Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms

Article Cell Biology

Apolipoprotein D modulates lipid mediators and osteopontin in an anti-inflammatory direction

Makoto Kurano et al.

Summary: ApoD is an anti-inflammatory apolipoprotein that can suppress inflammation by modulating lipid mediators and inflammatory factors.

INFLAMMATION RESEARCH (2023)

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Article Cell Biology

Resveratrol Improves the Progression of Osteoarthritis by Regulating the SIRT1-FoxO1 Pathway-Mediated Cholesterol Metabolism

ChuanCai Liang et al.

Summary: This study investigated the effect of resveratrol on cholesterol accumulation in osteoarthritic articular cartilage via the SIRT1/FoxO1 pathway, and found that resveratrol can increase SIRT1 and FoxO1 expression, promote cholesterol efflux, and inhibit cholesterol synthesis, thereby reducing cholesterol buildup in OA cartilage.

MEDIATORS OF INFLAMMATION (2023)

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Article Chemistry, Multidisciplinary

Radical-Scavenging and Subchondral Bone-Regenerating Nanomedicine for Osteoarthritis Treatment

Hengli Lu et al.

Summary: A dual-functional medication has been developed to protect cartilage and repair subchondral bone simultaneously. Black phosphorus nanosheets (BPNSs) effectively eliminate intracellular reactive oxygen species (ROS), restore chondrocyte function, and regulate inflammation, providing disease-modifying effects on osteoarthritis (OA). In vivo assessments confirm that BPNSs inhibit cartilage degradation and prevent OA progression, making them a competitive candidate for OA treatment.

ACS NANO (2023)

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Review Cell Biology

Role of pro-inflammatory interleukins in osteoarthritis: a narrative review

Asma Ines Sana Jrad et al.

Summary: This manuscript summarizes the role of pro-inflammatory cytokines in the pathogenesis of osteoarthritis and discusses newly discovered cytokines. Pro-inflammatory cytokines play a crucial role in the inflammatory processes of this complex disease.

CONNECTIVE TISSUE RESEARCH (2023)

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Article Biochemical Research Methods

Advanced glycation end products in musculoskeletal system and disorders

Akinobu Suzuki et al.

Summary: The global aging population and the increase in diabetes cases have led to a high prevalence of musculoskeletal disorders in elderly and diabetic patients, which are associated with advanced glycation end products (AGEs). AGEs accumulate in tissues and contribute to various aging and diabetes-related conditions such as osteoporosis, osteoarthritis, and neuropathy. Understanding the mechanisms of AGEs can potentially lead to the development of novel prevention and therapy methods for these disorders, improving patients' quality of life.

METHODS (2022)

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Article Rheumatology

Association of Serum Low-Density Lipoprotein, High-Density Lipoprotein, and Total Cholesterol With Development of Knee Osteoarthritis

Jessica L. Schwager et al.

Summary: The study finds no significant association between total serum cholesterol, LDL, HDL, and the risk of knee osteoarthritis (OA) or its outcomes.

ARTHRITIS CARE & RESEARCH (2022)

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Review Cell Biology

Molecular mechanisms for ABCA1-mediated cholesterol efflux

Lei Chen et al.

Summary: The maintenance of cellular cholesterol homeostasis is crucial for normal cell function and viability. Excessive cholesterol accumulation is the molecular basis of many diseases. Peripheral cells eliminate excessive cholesterol through cholesterol efflux, which is mainly mediated by ATP-binding cassette transporter A1 (ABCA1). This article focuses on the mechanisms underlying ABCA1-mediated cholesterol efflux, providing important insights for future investigation and lipid-lowering therapy.

CELL CYCLE (2022)

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Article Oncology

Fermentation supernatant of Staphylococcus aureus drives catabolism in chondrocytes via NF-KB signaling mediated increase of cholesterol metabolism

Qian Wang et al.

Summary: Exposure to the fermentation supernatant of Staphylococcus aureus (S. aureus) leads to increased cholesterol metabolism in chondrocytes, activating NF-KB signaling and promoting the production of catabolic factors.

EXPERIMENTAL CELL RESEARCH (2022)

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Article Orthopedics

Oral administration of berberine limits post-traumatic osteoarthritis development and associated pain via AMP-activated protein kinase (AMPK) in mice

J. Li et al.

Summary: The study demonstrates that berberine reduces joint structural damage and pain associated with post-traumatic OA in mice through activation of AMPK signaling. The findings suggest that targeting AMPK activity in chondrocytes may have therapeutic potential for OA.

OSTEOARTHRITIS AND CARTILAGE (2022)

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Article Multidisciplinary Sciences

Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis

Donghyun Kang et al.

Summary: Osteoarthritis is caused by the accumulation of oxidative stress. This study reveals that dysregulation of the selenium metabolic pathway disrupts redox homeostasis in chondrocytes, leading to the development of osteoarthritis. The downregulation of SEPHS1 impairs the synthesis of oxidoreductase selenoproteins, increases reactive oxygen species levels, and induces chondrocyte senescence.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

PPARα-ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis

Sujeong Park et al.

Summary: The study reveals that ACOT12 plays a critical role in maintaining cartilage homeostasis by regulating de novo lipogenesis. ACOT12 levels are suppressed in cartilage of OA patients and OA-induced animal models. ACOT12 knockout mice exhibit severe cartilage degradation, matrix MMPs stimulation, and chondrocyte apoptosis through acetyl CoA accumulation. Restoration of ACOT12 effectively rescues the pathophysiological features of OA.

NATURE COMMUNICATIONS (2022)

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Review Endocrinology & Metabolism

Insulin Resistance: From Mechanisms to Therapeutic Strategies

Shin-Hae Lee et al.

Summary: Insulin resistance, characterized by reduced responsiveness of insulin-targeting tissues to physiological levels of insulin, is a key pathogenic component of many metabolic diseases. This review summarizes the functions of insulin in glucose metabolism and discusses the mechanisms proposed for insulin resistance, such as ectopic lipid accumulation, endoplasmic reticulum stress, and inflammation. Potential therapeutic strategies for addressing insulin resistance are also suggested.

DIABETES & METABOLISM JOURNAL (2022)

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Article Engineering, Biomedical

Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy

Tao Gui et al.

Summary: Oxidative stress and reactive oxygen species play important roles in the development and progression of osteoarthritis (OA). This study utilized SOD-loaded nanoparticles to deliver antioxidant enzymes to mouse knee joints, demonstrating the accumulation of nanoparticles in the synovium and reduction of oxidative damage. Intra-articular injections of the nanoparticles were effective in attenuating OA initiation and progression, via reduction of reactive oxygen species production and catabolic protease synthesis.

BIOMATERIALS (2022)

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Article Cell Biology

Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression

Ke Lu et al.

Summary: Hepatic osteodystrophy (HOD) is a metabolic bone disease associated with chronic liver disease. Upregulation of the phosphatase PP2Aca in the liver during HOD leads to downregulation of hepatokine lecithin-cholesterol acyltransferase (LCAT). Loss of LCAT function exacerbates bone loss in HOD mice. Cholesterol levels play a role in the regulation of osteoblast and osteoclast activities. LCAT improves liver function and reduces liver fibrosis in the HOD mouse model by promoting cholesterol transport from bone to liver.

CELL METABOLISM (2022)

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Review Cell Biology

The molecular structure and role of LECT2 or CHM-II in arthritis, cancer, and other diseases

Sipin Zhu et al.

Summary: LECT2, also known as chondromodulin II, functions as a versatile factor involved in various tissues, regulating inflammatory reactions, glucose metabolism, obesity, liver diseases, and cancers. Further research is needed to fully understand how LECT2 regulates different pathogenic conditions, which could help develop it as a biomarker for diagnosis and therapy.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

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Article Nutrition & Dietetics

Causal Associations of Circulating Lipids with Osteoarthritis: A Bidirectional Mendelian Randomization Study

Hongen Meng et al.

Summary: This study used Mendelian randomization to evaluate the genetic causal effects of circulating apolipoproteins and lipoprotein lipids on osteoarthritis (OA) risk. The results showed that genetic predisposition to Apolipoprotein B (APOB) and low-density lipoprotein (LDL) was associated with a decreased risk of OA, providing new insights into the relationship between lipids and OA risk.

NUTRIENTS (2022)

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Review Endocrinology & Metabolism

Adiponectin, May Be a Potential Protective Factor for Obesity-Related Osteoarthritis

Hai Jiang et al.

Summary: Osteoarthritis (OA) is a common joint disease in elderly individuals, caused by chronic inflammation and abnormal lipid metabolism. Adiponectin, as a adipokine, may have a protective effect on OA by regulating inflammatory factors and lipid metabolism.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2022)

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Article Nutrition & Dietetics

Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial

Welma Stonehouse et al.

Summary: This study showed that a commercially available krill oil supplement can improve knee pain, stiffness, and physical function in adults with mild to moderate knee osteoarthritis. The supplement is safe to consume.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2022)

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Article Multidisciplinary Sciences

Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4

Chenxi Cao et al.

Summary: This study demonstrates the role of cholesterol metabolism-related gene Lrp3 in cartilage degeneration and osteoarthritis pathogenesis. LRP3 regulates cartilage extracellular matrix metabolism by targeting syndecan-4 via Ras signalling, implicating the cholesterol-LRP3-SDC4 axis in osteoarthritic cartilage degeneration.

NATURE COMMUNICATIONS (2022)

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Review Biochemistry & Molecular Biology

Therapeutic effects of statins on osteoarthritis: A review

Shirin Saberianpour et al.

Summary: Osteoarthritis (OA) is a progressive joint disease with multifactorial etiology. Current treatments for OA are not very effective, and there is no definitive treatment. Hypercholesterolemia is considered a novel risk factor for OA. Statins, by reducing cholesterol levels, have the potential to prevent cartilage deterioration in OA. Atorvastatin and simvastatin have been shown to have chondroprotective effects and anti-inflammatory effects on OA.

JOURNAL OF CELLULAR BIOCHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

Inhibition of NADPH Oxidases Prevents the Development of Osteoarthritis

Jin Han et al.

Summary: Increased oxidative stress in OA cartilage leads to extracellular matrix degradation and chondrocyte apoptosis. This study found that inhibiting NOX can decrease ROS production, suppress oxidative stress marker genes and catabolic proteases, and protect against OA by modulating oxidative stress and gene expression.

ANTIOXIDANTS (2022)

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Article Cell & Tissue Engineering

GDF11 inhibits abnormal adipogenesis of condylar chondrocytes in temporomandibular joint osteoarthritis

H. Wang et al.

Summary: Abnormal adipogenesis and decreased expression of GDF11 were observed in degenerative cartilage of TMJ OA. Supplementation of GDF11 effectively inhibits adipogenesis of chondrocytes and alleviates TMJ condylar cartilage degeneration. GDF11 may inhibit abnormal adipogenesis of chondrocytes by affecting the SUMOylation of PPAR gamma.

BONE & JOINT RESEARCH (2022)

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Article Integrative & Complementary Medicine

Pravastatin Reduces Matrix Metalloproteinases Expression and Promotes Cholesterol Efflux in Osteoarthritis Chondrocytes

Yunpeng Wu et al.

Summary: This study investigates the effects of statins on osteoarthritis chondrocytes and its underlying mechanism. The results show that pravastatin can reduce the expression of matrix metalloproteinases in interleukin-1 beta-induced human chondrocytes and protect the chondrocyte matrix. This may be achieved by promoting the expression of proteins related to the cholesterol efflux pathway and reducing the level of cellular cholesterol.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Endocrinology & Metabolism

A novel serological biomarker are associated with disease severity in patients with osteoarthritis

Bin Li et al.

Summary: In this study, the researchers investigated the potential role of Apolipoprotein D (ApoD) concentration in knee osteoarthritis (KOA). They found that the serum ApoD level was significantly lower in KOA patients compared to healthy controls, and it was correlated with disease progression and severity.

JOURNAL OF BONE AND MINERAL METABOLISM (2022)

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Review Nutrition & Dietetics

Lipid Metabolism in Cartilage Development, Degeneration, and Regeneration

Zhanpeng Su et al.

Summary: Lipids have a diverse impact on cartilage growth, injury, and regeneration. Lipid metabolism is a complex process that affects different aspects of cartilage. Proper lipid supplementation can help preserve cartilage function, while excessive lipid buildup is detrimental. Understanding the role of lipid metabolism in cartilage metabolism can lead to the development of new treatment techniques for metabolic cartilage damage.

NUTRIENTS (2022)

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Article Biochemistry & Molecular Biology

Metformin mitigates cholesterol accumulation via the AMPK/SIRT1 pathway to protect osteoarthritis chondrocytes

Hengte Xing et al.

Summary: In this study, it was found that metformin inhibits cholesterol synthesis and promotes cholesterol efflux in osteoarthritis chondrocytes by activating the AMPK/SIRT1 pathway.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Review Cell & Tissue Engineering

Current understanding of osteoarthritis pathogenesis and relevant new approaches

Liping Tong et al.

Summary: This review discusses the research advances in the pathological mechanisms and treatment approaches of osteoarthritis (OA). It focuses on the epigenetic regulation, key mediators of OA-associated pain, innovative techniques, and cell death regulation in OA. The review highlights new research directions on the role of the synovial lymphatic system in OA.

BONE RESEARCH (2022)

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Review Oncology

Role of peroxisome proliferator-activated receptors in osteoarthritis

Gang Huang et al.

Summary: PPARs regulate cartilage homeostasis and reduce inflammation in OA, deficiency of PPARs may accelerate OA progression. PPAR agonists can inhibit catabolic and inflammatory factors synthesis, reducing cartilage lesions development in OA.

MOLECULAR MEDICINE REPORTS (2021)

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Article Medicine, General & Internal

Osteoarthritis of the Knee

Leena Sharma

Summary: Knee osteoarthritis is common among older adults and can be treated with a combination of exercise, weight management, training in self-efficacy and pain-coping skills, and medications such as NSAIDs.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Lipid metabolism in cartilage and its diseases: a concise review of the research progress

Yueyi Yang et al.

Summary: The homeostasis of vertebrate body relies on anabolic and catabolic activities inside and outside of cells, with lipid metabolism playing a crucial role. While little is known about the role of lipid metabolism in cartilage and its diseases, exploring this area could lead to new treatment methods for various cartilage diseases.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2021)

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Article Medicine, Research & Experimental

Vaspin regulated cartilage cholesterol metabolism through miR155/LXRα and participated in the occurrence of osteoarthritis in rats

Hangyuan He et al.

Summary: This study explored the role of Vaspin and cholesterol metabolism in osteoarthritis (OA) through in vitro and in vivo experiments. It was found that Vaspin reversed IL-1 beta-induced expression changes in chondrocytes, but miR155 mimics could reverse the effects on cholesterol efflux pathway. Furthermore, in a rat OA model, the decreased expression of cholesterol efflux related genes was associated with reduced Vaspin levels and increased miR155 expression in OA knee cartilage.

LIFE SCIENCES (2021)

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Article Orthopedics

Identification of a distinct lipidomic profile in the osteoarthritic synovial membrane by mass spectrometry imaging

B. Rocha et al.

Summary: This study examined the abundance and distribution of lipids in the synovial membrane of human joints, revealing differential profiles in Osteoarthritis (OA) compared to control samples. Elevated levels of phosphatidylcholines, fatty acids, and lysophosphatidic acids were found in OA synovium, along with lower levels of lysophosphatidylcholines. Spatial distribution of specific glycerophospholipids was correlated with hypertrophic, inflamed, or vascularized synovial areas. Compared to other inflammatory arthropathies, OA tissue showed lower amounts of phosphatidylethanolamine-based plasmalogens.

OSTEOARTHRITIS AND CARTILAGE (2021)

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Article Orthopedics

Novel high-intensive cholesterol-lowering therapies do not ameliorate knee OA development in humanized dyslipidemic mice

Y. van Gemert et al.

Summary: The study found that therapeutic cholesterol lowering did not reduce cartilage degradation progression in dyslipidemic mice, suggesting that inflammation is a key feature of the disease and therapeutic cholesterol-lowering strategies may still hold promise.

OSTEOARTHRITIS AND CARTILAGE (2021)

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Article Cell Biology

Inhibition of nuclear receptor RORα attenuates cartilage damage in osteoarthritis by modulating IL-6/STAT3 pathway

Tongzhou Liang et al.

Summary: Evidence suggests that ROR alpha plays a crucial role in cartilage development and OA pathogenesis by regulating the expression of cartilage matrix components. Blocking ROR alpha can reverse cartilage damage and elevate the expression of cartilage matrix components. Additionally, ROR alpha affects the IL-6/STAT3 signaling pathway, highlighting its potential as a treatment target in OA therapy.

CELL DEATH & DISEASE (2021)

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Review Medicine, Research & Experimental

Adipose tissue and insulin resistance in obese

Bulbul Ahmed et al.

Summary: This review discusses the potential mechanisms behind obesity-associated insulin resistance, such as dysfunctional adipose tissue, excessive release of free fatty acids, and the impact of lipotoxicity on cellular dysfunction leading to systemic inflammation and disruption of the insulin signaling pathway. It highlights that hepatic insulin resistance is the primary event that triggers peripheral tissue insulin resistance.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Cell & Tissue Engineering

Ultrasound-targeted simvastatin-loaded microbubble destruction promotes OA cartilage repair by modulating the cholesterol efflux pathway mediated by PPARγ in rabbits

X. Wang et al.

Summary: The study revealed that ultrasound-targeted simvastatin-loaded microbubble destruction can promote cartilage extracellular matrix synthesis in osteoarthritis rabbits by modulating the cholesterol efflux pathway mediated by PPAR gamma.

BONE & JOINT RESEARCH (2021)

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Article Orthopedics

Apolipoprotein D as a Potential Biomarker and Construction of a Transcriptional Regulatory-Immune Network Associated with Osteoarthritis by Weighted Gene Coexpression Network Analysis

Yong Qin et al.

Summary: This study aimed to identify potential biomarkers and analyze transcriptional regulatory-immune mechanisms of synovitis in OA using weighted gene coexpression network analysis (WGCNA). The results indicated a correlation between certain genes and type 17 T helper cells, suggesting potential significance for OA therapy.

CARTILAGE (2021)

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Article Orthopedics

High-Density Lipoprotein Cholesterol and Apolipoprotein A1 in Synovial Fluid: Potential Predictors of Disease Severity of Primary Knee Osteoarthritis

Kaibin Zhang et al.

Summary: This study aimed to detect levels of common lipid species in the serum and synovial fluid of primary knee osteoarthritis patients and investigate their correlations with disease severity. The results showed that levels of HDL-C and ApoA1 in synovial fluid were negatively correlated with cartilage damage, radiographic severity, and symptomatic severity of OA, serving as potential biomarkers for predicting disease severity.

CARTILAGE (2021)

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Article Cell Biology

Glucagon-like peptide-1 attenuated carboxymethyl lysine induced neuronal apoptosis via peroxisome proliferation activated receptor-γ

Haoqiang Zhang et al.

Aging-US (2021)

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Article Rheumatology

Current Epidemiology and Risk Factors for the Development of Hand Osteoarthritis

Benjamin Plotz et al.

Summary: Hand osteoarthritis (hand OA) is a common joint disease, with obesity being an important risk factor and potential associations with diabetes and cardiovascular disease. There are various modifiable and non-modifiable risk factors for hand OA, including genetic and environmental factors, that may influence disease severity and pathogenesis.

CURRENT RHEUMATOLOGY REPORTS (2021)

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Article Pharmacology & Pharmacy

MicroRNA-10a-3p Improves Cartilage Degeneration by Regulating CH25H-CYP7B1-RORα Mediated Cholesterol Metabolism in Knee Osteoarthritis Rats

Xiaochen Li et al.

Summary: This study identifies miR-10a-3p as a key regulator in osteoarthritis, suppressing inflammatory responses, cholesterol metabolism, and extracellular matrix degradation. Additionally, miR-10a-3p is found to reverse OA features by targeting the CH25H/CYP7B1/ROR alpha axis, suggesting a promising therapeutic strategy for osteoarthritis.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Cell Biology

AMPK Signaling in Energy Control, Cartilage Biology, and Osteoarthritis

Dan Yi et al.

Summary: AMPK functions as an energy sensor maintaining energy homeostasis in cells through phosphorylation under low ATP levels, participating in energy metabolism regulation in various organs and can be targeted by drugs in clinical settings. Its role in skeletal development and chondrocyte homeostasis is still unclear, but its significant involvement in osteoarthritis development has been highlighted.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Cell & Tissue Engineering

Subchondral bone microenvironment in osteoarthritis and pain

Yan Hu et al.

Summary: Osteoarthritis is a joint disorder characterized by cartilage degeneration and pain, with increasing global incidence due to aging and obesity trends. Research on the role of subchondral bone in osteoarthritis initiation and progression is crucial for understanding and treating the disease.

BONE RESEARCH (2021)

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Article Orthopedics

Synovial Fluid Fatty Acid Profiles Differ between Osteoarthritis and Healthy Patients

Arne van de Vyver et al.

CARTILAGE (2020)

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Article Orthopedics

The association of plasma fatty acids with hand and knee osteoarthritis: the NEO study

M. Loef et al.

OSTEOARTHRITIS AND CARTILAGE (2020)

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Article Rheumatology

Association of glucose homeostasis and metabolic syndrome with knee cartilage defects and cartilage volume in young adults

Tao Meng et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2020)

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Article Rheumatology

Using Cumulative Load to Explain How Body Mass Index and Daily Walking Relate to Worsening Knee Cartilage Damage Over Two Years: The MOST Study

Dana Voinier et al.

ARTHRITIS & RHEUMATOLOGY (2020)

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Article Cell Biology

Insulin Exacerbates Inflammation in Fibroblast-Like Synoviocytes

Li Qiao et al.

INFLAMMATION (2020)

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Article Nutrition & Dietetics

Acute Hyperenergetic, High-Fat Feeding Increases Circulating FGF21, LECT2, and Fetuin-A in Healthy Men

Scott A. Willis et al.

JOURNAL OF NUTRITION (2020)

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Article Endocrinology & Metabolism

Lipidomic identification of plasma lipids associated with pain behaviour and pathology in a mouse model of osteoarthritis

P. Pousinis et al.

METABOLOMICS (2020)

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Article Rheumatology

Metformin limits osteoarthritis development and progression through activation of AMPK signalling

Jun Li et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Article Rheumatology

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee

Sharon L. Kolasinski et al.

ARTHRITIS & RHEUMATOLOGY (2020)

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Article Orthopedics

Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model

Masanori Tsubosaka et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2020)

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Article Clinical Neurology

Blue Mussel (Mytilus edulis) Water Extract Ameliorates Inflammatory Responses and Oxidative Stress on Osteoarthritis in Obese Rats

Heng-Wei Chang et al.

JOURNAL OF PAIN RESEARCH (2020)

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Article Medicine, General & Internal

Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee

Gail D. Deyle et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Rheumatology

The Effects of Vitamin D and Marine Omega-3 Fatty Acid Supplementation on Chronic Knee Pain in Older US Adults: Results From a Randomized Trial

Lindsey A. MacFarlane et al.

ARTHRITIS & RHEUMATOLOGY (2020)

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Review Medicine, Research & Experimental

Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols

Mohammad Yunus Ansari et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Multidisciplinary Sciences

Effect of high fat diet and excessive compressive mechanical force on pathologic changes of temporomandibular joint

Jing Du et al.

SCIENTIFIC REPORTS (2020)

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Review Rheumatology

How to Treat Osteoarthritis in Obese Patients?

Thierry Conrozier

CURRENT RHEUMATOLOGY REVIEWS (2020)

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Review Rheumatology

Diet-induced weight loss alone or combined with exercise in overweight or obese people with knee osteoarthritis: A systematic review and meta-analysis

Michelle Hall et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2019)

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Review Biochemistry & Molecular Biology

Reactive oxygen species, aging and articular cartilage homeostasis

Jesalyn A. Bolduc et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Redox and NF-κB signaling in osteoarthritis

Panagiotis Lepetsos et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Review Rheumatology

Fatty acids and osteoarthritis: different types, different effects

Marieke Loef et al.

JOINT BONE SPINE (2019)

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Article Orthopedics

The effects of metabolic syndrome, obesity, and the gut microbiome on load-induced osteoarthritis

J. D. Guss et al.

OSTEOARTHRITIS AND CARTILAGE (2019)

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Article Engineering, Biomedical

Effects of ultrasound therapy on the synovial fluid proteome in a rabbit surgery-induced model of knee osteoarthritis

Qinglu Luo et al.

BIOMEDICAL ENGINEERING ONLINE (2019)

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Article Cell Biology

Chondroprotection of PPARα activation by WY14643 via autophagy involving Akt and ERK in LPS-treated mouse chondrocytes and osteoarthritis model

Yang Zhou et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Anterior cruciate ligament transection alters the n-3/n-6 fatty acid balance in the lapine infrapatellar fat pad

Anne-Mari Mustonen et al.

LIPIDS IN HEALTH AND DISEASE (2019)

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Article Multidisciplinary Sciences

The CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis

Wan-Su Choi et al.

NATURE (2019)

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Review Nutrition & Dietetics

Lipid Accumulation and Chronic Kidney Disease

Zhibo Gai et al.

NUTRIENTS (2019)

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Article Biochemistry & Molecular Biology

Simvastatin promotes restoration of chondrocyte morphology and phenotype

Kenya Terabe et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

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Article Cell Biology

Isorhamnetin attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through modulating reactive oxygen species homeostasis

Feng Zhou et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Review Medicine, General & Internal

Osteoarthritis

David J. Hunter et al.

LANCET (2019)

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Article Orthopedics

OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis

R. R. Bannuru et al.

OSTEOARTHRITIS AND CARTILAGE (2019)

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Article Multidisciplinary Sciences

Activation of The Phosphatidylcholine to Lysophosphatidylcholine Pathway Is Associated with Osteoarthritis Knee Cartilage Volume Loss Over Time

Guangju Zhai et al.

SCIENTIFIC REPORTS (2019)

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Article Medicine, General & Internal

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

Uxia Nogueira-Recalde et al.

EBIOMEDICINE (2019)

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Editorial Material Medicine, General & Internal

Pleiotropic effect of fibrates on senescence and autophagy in osteoarthritis

Marta Anna Szychlinska et al.

EBIOMEDICINE (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

Statin Use and Knee Osteoarthritis Outcome Measures according to the Presence of Heberden Nodes: Results from the Osteoarthritis Initiative

Arya Haj-Mirzaian et al.

RADIOLOGY (2019)

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Review Nutrition & Dietetics

Polyphenol Effects on Cholesterol Metabolism via Bile Acid Biosynthesis, CYP7A1: A Review

Karen F. Chambers et al.

NUTRIENTS (2019)

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Review Immunology

Reactive oxygen species (ROS) in macrophage activation and function in diabetes

Erika Rendra et al.

IMMUNOBIOLOGY (2019)

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Article Cell & Tissue Engineering

Attenuation of osteoarthritis progression in mice following intra-articular administration of simvastatin-conjugated gelatin hydrogel

Toshikazu Tanaka et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2019)

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Advanced glycation end-products induced VEGF production and inflammatory responses in human synoviocytes via RAGE-NF-B pathway activation

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Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation

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Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis

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Suppressive Effects of Insulin on Tumor Necrosis Factor-Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus

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A low ratio of n-6/n-3 polyunsaturated fatty acids suppresses matrix metalloproteinase 13 expression and reduces adjuvant-induced arthritis in rats

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MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes

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Peroxisome Proliferator-Activated Receptor δ Promotes the Progression of Posttraumatic Osteoarthritis in a Mouse Model

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Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice

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Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden. CETP mice-a translational model for atherosclerosis

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Palmitate Has Proapoptotic and Proinflammatory Effects on Articular Cartilage and Synergizes With Interleukin-1

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Perturbations in the HDL metabolic pathway predispose to the development of osteoarthritis in mice following long-term exposure to western-type diet

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Monounsaturated and Saturated, but Not n-6 Polyunsaturated Fatty Acids Decrease Cartilage Destruction under Inflammatory Conditions: A Preliminary Study

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Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study

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Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

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Cytokine production by infrapatellar fat pad can be stimulated by interleukin 1β and inhibited by peroxisome proliferator activated receptor α agonist

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Antioxidant activities of recombinant amphioxus (Branchiostoma belcheri) apolipoprotein D

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Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for advanced glycation end product-mediated activation of mitogen-activated protein kinases and nuclear factor-κB in human osteoarthritis chondrocytes

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Advanced glycation end products cause collagen II reduction by activating Janus kinase/signal transducer and activator of transcription 3 pathway in porcine chondrocytes

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Synovial fluid level of adiponectin correlated with levels of aggrecan degradation markers in osteoarthritis

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Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways

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Leptin plays a catabolic role on articular cartilage

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Release of Inflammatory Mediators by Human Adipose Tissue Is Enhanced in Obesity and Primarily by the Nonfat Cells: A Review

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MEDIATORS OF INFLAMMATION (2010)

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The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review

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Adiponectin is a potential catabolic mediator in osteoarthritis cartilage

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Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: a population-based prospective cohort study

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The Infrapatellar Fat Pad in Knee Osteoarthritis An Important Source of Interleukin-6 and Its Soluble Receptor

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Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis

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Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage Reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis

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Increased Prevalence of Metabolic Syndrome in Individuals with Osteoarthritis: An Analysis of NHANES III Data

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Increase levels of apo-A1 and apo B are associated in knee osteoarthritis:: lack of association with VEGF -460 T/C and +405 C/G polymorphisms

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Inverse relationship between matrix remodeling and lipid metabolism during osteoarthritis progression in the STR/Ort mouse

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Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study

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Evidence for a protective role for adiponectin in osteoarthritis

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Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes

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