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The Role of Apolipoproteins in the Commonest Cancers: A Review

CANCERS (2023)

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Article Oncology

ZNF460 mediates epithelial-mesenchymal transition to promote gastric cancer progression by transactivating APOC1 expression

Liangliang An et al.

Summary: This study revealed the significant up-regulation of ZNF460 in gastric cancer, and its expression correlated with tumor grade, lymph node metastasis, and H. pylori infection. Functionally, diminished ZNF460 expression inhibited gastric cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro, and suppressed tumor growth in vivo. Mechanistically, ZNF460 combined with apolipoprotein C1 (APOC1) promoter to facilitate APOC1 transcription and accelerated EMT, thereby promoting gastric cancer progression.

EXPERIMENTAL CELL RESEARCH (2023)

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Article Immunology

Levels of pretreatment serum lipids predict responses to PD-1 inhibitor treatment in advanced intrahepatic cholangiocarcinoma

Zhenyun Yang et al.

Summary: This study aimed to clarify the prognostic value of serum lipids and establish an effective nomogram for predicting overall survival in iCCA patients receiving anti-PD1 therapy. The results showed that serum lipid levels were associated with patient prognosis, with APOA1 and TG being significant independent predictors for overall survival in multivariate analysis. By constructing a predictive nomogram, the survival rate of iCCA patients can be more accurately predicted.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

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Article Biochemistry & Molecular Biology

BAL Proteomic Signature of Lung Adenocarcinoma in IPF Patients and Its Transposition in Serum Samples for Less Invasive Diagnostic Procedures

Lorenza Vantaggiato et al.

Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic and irreversible fibrosing interstitial pneumonia of unknown cause. IPF increases the risk of lung cancer (LC), and the two diseases share similar risk factors and pathogenic pathways. A proteomic study on bronchoalveolar lavage fluid (BALF) samples identified dysregulated proteins related to inflammation, immune response, lipid metabolism, and cell adhesion in LC associated with IPF (LC-IPF) patients. These potential biomarkers could potentially improve the management of LC-IPF.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Oncology

Carbohydrate, Lipid, and Apolipoprotein Biomarkers in Blood and Risk of Thyroid Cancer: Findings from the AMORIS Cohort

Xue Xiao et al.

Cancers (2023)

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Article Plant Sciences

Elevated expression of ISY1, APOA-1, SYNE1, MTG1, and MMP10 at HCC initiation: HCC specific protein network involving interactions of key regulators of lipid metabolism, EGFR signaling, MAPK, and splicing pathways

Laila H. Faraj Shaglouf et al.

Summary: This study aimed to identify molecular regulators of hepatocellular carcinoma (HCC) initiation and progression using a combination of protein and gene expression analyses. The researchers induced HCC in male Wistar rats and characterized differentially expressed proteins in early stage HCC tissues. They also analyzed the mRNA expression of these proteins and their interacting partners, as well as the molecular mechanisms associated with signaling pathways involved in HCC progression. The study identified an upregulated protein called ISY1, which is associated with HCC initiation, progression, and tumor stages, and validated its interacting partners. The dysregulation of mRNA and protein expression of these regulators may play a critical role in HCC initiation and progression.

PROTOPLASMA (2023)

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Article Oncology

Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer

Nicolo Bancaro et al.

Summary: Tumor cells promote the recruitment of immunosuppressive neutrophils, a subset of myeloid cells driving immune suppression, tumor proliferation, and treatment resistance. We have identified a subset of neutrophils that have upregulated expression of cellular senescence markers and persist in the tumor microenvironment. These senescent-like neutrophils express TREM2 and are more immunosuppressive and tumor-promoting than canonical immunosuppressive neutrophils.

CANCER CELL (2023)

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Article Cell & Tissue Engineering

Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion

Emma Guilbaud et al.

Summary: Cholesterol efflux pathways play a role in tumor biology and can be targeted as a metabolic therapy for lung cancer. Disruption of these pathways in epithelial progenitor cells promotes tumor growth and creates a pro-tolerogenic tumor microenvironment. Increasing HDL levels protects against tumor development by inhibiting the positive feedback loop between growth factor signaling and cholesterol efflux pathways. Cholesterol removal therapy using cyclodextrin reduces tumor burden by suppressing the proliferation and expansion of tumor progenitor cells.

CELL STEM CELL (2023)

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Article Multidisciplinary Sciences

Increased plasma lipids in triple-negative breast cancer and impairment in HDL functionality in advanced stages of tumors

Maria Isabela Bloise Alves Caldas Sawada et al.

Summary: The association between plasma lipids and breast cancer, especially high-density lipoprotein cholesterol (HDLc) levels, is still conflicting. HDLc may not reflect the role of HDL in limiting tumor growth, inflammation, and metastasis.

SCIENTIFIC REPORTS (2023)

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Review Medicine, Research & Experimental

From degenerative disease to malignant tumors: Insight to the function of ApoE

Ganggang Miao et al.

Summary: Apolipoprotein E (ApoE) is a multifunctional protein that plays a role in lipid transport, inflammation regulation, and immune function. Its genetic polymorphisms are associated with the risk of degenerative diseases and its overexpression has been found in various solid tumors. ApoE can regulate macrophage polarization, tumor immune microenvironment, inflammation, and tumor progression, invasion, and metastasis. However, further research is needed to fully understand the functions of ApoE and its relationship with diseases.

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Article Oncology

Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor

Kohei Amada et al.

Summary: Constitutive activation of the MAPK signaling pathway is necessary for PDAC tumorigenesis, but targeting this pathway with inhibitor treatment has not yielded positive clinical results. By studying the response of PDAC cells to the MAPK inhibitor PD0325901, it was found that overexpression of clusterin (CLU) played a role in the development of resistance to the inhibitor. PD0325901 and CLU downregulation together showed synergistic or additive effects in reducing PDAC cell proliferation. Overexpression of CLU was also observed in surgically resected PDAC tissues. These findings suggest a potential therapeutic strategy for PDAC patients using inhibitors targeting the MAPK signaling pathway and CLU.

CANCER SCIENCE (2023)

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Review Oncology

Metabolic syndrome and thyroid Cancer: risk, prognosis, and mechanism

Ling-Rui Li et al.

Summary: The increasing incidence of thyroid cancer (TC) cannot be fully explained by overdiagnosis. Metabolic syndrome (Met S) is highly prevalent due to the modern lifestyle, which can lead to the development of tumors. This review discusses the relationship between Met S and TC, including risk, prognosis, and potential biological mechanisms. The association between Met S and TC risk and aggressiveness has been observed, with gender differences in most studies. Abnormal metabolism and the influence of hormones play key roles in tumorigenesis, and markers of metabolic disorders are expected to aid in diagnosis and prognosis. Targeting specific signaling pathways may provide new treatment options for TC.

DISCOVER ONCOLOGY (2023)

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Review Medicine, Research & Experimental

The role and function of CLU in cancer biology and therapy

Yefei Zhang et al.

Summary: This review summarizes the multiple functions and mechanisms of the glycoprotein CLU in regulating tumor progression of various cancers and discusses the use of CLU inhibitors in targeted cancer therapies.

CLINICAL AND EXPERIMENTAL MEDICINE (2023)

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Article Oncology

Serum apolipoprotein B to apolipoprotein A-I ratio is an independent predictor of liver metastasis from locally advanced rectal cancer in patients receiving neoadjuvant chemoradiotherapy plus surgery

Chen Chen et al.

Summary: This retrospective study found that serum apoB-to-apoAI ratio can be used as a biomarker for predicting the risk of liver metastasis in locally advanced rectal cancer. Other factors, including other metastasis, overall survival, and various clinical characteristics, were also found to be correlated.

BMC CANCER (2022)

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Article Oncology

Noninvasive risk stratification of intraductal papillary mucinous neoplasia with malignant potential by serum apolipoprotein-A2-isoforms

Klaus Felix et al.

Summary: This study found that serum apoA2-i has potential clinical value in risk stratification of IPMN and associated cancer. It showed higher accuracy and sensitivity in diagnosing IPMN-associated cancer compared to the routine biomarker CA 19-9. Further validation in larger and independent international cohort studies is needed for clinical application.

INTERNATIONAL JOURNAL OF CANCER (2022)

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Article Medical Laboratory Technology

Integrated weighted gene co-expression network analysis reveals biomarkers associated with prognosis of high-grade serous ovarian cancer

Bo Wang et al.

Summary: This study utilized proteomic data to construct a co-expression network for HGSOC samples. The hub genes ALB, APOB, and SERPINA1 were identified as potential biomarkers for HGSOC prognosis. The findings suggest potential applications for these biomarkers in the treatment of HGSOC.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022)

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Article Oncology

FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner

Jiapeng Huang et al.

Summary: This study reveals the importance of m(6)A modification in papillary thyroid cancer (PTC) and demonstrates that m(6)A regulates glucose metabolism and tumor growth by modulating the expression of fat-mass and obesity-associated protein (FTO) and apolipoprotein E (APOE).

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

Chen Zhang et al.

Summary: Ferroptosis, an iron-dependent form of cell death, plays a crucial role in tumor suppression and has the potential to reverse cancer therapy resistance.

MOLECULAR CANCER (2022)

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Correction Immunology

Inhibition of Lung Tumor Development in ApoE Knockout Mice via Enhancement of TREM-1 Dependent NK Cell Cytotoxicity (vol 10, 1379, 2019)

Yong Sun Lee et al.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Diagnostic performance of clusterin in hepatocellular carcinoma: A meta-analysis

Ge Gao et al.

Summary: This meta-analysis is the first evaluation of the diagnostic performance of Clusterin (CLU) in hepatocellular carcinoma (HCC). The results showed that serum CLU is a better biomarker than alpha-fetoprotein (AFP) for the diagnosis of HCC, with higher sensitivity, diagnostic odds ratio (DOR), and area under the curve (AUC). Moreover, the combination of CLU and AFP further improved the diagnostic performance.

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2022)

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Article Biochemistry & Molecular Biology

Novel efficacious microRNA-30c analogs reduce apolipoprotein B secretion in human hepatoma and primary hepatocyte cells

Pradeep Kumar Yadav et al.

Summary: Researchers have successfully synthesized a series of miR-30c analogs that can increase the stability and delivery of miR-30c to liver cells. These analogs reduce the secretion of apolipoprotein B without affecting the secretion of apolipoprotein A1 and cellular lipid levels. These findings provide a proof of concept for the development of more efficacious analogs for the treatment of hyperlipidemias and cardiovascular diseases.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

Chromosomally Unstable Gastric Cancers Overexpressing Claudin-6 Disclose Cross-Talk between HNF1A and HNF4A, and Upregulated Cholesterol Metabolism

Sanyog Dwivedi et al.

Summary: Abnormally increased expression of Claudin-6 in gastric cancer is associated with the chromosomal unstable molecular subtype and worse prognosis. The expression of Claudin-6 is correlated with higher mutations in genes such as TP53, MIEN1, STARD3, PGAP3, and CCNE1.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Pharmacology & Pharmacy

Apolipoproteins: New players in cancers

Yingcheng He et al.

Summary: This article summarizes the roles of apolipoproteins (APOs) in cancers, their use as biomarkers, and their genetic polymorphism associated with cancer risk. Studies have shown that APOs interact with classical pathways of tumorigenesis and their dysregulation may indicate cancer occurrence and progression. Additionally, the potential use of APOs in developing new anti-cancer therapies is discussed.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Oncology

Aberrant APOBEC3C expression induces characteristic genomic instability in pancreatic ductal adenocarcinoma

Yunzhen Qian et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a lethal and heterogeneous disease. This study investigates the significance of APOBEC3C gene in PDAC and found that high APOBEC3C expression is associated with increased mutations in specific genes and enhanced immune activity. APOBEC3C is substantially upregulated in PDAC and predicts shorter survival. These findings suggest that APOBEC3C could serve as a potential therapeutic target for PDAC and guide immunotherapy.

ONCOGENESIS (2022)

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Article Health Care Sciences & Services

Assessing Metabolic Risk Factors for LVSI in Endometrial Cancer: A Cross-Sectional Study

Qiaoyan Lin et al.

Summary: This study analyzed the metabolic factors associated with lymphovascular space invasion (LVSI) and compared the differences between type 1 and type 2 endometrial cancer (EC). The results showed that CA125, ROMA, FBG, and TC were positively associated with LVSI. Different metabolic factors were identified as independent risk factors for LVSI in different types of EC.

THERAPEUTICS AND CLINICAL RISK MANAGEMENT (2022)

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Review Medicine, General & Internal

Effect of Serum Lipid Profile on the Risk of Breast Cancer: Systematic Review and Meta-Analysis of 1,628,871 Women

Mehran Nouri et al.

Summary: In this meta-analysis, the relationship between serum lipid profile and breast cancer risk was investigated. The results showed a negative association between high-density lipoprotein cholesterol (HDL-C) level and breast cancer risk, while other indicators such as TG, TC, ApoA and LDL-C were not associated with breast cancer development.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Apolipoprotein A-II, a Player in Multiple Processes and Diseases

Gabriela Florea et al.

Summary: Apolipoprotein A-II (apoA-II) plays an important role in lipid metabolism and may have different effects in humans and mice. It influences lipid metabolism and may be associated with vascular diseases. Findings regarding its role in atherogenesis have been conflicting. In humans, apoA-II deficiency has little effect on lipoprotein levels, while in mice it causes HDL deficit. Increased plasma apoA-II concentration leads to hypertriglyceridemia and lowers HDL levels, potentially causing type 2 diabetes.

BIOMEDICINES (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Analysis of the Relationship between the Expression Level of TTR and APOH and Prognosis in Patients with Colorectal Cancer Metastasis Based on Bioinformatics

Ye Lu et al.

Summary: The expression of TTR and APOH genes and their relationship with prognosis in patients with colorectal cancer (CRC) metastasis were explored using bioinformatics analysis techniques. The experimental results confirmed a close relationship between TTR, APOH, and patients with CRC metastasis, and regular detection of serum TTR and APOH expression can effectively assess the patient's condition.

CONTRAST MEDIA & MOLECULAR IMAGING (2022)

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Article Gastroenterology & Hepatology

Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling

Hui Wang et al.

Hepatobiliary & Pancreatic Diseases International (2022)

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Article Multidisciplinary Sciences

BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling

Lee Shaashua et al.

Summary: Tumors are initiated by mutations in cancer cells and progress through interactions with non-malignant cells of the tumor microenvironment. This study examines how different mutations in cancer cells affect the transcriptional rewiring of cancer-associated fibroblasts (CAFs) in pancreatic cancer. The researchers find that BRCA mutations lead to an increase in a specific subset of immune-regulatory CAFs, mediated by activation of heat-shock factor 1.

NATURE COMMUNICATIONS (2022)

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Article Biochemistry & Molecular Biology

Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing

Xiaopei Hao et al.

Summary: This study demonstrates that inhibiting APOC1 can promote the transformation of M2 macrophages into M1 macrophages via the ferroptosis pathway, thereby reshaping the tumor immune microenvironment and improving the anti-PD1 immunotherapy for hepatocellular carcinoma (HCC).

REDOX BIOLOGY (2022)

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Article Oncology

Dysregulation of HNF1B/Clusterin axis enhances disease progression in a highly aggressive subset of pancreatic cancer patients

Shouhui Yang et al.

Summary: This study uncovers a novel HNF1B/Clusterin axis that negatively regulates disease aggressiveness in a highly aggressive subset of PDAC by enhancing proteasomal degradation of ZEB1 and regulating EMT. Therapies targeting HNF1B/Clusterin may potentially improve disease outcome in PDAC patients.

CARCINOGENESIS (2022)

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Article Obstetrics & Gynecology

Multiple biomarkers are more accurate than a combination of carbohydrate antigen 125 and human epididymis protein 4 for ovarian cancer screening

Kyung Nam Kang et al.

Summary: This study compares and evaluates the diagnostic value of different serum biomarkers for ovarian cancer. It shows that combining multiple biomarkers, including CA125 and HE4, can be an effective strategy for ovarian cancer diagnosis.

OBSTETRICS & GYNECOLOGY SCIENCE (2022)

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Review Geriatrics & Gerontology

The Functional Role of Lipoproteins in Atherosclerosis: Novel Directions for Diagnosis and Targeting Therapy

Yongzheng Lu et al.

Summary: Dyslipidemia increases the risk of atherosclerosis, and lipoproteins play a significant role in its development. Understanding lipoprotein function can help predict risk and provide novel treatment approaches for atherosclerosis.

AGING AND DISEASE (2022)

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Article Oncology

APOE Is a Prognostic Biomarker and Correlates with Immune Infiltrates in Papillary Thyroid Carcinoma

Xu Lin et al.

Summary: This study found that abnormal lipid metabolism is associated with papillary thyroid carcinoma (PTC), and APOE may serve as an independent biomarker for PTC. Additionally, APOE expression is positively correlated with immune cell infiltration in PTC.

JOURNAL OF CANCER (2022)

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Article Biochemistry & Molecular Biology

TRIM15 promotes the invasion and metastasis of pancreatic cancer cells by mediating APOA1 ubiquitination and degradation

Yan Sun et al.

Summary: Pancreatic ductal adenocarcinomas (PDACs) are often diagnosed at an advanced stage, with metastasis posing a challenge to patient survival. The TRIM15 gene is implicated in cancer development, particularly in PDAC metastasis regulation. High TRIM15 expression in PDAC tissues is associated with poor prognosis and its interaction with APOA1 promotes lipid anabolism, potentially aiding in PDAC metastasis. Targeting the TRIM15-APOA1-LDLR axis may be a strategy to inhibit PDAC metastasis by blocking triglyceride synthesis.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

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Article Biotechnology & Applied Microbiology

Comprehensive Identification of Potential Crucial Genes and miRNA-mRNA Regulatory Networks in Papillary Thyroid Cancer

Ben-yu Nan et al.

Summary: This study identified potential biomarkers and therapeutic targets for papillary thyroid cancer through analysis of multiple datasets and databases. Specifically, CLU and APOE were found to be important players in the molecular mechanisms of papillary thyroid cancer, while hsa-miR-424-5p may reverse the progression of papillary thyroid cancer by modulating hub genes.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Cell Biology

ApoPred: Identification of Apolipoproteins and Their Subfamilies With Multifarious Features

Ting Liu et al.

Summary: This study aimed to establish a high-efficiency prediction model for apolipoproteins, which showed promising results in discriminating apolipoprotein from non-apolipoprotein with high accuracy. The developed model also successfully predicted apolipoprotein subfamilies with high overall accuracy. The establishment of a convenient webserver called ApoPred is expected to contribute to apolipoprotein function research and drug development in relevant diseases.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Oncology

Serum Metabolic Profiling Analysis of Chronic Gastritis and Gastric Cancer by Untargeted Metabolomics

Lin Yu et al.

Summary: This study revealed that lipid metabolism may play a crucial role in the progression from chronic gastritis to gastric cancer. Hexadecasphinganine, linoleamide, and N-Hydroxy arachidonoyl amine were identified as candidate diagnostic markers for chronic gastritis and gastric cancer. Additionally, changes in serum lipid levels, including total cholesterol, high-density lipoprotein cholesterol, and apolipoprotein A1, were observed with disease progression.

FRONTIERS IN ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Down-regulation of RBP4 indicates a poor prognosis and correlates with immune cell infiltration in hepatocellular carcinoma

Mingxing Li et al.

Summary: Recent research has shown that metabolically related genes play important roles in the development of hepatocellular carcinoma (HCC). Low expression of retinol-binding protein 4 (RBP4) in HCC is associated with age, tumor stage, and grade, while higher RBP4 expression is linked to better overall survival in HCC patients. RBP4 may serve as a novel biomarker for HCC prognosis.

BIOSCIENCE REPORTS (2021)

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Article Endocrinology & Metabolism

Apolipoprotein A1 is negatively associated with male papillary thyroid cancer patients: a cross-sectional study of single academic center in China

Maoguang Ma et al.

Summary: This study found a negative association between serum lipid ApoA-1 and PTC in male patients, contributing to further research on this common type of thyroid cancer.

BMC ENDOCRINE DISORDERS (2021)

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Article Cell Biology

Construction of a novel mRNA-miRNA-lncRNA network and identification of potential regulatory axis associated with prognosis in colorectal cancer liver metastases

Chen Lu et al.

Summary: The study identified a ceRNA regulatory network involving ZEB1-AS1, miR-335-5p, and APOC1, which plays a significant role in colorectal cancer (CRC) and colorectal liver metastases (CRLM). This network provides valuable predictors for prognosis and potential therapeutic targets for CRC patients.

AGING-US (2021)

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Article Oncology

Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1

Samantha B. Kemp et al.

Summary: Elevated levels of apolipoprotein E in PDAC are associated with immune suppression and poor patient survival. ApoE induces expression of immunosuppressive factors in pancreatic tumor cells, potentially playing a novel immunosuppressive role in the PDAC microenvironment.

CANCER RESEARCH (2021)

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Article Biotechnology & Applied Microbiology

A Five-Gene Prognostic Nomogram Predicting Disease-Free Survival of Differentiated Thyroid Cancer

Pan Ruchong et al.

Summary: This study developed a nomogram using gene expression and clinical data to predict the disease-free survival (DFS) rate of DTC patients, which showed good prediction ability and identified independent risk factors. The nomogram could accurately predict 1-year, 3-year, and 5-year DFS rates for DTC patients.

DISEASE MARKERS (2021)

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Article Biochemistry & Molecular Biology

Ellagic Acid Suppresses ApoB Secretion and Enhances ApoA-1 Secretion from Human Hepatoma Cells, HepG2

Ayana Ieda et al.

Summary: The study found that ellagic acid (EA) can inhibit the secretion of apolipoprotein B from hepatic cells while enhancing the secretion of apolipoprotein A-1, benefiting lipoprotein metabolism and the prevention of lifestyle-related diseases. Further exploration of the detailed mechanisms behind these effects is needed, but EA shows promise as an antihyperlipidemic compound derived from food.

MOLECULES (2021)

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Article Oncology

Apolipoprotein mimetics in cancer

Samuel C. Delk et al.

Summary: Peptides have advantages over traditional therapeutics due to low toxicity and immunogenicity and have shown efficacy in treating various cancers. Apolipoprotein mimetic peptides, such as oral apoA-I mimetic peptides, can remodel HDL and improve cancer progression.

SEMINARS IN CANCER BIOLOGY (2021)

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Article Cell Biology

Oncogene APOL1 promotes proliferation and inhibits apoptosis via activating NOTCH1 signaling pathway in pancreatic cancer

Jiewei Lin et al.

Summary: APOL1 is aberrantly expressed in pancreatic cancer and associated with poor prognosis. Functional experiments showed that APOL1 promotes proliferation and inhibits apoptosis in pancreatic cancer through activating NOTCH1 signaling pathway.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

The expression of FLNA and CLU in PBMCs as a novel screening marker for hepatocellular carcinoma

Rathasapa Patarat et al.

Summary: Early detection is crucial for improving survival rates and increasing curative probabilities of hepatocellular carcinoma (HCC). In this study, a potential marker for HCC screening was identified using gene expression analysis of peripheral blood mononuclear cells (PBMCs), with FLNA and CLU combination showing promising results as novel markers for HCC. Further research on gene expression may lead to the identification of more potential markers and improved diagnosis methods.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Apolipoprotein C-II induces EMT to promote gastric cancer peritoneal metastasis via PI3K/AKT/mTOR pathway

Chao Wang et al.

Summary: This study found that APOC2 is overexpressed in GC PM tissues and correlates with poor prognosis in GC patients. APOC2 promotes invasion, migration, and proliferation of GC cells through CD36-mediated PI3K/AKT/mTOR signaling pathway.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Oncology

Prognostic Value of Serum Apolipoprotein B to Apolipoprotein A-I Ratio in Hepatocellular Carcinoma Patients Treated with Transcatheter Arterial Chemoembolization: A Propensity Score-Matched Analysis

Meng-Meng Liu et al.

Summary: This study showed that in HCC patients undergoing TACE, a high serum ApoB/ApoA-I level is associated with aggressive clinicopathological characteristics and poor prognosis.

ONCOLOGY RESEARCH AND TREATMENT (2021)

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Article Andrology

Identifying the role of apolipoprotein A-I in prostate cancer

Jing Wang et al.

Summary: The study found that ApoA-I is upregulated in prostate cancer, potentially driving therapeutic resistance and disease progression, and regulated by the oncogene MYC. This discovery provides a new indicator for predicting prognosis and recurrence, benefiting patients prone to progress to metastasis or even NEPC.

ASIAN JOURNAL OF ANDROLOGY (2021)

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Article Oncology

Identification of Novel Biomarkers Associated With the Prognosis and Potential Pathogenesis of Breast Cancer via Integrated Bioinformatics Analysis

Meng Wu et al.

Summary: Novel biomarkers such as ADH1A and IGSF10, as well as 14 microRNAs associated with breast cancer prognosis, were identified through gene expression analysis. These findings have the potential to improve diagnostic, treatment, and prognostic strategies for breast cancer.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2021)

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Article Oncology

Serum lipid profiles and risk of colorectal cancer: a prospective cohort study in the UK Biobank

Zhe Fang et al.

Summary: Serum lipid profiles were not associated with colorectal cancer risk after adjusting for obesity indicators. The potential subsite-specific effects of triglycerides and apolipoprotein A require further confirmation.

BRITISH JOURNAL OF CANCER (2021)

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Article Medicine, Research & Experimental

Secretory clusterin promotes hepatocellular carcinoma progression by facilitating cancer stem cell properties via AKT/GSK-3β/β-catenin axis

Wenjie Zheng et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Revelation of Proteomic Indicators for Colorectal Cancer in Initial Stages of Development

Arthur T. Kopylov et al.

MOLECULES (2020)

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Article Cell Biology

A dual apolipoprotein C-II mimetic-apolipoprotein C-III antagonist peptide lowers plasma triglycerides

Anna Wolska et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc-p21Waf1 signalling pathway

Shaoxia Du et al.

BIOCHEMISTRY AND CELL BIOLOGY (2020)

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Article Oncology

APOB Genotypes and CDH13 Haplotypes in the Cholesterol-Related Pathway Genes Predict Non-Small Cell Lung Cancer Survival

Wei Deng et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2020)

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Review Oncology

Apolipoproteins, as the carrier proteins for lipids, are involved in the development of breast cancer

Y. Zhou et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2020)

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Article Pharmacology & Pharmacy

Apolipoprotein A-I Mimetic Peptide L-4F Suppresses Granulocytic-Myeloid-Derived Suppressor Cells in Mouse Pancreatic Cancer

Meiyu Peng et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Oncology

Apolipoprotein: prospective biomarkers in digestive tract cancer

Yibo Zhang et al.

Translational Cancer Research (2020)

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Article Oncology

Neuronal Calcium Sensor 1 is up-regulated in response to stress to promote cell survival and motility in cancer cells

Henrike K. Grosshans et al.

MOLECULAR ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

Identification of key genes of papillary thyroid carcinoma by integrated bioinformatics analysis

Gang Xue et al.

BIOSCIENCE REPORTS (2020)

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Article Multidisciplinary Sciences

Novel circulating protein biomarkers for thyroid cancer determined through data-independent acquisition mass spectrometry

Dandan Li et al.

PEERJ (2020)

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Article Oncology

Systemic Proteome Alterations Linked to Early Stage Pancreatic Cancer in Diabetic Patients

Hong Peng et al.

CANCERS (2020)

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Article Pathology

Diagnostic value of clusterin immunostaining in hepatocellular carcinoma

Yuan Li et al.

DIAGNOSTIC PATHOLOGY (2020)

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Article Oncology

Low high-density lipoprotein and increased risk of several cancers: 2 population-based cohort studies including 116,728 individuals

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JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Clusterin contributes to hepatitis C virus-related hepatocellular carcinoma by regulating autophagy

Na Fu et al.

LIFE SCIENCES (2020)

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Plasma proteome atlas for differentiating tumor stage and post-surgical prognosis of hepatocellular carcinoma and cholangiocarcinoma

Ting-Tsung Chang et al.

PLOS ONE (2020)

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Liver X Receptor β Related to Tumor Progression and Ribosome Gene Expression in Papillary Thyroid Cancer

Seonhyang Jeong et al.

ENDOCRINOLOGY AND METABOLISM (2020)

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Article Oncology

Prognostic value of the serum apolipoprotein B to apolipoprotein A-I ratio in metastatic colorectal cancer patients

Dong-Dong Yang et al.

JOURNAL OF CANCER (2020)

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Article Biochemical Research Methods

Molecular signatures of medullary thyroid carcinoma by matrix-assisted laser desorption/ionisation mass spectrometry imaging

Andrew Smith et al.

JOURNAL OF PROTEOMICS (2019)

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Anti-tumorigenic and Platinum-Sensitizing Effects of Apolipoprotein A1 and Apolipoprotein A1 Mimetic Peptides in Ovarian Cancer

Aline T. Marinho et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Clinical Significance of Plasma Apolipoprotein-AII Isoforms as a Marker of Pancreatic Exocrine Disorder for Patients with Pancreatic Adenocarcinoma Undergoing Chemoradiotherapy, Paying Attention to Pancreatic Morphological Changes

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BIOMED RESEARCH INTERNATIONAL (2019)

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Apolipoprotein AI and B as risk factors for development of intraocular metastasis in patients with breast cancer

Jia-Xiang Liu et al.

CANCER MANAGEMENT AND RESEARCH (2019)

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Apolipoprotein C1 (APOC1) promotes tumor progression via MAPK signaling pathways in colorectal cancer

Hui Ren et al.

CANCER MANAGEMENT AND RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Diagnostic and prognostic significance of mRNA expressions of apolipoprotein A and C family genes in hepatitis B virus-related hepatocellular carcinoma

Xiangkun Wang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Multidisciplinary Sciences

Oxidative stress in lung cancer patients is associated with altered serum markers of lipid metabolism

Katarzyna Zablocka-Slowinska et al.

PLOS ONE (2019)

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Cholesterol and 27-hydroxycholesterol promote thyroid carcinoma aggressiveness

Giovanna Revilla et al.

SCIENTIFIC REPORTS (2019)

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Apolipoprotein C1 (APOC1) as a novel diagnostic and prognostic biomarker for gastric cancer

Jie Yi et al.

ANNALS OF TRANSLATIONAL MEDICINE (2019)

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Review Oncology

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Liwen Ren et al.

CANCER MEDICINE (2019)

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Neuronal calcium sensor 1 (NCS1) promotes motility and metastatic spread of breast cancer cells in vitro and in vivo

Jonathan E. Apasu et al.

FASEB JOURNAL (2019)

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Alterations in the gut microbiota and metabolite profiles of thyroid carcinoma patients

Jing Feng et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

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Functions of N6-methyladenosine and its role in cancer

Liuer He et al.

MOLECULAR CANCER (2019)

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Article Nutrition & Dietetics

Apolipoprotein C-II Mimetic Peptide Promotes the Plasma Clearance of Triglyceride-Rich Lipid Emulsion and the Incorporation of Fatty Acids into Peripheral Tissues of Mice

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Article Biochemistry & Molecular Biology

Serum proteome mapping of EGF transgenic mice reveal mechanistic biomarkers of lung cancer precursor lesions with clinical significance for human adenocarcinomas

Juergen Borlak et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

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LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer

Masoud F. Tavazoie et al.

CELL (2018)

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Apolipoprotein C1 promotes prostate cancer cell proliferation in vitro

Wei-peng Su et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2018)

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Dipeptidyl peptidase 4 inhibitor anagliptin ameliorates hypercholesterolemia in hypercholesterolemic mice through inhibition of intestinal cholesterol transport

Moritaka Goto et al.

JOURNAL OF DIABETES INVESTIGATION (2018)

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Article Multidisciplinary Sciences

Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer

Arnab Chattopadhyay et al.

SCIENTIFIC REPORTS (2018)

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Article Biochemical Research Methods

Identification of serum proteins AHSG, FGA and APOA-I as diagnostic biomarkers for gastric cancer

Feiyu Shi et al.

CLINICAL PROTEOMICS (2018)

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Article Pharmacology & Pharmacy

Association between thyroid function and lipid profiles, apolipoproteins, and high-density lipoprotein function

Kyong Yeun Jung et al.

JOURNAL OF CLINICAL LIPIDOLOGY (2017)

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Article Oncology

Apolipoprotein A-I mimetic peptide 4F suppresses tumor-associated macrophages and pancreatic cancer progression

Meiyu Peng et al.

ONCOTARGET (2017)

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Review Cardiac & Cardiovascular Systems

Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism

Anna Wolska et al.

ATHEROSCLEROSIS (2017)

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Glucose and lipoprotein biomarkers and breast cancer severity using data from the Swedish AMORIS cohort

Jennifer C. Melvin et al.

BMC CANCER (2017)

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ApoE deficiency promotes colon inflammation and enhances the inflammatory potential of oxidized-LDL and TNF-α in primary colon epithelial cells

Ali H. El-Bahrawy et al.

BIOSCIENCE REPORTS (2016)

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Diagnostic and prognostic significance of serum apolipoprotein C-I in triple-negative breast cancer based on mass spectrometry

Dongjian Song et al.

CANCER BIOLOGY & THERAPY (2016)

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Apolipoproteins, lipids and risk of cancer

Signe Borgquist et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

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ApolipoproteinL1 is expressed in papillary thyroid carcinomas

Mounia Chidiac et al.

PATHOLOGY RESEARCH AND PRACTICE (2016)

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Apolipoproteins as Differentiating and Predictive Markers for Assessing Clinical Outcomes in Patients with Small Cell Lung Cancer

Jian Shi et al.

YONSEI MEDICAL JOURNAL (2016)

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Article Multidisciplinary Sciences

ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer

Lidia Cedo et al.

SCIENTIFIC REPORTS (2016)

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Review Pharmacology & Pharmacy

High-density Lipoproteins and Apolipoprotein A-I: Potential New Players in the Prevention and Treatment of Lung Disease

Elizabeth M. Gordon et al.

FRONTIERS IN PHARMACOLOGY (2016)

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Article Multidisciplinary Sciences

Tissue and serum samples of patients with papillary thyroid cancer with and without benign background demonstrate different altered expression of proteins

Mardiaty Iryani Abdullah et al.

PEERJ (2016)

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Article Pharmacology & Pharmacy

Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic Peptides

Toshihiro Sakurai et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)

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Review Biochemistry & Molecular Biology

Apolipoprotein A-I: A Molecule of Diverse Function

Manaswini Mangaraj et al.

INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY (2016)

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Prospective associations between serum biomarkers of lipid metabolism and overall, breast and prostate cancer risk

Mathilde His et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2014)

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Article Biochemical Research Methods

Absolute quantification of apolipoproteins and associated proteins on human plasma lipoproteins

Anne von Zychlinski et al.

JOURNAL OF PROTEOMICS (2014)

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Discovery of serum biomarkers of ovarian cancer using complementary proteomic profiling strategies

John F. Timms et al.

PROTEOMICS CLINICAL APPLICATIONS (2014)

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Review Biotechnology & Applied Microbiology

Clusterin: a key player in cancer chemoresistance and its inhibition

Tomas Koltai

ONCOTARGETS AND THERAPY (2014)

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Article Cell Biology

Apolipoprotein L2 contains a BH3-like domain but it does not behave as a BH3-only protein

J. Galindo-Moreno et al.

CELL DEATH & DISEASE (2014)

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Article Oncology

Apolipoprotein E genetic polymorphism, serum lipoprotein levels and breast cancer risk: A case-control study

Gabriela Herrmann Cibeira et al.

MOLECULAR AND CLINICAL ONCOLOGY (2014)

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Article Oncology

Novel serum protein biomarker panel revealed by mass spectrometry and its prognostic value in breast cancer

Liping Chung et al.

BREAST CANCER RESEARCH (2014)

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Association Between Urinary Albumin Excretion and Low-density Lipoprotein Heterogeneity Following Treatment of Type 2 Diabetes Patients with the Dipeptidyl Peptidase-4 Inhibitor, Vildagliptin: A Pilot Study

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AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS (2013)

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Apolipoprotein Concentrations Are Elevated in Malignant Ovarian Cyst Fluids Suggesting That Lipoprotein Metabolism Is Dysregulated in Epithelial Ovarian Cancer

Iwona Podzielinski et al.

CANCER INVESTIGATION (2013)

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Review Cell Biology

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

Franziska Baenke et al.

DISEASE MODELS & MECHANISMS (2013)

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Article Oncology

Apolipoprotein C-II Is a Potential Serum Biomarker as a Prognostic Factor of Locally Advanced Cervical Cancer After Chemoradiation Therapy

Yoko Harima et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2013)

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Article Biochemistry & Molecular Biology

The Cardioprotective Protein Apolipoprotein A1 Promotes Potent Anti-tumorigenic Effects

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JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Editorial Material Oncology

An apolipoprotein A-I mimetic targets scavenger receptor A on tumor-associated macrophages: A prospective anticancer treatment?

Claudine Neyen et al.

ONCOIMMUNOLOGY (2013)

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Review Cardiac & Cardiovascular Systems

Novel Biological Functions of High-Density Lipoprotein Cholesterol

Chieko Mineo et al.

CIRCULATION RESEARCH (2012)

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Article Medical Laboratory Technology

Proteomic identification of serum biomarkers for gastric cancer using multi-dimensional liquid chromatography and 2D differential gel electrophoresis

Wentao Liu et al.

CLINICA CHIMICA ACTA (2012)

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Review Biochemistry & Molecular Biology

Human apolipoprotein L1 (ApoL1) in cancer and chronic kidney disease

Chien-An A. Hu et al.

FEBS LETTERS (2012)

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Article Oncology

D-4F, an apoA-I mimetic peptide, inhibits proliferation and tumorigenicity of epithelial ovarian cancer cells by upregulating the antioxidant enzyme MnSOD

Ekambaram Ganapathy et al.

INTERNATIONAL JOURNAL OF CANCER (2012)

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Search for Breast Cancer Biomarkers in Fractionated Serum Samples by Protein Profiling With SELDI-TOF MS

Annemieke W. J. Opstal-van Winden et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2012)

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Article Medicine, Research & Experimental

Stable Knockdown of Clusterin by Vector-based RNA Interference in a Human Breast Cancer Cell Line Inhibits Tumour Cell Invasion and Metastasis

J. Li et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2012)

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Multiplexed bead-based immunoassay of four serum biomarkers for diagnosis of ovarian cancer

Yong-Wan Kim et al.

ONCOLOGY REPORTS (2012)

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Screening and identification of serum proteomic biomarkers for gastric adenocarcinoma

Chibo Liu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2012)

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Apolipoprotein E (APOE) Polymorphisms and Susceptibility to Breast Cancer: A Meta-Analysis

Mostafa Saadat

CANCER RESEARCH AND TREATMENT (2012)

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Article Pharmacology & Pharmacy

Apolipoprotein A-I Mimetic Peptides Inhibit Expression and Activity of Hypoxia-Inducible Factor-1α in Human Ovarian Cancer Cell Lines and a Mouse Ovarian Cancer Model

Feng Gao et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)

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Proteomic biomarkers apolipoprotein A1, truncated transthyretin and connective tissue activating protein III enhance the sensitivity of CA125 for detecting early stage epithelial ovarian cancer

Charlotte H. Clarke et al.

GYNECOLOGIC ONCOLOGY (2011)

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Article Cell Biology

L-5F, an apolipoprotein A-I mimetic, inhibits tumor angiogenesis by suppressing VEGF/basic FGF signaling pathways

Feng Gao et al.

INTEGRATIVE BIOLOGY (2011)

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Article Cell Biology

A Novel Anti-Apoptotic Role for Apolipoprotein L2 in IFN-γ-Induced Cytotoxicity in Human Bronchial Epithelial Cells

Wupeng Liao et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2011)

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Article Biochemistry & Molecular Biology

Apolipoprotein A1 -75 G/A and +83 C/T polymorphisms: susceptibility and prognostic implications in breast cancer

Bechr Hamrita et al.

MOLECULAR BIOLOGY REPORTS (2011)

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Article Oncology

Apolipoprotein E expression promotes lung adenocarcinoma proliferation and migration and as a potential survival marker in lung cancer

Wen-Pin Su et al.

LUNG CANCER (2011)

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Article Multidisciplinary Sciences

A Novel Peptide Derived from Human Apolipoprotein E Is an Inhibitor of Tumor Growth and Ocular Angiogenesis

Partha S. Bhattacharjee et al.

PLOS ONE (2011)

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Article Multidisciplinary Sciences

Serum Apolipoproteins C-I and C-III Are Reduced in Stomach Cancer Patients: Results from MALDI-Based Peptidome and Immuno-Based Clinical Assays

Meital Cohen et al.

PLOS ONE (2011)

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Article Multidisciplinary Sciences

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

Christina Christoffersen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Review Medical Laboratory Technology

Apolipoproteins: metabolic role and clinical biochemistry applications

Marek H. Dominiczak et al.

ANNALS OF CLINICAL BIOCHEMISTRY (2011)

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Article Oncology

Plasmin-clipped β2-glycoprotein-I inhibits endothelial cell growth by down-regulating cyclin A, B and D1 and up-regulating p21 and p27

Wolf-Dietrich C. Beecken et al.

CANCER LETTERS (2010)

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Article Biochemistry & Molecular Biology

Family-based association analysis of 42 hereditary prostate cancer families identifies the Apolipoprotein L3 region on chromosome 22q12 as a risk locus

Bo Johanneson et al.

HUMAN MOLECULAR GENETICS (2010)

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Article Multidisciplinary Sciences

Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer

Feng Su et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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The isolation and identification of apolipoprotein C-I in hormone-refractory prostate cancer using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry

Kaori Yamamoto-Ishikawa et al.

ASIAN JOURNAL OF ANDROLOGY (2009)

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Article Oncology

Overexpression of Clusterin in Ovarian Cancer is Correlated With Impaired Survival

Guofen F. Yang et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2009)

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Article Biochemistry & Molecular Biology

Discovery and identification of potential biomarkers of papillary thyroid carcinoma

Yuxia Fan et al.

MOLECULAR CANCER (2009)

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Article Medicine, Research & Experimental

Increased apolipoprotein E gene expression and protein concentration in lung cancer tissue do not contribute to the clinical assessment of non-small cell lung cancer patients

Zoran Trost et al.

ARCHIVES OF MEDICAL RESEARCH (2008)

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Review Cardiac & Cardiovascular Systems

Multiple actions of high-density lipoprotein

Matilda Florentin et al.

CURRENT OPINION IN CARDIOLOGY (2008)

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Article Oncology

Microarray analysis of normal cervix, carcinoma in situ, and invasive cervical cancer: identification of candidate genes in pathogenesis of invasion in cervical cancer

J. Y. Song et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2008)

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Article Genetics & Heredity

Influence of Apolipoprotein E Gene Polymorphism on the Risk for Breast Cancer

D. Surekha et al.

INTERNATIONAL JOURNAL OF HUMAN GENETICS (2008)

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Article Biochemical Research Methods

Fine-needle aspiration of thyroid nodules: Proteomic analysis to identify cancer biomarkers

Laura Giusti et al.

JOURNAL OF PROTEOME RESEARCH (2008)

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Article Biochemical Research Methods

2-D difference gel electrophoresis of the lung squamous cell carcinoma versus normal sera demonstrates consistent alterations in the levels of ten specific proteins

Paul Dowling et al.

ELECTROPHORESIS (2007)

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Review Medicine, General & Internal

HDL-c is a powerful lipid predictor of cardiovascular diseases

E. Bruckert et al.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2007)

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Review Cardiac & Cardiovascular Systems

Subendothelial lipoprotein retention as the initiating process in atherosclerosis -: Update and therapeutic implications

Ira Tabas et al.

CIRCULATION (2007)

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Article Oncology

Anticlusterin treatment of breast cancer cells increases the sensitivities of chemotherapy and tamoxifen and counteracts the inhibitory action of dexamethasone on chemotherapy-induced cytotoxicity

Maximino Redondo et al.

BREAST CANCER RESEARCH (2007)

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Article Oncology

Association between the apolipoprotein E genotypes and breast cancer patients in Taiwanese

Shun-Jen Chang et al.

BREAST CANCER RESEARCH AND TREATMENT (2006)

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Apolipoprotein E expression in anaplastic thyroid carcinoma

Yasuhiro Ito et al.

ONCOLOGY (2006)

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Article Oncology

Knockdown of the cytoprotective chaperone, clusterin, chemosensitizes human breast cancer cells both in vitro and in vivo

A So et al.

MOLECULAR CANCER THERAPEUTICS (2005)

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Article Oncology

Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan

NW Chang et al.

BREAST CANCER RESEARCH AND TREATMENT (2005)

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Article Oncology

Gene expression profile of gastric carcinoma: Identification of genes and tags potentially involved in invasion, metastasis, and carcinogenesis by serial analysis of gene expression

N Oue et al.

CANCER RESEARCH (2004)

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Article Oncology

Silencing expression of the clusterin/apolipoprotein J gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress

IP Trougakos et al.

CANCER RESEARCH (2004)

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Article Endocrinology & Metabolism

Apolipoprotein-D: A novel cellular marker for HGPIN and prostate cancer

RE Hall et al.

PROSTATE (2004)

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Article Multidisciplinary Sciences

Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis

AF Valledor et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Article Oncology

Association of NQOI polymorphism with spontaneous breast cancer in two independent populations

HJ Menzel et al.

BRITISH JOURNAL OF CANCER (2004)

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Letter Oncology

The apolipoprotein E ε4 allele is not a risk factor for Turkish breast cancer patients

I Yaylim et al.

CANCER GENETICS AND CYTOGENETICS (2003)

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Review Endocrinology & Metabolism

The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues

A Rigotti et al.

ENDOCRINE REVIEWS (2003)

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Article Cardiac & Cardiovascular Systems

L-4F, an apolipoprotein A-1 mimetic, restores nitric oxide and superoxide anion balance in low-density lipoprotein-treated endothelial cells

ZJ Ou et al.

CIRCULATION (2003)

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Article Hematology

Apolipoprotein D inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell proliferated by preventing translocation of phosphorylated extracellular signal regulated kinase 1/2 to the nucleus

JM Sarjeant et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2003)

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Article Public, Environmental & Occupational Health

Apolipoprotein E phenotype, cholesterol and breast and prostate cancer

M Niemi et al.

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH (2000)

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Review Biochemistry & Molecular Biology

Apolipoprotein D

E Rassart et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY (2000)

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Article Oncology

Apolipoprotein E polymorphism and breast carcinoma: correlation with cell proliferation indices and clinical outcome

E Zunarelli et al.

BREAST CANCER RESEARCH AND TREATMENT (2000)

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Article Oncology

Expression and clinical significance of apolipoprotein D in epithelial ovarian carcinomas

J Vazquez et al.

GYNECOLOGIC ONCOLOGY (2000)

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