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The role of cellular senescence in skin aging and age-related skin pathologies

FRONTIERS IN PHYSIOLOGY (2023)

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Review Biochemistry & Molecular Biology

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics

Lei Zhang et al.

Summary: The concept of geroscience focuses on targeting the ageing process itself as a means to improve human health. Cellular senescence, a state of irreversible cell arrest, has emerged as a potential therapeutic target to extend healthspan. Senescent cells develop a secretory phenotype that promotes chronic inflammation and tissue dysfunction. Therapeutic drugs that induce selective cell death of senescent cells or suppress the expression of senescence markers are being developed.

FEBS JOURNAL (2023)

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Article Biochemistry & Molecular Biology

Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen

Tatsuya Hasegawa et al.

Summary: Senescent fibroblast accumulation in aging human skin is controlled by a virus-immune axis. Senescent fibroblasts increase in old skin, but not in the elderly, which is associated with increased recruitment of CXCL9 and cytotoxic CD4+ T cells. Skin-resident CD4 CTLs eliminate senescent fibroblasts expressing HLA-II and HCMV-gB through an HLA-II-dependent mechanism.

CELL (2023)

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Article Multidisciplinary Sciences

Signalling by senescent melanocytes hyperactivates hair growth

Xiaojie Wang et al.

Summary: It has been found that senescent melanocytes in melanocytic skin nevi can activate hair stem cells to enhance hair growth. The secretome of senescent cells, such as osteopontin, plays a crucial role in stimulating hair growth. This finding has significant implications for the treatment of regenerative disorders.

NATURE (2023)

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Review Biochemistry & Molecular Biology

Inflammation and aging: signaling pathways and intervention therapies

Xia Li et al.

Summary: Aging is characterized by systemic chronic inflammation and its associated consequences. Inflammation and senescence form a vicious cycle, with senescent cells promoting chronic inflammation and inflammation accelerating cellular senescence. The persistence of elevated inflammation levels in organs leads to organ damage and age-related diseases. Understanding the mechanisms of inflammation and aging is crucial for developing effective anti-aging strategies.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

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Letter Dermatology

The potential skin-lightening candidate, senolytic drug ABT263, for photoageing pigmentation

Ji Hee Park et al.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Letter Dermatology

Identification and quantification of senescent cell types by lamin B1 and HMGB1 in Actinic keratosis lesions

Audrey Shimei Wang et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2022)

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Article Dermatology

Nicotinamide Prevents UVB- and Oxidative Stress-Induced Photoaging in Human Primary Keratinocytes

Christina Yan Ru Tan et al.

Summary: This study investigates the effects of nicotinamide (NAM) on photoaging in different models and demonstrates that NAM can delay cell differentiation and slow down aging. Additionally, NAM protects DNA from damage and improves energy metabolism. These findings highlight the protective role of NAM in the human epidermis.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

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Review Biotechnology & Applied Microbiology

The functional impact of nuclear reorganization in cellular senescence

Azucena Rocha et al.

Summary: The article provides an overview of the nuclear changes that occur in different forms of senescence, including changes in chromatin state and composition, three-dimensional organization of the genome, nuclear envelope, and accessibility of repetitive genomic regions. These changes are shared across all forms of senescence, indicating that nuclear organization plays a fundamental role in the senescent state and interaction of senescent cells with the surrounding tissue.

BRIEFINGS IN FUNCTIONAL GENOMICS (2022)

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Review Cell Biology

Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development

Li Hu et al.

Summary: Cellular senescence is an irreversible process of cell growth arrest caused by various stresses, and elimination of senescent cells may have significant implications for delaying aging and treating age-related diseases. However, senescent cells exhibit resistance to apoptosis, highlighting the importance of studying the underlying mechanisms of apoptotic resistance for the development of targeted therapies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Diesel Particulate Extract Accelerates Premature Skin Aging in Human Fibroblasts via Ceramide-1-Phosphate-Mediated Signaling Pathway

Kyong-Oh Shin et al.

Summary: Both intrinsic and extrinsic factors, such as an individual's body clock and air pollutants, accelerate premature aging. This study demonstrates that diesel particulate extract (DPE) increases cell senescence and activates matrix metalloprotease (MMP)-1 and MMP-3, leading to collagen degradation in human dermal fibroblasts. DPE activates NADPH oxidase and increases ceramide production, which in turn activates the arachidonate cascade and promotes MMP activity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Immunology

Skin immunity: dissecting the complex biology of our body's outer barrier

Chenlu Zhang et al.

Summary: Our skin plays a critical role in maintaining health by acting as a barrier and defending against external threats. Skin immunity is essential for living in harmony with commensal microbes and other environmental stimuli. This article provides an overview of skin as an immune organ, highlighting its unique features related to its topography, chemical composition, and microbial ecology. It discusses innate and adaptive immune functions and focuses on how skin-specific structures like hair follicles and sebaceous glands contribute to these processes. The article also introduces emerging areas of interest in skin immunity for the mucosal immunology community.

MUCOSAL IMMUNOLOGY (2022)

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Review Physiology

Lipids as Regulators of Cellular Senescence

Shruthi Hamsanathan et al.

Summary: Lipids play a crucial role in cellular senescence and its regulation. Changes in lipid composition and levels can impact cell function and are associated with aging and inflammation. While there is some understanding of lipid metabolism in cellular senescence, the link between key regulators and lipid changes is still not fully understood.

FRONTIERS IN PHYSIOLOGY (2022)

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Review Oncology

Cellular senescence in cancer: clinical detection and prognostic implications

Andreas Domen et al.

Summary: Cellular senescence is a mechanism in which cells enter a state of stable cell-cycle arrest with secretory features in response to cellular stress. It has been historically seen as a protective mechanism against cancer by eliminating damaged cells. However, the accumulation of senescent cells can have long-term detrimental effects and contribute to age-related diseases, including cancer. The role of cellular senescence in cancer is ambiguous and controversial, and its detection and study in cancer patients present challenges. This review highlights the methods and challenges of detecting cellular senescence in cancer patients, and discusses its prognostic implications.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Article Dermatology

Early onset of senescence and imbalanced epidermal homeostasis across the decades in photoexposed human skin: Fingerprints of inflammaging

Bradley B. Jarrold et al.

Summary: Inflammaging theory suggests that chronic inflammation contributes to cellular dysfunction and premature aging. In this study using a system biology approach, we found characteristic skin aging changes including epidermal thinning, loss of rete ridge pathlength, and thickening of the stratum corneum. We also observed elevated levels of inflammatory markers IL-8 and IL-1RA/IL1-alpha in the face, and elevated levels of cis/trans-urocanic acid in the arms and face with age. Additionally, older arms showed increased DNA damage response and accelerated epigenetic aging. Genes associated with differentiation and senescence increased in expression in the 30s, while genes associated with hypoxia and glycolysis increased in the 50s. Proteomic analysis confirmed elevated levels of differentiation and glycolytic-related proteins in the 60s compared to the 20s.

EXPERIMENTAL DERMATOLOGY (2022)

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Review Cell Biology

Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

Antero Salminen et al.

Summary: Excessive exposure of the skin to UV radiation can trigger immune system remodeling, leading to a photoaging state similar to chronological aging. Photoaging and normal aging seem to involve similar processes of immune system remodeling, but there may be different molecular mechanisms inducing inflammation and immunosuppression in accelerated photoaging and chronological aging processes.

INFLAMMATION RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Cellular senescence and senolytics: the path to the clinic

Selim Chaib et al.

Summary: Cellular senescence has emerged as a promising therapeutic target for disorders across the lifespan; targeting persistent senescent cells causing tissue damage may delay, prevent, or alleviate multiple diseases.

NATURE MEDICINE (2022)

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Review Biology

Role of Senescent Cells in Cutaneous Wound Healing

Allison M. M. Andrade et al.

Summary: Cellular senescence plays a significant role in aging, tissue and wound repair, tumor biology, and development. It is an irreversible growth arrest induced by internal and external stress mechanisms. Senescent cell populations are diverse and finding a specific biomarker for this state is challenging. Despite its involvement in wound healing and tissue repair, the mechanisms by which senescent cells modulate regenerative processes remain unclear.

BIOLOGY-BASEL (2022)

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Review Environmental Sciences

Recent Insights into Particulate Matter (PM2.5)-Mediated Toxicity in Humans: An Overview

Prakash Thangavel et al.

Summary: PM2.5, a type of ambient fine particulate matter, is considered a significant potential danger to human health, with causal associations to cardiopulmonary illnesses and cancers. The toxic effects and potential mechanisms of PM2.5 have been described in various studies.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

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Article Engineering, Environmental

Updated World Health Organization Air Quality Guidelines Highlight the Importance of Non-anthropogenic PM2.5

Sidhant J. Pai et al.

Summary: The recent update by the World Health Organization indicates that over 90% of the global population is exposed to PM2.5 concentrations that exceed their guidelines. Even under extreme abatement scenarios, more than half of the world's population will still experience PM2.5 exposures above the recommended level. A speciated aerosol exposure guideline is suggested for region-specific air quality management decisions and health-burden estimates.

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2022)

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Review Cell Biology

Effects of Air Pollution on Cellular Senescence and Skin Aging

Ines Martic et al.

Summary: This review summarizes the current knowledge about the effects of air pollution on the skin, including the relationship between air pollution components and cellular senescence, as well as the current therapeutic and cosmetic interventions.

CELLS (2022)

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Review Emergency Medicine

Senescence in chronic wounds and potential targeted therapies

Xuerong Wei et al.

Summary: Cellular senescence plays a crucial role in chronic wounds, and novel strategies targeting senescence can be applied for their treatment.

BURNS & TRAUMA (2022)

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Article Cell Biology

Role of Nrf2 in cell senescence regulation

Huan Yuan et al.

Summary: Nrf2 is a key transcription factor involved in maintaining cell redox balance and signal transduction, playing a crucial role in reducing oxidative stress damage and delaying cell senescence. Researchers have focused on elucidating the regulatory mechanism of Nrf2 in the prevention of cell senescence, which involves coordinated regulation of multiple signaling molecules.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

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Review Cell Biology

How good is the evidence that cellular senescence causes skin ageing?

Evon Low et al.

Summary: Skin, as the largest organ of the body, is compromised with time due to intrinsic and extrinsic ageing processes, primarily at the cellular level through cellular senescence. While evidence suggests that cellular senescence is a relevant cause of intrinsic skin ageing, it is not yet completely conclusive.

AGEING RESEARCH REVIEWS (2021)

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Review Dermatology

Cellular Senescence and the SenescenceAssociated Secretory Phenotype as Drivers of Skin Photoaging

Eleni Fitsiou et al.

Summary: This paper reviews how chronic UV exposure causes cells to prematurely enter senescence, leading to the accumulation of senescent cells in the skin and promoting impaired regenerative capacity, chronic inflammation, and tumorigenesis associated with photoaging. It concludes by highlighting the potential of senolytic drugs in delaying the onset and progression of age-related phenotypes in the skin.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Dermatology

Epilipidomics of Senescent Dermal Fibroblasts Identify Lysophosphatidylcholines as Pleiotropic Senescence-Associated Secretory Phenotype (SASP) Factors

Marie-Sophie Narzt et al.

Summary: During aging, skin accumulates senescent cells which play a key role in tissue repair and homeostasis when transiently present. However, the persistence of senescent cells that evade clearance leads to age-related deterioration of the skin. Research suggests that lysophospholipids may contribute to immune evasion and chronic inflammation in skin aging.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Multidisciplinary Sciences

A single dose of Ultraviolet-A induces proteome remodeling and senescence in primary human keratinocytes

Hellen Paula Valerio et al.

Summary: UVA induces proteome remodeling and senescence in primary keratinocytes, eliciting potent antioxidant and pro-inflammatory responses. Additionally, UVA modulates the secretory phenotype of these cells to the extent of inducing paracrine oxidative stress and immune system activation in pre-malignant keratinocytes.

SCIENTIFIC REPORTS (2021)

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Article Dermatology

Air pollution-induced tanning of human skin

S. Grether-Beck et al.

Summary: The study found that human skin exposed to diesel exhaust particles (DEP) may result in an increase in melanin production, which is likely mediated by oxidative stress response. Further research indicates that DEP-induced skin pigmentation is associated with cellular oxidative stress.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Biochemistry & Molecular Biology

Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner

Anthony Lagnado et al.

Summary: The research shows that neutrophils cause oxidative damage to telomeres in non-immune cells, promoting cellular senescence. In aged liver, senescent cells recruit neutrophils, potentially leading to the spread of senescence.

EMBO JOURNAL (2021)

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Article Biochemistry & Molecular Biology

BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology

Camille Bigenwald et al.

Summary: The study found that the BRAF(V600E) mutation induces a senescence program in multipotent hematopoietic progenitor cells, leading to the development of LCH disease, suggesting that senescent cells may be a new target for the treatment of LCH.

NATURE MEDICINE (2021)

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Review Cell Biology

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Ruchi Kumari et al.

Summary: Cellular senescence is a stable cell cycle arrest triggered in response to various stimuli, characterized by dynamic changes in senescent cells. It has both positive effects on tissue repair and anti-cancer mechanisms, but can also negatively impact organismal health. Multiple pathways, including p53/p21 and p16/pRB, play central roles in regulating this process.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Medicine, Research & Experimental

Natural compounds protect the skin from airborne particulate matter by attenuating oxidative stress

Ping Diao et al.

Summary: The review highlights the mechanisms of skin damage caused by particulate matter (PM), emphasizing the effects of reactive oxygen species accumulation and autophagy, while suggesting that extracts with high antioxidant capacity from plants and natural compounds may have potential protective effects against air pollution-related skin damage.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Environmental Sciences

Particulate matter promotes hyperpigmentation via AhR/MAPK signaling activation and by increasing a-MSH paracrine levels in keratinocytes

Yaqian Shi et al.

Summary: PM2.5 has become a global concern for public health and the environment, with the ability to induce skin aging and hyperpigmentation. By activating specific signaling pathways, PM2.5 can induce melanogenesis and promote hyperpigmentation.

ENVIRONMENTAL POLLUTION (2021)

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Review Biochemistry & Molecular Biology

CD39 Regulation and Functions in T Cells

Eleonora Timperi et al.

Summary: CD39, along with CD73, plays a crucial role in converting adenosine triphosphate into an immunosuppressive form of adenosine in the tumor microenvironment. Environmental and genetic factors shape the expression of CD39, which has significant functions in regulating T cell activities. Studies from preclinical models to clinical trials have contributed essential insights into novel combinatorial approaches for cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

Faces of cellular senescence in skin aging

Chin Yee Ho et al.

Summary: Skin is composed of different cell types with varying proliferative capacities, and aging occurs due to both chronological factors and exposure to external stimuli. The accumulation of senescent cells in different skin compartments during aging can lead to impaired skin physiology. The specific mechanisms by which different skin cell types respond to senescence-inducing stimuli and contribute to aging-related skin phenotypes and pathologies remain unclear.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

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Aging, Cell Senescence, the Pathogenesis and Targeted Therapies of Osteoarthritis

Xin-Xin Zhang et al.

Summary: Osteoarthritis is a chronic joint disease characterized by cartilage destruction, with aging playing a key role. Current treatments are palliative, and there is a need for disease-modifying drugs. Cellular senescence, synovial inflammation, and epigenetic changes may contribute to its pathogenesis.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Anesthesiology

Coagulation and Aging: Implications for the Anesthesiologist

Sarina L. Tschan et al.

Summary: This narrative review focuses on aging-related modifications in coagulation leading to increased thromboembolic and hemorrhagic risk in elderly patients. The article further discusses the perioperative treatment of elderly patients with antithrombotic therapy, emphasizing the need for special attention to both thromboembolic and bleeding risks.

CURRENT ANESTHESIOLOGY REPORTS (2021)

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Cell senescence contributes to tissue regeneration in zebrafish

Sabela Da Silva-Alvarez et al.

AGING CELL (2020)

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Cellular senescence and chronological age in various human tissues: A systematic review and meta-analysis

Camilla S. L. Tuttle et al.

AGING CELL (2020)

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A proteomic atlas of senescence-associated secretomes for aging biomarker development

Nathan Basisty et al.

PLOS BIOLOGY (2020)

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An Optimized Protocol for Histochemical Detection of Senescence-associated Beta-galactosidase Activity in Cryopreserved Liver Tissue

Giulia Jannone et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2020)

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Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging

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NPJ AGING AND MECHANISMS OF DISEASE (2020)

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Ryosuke Tadokoro et al.

DEVELOPMENTAL BIOLOGY (2019)

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Article Cell Biology

NAD+ metabolism governs the proinflammatory senescence-associated secretome

Timothy Nacarelli et al.

NATURE CELL BIOLOGY (2019)

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FASN activity is important for the initial stages of the induction of senescence

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Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

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SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells

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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

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Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

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EMBO JOURNAL (2019)

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Proteome-wide changes in primary skin keratinocytes exposed to diesel particulate extract A role for antioxidants in skin health

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Antagonism of cysteinyl leukotriene receptor 1 (cysLTR1) by montelukast suppresses cell senescence of chondrocytes

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Urban particulate matter in air pollution penetrates into the barrier-disrupted skin and produces ROS-dependent cutaneous inflammatory response in vivo

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Article Biochemistry & Molecular Biology

Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter (PM10) on Human Dermal Fibroblasts

Seo-Yeon Park et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Fisetin Regulates Nrf2 Expression and the Inflammation-Related Signaling Pathway to Prevent UVB-Induced Skin Damage in Hairless Mice

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Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway

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TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion

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Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

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NATURE COMMUNICATIONS (2016)

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Article Cell Biology

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

EA Georgakopoulou et al.

Aging-US (2016)

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Article Cell Biology

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu et al.

AGING CELL (2015)

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Article Dermatology

Characteristics of keratinocytes in facial solar lentigo with flattened rete ridges: comparison with melasma

J. Shin et al.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2015)

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Article Dermatology

Characterization of Skin Aging-Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin

Daniel M. Waldera Lupa et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

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Article Medicine, Research & Experimental

Natural and Sun-Induced Aging of Human Skin

Laure Rittie et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2015)

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Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria

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ELIFE (2015)

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Recurrent turnover of senescent cells during regeneration of a complex structure

Maximina H. Yun et al.

ELIFE (2015)

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Intermittent High Glucose Implements Stress-Induced Senescence in Human Vascular Endothelial Cells: Role of Superoxide Production by NADPH Oxidase

Morihiko Maeda et al.

PLOS ONE (2015)

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Review Oncology

Forging a signature of in vivo senescence

Norman E. Sharpless et al.

NATURE REVIEWS CANCER (2015)

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Review Endocrinology & Metabolism

Cellular senescence and the senescent secretory phenotype in age-related chronic diseases

Yi Zhu et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2014)

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An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

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DEVELOPMENTAL CELL (2014)

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Memory regulatory T cells reside in human skin

Robert Sanchez Rodriguez et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

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Pollution and skin: From epidemiological and mechanistic studies to clinical implications

Jean Krutmann et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2014)

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Letter Dermatology

p16INK4A Influences the Aging Phenotype in the Living Skin Equivalent

Jean Adamus et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

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Review Cell Biology

Cellular senescence: from physiology to pathology

Daniel Munoz-Espin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

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Dysfunction of dendritic cells in aged C57BL/6 mice leads to failure of natural killer cell activation and of tumor eradication

Zhenhong Guo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Review Cell Biology

NAD+ and sirtuins in aging and disease

Shin-ichiro Imai et al.

TRENDS IN CELL BIOLOGY (2014)

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Expression of catalytically active matrix metalloproteinase-1 in dermal fibroblasts induces collagen fragmentation and functional alterations that resemble aged human skin

Wei Xia et al.

AGING CELL (2013)

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Review Physiology

Aging, Cellular Senescence, and Cancer

Judith Campisi

ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 (2013)

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Non-Cell-Autonomous Tumor Suppression by p53

Amaia Lujambio et al.

CELL (2013)

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Lamin B1 fluctuations have differential effects on cellular proliferation and senescence

Oliver Dreesen et al.

JOURNAL OF CELL BIOLOGY (2013)

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Lysosome-mediated processing of chromatin in senescence

Andre Ivanov et al.

JOURNAL OF CELL BIOLOGY (2013)

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Review Medicine, Research & Experimental

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

Tamara Tchkonia et al.

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A complex secretory program orchestrated by the inflammasome controls paracrine senescence

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NATURE CELL BIOLOGY (2013)

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A senescent cell bystander effect: senescence-induced senescence

Glyn Nelson et al.

AGING CELL (2012)

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The number of p16INK4a positive cells in human skin reflects biological age

Mariette E. C. Waaijer et al.

AGING CELL (2012)

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Aging affects epidermal Langerhans cell development and function and alters their miRNA gene expression profile

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AGING-US (2012)

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Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

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NATURE MEDICINE (2012)

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UV, stress and aging

Florence Debacq-Chainiaux et al.

DERMATO-ENDOCRINOLOGY (2012)

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Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity

Yuchen Chien et al.

GENES & DEVELOPMENT (2011)

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Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

Jean-Philippe Coppe et al.

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Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?

Arne N. Akbar et al.

NATURE REVIEWS IMMUNOLOGY (2011)

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Cell Motility and Mechanics in Three-Dimensional Collagen Matrices

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ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 26 (2010)

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The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

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ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

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DNA Damage-Mediated Induction of a Chemoresistant Niche

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CELL (2010)

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The essence of senescence

Thomas Kuilman et al.

GENES & DEVELOPMENT (2010)

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Sterol Regulatory Element-binding Protein (SREBP)-1-mediated Lipogenesis Is Involved in Cell Senescence

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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Article Dermatology

Airborne Particle Exposure and Extrinsic Skin Aging

Andrea Vierkoetter et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)

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Article Biochemistry & Molecular Biology

Feedback between p21 and reactive oxygen production is necessary for cell senescence

Joao F. Passos et al.

MOLECULAR SYSTEMS BIOLOGY (2010)

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The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

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NATURE CELL BIOLOGY (2010)

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A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen

Jean-Philippe Coppe et al.

PLOS ONE (2010)

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Article Pathology

Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin

Gary J. Fisher et al.

AMERICAN JOURNAL OF PATHOLOGY (2009)

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Review Biochemistry & Molecular Biology

Signal co-operation between integrins and other receptor systems

Charles H. Streuli et al.

BIOCHEMICAL JOURNAL (2009)

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Inflammatory signaling and cellular senescence

Jian-Lin Ren et al.

CELLULAR SIGNALLING (2009)

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Adhesion signaling - crosstalk between integrins, Src and Rho

Stephan Huveneers et al.

JOURNAL OF CELL SCIENCE (2009)

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External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers

Akiharu Kubo et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)

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Article Cell Biology

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Francis Rodier et al.

NATURE CELL BIOLOGY (2009)

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Protocols to detect senescence-associated beta-galactosidase (SA-beta gal) activity, a biomarker of senescent cells in culture and in vivo

Florence Debacq-Chainiaux et al.

NATURE PROTOCOLS (2009)

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Integrin switching modulates adhesion dynamics and cell migration

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CELL ADHESION & MIGRATION (2009)

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Ultraviolet B suppresses immunity by inhibiting effector and memory T cells

Sabita Rana et al.

AMERICAN JOURNAL OF PATHOLOGY (2008)

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Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

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CELL (2008)

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Human health effects of air pollution

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ENVIRONMENTAL POLLUTION (2008)

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Review Geriatrics & Gerontology

Hemostasis factors and aging

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EXPERIMENTAL GERONTOLOGY (2008)

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Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers

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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)

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Article Medicine, General & Internal

Phenotype and course of Hutchinson-Gilford progeria syndrome

Melissa A. Merideth et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Article Biochemistry & Molecular Biology

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Jean-Philippe Coppe et al.

PLOS BIOLOGY (2008)

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Review Biochemistry & Molecular Biology

The protective role of melanin against UV damage in human skin

Michaela Brenner et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2008)

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Review Biochemistry & Molecular Biology

DNA damage, cellular senescence and organismal ageing: causal or correlative?

Jian-Hua Chen et al.

NUCLEIC ACIDS RESEARCH (2007)

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Wen Xue et al.

NATURE (2007)

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Review Cell Biology

Cellular senescence: when bad things happen to good cells

Judith Campisi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

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Sphingosine-1-phosphate lyase potentiates apoptosis via p53-and p38-dependent pathways and is down-regulated in colon cancer

Babak Oskouian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Article Multidisciplinary Sciences

The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis

Gong Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Article Biochemistry & Molecular Biology

Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence

Jean-Philippe Coppe et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Article Cell Biology

Progressive loss of SIRT1 with cell cycle withdrawal

Tsutomu Sasaki et al.

AGING CELL (2006)

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Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance

Nozomu Kamei et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Article Endocrinology & Metabolism

Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells

Toyohiko Yokoi et al.

DIABETES (2006)

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Article Cell Biology

Senescence-associated β-galactosidase is lysosomal β-galactosidase

BY Lee et al.

AGING CELL (2006)

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Measurements of UV-generated free radicals/reactive oxygen species (ROS) in skin

T Herrling et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2006)

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Article Oncology

The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms

C Bavik et al.

CANCER RESEARCH (2006)

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Heterogeneity in premature senescence by oxidative stress correlates with differential DNA damage during the cell cycle

JH Chen et al.

DNA REPAIR (2005)

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

C Michaloglou et al.

NATURE (2005)

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Review Chemistry, Multidisciplinary

Atmospheric aerosols: Composition, transformation, climate and health effects

U Poschl

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)

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Article Biochemistry & Molecular Biology

Morphological adjustment of senescent cells by modulating caveolin-1 status

KA Cho et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior

K Nilsson et al.

MODERN PATHOLOGY (2004)

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Article Oncology

Matrix metalloproteinase inhibitor GM 6001 attenuates keratinocyte migration, contraction and myofibroblast formation in skin wounds

U Mirastschijski et al.

EXPERIMENTAL CELL RESEARCH (2004)

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Correction Oncology

Integrins in regulation of tissue development and function (vol 200, pg 471, 2003)

EHJ Danen et al.

JOURNAL OF PATHOLOGY (2003)

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A DNA damage checkpoint response in telomere-initiated senescence

FD di Fagagna et al.

NATURE (2003)

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Article Pathology

Immunohistochemical comparison of p16 expression in actinic keratoses and squamous cell carcinomas of the skin

A Hodges et al.

MODERN PATHOLOGY (2002)

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Article Biochemistry & Molecular Biology

Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs

CW Franzke et al.

EMBO JOURNAL (2002)

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Article Endocrinology & Metabolism

Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients

R Lobmann et al.

DIABETOLOGIA (2002)

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Article Oncology

'Senescence-associated' β-galactosidase activity in the upper gastrointestinal tract

JJ Going et al.

JOURNAL OF PATHOLOGY (2002)

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Cell contact-dependent immunosuppression by CD4+CD25+ regulatory T cells is mediated by cell surface-bound transforming growth factor β

K Nakamura et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2001)

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Review Surgery

Synopsis on cellular senescence and apoptosis

JD Raffetto et al.

JOURNAL OF VASCULAR SURGERY (2001)

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Senescence and the healing rates of venous ulcers

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JOURNAL OF VASCULAR SURGERY (2001)

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