Nanocomposite Materials Based on Polylactide and Gold Complex Compounds for Absorbed Dose Diagnostics in BNCT

In this study, approaches to the synthesis of complex compound of gold with cysteine [AuCys]n for measuring absorbed dose in boron neutron capture therapy (BNCT) were developed. The dependence of the complex particle size on pH were established. Nanocomposite materials based on polylactide containing [AuCys]n particles with an average size of about 20 nm were obtained using the crazing mechanism. The structure of obtained materials was studied by electron microscopy. The release kinetics of [AuCys]n from polymer matrix were investigated. Release of [AuCys]n from the volume of the polymeric matrix had a delayed start-this process began only after 24 h and was characterized by an effective rate constant of 1 mu g/h from a 20 mg composite sample. At the same time, in vitro studies showed that the concentration of 6.25 mu g/mL was reliably safe and did not reduce the survival of U251 and SW-620 cells.

Automated summary

In this study, the synthesis of a complex compound of gold with cysteine [AuCys]n for measuring absorbed dose in boron neutron capture therapy was developed. The dependence of the complex particle size on pH was established, and the release kinetics of [AuCys]n from the polymer matrix were investigated. The results showed a delayed start and specific rate of release for [AuCys]n from the composite material.