Head and neck cancer stem cell maintenance relies on mTOR signaling, specifically involving the mechanistic target of rapamycin complexes 1 and 2 (mTORC1 and mTORC2)

Article Oncology

Analysis and Visualization of Longitudinal Genomic and Clinical Data from the AACR Project GENIE Biopharma Collaborative in cBioPortal

Ino de Bruijn et al.

CANCER RESEARCH (2023)

Article Dentistry, Oral Surgery & Medicine

Cephaeline is an inductor of histone H3 acetylation and inhibitor of mucoepidermoid carcinoma cancer stem cells

Luan Cesar Silva et al.

Summary: Cephaeline has demonstrated anti-cancer properties in all tested MEC cell lines by regulating tumor cells' viability, migration, proliferation, and disrupting the ability of cancer cells to generate tumorspheres.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2022)

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Article Pathology

Meta-analysis of the association between mTORC1-related genes polymorphisms and cancer risk

Xiaoling Lu et al.

Summary: The meta-analysis revealed a significant association between SNPs rs2295080, rs17036508, and rs1034528 in the mTOR gene and cancer risk, while target genetic polymorphisms in the mLST8 gene or RPTOR gene may not be associated with cancer risk. Further large-scale and well-designed studies in different ethnic populations are needed to confirm or strengthen these findings.

PATHOLOGY RESEARCH AND PRACTICE (2022)

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Article Chemistry, Multidisciplinary

Targeting mTORC2/HDAC3 Inhibits Stemness of Liver Cancer Cells Against Glutamine Starvation

Hui-Lu Zhang et al.

Summary: Liver cancer cells display stem-like characteristics upon glutamine shortage and promote transformation into stem-like cells. Increased expression of glutamine synthetase is essential for maintaining and promoting stem-like characteristics. Mechanistically, glutamine starvation activates Rictor/mTORC2 pathway to induce HDAC3-mediated deacetylation and stabilization of glutamine synthetase.

ADVANCED SCIENCE (2022)

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Review Oncology

Recent Advances and Future Directions in Clinical Management of Head and Neck Squamous Cell Carcinoma

Jameel Muzaffar et al.

Summary: Head and neck squamous cell carcinoma (HNSCC) is the most common cancer in the head and neck region, with smoking, excessive drinking, and HPV infection as the main risk factors. While the prognosis of non-metastatic HNSCC continues to improve, the treatment of metastatic disease remains challenging.

CANCERS (2021)

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Article Cell Biology

The IL-6R and Bmi-1 axis controls self-renewal and chemoresistance of head and neck cancer stem cells

Alexandra E. Herzog et al.

Summary: The study highlights the significant role of cancer stem-like cells (CSCs) in the development of head and neck squamous cell carcinoma (HNSCC), and suggests that therapeutic blockade of IL-6R may be a promising strategy to overcome chemoresistance in these patients.

CELL DEATH & DISEASE (2021)

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Review Oncology

Worldwide prevalence of PI3K-AKT-mTOR pathway mutations in head and neck cancer: A systematic review and meta-analysis

Adriana Castelo de Moura et al.

Summary: The systematic review and meta-analysis examined the prevalence of PI3K-AKT-mTOR pathway mutations in head and neck cancer patients, identifying significant associations with advanced TNM stage and oropharyngeal HPV-positive tumors. Different mutation rates were found for genes like PIK3CA and PTEN, showing relevance to tumor characteristics and risk factors. The study suggests that these mutations could serve as potential prognostic factors and may guide future therapeutic targeting in HNC patients.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

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Review Oncology

Systemic Therapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma- A Systematic Review and Meta-Analysis

Ashley Lau et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

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Article Dentistry, Oral Surgery & Medicine

Loss of PTEN sensitizes head and neck squamous cell carcinoma to 5-AZA-2′-deoxycytidine

Gabriell Bonifacio Borgato et al.

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY (2020)

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Review Oncology

Immunotherapy improves efficacy and safety of patients with HPV positive and negative head and neck cancer: A systematic review and meta-analysis

Marisol Miranda Galvis et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

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Article Oncology

Head and Neck Cancers, Version 2.2020

David G. Pfister et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2020)

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Review Otorhinolaryngology

mTOR inhibitor use in head and neck squamous cell carcinoma: A meta-analysis on survival, tumor response, and toxicity

Jaimin Patel et al.

LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY (2020)

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Review Biochemistry & Molecular Biology

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy

Tian Tian et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Hypoxic niches are endowed with a protumorigenic mechanism that supersedes the protective function of PTEN

Carlos H. V. Nascimento-Filho et al.

FASEB JOURNAL (2019)

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Review Cell & Tissue Engineering

Cancer Stem Cells: Powerful Targets to Improve Current Anticancer Therapeutics

Rayana L. Bighetti-Trevisan et al.

STEM CELLS INTERNATIONAL (2019)

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Review Biochemistry & Molecular Biology

mTORC1 and mTORC2 in cancer and the tumor microenvironment

L. C. Kim et al.

ONCOGENE (2017)

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Article Oncology

A phase II study of temsirolimus added to low-dose weekly carboplatin and paclitaxel for patients with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC)

L. A. Dunn et al.

ANNALS OF ONCOLOGY (2017)

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Review Biochemistry & Molecular Biology

Cancer stem cell heterogeneity: origin and new perspectives on CSC targeting

Kiyoung Eun et al.

BMB REPORTS (2017)

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Review Dentistry, Oral Surgery & Medicine

mTOR pathway protein immunoexpression as a prognostic factor for survival in head and neck cancer patients: a systematic review and meta-analysis

Ana Elizia Mascarenhas Marques et al.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2016)

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Article Oncology

PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells

Camila S. Matsumoto et al.

ONCOTARGET (2016)

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Article Oncology

Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells

Douglas M. Guimaraes et al.

ONCOTARGET (2016)

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Article Oncology

Profiling the Behavior of Distinct Populations of Head and Neck Cancer Stem Cells

Luciana O. Almeida et al.

CANCERS (2016)

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Review Oncology

Cancer stem cell metabolism

Maria Peiris-Pages et al.

BREAST CANCER RESEARCH (2016)

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Article Oncology

ALDH/CD44 identifies uniquely tumorigenic cancer stem cells in salivary gland mucoepidermoid carcinomas

April Adams et al.

ONCOTARGET (2015)

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Article Oncology

Inhibition of specificity protein 1 by dibenzylideneacetone, a curcumin analogue, induces apoptosis in mucoepidermoid carcinomas and tumor xenografts through Bim and truncated Bid

Heang-Eun Lee et al.

ORAL ONCOLOGY (2014)

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Article Biochemistry & Molecular Biology

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Jianjiong Gao et al.

SCIENCE SIGNALING (2013)

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Article Oncology

PTEN Deficiency Contributes to the Development and Progression of Head and Neck Cancer

Cristiane H. Squarize et al.

NEOPLASIA (2013)

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Review Biochemistry & Molecular Biology

mTOR Signaling in Growth Control and Disease

Mathieu Laplante et al.

CELL (2012)

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Editorial Material Oncology

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data

Ethan Cerami et al.

CANCER DISCOVERY (2012)

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Article Multidisciplinary Sciences

Holoclone Forming Cells from Pancreatic Cancer Cells Enrich Tumor Initiating Cells and Represent a Novel Model for Study of Cancer Stem Cells

Lei Tan et al.

PLOS ONE (2011)

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Article Otorhinolaryngology

PHARMACODYNAMIC EVALUATION OF TEMSIROLIMUS IN PATIENTS WITH NEWLY DIAGNOSED ADVANCED-STAGE HEAD AND NECK SQUAMOUS CELL CARCINOMA

Oleksandr Ekshyyan et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2010)

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Review Oncology

Biomarker Development for the Clinical Activity of the mTOR Inhibitor Everolimus (RAD001): Processes, Limitations, and Further Proposals

Terence O'Reilly et al.

TRANSLATIONAL ONCOLOGY (2010)

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Review Biotechnology & Applied Microbiology

Targeting the phosphoinositide 3-kinase pathway in cancer

Pixu Liu et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

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Article Biochemistry & Molecular Biology

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

DD Sarbassov et al.

MOLECULAR CELL (2006)

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Article Cell Biology

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

E Jacinto et al.

NATURE CELL BIOLOGY (2004)

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Article Dentistry, Oral Surgery & Medicine

Immunohistochemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system

CH Squarize et al.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2002)

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Article Otorhinolaryngology

Loss of PTEN expression as a prognostic marker for tongue cancer

JI Lee et al.

ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY (2001)

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Head and neck cancer stem cell maintenance relies on mTOR signaling, specifically involving the mechanistic target of rapamycin complexes 1 and 2 (mTORC1 and mTORC2)

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