Pterostilbene alleviates abdominal aortic aneurysm via inhibiting macrophage pyroptosis by activating the miR-146a-5p/TRAF6 axis

Article Plant Sciences

Pterostilbene alleviated NAFLD via AMPK/mTOR signaling pathways and autophagy by promoting Nrf2

Bingyu Shen et al.

Summary: This study provides insights into the mechanism of PTE affecting oxidative stress and autophagy in NAFLD mice.

PHYTOMEDICINE (2023)

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Article Biochemistry & Molecular Biology

Human umbilical cord mesenchymal stem cell-derived exosomal microRNA-148a-3p inhibits neointimal hyperplasia by targeting Serpine1

Xiaoyu Zhang et al.

Summary: The study found that hucMSC-Exos targeted Serpine1 by delivering miR-148a-3p to VSMCs, thereby inhibiting neointimal hyperplasia (NIH) and VSMC phenotypic switching and migration.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2022)

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Article Obstetrics & Gynecology

Low-dose aspirin improves blood perfusion of endometrium of unexplained recurrent biochemical pregnancy loss

Xiaoxin Zhang et al.

Summary: The study found that patients with URBPL had higher resistance of endometrial perfusion compared to normal group, with predictive values. After treatment with LDA, there was a significant improvement in endometrial blood perfusion in patients with URBPL.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2022)

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Article Pharmacology & Pharmacy

Pterostilbene alleviates liver ischemia/reperfusion injury via PINK1-mediated mitophagy

Qiangqiang Shi et al.

Summary: The study indicates that pterostilbene derived from blueberries and grapes exerts hepatoprotective effects in hepatic ischemia/reperfusion injury by enhancing PINK1-mediated mitophagy and promoting hepatocyte proliferation.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Sunitinib and Pterostilbene Combination Treatment Exerts Antitumor Effects in Gastric Cancer via Suppression of PDZD8

Yudai Hojo et al.

Summary: The use of molecular-targeted drugs in gastric cancer treatment is increasing, but the variety of these drugs is still limited. In this study, the combination of sunitinib and pterostilbene showed significant suppression of cell proliferation and increased oxidative stress. The combination therapy also had a pronounced antitumor effect in a mouse tumor model. These findings suggest that the combined use of sunitinib and pterostilbene may be a new molecular-targeted therapy for gastric cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Dual Inhibition of BRAF-MAPK and STAT3 Signaling Pathways in Resveratrol-Suppressed Anaplastic Thyroid Cancer Cells with BRAF Mutations

Meng-Di Lu et al.

Summary: Resveratrol inhibits the growth of ATC cells and has a more powerful inhibitory effect on THJ-16T and THJ-21T cells with BRAF mutation. It reduces the levels of MAPK pathway-associated proteins and pSTAT3, making it a promising therapeutic agent for ATCs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Cell Biology

Targeting NLRP3 Inflammasome Alleviates Synovitis by Reducing Pyroptosis in Rats with Experimental Temporomandibular Joint Osteoarthritis

Yinzi Xin et al.

Summary: This study investigated the role of NLRP3 inflammasome in synovitis of temporomandibular joint osteoarthritis (TMJOA) and explored the therapeutic potential of caspase-1 and NLRP3 inhibitors. The findings suggest that NLRP3 inflammasome-mediated pyroptosis contributes to synovial inflammation in TMJOA, and interfering with this process could be a potential option for controlling TMJOA development.

MEDIATORS OF INFLAMMATION (2022)

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Article Biotechnology & Applied Microbiology

Huc-MSCs-derived exosomes attenuate inflammatory pain by regulating microglia pyroptosis and autophagy via the miR-146a-5p/TRAF6 axis

Tong Hua et al.

Summary: This study demonstrates that huc-MSCs-derived exosomes attenuated chronic inflammatory pain, possibly through the regulation of autophagy and pyroptosis by miR-146a-5p/TRAF6.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Oxidative stability and gelation properties of myofibrillar protein from chicken breast after post-mortem frozen storage as influenced by phenolic compound-pterostilbene

Yingjie Wang et al.

Summary: The aim of this study was to investigate the effects of dietary pterostilbene supplementation on physicochemical changes and gel properties of myofibrillar protein (MP) in chicken during short-term frozen storage. The results demonstrated that pterostilbene supplementation reduced the oxidation of MP, slowed the loss of sulfhydryl and free amino groups, and decreased the surface hydrophobicity and insolubility of MP. Furthermore, dietary pterostilbene inhibited the unfolding of protein structure and the transition of alpha-helix to beta-sheet structure. These effects contributed to the improved gel quality, including enhanced strength, whiteness, and water-holding capacity, as well as the formation of a dense and homogeneous gel network structure. Overall, these findings suggest that pterostilbene can be used as a dietary supplement to maintain the structural stability of MP in chicken breast muscle during postmortem storage and enhance gel functional properties.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Review Pharmacology & Pharmacy

Dietary stilbenes as modulators of specific miRNAs in prostate cancer

Anait S. Levenson

Summary: Accumulated experimental data suggest that natural plant products may have chemopreventive and therapeutic effects by modulating miRNA expression. Dietary polyphenols, including flavonoids, stilbenes, and lignans, have been extensively studied for their miRNA-mediated cardioprotective, antioxidant, anti-inflammatory, and anticancer properties. This review focuses on the role of stilbene-regulated miRNAs in cancer, particularly their interaction with MTA1 signaling in prostate cancer.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Improved oral nutraceutical-based intervention for the management of obesity: pterostilbene-loaded chitosan nanoparticles

Lamia A. Heikal et al.

Summary: This study aimed to formulate and evaluate the oral anti-obesity effect of pterostilbene-loaded nanoparticles. The nanoparticles were successfully prepared and showed improved bioavailability and an enhanced anti-obesity effect compared to free pterostilbene. The nanoparticles decreased cholesterol levels and facilitated the conversion of white fat to brown fat, resulting in sustainable weight loss and minimal side effects. These findings suggest that orally administered pterostilbene nanoparticles could be a promising anti-obesity strategy with significant socio-economic impact.

NANOMEDICINE (2022)

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Article Biotechnology & Applied Microbiology

CTRP13 Mitigates Abdominal Aortic Aneurysm Formation via NAMPT1

Wenjing Xu et al.

Summary: The study reveals the important role of CTRP13 in preventing AAA formation, showing its ability to reduce the incidence and severity of AAA, as well as decrease vascular inflammation and SMC apoptosis.

MOLECULAR THERAPY (2021)

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Article Cell Biology

Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke

Zhongfei Zhang et al.

Aging-US (2021)

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Article Medicine, Research & Experimental

TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm

Marie Vandestienne et al.

Summary: The study demonstrated that TREM-1 plays a crucial role in the pathophysiology of AAA and could be a potential therapeutic target for the disease in humans.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Biochemistry & Molecular Biology

Resveratrol and its derivative pterostilbene attenuate oxidative stress-induced intestinal injury by improving mitochondrial redox homeostasis and function via SIRT1 signaling

Yanan Chen et al.

Summary: This study found that PTS is more effective than RSV in protecting mitochondrial function and intestinal integrity against oxidative stress-induced injury. Both compounds work by regulating mitochondrial redox homeostasis and function through the SIRT1 signaling pathway.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Pharmacology & Pharmacy

Protective Effects of Pterostilbene on Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting NF-κB and Activating Nrf2/HO-1 Signaling Pathways

Yong Zhang et al.

Summary: PTER, a stilbene compound with biological activities, shows protective effect against LPS-induced ALI by inhibiting inflammatory response and oxidative stress, suggesting its potential therapeutic application in ALI intervention.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Cell Biology

miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases

Fabiola Olivieri et al.

Summary: Inflammaging is a key concept in understanding how aging contributes to the development of age-related diseases, with a focus on the role of miRNAs in regulating inflammatory pathways. The assessment of individual genetic make-up alone is insufficient to depict the trajectories of age-related inflammation, and studies have shown that circulating inflammamiRs could be used to measure the degree of inflammaging.

AGEING RESEARCH REVIEWS (2021)

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Article Biochemistry & Molecular Biology

The effects of Naja sumatrana venom cytotoxin, sumaCTX on alteration of the secretome in MCF-7 breast cancer cells following membrane permeabilization

Jia Jin Hiu et al.

Summary: The study found that Naja sumatrana venom cytotoxin (sumaCTX) induced membrane permeabilization in MCF-7 cells at high concentrations, altering the secretome composition. High concentrations of sumaCTX caused the release of intracellular proteins, triggering necroptotic response in the cells.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Multidisciplinary Sciences

Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress

Qing Zhang et al.

Summary: This study summarized natural compounds that exert protective effects against oxidative stress in vascular endothelial cells (ECs), including phenylpropanoids, flavonoids, terpenoids, and alkaloids. These compounds alleviate EC apoptosis by activating the Nrf2/HO-1 signaling pathway, showing potential for the treatment of atherosclerosis.

JOURNAL OF ADVANCED RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Pterostilbene Changes Epigenetic Marks at Enhancer Regions of Oncogenes in Breast Cancer Cells

Sadaf Harandi-Zadeh et al.

Summary: Epigenetic aberrations are associated with sporadic breast cancer, and dietary polyphenols such as pterostilbene have been shown to regulate gene expression by altering epigenetic patterns. The study reveals an impact of pterostilbene on enhancer regions in breast cancer cells, affecting DNMT3B binding, H3K36me3 levels, enhancer hypermethylation, and gene expression downregulation. Additionally, the research highlights the involvement of oncogenic transcription factor OCT1 in mediating the effects of pterostilbene on enhancers and gene expression in breast cancer cells.

ANTIOXIDANTS (2021)

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Article Biochemistry & Molecular Biology

Pterostilbene modifies triglyceride metabolism in hepatic steatosis induced by high-fat high-fructose feeding: a comparison with its analog resveratrol

S. Gomez-Zorita et al.

Summary: In this study, pterostilbene was found to partially prevent high-fat high-fructose feeding induced liver steatosis in rats, showing a dose-response pattern. It mainly acts by reducing de novo lipogenesis and increasing triglyceride assembly and release, with an improvement in mitochondrial functionality observed. At the same dose, the effects induced by pterostilbene and resveratrol, as well as the mechanisms involved, were similar.

FOOD & FUNCTION (2021)

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Article Cell Biology

Silencing lncRNA Lfar1 alleviates the classical activation and pyoptosis of macrophage in hepatic fibrosis

Kun Zhang et al.

CELL DEATH & DISEASE (2020)

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Article Multidisciplinary Sciences

Siah2 control of T-regulatory cells limits anti-tumor immunity

Marzia Scortegagna et al.

NATURE COMMUNICATIONS (2020)

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Article Biochemistry & Molecular Biology

Identification of Novel microRNA Profiles Dysregulated in Plasma and Tissue of Abdominal Aortic Aneurysm Patients

Emma Plana et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Medicine, General & Internal

Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2

Haoyu Song et al.

EBIOMEDICINE (2020)

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Article Biochemistry & Molecular Biology

Macrophage pyroptosis is mediated by immunoproteasome subunit b5i (LMP7) in abdominal aortic aneurysm

Xu Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Review Medicine, Research & Experimental

The relevance of pyroptosis in the pathogenesis of liver diseases

Huiting Guo et al.

LIFE SCIENCES (2019)

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Article Cell Biology

Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome

Lingbin Sun et al.

CELL DEATH & DISEASE (2019)

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Article Cardiac & Cardiovascular Systems

Meta-analysis of the growth rates of abdominal aortic aneurysm in the Chinese population

Tingting Huang et al.

BMC CARDIOVASCULAR DISORDERS (2019)

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Article Immunology

Resveratrol protects BV2 mouse microglial cells against LPS-induced inflammatory injury by altering the miR-146a-5p/TRAF6/NF-κB axis

Yu-Ting Ge et al.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2019)

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Article Agriculture, Multidisciplinary

Pterostilbene Attenuates Experimental Atherosclerosis through Restoring Catalase-Mediated Redox Balance in Vascular Smooth Muscle Cells

Wei Wang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

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Review Cell Biology

Role of pyroptosis in cardiovascular disease

Zeng Zhaolin et al.

CELL PROLIFERATION (2019)

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Review Cardiac & Cardiovascular Systems

Abdominal aortic aneurysm: update on pathogenesis and medical treatments

Jonathan Golledge

NATURE REVIEWS CARDIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Metabolism and pharmacokinetics of resveratrol and pterostilbene

Pei Wang et al.

BIOFACTORS (2018)

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Review Medical Laboratory Technology

Pyroptosis and its relationship to atherosclerosis

Yuan-Jun Xu et al.

CLINICA CHIMICA ACTA (2018)

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Review Pharmacology & Pharmacy

Current Theories and Clinical Trial Evidence for Limiting Human Abdominal Aortic Aneurysm Growth

Jing Yu et al.

CURRENT DRUG TARGETS (2018)

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Article Medicine, General & Internal

Effect of Alteplase vs Aspirin on Functional Outcome for Patients With Acute Ischemic Stroke and Minor Nondisabling Neurologic Deficits The PRISMS Randomized Clinical Trial

Pooja Khatri et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

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Article Surgery

The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm

Elliot L. Chaikof et al.

JOURNAL OF VASCULAR SURGERY (2018)

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Article Peripheral Vascular Disease

3D printing guiding stent graft fenestration: A novel technique for fenestration in endovascular aneurysm repair

Jianhua Huang et al.

VASCULAR (2017)

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Review Cell Biology

Gasdermins: Effectors of Pyroptosis

Stephen B. Kovacs et al.

TRENDS IN CELL BIOLOGY (2017)

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Article Hematology

Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin-Converting Enzyme 2

Corey S. Moran et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)

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Review Multidisciplinary Sciences

Resveratrol and pterostilbene as a microRNA-mediated chemopreventive and therapeutic strategy in prostate cancer

Avinash Kumar et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)

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Article Medicine, Research & Experimental

Pterostilbene, a novel natural plant conduct, inhibits high fat-induced atherosclerosis inflammation via NF-κB signaling pathway in Toll-like receptor 5 (TLR5) deficient mice

Yuan Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

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Article Hematology

Membrane-Bound Thrombomodulin Regulates Macrophage Inflammation in Abdominal Aortic Aneurysm

Kuan-Chieh Wang et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

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Article Immunology

MicroRNA-146a-5p attenuates neuropathic pain via suppressing TRAF6 signaling in the spinal cord

Ying Lu et al.

BRAIN BEHAVIOR AND IMMUNITY (2015)

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Review Cardiac & Cardiovascular Systems

Abdominal aortic aneurysm: novel mechanisms and therapies

Frank M. Davis et al.

CURRENT OPINION IN CARDIOLOGY (2015)

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Article Food Science & Technology

Pterostilbene Inhibits Vascular Smooth Muscle Cells Migration and Matrix Metalloproteinase-2 through Modulation of MAPK Pathway

Hsing-Chun Lin et al.

JOURNAL OF FOOD SCIENCE (2015)

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Article Medicine, General & Internal

Screening for Abdominal Aortic Aneurysm: U.S. Preventive Services Task Force Recommendation Statement

Michael L. LeFevre

ANNALS OF INTERNAL MEDICINE (2014)

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Article Gastroenterology & Hepatology

NLRP3 Inflammasome Activation Results in Hepatocyte Pyroptosis, Liver Inflammation, and Fibrosis in Mice

Alexander Wree et al.

HEPATOLOGY (2014)

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Article Endocrinology & Metabolism

Pyroptotic neuronal cell death mediated by the AIM2 inflammasome

Stephanie E. Adamczak et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2014)

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Review Cardiac & Cardiovascular Systems

Estimation of Global and Regional Incidence and Prevalence of Abdominal Aortic Aneurysms 1990 to 2010

Uchechukwu K. A. Sampson et al.

GLOBAL HEART (2014)

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Review Medical Laboratory Technology

Pterostilbene: Biomedical applications

Jose M. Estrela et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2013)

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Article Biochemistry & Molecular Biology

Pterostilbene protects vascular endothelial cells against oxidized low-density lipoprotein-induced apoptosis in vitro and in vivo

Lu Zhang et al.

APOPTOSIS (2012)

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Review Surgery

Pterostilbene and Cancer: Current Review

Denise McCormack et al.

JOURNAL OF SURGICAL RESEARCH (2012)

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Article Cardiac & Cardiovascular Systems

Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization

Hidehiro Kaneko et al.

ATHEROSCLEROSIS (2011)

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Article Surgery

Resveratrol Counteracts Systemic and Local Inflammation Involved in Early Abdominal Aortic Aneurysm Development

Daniela Palmieri et al.

JOURNAL OF SURGICAL RESEARCH (2011)

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Article Pharmacology & Pharmacy

Pterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathway

Eun-Seok Park et al.

VASCULAR PHARMACOLOGY (2010)

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Article Oncology

Downregulation of SIAH2, an ubiquitin E3 ligase, is associated with resistance to endocrine therapy in breast cancer

Maurice P. H. M. Jansen et al.

BREAST CANCER RESEARCH AND TREATMENT (2009)

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Article Biochemistry & Molecular Biology

Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms

Kimio Satoh et al.

NATURE MEDICINE (2009)

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Article Chemistry, Medicinal

Pharmacometrics of pterostilbene:: Preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity

Connie M. Remsberg et al.

PHYTOTHERAPY RESEARCH (2008)

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Pterostilbene alleviates abdominal aortic aneurysm via inhibiting macrophage pyroptosis by activating the miR-146a-5p/TRAF6 axis

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