Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms

Although aging has traditionally been viewed as the most important risk factor for osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the association between metabolic abnormalities and OA, particularly in younger individuals. Metabolic abnormalities, such as obesity and type II diabetes, are strongly linked to OA, and they affect both weight-bearing and non-weight-bearing joints, thus suggesting that the pathogenesis of OA is more complicated than the mechanical stress induced by overweight. This review aims to explore the recent advances in research on the relationship between metabolic abnormalities and OA risk, including the impact of abnormal glucose and lipid metabolism, the potential pathogenesis and targeted therapeutic strategies.

Automated summary

Although aging has traditionally been considered the most important risk factor for osteoarthritis, recent epidemiological evidence suggests a strong association between metabolic abnormalities and osteoarthritis risk, especially in younger individuals. Abnormalities such as obesity and type II diabetes are closely linked to osteoarthritis and affect both weight-bearing and non-weight-bearing joints, implying that the pathogenesis of osteoarthritis is more complex than mechanical stress caused by overweight.