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Pauline E. M. van Schaik et al.
Summary: Multiple sclerosis is a neuroinflammatory and neurodegenerative disease with unknown etiology that can be characterized by demyelinated lesions. Remyelination is essential for axonal survival and functional recovery, but fibronectin inhibits this process. The blood-brain barrier poses a challenge for delivering therapeutic interventions to the lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Jianxia Qiao et al.
Summary: This research successfully synthesized an esterase-responsive hyperbranched polyprodrug which can release antitumor drugs in a high esterase environment for cancer therapy in vitro, demonstrating its potential application value.
Article
Automation & Control Systems
Jihun Lee et al.
Summary: This paper proposes a mucoadhesive patch for gastrointestinal tracts that utilizes a magnetically actuated capsule for active drug delivery, hyperthermia, and controlled drug release. The patch demonstrates excellent adhesion to the gastrointestinal tract and contains magnetic nanoparticles and anticancer drug doxorubicin. Through an alternating magnetic field (AMF), the patch enables hyperthermia and controlled release of the drug. Additionally, the patch can be delivered to multiple intestinal target lesions using a magnetically actuated capsule. Experimental tests and analyses confirm the feasibility of delivering the patch into the gastrointestinal tract and demonstrate the therapeutic effect of the patch in killing tumor cells.
ADVANCED INTELLIGENT SYSTEMS
(2022)
Article
Pharmacology & Pharmacy
Yuli Wang et al.
Summary: The study aimed to combine nanocarriers with erythrocytes carriers to enhance the sustained release and prolonged circulation time of vitamin K-1. Experimental results showed that erythrocyte-hitchhiking chitosan nanoparticles had longer circulation time and higher drug exposure compared to nanoparticles alone.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Xiangru Feng et al.
Summary: The physicochemical characteristics of nanoparticles play a crucial role in determining their drug delivery performance, and altering the amino acid composition can adjust the drug release profile and antitumor efficacy of nanogels.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Yi Lu et al.
Summary: A stimuli-responsive prodrug nanogel was developed using a two-in-one cross-linking strategy to deliver a combination of chemotherapeutic drugs for improving the deficiencies of chemotherapy and enhancing cancer therapeutic efficiency. The high drug loading capacity and suitable nanoscale size of the obtained nanogel facilitate cell uptake and tumor penetration, leading to enhanced tumor growth inhibition by the synergistic DNA damage in response to the reductive tumor microenvironment. This unique prodrug nanogel shows promise as a candidate for effective tumor treatment-based chemotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Environmental
Yiming Ding et al.
Summary: This review firstly analyzed the characteristics and functions of GSH in normal and cancer cells, then comprehensively summarized the recent advances in GSH-mediated nanomedicines for cancer diagnosis and therapy, discussing different strategies and proposing future perspectives and challenges in this field.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Biomedical
Kim Tien Nguyen et al.
Summary: This study proposes a novel method utilizing a magnetically guided self-rolled microrobot for targeted drug delivery, combined with real-time X-ray imaging and microrobot retrieval. The microrobot features precise localization and rapid drug release, showing potential for use in precise localized drug delivery systems.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biophysics
Jiagen Li et al.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Shuang Bai et al.
Article
Biophysics
Jiagen Li et al.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Review
Pharmacology & Pharmacy
Amar Patil et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Nanoscience & Nanotechnology
Shuang Bai et al.
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Chemistry, Multidisciplinary
Xiao Duan et al.
CHEMISTRY-AN ASIAN JOURNAL
(2018)
Article
Materials Science, Biomaterials
Xiao Duan et al.
JOURNAL OF MATERIALS CHEMISTRY B
(2018)
Article
Polymer Science
Jiagen Li et al.
MACROMOLECULAR RAPID COMMUNICATIONS
(2018)
Review
Biochemistry & Molecular Biology
Daniela Giustarini et al.
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Review
Materials Science, Biomaterials
Zhenhua Song et al.
BIOMATERIALS SCIENCE
(2017)
Article
Nanoscience & Nanotechnology
Yanan Xue et al.
ACS APPLIED MATERIALS & INTERFACES
(2017)
Article
Materials Science, Biomaterials
Juan Huang et al.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2015)
Article
Polymer Science
Ye-Zi You et al.
Article
Chemistry, Multidisciplinary
Chun-Yan Hong et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2007)
