相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。
Article
Medicine, Research & Experimental
Pere Dosta et al.
Summary: This study reports on the design of a microneedle (MN) platform capable of delivering immune activators and collecting interstitial skin fluid (ISF) to monitor therapeutic responses. The MNs showed effective transdermal drug delivery into immune cells in the tumor microenvironment, enabling the study of immune response to therapy over time. This platform has potential for theranostic applications.
Article
Materials Science, Biomaterials
Hye Su Min et al.
Summary: Dissolving microneedles (DMNs) are used for minimally invasive transdermal drug delivery. The insertion depth of DMN is crucial for accurate drug delivery, but the standard for incomplete insertion is unknown. In this study, we analyzed the volumetric distribution of three types of DMN shapes and introduced a new insertion evaluation criterion. Our approach considered the correlation between DMN shape and insertion depth, providing insights for DMN design and maximizing drug delivery.
BIOMATERIALS ADVANCES
(2023)
Article
Materials Science, Multidisciplinary
Khanh T. M. Tran et al.
Summary: This study presents a new approach to thermally stabilize protein-based antigens and develops a single-administration microneedle patch for delivering a COVID-19 vaccine model. The results show that the new vaccine is stable at high temperatures and average human body temperature, and can induce the same level of immune response as multiple injections stored under conventional cold-chain conditions.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Nanoscience & Nanotechnology
Hongxia Duan et al.
Summary: This study constructed a sequential drug delivery system to remodel the fibrotic tumor microenvironment and enhance chemotherapy efficacy, showing potential in anti-breast cancer treatment.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Pharmacology & Pharmacy
Ahlam Zaid Alkilani et al.
Summary: Transdermal drug delivery (TDD) is a non-invasive approach that is convenient and easy to use, especially for vulnerable age groups. However, its applicability is limited to drugs with specific physicochemical properties due to the barrier posed by the skin. Various techniques, including chemical and passive methods, have been investigated to enhance drug permeability across the skin. Hybrid approaches combining chemical penetration enhancement technologies with physical technologies are also being intensely researched.
Review
Oncology
Taylor Rager et al.
Summary: Immunotherapies and molecularly targeted therapies have transformed the treatment approach for unresectable advanced or metastatic melanoma. This review discusses various combination therapies that aim to reduce toxicity, enhance efficacy, and prevent recurrences in melanoma patients.
Review
Pharmacology & Pharmacy
SeungHyun Park et al.
Summary: Novel MN technologies are expected in terms of designs, fabrication methods, materials, and possible application sites given the recent advances in DeMNs.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Review
Pharmacology & Pharmacy
Zeenat A. Shyr et al.
Summary: Combination therapy has been successful in treating chronic viral infections, improving clinical outcomes and reducing viral load and mortality. For emerging and re-emerging viral infections, drug combinations can enhance therapeutic efficacy through additive and synergistic effects.
DRUG DISCOVERY TODAY
(2021)
Review
Pharmacology & Pharmacy
Mohammed S. Alqahtani et al.
Summary: Oral route is the most common and preferred way of drug administration, due to its non-invasiveness and convenience. Factors affecting oral drug absorption include solubility, mucosal permeability, and stability in the gastrointestinal tract. Various pharmaceutical technologies like nanocarriers and micelles have been explored to improve oral drug absorption.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Pooyan Makvandi et al.
Summary: Transdermal microneedle patches are a promising tool for delivering active compounds into the skin, requiring sufficient skin penetration to ensure cargo release at predetermined locations. Pain signal and management during microneedle and hypodermic needle application are compared, alongside discussions on factors affecting insertion and recent strategies to improve skin penetration.
NANO-MICRO LETTERS
(2021)
Review
Pharmacology & Pharmacy
Tao Sheng et al.
Summary: The application of microneedles for vaccine delivery has gained widespread interests due to its high compliance, minimal invasiveness, and convenience. Recent advances in the development and application of microneedles for vaccination based on different delivery strategies have been introduced. The prospects for its application including opportunities and challenges are further discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Nanoscience & Nanotechnology
Zahra Faraji Rad et al.
Summary: Microneedle-based microdevices offer a new way to deliver vaccines and therapeutic agents through the skin and extract biofluids for point-of-care diagnostics. They provide advantages over hypodermic needles with the benefits of unskilled and painless applications for blood collection or drug delivery. Development of microneedle fabrication processes has the potential to revolutionize health care delivery by changing the landscape of fluid sampling and subcutaneous drug delivery.
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2021)
Review
Engineering, Biomedical
Woo Yeup Jeong et al.
Summary: Transdermal drug delivery systems (TDDS) offer a non-invasive alternative to conventional needle injections, with advantages including low rejection rate, convenience, and applicability to pharmaceuticals and cosmetics. Despite obstacles presented by skin physicochemical properties, research has made progress in overcoming these challenges to harness the high efficiency inherent to TDDS.
BIOMATERIALS RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Jae Hwan Jung et al.
Summary: Transdermal drug delivery has the advantage of bypassing the first-pass effect and allowing sustained release of the drug. Microneedles are a painless, less invasive, and easy to self-administer transdermal drug delivery system with high drug bioavailability. With advancements in formulation technologies, the drug-loading capability of microneedles can be improved.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2021)
Review
Pharmacology & Pharmacy
Rabin Neupane et al.
Article
Nanoscience & Nanotechnology
Xue Jiang et al.
MICROSYSTEMS & NANOENGINEERING
(2020)
Review
Medicine, Research & Experimental
Tejashree Waghule et al.
BIOMEDICINE & PHARMACOTHERAPY
(2019)
Article
Engineering, Biomedical
Wei Li et al.
NATURE BIOMEDICAL ENGINEERING
(2019)
Article
Oncology
Yingwen Hu et al.
Article
Multidisciplinary Sciences
Jicheng Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Review
Pharmacology & Pharmacy
Ahlam Zaid Alkilani et al.
Article
Materials Science, Multidisciplinary
Xiaoyun Hong et al.
Nano-Micro Letters
(2014)
Article
Biochemistry & Molecular Biology
Mei-Chin Chen et al.
Review
Biotechnology & Applied Microbiology
Mark R. Prausnitz et al.
NATURE BIOTECHNOLOGY
(2008)
