期刊
JOURNAL OF BIOPHOTONICS
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.202300375
关键词
diagnostics; hemangioma; hyperspectral imaging
This study aims to advance personalized prognosis of hemangioma by developing a rapid hyperspectral sensor that can quantify hemoglobin oxygenation and vascularization dynamics. Clinical studies have shown a 90% agreement between the quantitative parameter and clinician's conclusion. This method has the potential to be used as a supportive tool for accurate hemangioma diagnostics in clinics.
Hemangioma, the predominant benign tumor occurring in infancy, exhibits a wide range of prognoses and associated outcomes. The accurate determination of prognosis through noninvasive imaging modalities holds essential importance in enabling effective personalized treatment strategies and minimizing unnecessary surgical interventions for individual patients. The present study focuses on advancing the personalized prognosis of hemangioma by leveraging noninvasive optical sensing technologies by the development of a novel rapid hyperspectral sensor (image collection in 5 s, lateral resolution of 10 mu m) that is capable of quantifying hemoglobin oxygenation and vascularization dynamics during the course of tumor evolution. We have developed a quantitative parameter for hemangioma assessment, that demonstrated agreement with the clinician's conclusion in 90% among all cases during clinical studies on six patients, who visited clinician from two to four times. The presented methodology has potential to be implemented as a supportive tool for accurate hemangioma diagnostics in clinics. A handheld low-cost device for infantile hemangioma imaging allows quantitative analysis of the lesion's changes in time.image
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