相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods
Stephen Burgess et al.
STATISTICS IN MEDICINE (2016)
Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes A Meta-analysis
Luca A. Lotta et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)
Human gut microbes impact host serum metabolome and insulin sensitivity
Helle Krogh Pedersen et al.
NATURE (2016)
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
Robert A. Scott et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics
Pasi Soininen et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2015)
Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans
Erin L. Glynn et al.
DIABETOLOGIA (2015)
Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study
Therese Tillin et al.
DIABETOLOGIA (2015)
Metabolomic Profile Associated With Insulin Resistance and Conversion to Diabetes in the Insulin Resistance Atherosclerosis Study
Nicholette D. Palmer et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)
Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1, HMGCR, or Both
Brian A. Ference et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)
New genetic loci link adipose and insulin biology to body fat distribution
Dmitry Shungin et al.
NATURE (2015)
Genetic studies of body mass index yield new insights for obesity biology
Adam E. Locke et al.
NATURE (2015)
Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis
Po-Ru Loh et al.
NATURE GENETICS (2015)
An atlas of genetic correlations across human diseases and traits
Brendan Bulik-Sullivan et al.
NATURE GENETICS (2015)
Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study
Soren D. Ostergaard et al.
PLOS MEDICINE (2015)
Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics
Pasi Soininen et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2015)
Impaired Adiponectin Signaling Contributes to Disturbed Catabolism of Branched-Chain Amino Acids in Diabetic Mice
Kun Lian et al.
DIABETES (2015)
Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism
Andrew C. Shin et al.
CELL METABOLISM (2014)
Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity
Robert A. Scott et al.
DIABETES (2014)
Roux-en-Y Gastric Bypass Surgery, but Not Calorie Restriction, Reduces Plasma Branched-Chain Amino Acids in Obese Women Independent of Weight Loss or the Presence of Type 2 Diabetes
Miriam A. Lips et al.
DIABETES CARE (2014)
Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase
Shih-Chia Tso et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Sodium phenylbutyrate decreases plasma branched-chain amino acids in patients with urea cycle disorders
Lindsay C. Burrage et al.
MOLECULAR GENETICS AND METABOLISM (2014)
An atlas of genetic influences on human blood metabolites
So-Youn Shin et al.
NATURE GENETICS (2014)
Branched-chain amino acids in metabolic signalling and insulin resistance
Christopher J. Lynch et al.
NATURE REVIEWS ENDOCRINOLOGY (2014)
Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease
Nathan O. Stitziel et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight Change
Peter Wurtz et al.
PLOS MEDICINE (2014)
A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort
Eugene P. Rhee et al.
CELL METABOLISM (2013)
Genetic Determinant for Amino Acid Metabolites and Changes in Body Weight and Insulin Resistance in Response to Weight-Loss Diets The Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) Trial
Min Xu et al.
CIRCULATION (2013)
Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach
Anna Floegel et al.
DIABETES (2013)
Metabolite Profiles During Oral Glucose Challenge
Jennifer E. Ho et al.
DIABETES (2013)
Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach
Cristina Menni et al.
DIABETES (2013)
Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data
Stephen Burgess et al.
GENETIC EPIDEMIOLOGY (2013)
The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH)
Eiji Kakazu et al.
HEPATOLOGY INTERNATIONAL (2013)
A Novel Regulatory Defect in the Branched-Chain -Keto Acid Dehydrogenase Complex Due to a Mutation in the PPM1K Gene Causes a Mild Variant Phenotype of Maple Syrup Urine Disease
Alfonso Oyarzabal et al.
HUMAN MUTATION (2013)
Discovery and refinement of loci associated with lipid levels
Cristen J. Willer et al.
NATURE GENETICS (2013)
Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase
Shih-Chia Tso et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Vanessa K. Ridaura et al.
SCIENCE (2013)
A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets
Jalal Taneera et al.
CELL METABOLISM (2012)
Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance
Christopher B. Newgard
CELL METABOLISM (2012)
What makes UK Biobank special?
Rory Collins
LANCET (2012)
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Benjamin F. Voight et al.
LANCET (2012)
Novel biomarkers for pre-diabetes identified by metabolomics
Rui Wang-Sattler et al.
MOLECULAR SYSTEMS BIOLOGY (2012)
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Andrew P. Morris et al.
NATURE GENETICS (2012)
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Robert A. Scott et al.
NATURE GENETICS (2012)
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Alisa K. Manning et al.
NATURE GENETICS (2012)
Genome-wide association study identifies multiple loci influencing human serum metabolite levels
Johannes Kettunen et al.
NATURE GENETICS (2012)
Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans
Changting Xiao et al.
DIABETES (2011)
Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
C. Langenberg et al.
DIABETOLOGIA (2011)
Phenylbutyrate therapy for maple syrup urine disease
Nicola Brunetti-Pierri et al.
HUMAN MOLECULAR GENETICS (2011)
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
Eugene P. Rhee et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Metabolite profiles and the risk of developing diabetes
Thomas J. Wang et al.
NATURE MEDICINE (2011)
METAL: fast and efficient meta-analysis of genomewide association scans
Cristen J. Willer et al.
BIOINFORMATICS (2010)
Molecular and Metabolic Evidence for Mitochondrial Defects Associated With β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes
Hongfang Lu et al.
DIABETES (2010)
Genotype imputation for genome-wide association studies
Jonathan Marchini et al.
NATURE REVIEWS GENETICS (2010)
A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
Christopher B. Newgard et al.
CELL METABOLISM (2009)
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
Nicola L. Beer et al.
HUMAN MOLECULAR GENETICS (2009)
Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells
Gang Lu et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
Andrew D. Johnson et al.
BIOINFORMATICS (2008)
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
Oded Shaham et al.
MOLECULAR SYSTEMS BIOLOGY (2008)
Evidence for a role of superoxide generation in glucose-induced β-cell dysfunction in vivo
Christine Tang et al.
DIABETES (2007)
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
JC Cohen et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Normalization of real-time quantitative reverse transcription-PCR data: A model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets
CL Andersen et al.
CANCER RESEARCH (2004)
Molecular mechanism for regulation of the human mitochondrial branched-chain α-ketoacid dehydrogenase complex by phosphorylation
RM Wynn et al.
STRUCTURE (2004)
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?
GD Smith et al.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2003)