期刊
PLOS COMPUTATIONAL BIOLOGY
卷 12, 期 2, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pcbi.1004778
关键词
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资金
- European Commission under the program Marie Curie Network for Initial Training [289146]
- A*MIDEX - French Government [ANR-11-IDEX-0001-02]
- US National Institutes of Health [NS078435, MH101697, DA032259, NS094375]
- Departamento Adminsitrativo de Ciencia Tecnologia e Innovacion - Colciencias through the program Doctorados en el exterior
Striatal projection neurons form a sparsely-connected inhibitory network, and this arrangement may be essential for the appropriate temporal organization of behavior. Here we show that a simplified, sparse inhibitory network of Leaky-Integrate-and-Fire neurons can reproduce some key features of striatal population activity, as observed in brain slices. In particular we develop a new metric to determine the conditions under which sparse inhibitory networks form anti-correlated cell assemblies with time-varying activity of individual cells. We find that under these conditions the network displays an input-specific sequence of cell assembly switching, that effectively discriminates similar inputs. Our results support the proposal that GABAergic connections between striatal projection neurons allow stimulus-selective, temporally-extended sequential activation of cell assemblies. Furthermore, we help to show how altered intrastriatal GABAergic signaling may produce aberrant network-level information processing in disorders such as Parkinson's and Huntington's diseases.
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