☆ 4.6 Review

Retroperitoneal Soft Tissue Sarcoma: Emerging Therapeutic Strategies

CANCERS (2023)

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Article Oncology

Histology-tailored multidisciplinary management of primary retroperitoneal sarcomas

S. Bonvalot et al.

Summary: Until recently, the recommended approach for primary retroperitoneal sarcomas (RPS) was complete en-bloc gross excision, with (neo) adjuvant treatments as optional and unvalidated by randomized studies, leading to variations in practice among different centers. However, recent studies on surgery and adjuvant treatments have provided insights to refine these recommendations. This review aims to summarize the recent advancements and future directions in RPS management.

EJSO (2023)

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Article Surgery

Preoperative Radiotherapy in Patients With Primary Retroperitoneal Sarcoma EORTC-62092 Trial (STRASS) Versus Off-trial (STREXIT) Results

Dario Callegaro et al.

Summary: The objective of this study was to compare the effect of radiotherapy (RT) on abdominal recurrence-free survival (ARFS) in patients with primary retroperitoneal sarcoma treated in two different cohorts and to test the hypothesis that RT improves ARFS in patients with liposarcoma. The study found that RT was associated with better ARFS in patients with primary well-differentiated liposarcoma.

ANNALS OF SURGERY (2023)

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Article Oncology

Organ Infiltration and Patient Risk After Multivisceral Surgery for Primary Retroperitoneal Liposarcomas

Luca Improta et al.

Summary: This study investigated the impact of histological organ involvement (HOI) on the prognosis of primary retroperitoneal liposarcoma. Initial and advanced HOIs were frequently detected in both well-differentiated and de-differentiated liposarcomas, suggesting the need for multivisceral resection. HOI stratifies the risk of patients with primary retroperitoneal liposarcoma.

ANNALS OF SURGICAL ONCOLOGY (2023)

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Article Oncology

Significant Predictors of Postoperative Morbidity After Radical Resection of Retroperitoneal Sarcoma in a Tertiary Center

Claudia Di Prata et al.

Summary: A retrospective study on the adverse events of patients undergoing multivisceral resection surgery for retroperitoneal sarcoma reveals that male gender, performance status, dedifferentiated liposarcoma histology, and low serum albumin level are significant predictors of major complications. Transfusion requirement is the only significant factor in predicting operative risk. Postoperative adverse events have no impact on overall survival or local recurrence.

ANNALS OF SURGICAL ONCOLOGY (2023)

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Article Oncology

Clinical Impact of External Beam Radiotherapy for Surgically Resected Primary Retroperitoneal Liposarcoma

Derek J. Erstad et al.

Summary: This study investigated the real-world use and outcomes of radiotherapy for the management of retroperitoneal liposarcoma and found that it was not associated with improved overall survival in patients who underwent surgical resection.

ANNALS OF SURGICAL ONCOLOGY (2023)

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Article Oncology

The role of standard and novel radiotherapy approaches in management of retroperitoneal sarcomas

L. M. Wiltink et al.

Summary: Primary non-metastatic retroperitoneal soft tissue sarcoma patients can be cured by radical surgery, but there is a risk of local recurrence. Preoperative radiotherapy may benefit patients with low grade liposarcomas. This review summarizes all issues related to the irradiation of patients with retroperitoneal soft tissue sarcoma.

EJSO (2023)

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Article Chemistry, Multidisciplinary

Metabolic Intervention Liposome Boosted Lung Cancer Radio-Immunotherapy via Hypoxia Amelioration and PD-L1 Restraint

Saijun Wang et al.

Summary: Currently, the limited success of radiotherapy in clinical practice is attributed to reduced DNA damage under hypoxia and acquired immune tolerance due to increased expression of PD-L1. This study demonstrates that intracellular PD-L1 depression can sensitize radiotherapy by inhibiting DNA damage repair. However, the effectiveness of radio-immunotherapy is still limited by the inability of clinically used antibodies to disrupt extracellular PD-L1 function. Therefore, better PD-L1 regulation strategies are urgently needed. The synthesis of TPP-LND and its encapsulation in liposomes can sensitize radiotherapy by reversing the hypoxic tumor microenvironment and reducing PD-L1 expression.

ADVANCED SCIENCE (2023)

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Article Surgery

New Sarculator Prognostic Nomograms for Patients with Primary Retroperitoneal Sarcoma

Dario Callegaro et al.

ANNALS OF SURGERY (2023)

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Review Oncology

The Landscape of Immunotherapy for Retroperitoneal Sarcoma

Alicia A. Gingrich et al.

Summary: Significant efforts have been made to understand soft tissue sarcomas, including retroperitoneal sarcomas (RPS), which currently lack effective therapies. This review focuses on the relationship between immunotherapy and RPS histologic subtypes. Initial outcomes with immune checkpoint inhibition alone have been disappointing, but subsequent analyses have provided insight into the interplay between sarcomas and immunotherapy, identifying potential targets for future trials. With this insight, combination treatments tailored to the molecular characteristics of RPS show promise for improving response rates and outcomes.

CURRENT ONCOLOGY (2023)

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Article Oncology

Neoadjuvant chemotherapy in high-risk soft tissue sarcomas: A Sarculator-based risk stratification analysis of the ISG-STS 1001 randomized trial

Sandro Pasquali et al.

Summary: The study investigated the benefit of neoadjuvant chemotherapy in soft tissue sarcoma patients based on prognostic stratification using the Sarculator nomogram. It found that high-risk patients treated with AI performed better than predicted, supporting the efficacy of neoadjuvant AI in STS.

CANCER (2022)

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Article Oncology

Critical impact of radiotherapy protocol compliance and quality in the treatment of retroperitoneal sarcomas: Results from the EORTC 62092-22092 STRASS trial

Rick Haas et al.

Summary: This study investigates the impact of radiotherapy compliance on survival outcomes in patients with retroperitoneal sarcoma, showing that patients who complied with radiotherapy requirements had a significantly higher abdominal recurrence-free survival rate.

CANCER (2022)

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Review Radiology, Nuclear Medicine & Medical Imaging

Improving the synergistic combination of programmed death-1/programmed death ligand-1 blockade and radiotherapy by targeting the hypoxic tumour microenvironment

Faiqa Mudassar et al.

Summary: The combination of PD-1/PD-L1 blockade and radiotherapy has the potential to enhance anti-tumour immunity and improve clinical outcomes, but tumour hypoxia presents a significant challenge to the success of both therapies. Targeting tumour hypoxia with compounds that reduce hypoxia may optimize the efficacy of the combination.

JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY (2022)

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Review Oncology

Management of Locally Recurrent Retroperitoneal Sarcoma in the Adult: An Updated Consensus Approach from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group

William W. Tseng et al.

Summary: This article summarizes the treatment consensus for locally recurrent retroperitoneal sarcoma (RPS). Resection surgery is found to be safe in appropriately selected patients, and combined with new findings and expert recommendations, 36 evidence-based and recommended statements are provided. The updated document emphasizes the histologic type and intention of surgical treatment. The fundamental principle for optimal care of patients with recurrent RPS remains individualized treatment after multidisciplinary discussion by an experienced team.

ANNALS OF SURGICAL ONCOLOGY (2022)

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Article Oncology

Final Safety and Health-Related Quality of LIfe Results of the Phase 2/3 Act.In.Sarc Study With Preoperative NBTXR3 Plus Radiation Therapy Versus Radiation Therapy in Locally Advanced Soft-Tissue Sarcoma

Sylvie Bonvalot et al.

Summary: The study Act.In.Sarc demonstrated that NBTXR3, a first-in-class radioenhancer, activated by preoperative radiation therapy, can improve the pathologic complete response rate and achieve R0 resections in patients with locally advanced soft tissue sarcoma. The study also showed that NBTXR3 does not negatively impact health-related quality of life and safety.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

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Article Oncology

Soft Tissue Sarcoma, Version 2.2022

Margaret von Mehren et al.

Summary: Soft tissue sarcomas (STS) are rare malignancies with diverse clinical and pathological characteristics. The diagnosis and treatment of STS require a multidisciplinary team. The NCCN Clinical Practice Guidelines provide comprehensive recommendations for the management of STS, including diagnosis, evaluation, and treatment.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2022)

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Article Chemistry, Multidisciplinary

Tumor Selective Metabolic Reprogramming as a Prospective PD-L1 Depression Strategy to Reactivate Immunotherapy

Yu Liu et al.

Summary: In this study, a new PD-L1 regulation strategy was developed by selectively down-regulating PD-L1 expression in tumors using mitochondria-targeted IR-LND@Alb nanoparticles. The anti-tumor efficacy of this strategy was found to be superior to conventional anti-PD-L1 monoclonal antibodies. Interestingly, IR-LND also showed potential as a novel photodynamic therapy (PDT) drug with self-oxygen and self-PD-L1 regulation capability.

ADVANCED MATERIALS (2022)

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Review Oncology

Landmark Series: A Review of Landmark Studies in the Treatment of Primary Localized Retroperitoneal Sarcoma

Megan Delisle et al.

Summary: Primary localized retroperitoneal soft tissue sarcomas have shorter survival due to higher local recurrence rates, large tumor size, and anatomical constraints. The curative treatment is macroscopic en bloc resection with adjacent structures. Preoperative radiotherapy has not proven effective in reducing early local recurrences. Observational studies suggest that systemic therapy may benefit patients with high-grade histologies and borderline resectable tumors. Ongoing trials are evaluating histology-tailored chemotherapy for high-risk leiomyosarcoma and dedifferentiated liposarcoma. Biomarkers may help predict prognosis and treatment response.

ANNALS OF SURGICAL ONCOLOGY (2022)

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Article Oncology

Inoperable Primary Retroperitoneal Sarcomas: Clinical Characteristics and Reasons Against Resection at a Single Referral Institution

Andraz Perhavec et al.

Summary: The study analyzed a series of primary localized RPS patients at a large referral center and found that roughly 10% of patients were not suitable for surgical resection, with some having technically unresectable tumors and others having comorbidities/poor performance status.

ANNALS OF SURGICAL ONCOLOGY (2021)

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Article Oncology

Has the Outcome for Patients Who Undergo Resection of Primary Retroperitoneal Sarcoma Changed Over Time? A Study of Time Trends During the Past 15 years

Dario Callegaro et al.

Summary: The long-term survival of patients who underwent resection for primary RPS has improved over the past 15 years, attributed to better patient selection for resection, quality of surgery, and perioperative patient management, as indicated by the study data.

ANNALS OF SURGICAL ONCOLOGY (2021)

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Article Oncology

Postoperative Morbidity After Resection of Recurrent Retroperitoneal Sarcoma: A Report from the Transatlantic Australasian RPS Working Group (TARPSWG)

Carolyn Nessim et al.

Summary: This study evaluated perioperative morbidity after surgery for first locally recurrent retroperitoneal sarcoma, showing that a surgical approach to recurrent RPS is relatively safe and resection of recurrent RPS is a reasonable option. Efforts should be made to minimize the need for blood transfusions.

ANNALS OF SURGICAL ONCOLOGY (2021)

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Article Oncology

Defining the role of neoadjuvant systemic therapy in high-risk retroperitoneal sarcoma: A multi - institutional study from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group

William W. Tseng et al.

Summary: In high-risk RPS patients, the response to neoadjuvant systemic therapy is generally fair. Disease progression during therapy may be a predictor of survival post-surgery. Subtype-specific regimens should be further validated.

CANCER (2021)

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Article Oncology

Management of Primary Retroperitoneal Sarcoma (RPS) in the Adult: An Updated Consensus Approach from the Transatlantic Australasian RPS Working Group

Carol J. Swallow et al.

Summary: Primary retroperitoneal sarcomas are rare and complex malignancies that are best managed by experienced multidisciplinary teams in specialized referral centers. Individualized management plans based on consensus statements should be made, and participation in prospective trials and studies is encouraged to improve outcomes.

ANNALS OF SURGICAL ONCOLOGY (2021)

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Article Oncology

Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up

A. Gronchi et al.

ANNALS OF ONCOLOGY (2021)

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Article Surgery

Identifying the Minimum Volume Threshold for Retroperitoneal Soft Tissue Sarcoma Resection: Merging National Data with Consensus Expert Opinion

Anthony M. Villano et al.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2020)

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Article Oncology

Radiotherapy in the treatment of extracranial hemangiopericytoma/solitary fibrous tumor: Study from the Rare Cancer Network

Marco Krengli et al.

RADIOTHERAPY AND ONCOLOGY (2020)

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Article Oncology

Extrameningeal solitary fibrous tumors-surgery alone or surgery plus perioperative radiotherapy: A retrospective study from the global solitary fibrous tumor initiative in collaboration with the sarcoma patients EuroNet

Rick L. Haas et al.

CANCER (2020)

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Article Oncology

Neoadjuvant Chemotherapy in High-Risk Soft Tissue Sarcomas: Final Results of a Randomized Trial From Italian (ISG), Spanish (GEIS), French (FSG), and Polish (PSG) Sarcoma Groups

Alessandro Gronchi et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Oncology

Preoperative radiotherapy plus surgery versus surgery alone for patients with primary retroperitoneal sarcoma (EORTC-62092: STRASS): a multicentre, open-label, randomised, phase 3 trial

Sylvie Bonvolot et al.

LANCET ONCOLOGY (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Multiexponential T2 relaxometry of benign and malignant adipocytic tumours

Katerina Nikiforaki et al.

EUROPEAN RADIOLOGY EXPERIMENTAL (2020)

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Review Oncology

Perioperative radiotherapy versus surgery alone for retroperitoneal sarcomas: a systematic review and meta-analysis

Alexandros Diamantis et al.

RADIOLOGY AND ONCOLOGY (2020)

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Article Oncology

Role of nutritional status in the early postoperative prognosis of patients operated for retroperitoneal liposarcoma (RLS): A single center experience

Krassen M. Kirov et al.

EJSO (2019)

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Review Oncology

New research strategies in retroperitoneal sarcoma. The case of TARPSWG, STRASS and RESAR: making progress through collaboration

Winan J. van Houdt et al.

CURRENT OPINION IN ONCOLOGY (2019)

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Article Oncology

The impact of chemotherapy on survival of patients with extremity and trunk wall soft tissue sarcoma: revisiting the results of the EORTC-STBSG 62931 randomised trial

Sandro Pasquali et al.

EUROPEAN JOURNAL OF CANCER (2019)

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Article Oncology

Survival Benefit of the Surgical Management of Retroperitoneal Sarcoma in a Reference Center: A Nationwide Study of the French Sarcoma Group from the NetSarc Database

S. Bonvalot et al.

ANNALS OF SURGICAL ONCOLOGY (2019)

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Article Oncology

Hospital Volume Threshold for the Treatment of Retroperitoneal Sarcoma

Mohamed Abdelgadir Adam et al.

ANTICANCER RESEARCH (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

T2, T2*and spin coupling ratio as biomarkers for the study of lipomatous tumors

Katerina Nikiforaki et al.

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS (2019)

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Article Oncology

Early and Late Complications of Percutaneous Core Needle Biopsy of Retroperitoneal Tumors at Two Tertiary Sarcoma Centers

David Berger-Richardson et al.

ANNALS OF SURGICAL ONCOLOGY (2019)

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Article Oncology

NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act. In. Sarc): a multicentre, phase 2-3, randomised, controlled trial

Sylvie Bonvalot et al.

LANCET ONCOLOGY (2019)

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Article Oncology

Radiotherapy for retroperitoneal liposarcoma: A report from the Transatlantic Retroperitoneal Sarcoma Working Group

Rick L. M. Haas et al.

CANCER (2019)

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Review Oncology

Radiation therapy in retroperitoneal sarcoma management

Rick L. Haas et al.

JOURNAL OF SURGICAL ONCOLOGY (2018)

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Review Oncology

Major vascular resections in retroperitoneal sarcoma

Dimitri Tzanis et al.

JOURNAL OF SURGICAL ONCOLOGY (2018)

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Article Oncology

Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials

Sandra P. D'Angelo et al.

LANCET ONCOLOGY (2018)

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Article Oncology

Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients With Localized High-Risk Soft Tissue Sarcoma The EORTC 62961-ESHO 95 Randomized Clinical Trial

Rolf D. Issels et al.

JAMA ONCOLOGY (2018)

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Article Oncology

Treatment at low-volume hospitals is associated with reduced short-term and long-term outcomes for patients with retroperitoneal sarcoma

Emily Z. Keung et al.

CANCER (2018)

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Article Surgery

Postoperative Morbidity After Radical Resection of Primary Retroperitoneal Sarcoma A Report From the Transatlantic RPS Working Group

Andrea J. MacNeill et al.

ANNALS OF SURGERY (2018)

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Review Oncology

Needle Tract Seeding After Percutaneous Biopsy of Sarcoma: Risk/Benefit Considerations

David Berger-Richardson et al.

CANCER (2017)

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Article Oncology

Histotype-tailored neoadjuvant chemotherapy versus standard chemotherapy in patients with high-risk soft-tissue sarcomas (ISG-STS 1001): an international, open-label, randomised, controlled, phase 3, multicentre trial

Alessandro Gronchi et al.

LANCET ONCOLOGY (2017)

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Review Oncology

Contemporary reappraisal of the efficacy of adjuvant chemotherapy in resected retroperitoneal sarcoma: Evidence from a nationwide clinical oncology database and review of the literature

Jashodeep Datta et al.

SURGICAL ONCOLOGY-OXFORD (2017)

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Article Oncology

Improved survival using specialized multidisciplinary board in sarcoma patients

J-Y Blay et al.

ANNALS OF ONCOLOGY (2017)

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Article Oncology

Needle tract seeding following core biopsies in retroperitoneal sarcoma

W. J. Van Houdt et al.

EJSO (2017)

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Review Oncology

Primary retroperitoneal soft tissue sarcoma: Imaging appearances, pitfalls and diagnostic algorithm

C. Messiou et al.

EJSO (2017)

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Article Oncology

Short, full-dose adjuvant chemotherapy (CT) in high-risk adult soft tissue sarcomas (STS): long-term follow-up of a randomized clinical trial from the Italian Sarcoma Group and the Spanish Sarcoma Group

A. Gronchi et al.

ANNALS OF ONCOLOGY (2016)

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Article Surgery

Histology-based Classification Predicts Pattern of Recurrence and Improves Risk Stratification in Primary Retroperitoneal Sarcoma

Marcus C. B. Tan et al.

ANNALS OF SURGERY (2016)

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Article Surgery

Variability in Patterns of Recurrence After Resection of Primary Retroperitoneal Sarcoma (RPS): A Report on 1007 Patients From the Multi-institutional Collaborative RPS Working Group

Alessandro Gronchi et al.

ANNALS OF SURGERY (2016)

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Article Oncology

Development and external validation of two nomograms to predict overall survival and occurrence of distant metastases in adults after surgical resection of localised soft-tissue sarcomas of the extremities: a retrospective analysis

Dario Callegaro et al.

LANCET ONCOLOGY (2016)

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Article Oncology

Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: a case-control, propensity score-matched analysis of a nationwide clinical oncology database

Daniel P. Nussbaum et al.

LANCET ONCOLOGY (2016)

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Article Surgery

Comparison of Perioperative Radiation Therapy and Surgery Versus Surgery Alone in 204 Patients With Primary Retroperitoneal Sarcoma A Retrospective 2-Institution Study

Kaitlyn J. Kelly et al.

ANNALS OF SURGERY (2015)

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Article Surgery

Long-term morbidity after multivisceral resection for retroperitoneal sarcoma

D. Callegaro et al.

BRITISH JOURNAL OF SURGERY (2015)

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Article Oncology

Impact of chemotherapy on survival in surgically resected retroperitoneal sarcoma

J. T. Miura et al.

EJSO (2015)

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Article Oncology

Percutaneous Core Needle Biopsy in Retroperitoneal Sarcomas Does Not Influence Local Recurrence or Overall Survival

M. J. Wilkinson et al.

ANNALS OF SURGICAL ONCOLOGY (2015)

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Article Oncology

Retroperitoneal sarcomas: patterns of care at diagnosis, prognostic factors and focus on main histological subtypes: a multicenter analysis of the French Sarcoma Group

M. Toulmonde et al.

ANNALS OF ONCOLOGY (2014)

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Article Surgery

Effectiveness of Regional Hyperthermia With Chemotherapy for High-Risk Retroperitoneal and Abdominal Soft-Tissue Sarcoma After Complete Surgical Resection A Subgroup Analysis of a Randomized Phase-III Multicenter Study

Martin K. Angele et al.

ANNALS OF SURGERY (2014)

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Article Oncology

Locoregional Disease Patterns in Well-Differentiated and Dedifferentiated Retroperitoneal Liposarcoma: Implications for the Extent of Resection?

William W. Tseng et al.

ANNALS OF SURGICAL ONCOLOGY (2014)

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Review Oncology

Management of Recurrent Retroperitoneal Sarcoma

David E. Gyorki et al.

JOURNAL OF SURGICAL ONCOLOGY (2014)

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Article Oncology

Should adjuvant radiotherapy be administered in addition to front-line aggressive surgery (FAS) in patients with primary retroperitoneal sarcoma?

C. Le Pechoux et al.

ANNALS OF ONCOLOGY (2013)

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Article Oncology

Frontline extended surgery is associated with improved survival in retroperitoneal low- to intermediate-grade soft tissue sarcomas

A. Gronchi et al.

ANNALS OF ONCOLOGY (2012)

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Article Oncology

Technical Considerations in Surgery for Retroperitoneal Sarcomas: Position Paper from E-Surge, a Master Class in Sarcoma Surgery, and EORTC-STBSG

Syvie Bonvalot et al.

ANNALS OF SURGICAL ONCOLOGY (2012)

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Article Oncology

Aggressive Surgery in Retroperitoneal Soft Tissue Sarcoma Carried Out at High-Volume Centers is Safe and is Associated With Improved Local Control

Sylvie Bonvalot et al.

ANNALS OF SURGICAL ONCOLOGY (2010)

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Article Oncology

Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study

Rolf D. Issels et al.

LANCET ONCOLOGY (2010)

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Article Surgery

Multifocality in Retroperitoneal Sarcoma A Prognostic Factor Critical to Surgical Decision-Making

Daniel A. Anaja et al.

ANNALS OF SURGERY (2009)

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Article Surgery

Predicting Outcome by Growth Rate of Locally Recurrent Retroperitoneal Liposarcoma The One Centimeter Per Month Rule

James O. Park et al.

ANNALS OF SURGERY (2009)

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Article Surgery

Major Blood Vessel Reconstruction During Sarcoma Surgery

Tae K. Song et al.

ARCHIVES OF SURGERY (2009)

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Article Oncology

Primary and locally recurrent retroperitoneal soft-tissue sarcoma: Local control and survival

T. Lehnert et al.

EJSO (2009)

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Article Oncology

Primary Retroperitoneal Sarcomas: A Multivariate Analysis of Surgical Factors Associated With Local Control

Sylvie Bonvalot et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

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Article Oncology

Why Do Patients with Low-Grade Soft Tissue Sarcoma Die?

Robert J. Canter et al.

ANNALS OF SURGICAL ONCOLOGY (2008)

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Article Oncology

A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma

Nabeel Pervaiz et al.

CANCER (2008)

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Article Surgery

Outcomes for soft-tissue sarcoma in 8249 cases from a large state cancer registry

Juan C. Gutierrez et al.

JOURNAL OF SURGICAL RESEARCH (2007)

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Article Surgery

Should soft tissue sarcomas be treated at high-volume centers? An analysis of 4205 patients

Juan C. Gutierrez et al.

ANNALS OF SURGERY (2007)

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Article Oncology

Long-term prognosis of primary retroperitoneal soft tissue sarcoma

Th. van Dalen et al.

EJSO (2007)

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Article Surgery

Subtype specific prognostic nomogram for patients with primary liposarcoma of the retroperitoneum, extremity, or trunk

Kimberly Moore Dalal et al.

ANNALS OF SURGERY (2006)

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Article Surgery

Clinical results of surgery for retroperitoneal sarcoma with major blood vessel involvement

Matthias H. M. Schwarzbach et al.

JOURNAL OF VASCULAR SURGERY (2006)

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Article Oncology

Retroperitoneal sarcoma - A population-based analysis of epidemiology, surgery, and radiotherapy

GA Porter et al.

CANCER (2006)

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Article Oncology

Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma

AM Davis et al.

RADIOTHERAPY AND ONCOLOGY (2005)

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Article Surgery

Operative management of primary retroperitoneal sarcomas - A reappraisal of an institutional experience

I Hassan et al.

ANNALS OF SURGERY (2004)

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Article Oncology

Retroperitoneal soft tissue sarcomas - Patterns of recurrence in 167 patients treated at a single institution

A Gronchi et al.

CANCER (2004)

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Article Oncology

Function and health status outcomes in a randomized trial comparing preoperative and postoperative radiotherapy in extremity soft tissue sarcoma

AM Davis et al.

JOURNAL OF CLINICAL ONCOLOGY (2002)

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Article Medicine, General & Internal

Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial

B O'Sullivan et al.

LANCET (2002)

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Article Oncology

A randomised phase II study on neo-adjuvant chemotherapy for 'high-risk' adult soft-tissue sarcoma

E Gortzak et al.

EUROPEAN JOURNAL OF CANCER (2001)

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Article Oncology

Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: Results of the Italian randomized cooperative trial

S Frustaci et al.

JOURNAL OF CLINICAL ONCOLOGY (2001)

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