4.7 Article

Methods, bioinformatics tools and databases in ecDNA research: An overview

期刊

COMPUTERS IN BIOLOGY AND MEDICINE
卷 167, 期 -, 页码 -

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2023.107680

关键词

ecDNA; Bioinformatics; Database; Single-cell sequencing

向作者/读者索取更多资源

This article provides a comprehensive overview of the methods, bioinformatics tools, and database resources used in ecDNA research, highlighting their significance in tumor initiation and progression, and offering suggestions for current analysis and future research directions.
Extrachromosomal DNA (ecDNA), derived from chromosomes, is a cancer-specific circular DNA molecule. EcDNA drives tumor initiation and progression, which is associated with poor clinical outcomes and drug resistance in a wide range of cancers. Although ecDNA was first discovered in 1965, tremendous technological revolutions in recent years have provided crucial new insights into its key biological functions and regulatory mechanisms. Here, we provide a thorough overview of the methods, bioinformatics tools, and database resources used in ecDNA research, mainly focusing on their performance, strengths, and limitations. This study can provide important reference for selecting the most appropriate method in ecDNA research. Furthermore, we offer sug-gestions for the current bioinformatics analysis of ecDNA and provide an outlook to the future research.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据