Bidirectional regulation effect of rhubarb as laxative and astringent by metabolomics studies

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Impacts of Circadian Gene Period2 Knockout on Intestinal Metabolism and Hepatic Antioxidant and Inflammation State in Mice

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Pharmacology & Pharmacy

Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials

Maija Dambrova et al.

Summary: Acylcarnitines are fatty acid metabolites that play important roles in cellular energy metabolism and have potential as biomarkers and pharmaceutical agents for various diseases. This comprehensive review provides detailed information on the identity, nomenclature, classification, biochemistry, pathophysiology, and clinical trials of acylcarnitines. It also discusses their use as dietary supplements and the emerging opportunities for using them as biomarkers and interventions in different indications. The review lays a solid foundation for further understanding the physiological roles of acylcarnitines and the identification of new drug targets.

PHARMACOLOGICAL REVIEWS (2022)

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Review Nutrition & Dietetics

The Metabolome and the Gut Microbiota for the Prediction of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation: A Systematic Review

Laura Moschino et al.

Summary: This systematic review examines the use of untargeted metabolomics and gut microbiota analysis in evaluating the differences between neonates affected by NEC and healthy controls. The review finds that an early urinary alanine/histidine ratio >4 may serve as a predictive biomarker for NEC. Additionally, NEC specimens show increased relative abundance of Proteobacteria at phylum level and a lack or decreased abundance of Bifidobacterium at genus level. The study suggests that untargeted metabolomics and gut microbiota analysis can shed light on the pathophysiology of NEC and help identify potential biomarkers.

NUTRIENTS (2022)

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Article Neurosciences

Preliminary Findings on Proline-Rich Protein 14 as a Diagnostic Biomarker for Parkinson's Disease

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NEUROMOLECULAR MEDICINE (2021)

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Article Medicine, Research & Experimental

Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines

Sarah A. Smith et al.

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JOURNAL OF CLINICAL INVESTIGATION (2021)

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Review Biochemical Research Methods

Venn diagrams in bioinformatics

Anqiang Jia et al.

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Article Biochemistry & Molecular Biology

Voluntary wheel running is capable of improving cognitive function only in the young but not the middle-aged male APPSwe/PS1De9 mice

Guiping Wang et al.

Summary: The study found that voluntary wheel running improved cognitive function in young APP/PS1 mice through various mechanisms, such as reducing tau phosphorylation and neuro-inflammation, and increasing key synaptic plasticity-related proteins. For middle-aged APP/PS1 mice, voluntary exercise reduced protein expression in certain brain regions, but did not significantly affect circulating metabolites.

NEUROCHEMISTRY INTERNATIONAL (2021)

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Article Multidisciplinary Sciences

An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

Elisabeth E. L. Nystrom et al.

Summary: Intestinal goblet cells are not homogeneous, with several distinct subtypes forming two differentiation trajectories. Intercrypt goblet cells located at the colonic luminal surface produce mucus with different properties from crypt-residing goblet cells. Defective icGCs in mice lead to increased sensitivity to chemically induced colitis and spontaneous colitis with age, while alterations in mucus and reduced numbers of icGCs are observed in patients with ulcerative colitis, highlighting the importance of icGCs in maintaining functional epithelial protection.

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Article Chemistry, Analytical

An integrated metabolomics strategy to reveal dose-effect relationship and therapeutic mechanisms of different efficacy of rhubarb in constipation rats

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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2020)

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A plasma metabonomics study on the therapeutic effects of the Si-miao-yong-an decoction in hyperlipidemic rats

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An integrated serum and urinary metabonomic research of Rhizoma Curcumae-Rhizoma Sparganii drug pair in hysteromyoma rats based on UPLC-Q-TOF-MS analysis

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JOURNAL OF ETHNOPHARMACOLOGY (2019)

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Colonic epithelial cell diversity in health and inflammatory bowel disease

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NATURE (2019)

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Elucidating dosage-effect relationship of different efficacy of rhubarb in constipation model rats by factor analysis

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JOURNAL OF ETHNOPHARMACOLOGY (2019)

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Article Chemistry, Analytical

Pharmacokinetic comparisons of major bioactive components after oral administration of raw and steamed rhubarb by UPLC-MS/MS

Jing Zhang et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2019)

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Article Nutrition & Dietetics

Amelioration of obesity-related characteristics by a probiotic formulation in a high-fat diet-induced obese rat model

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EUROPEAN JOURNAL OF NUTRITION (2018)

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Alterations in lipid, amino acid, and energy metabolism distinguish Crohn's disease from ulcerative colitis and control subjects by serum metabolomic profiling

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METABOLOMICS (2018)

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Neutrophils Promote Amphiregulin Production in Intestinal Epithelial Cells through TGF-β and Contribute to Intestinal Homeostasis

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Article Chemistry, Multidisciplinary

Nonclassical Interactions of Phosphatidylcholine with Mucin Protect Intestinal Surfaces: A Microinterferometry Study

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LANGMUIR (2018)

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Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid- and lipopolysaccharide-induced TLR4 signalling

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JOURNAL OF PHYSIOLOGY-LONDON (2017)

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Article Chemistry, Analytical

Optimization of GC/TOF MS analysis conditions for assessing host-gut microbiota metabolic interactions: Chinese rhubarb alters fecal aromatic amino acids and phenol metabolism

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ANALYTICA CHIMICA ACTA (2017)

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Article Chemistry, Applied

Global metabolite profiling and diagnostic ion filtering strategy by LC-QTOF MS for rapid identification of raw and processed pieces of Rheum palmatum L.

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FOOD CHEMISTRY (2016)

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Article Biochemistry & Molecular Biology

Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD

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Article Fisheries

Dietary phenylalanine-improved intestinal barrier health in young grass carp (Ctenopharyngodon idella) is associated with increased immune status and regulated gene expression of cytokines, tight junction proteins, antioxidant enzymes and related signalling molecules

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Comparative studies of pharmacokinetics and anticoagulatory effect in rats after oral administration of Frankincense and its processed products

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Article Chemistry, Medicinal

Purgative components in rhubarbs: Adrenergic receptor inhibitors linked with glucose carriers

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FITOTERAPIA (2013)

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Review Chemistry, Applied

Phytoconstituents and therapeutic uses of Rheum emodi wall. ex Meissn

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FOOD CHEMISTRY (2011)

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Article Plant Sciences

Investigation of the dose-time-response relationships of rhubarb on carbon tetrachloride-induced liver injury in rats

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JOURNAL OF ETHNOPHARMACOLOGY (2011)

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Article Plant Sciences

Suppression on metastasis by rhubarb through modulation on MMP-2 and uPA in human A549 lung adenocarcinoma: An ex vivo approach

Chi-Sheng Shia et al.

JOURNAL OF ETHNOPHARMACOLOGY (2011)

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Article Plant Sciences

The diarrhoeogenic and antidiarrhoeal bidirectional effects of rhubarb and its potential mechanism

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JOURNAL OF ETHNOPHARMACOLOGY (2011)

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Article Pharmacology & Pharmacy

Delayed release phosphatidylcholine as new therapeutic drug for ulcerative colitis - a review of three clinical trials

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EXPERT OPINION ON INVESTIGATIONAL DRUGS (2010)

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Article Plant Sciences

Water extract of Rheum officinale Baill. induces apoptosis in human lung adenocarcinoma A549 an human breast cancer MCF-7 cell lines

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JOURNAL OF ETHNOPHARMACOLOGY (2009)

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Article Plant Sciences

Assessment of the renal protection and hepatotoxicity of rhubarb extract in rats

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JOURNAL OF ETHNOPHARMACOLOGY (2009)

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Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: Involvement of the transcription factor Nrf2

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Bidirectional regulation effect of rhubarb as laxative and astringent by metabolomics studies

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