Identifying a target group for selenium supplementation in high-risk cardiac surgery: a secondary analysis of the SUSTAIN CSX trial

Article Surgery

Effect of High-Dose Selenium on Postoperative Organ Dysfunction and Mortality in Cardiac Surgery Patients The SUSTAIN CSX Randomized Clinical Trial

Christian Stoppe et al.

Summary: High-dose intravenous sodium selenite treatment did not reduce morbidity or mortality in high-risk cardiac surgery patients.

JAMA SURGERY (2023)

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Review Pharmacology & Pharmacy

Research progress of glutathione peroxidase family (GPX) in redoxidation

Jun Pei et al.

Summary: Maintaining the balance of a cell's redox function is crucial for determining cell fate, and the GPX family of proteins, such as GPX1-GPX8, plays a significant role in combating oxidative stress and maintaining redox balance. Each member of the GPX family has a distinct mechanism of action and site of action in maintaining redox balance. Understanding the expression and regulatory mechanism of each member in the redox process is important for further clarifying the functional core of the GPX family.

FRONTIERS IN PHARMACOLOGY (2023)

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Article Cardiac & Cardiovascular Systems

The Association Between Serum Glutathione Peroxidase-3 Concentration and Risk of Acute Kidney Injury After Cardiac Surgery: A Nested Case-Control Study

Zhouping Zou et al.

Summary: Oxidative stress plays an important role in cardiac surgery-associated acute kidney injury. Serum GPx3 concentration is lower in CSA-AKI patients, and the GPx3 ratio can be used to predict the risk of CSA-AKI.

AMERICAN JOURNAL OF CARDIOLOGY (2023)

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Review Engineering, Biomedical

Narrative review of the systemic inflammatory reaction to cardiac surgery and cardiopulmonary bypass

Enrico Squiccimarro et al.

Summary: Systemic inflammation following cardiac surgery is common and occasionally clinically relevant. However, the specific mechanisms are still unclear, and clinicians face challenges in perceiving and differentiating high responder patients from those who do not react.

ARTIFICIAL ORGANS (2022)

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Article Immunology

Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe

Kamil Demircan et al.

Summary: In COVID-19 patients in Europe, serum levels of selenium and zinc are associated with mortality risk, with lower levels observed in non-survivors.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Redefining critical illness

David M. Maslove et al.

Summary: The authors propose a new conceptual model of critical illness that moves away from the current syndrome-based framework and focuses on more precise biological descriptors. They discuss the need to reconsider the current approach based on syndromes and instead emphasize the underlying biological changes that underpin critical illness states. By doing so, they believe it will lead to a better understanding of the pathobiology of critical illness and improved patient outcomes.

NATURE MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker

Raban Arved Heller et al.

Summary: The study found that zinc deficiency is common among COVID-19 patients and has predictive value for survival. Additionally, selenium deficiency is also prevalent in patients, and a combined deficit of zinc and selenium is associated with survival rates.

REDOX BIOLOGY (2021)

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Article Nutrition & Dietetics

Serum Selenium Status as a Diagnostic Marker for the Prognosis of Liver Transplantation

Safak Guel-Klein et al.

Summary: The study reveals that liver cancer patients undergoing transplantation have lower selenium and SELENOP levels compared to healthy subjects, particularly those with ethanol toxicity as the etiology. Non-survivors show a decreasing trend in selenium concentrations, indicating a pronounced selenium deficit in severe liver disease necessitating organ replacement. A recovering selenium status post-surgery is associated with positive prognosis, suggesting that selenium supplementation could support recovery.

NUTRIENTS (2021)

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Article Nutrition & Dietetics

Course and Survival of COVID-19 Patients with Comorbidities in Relation to the Trace Element Status at Hospital Admission

Gijs Du Laing et al.

Summary: The study found that selenium and/or zinc deficiency in COVID-19 patients is associated with higher mortality rates and more severe disease course, especially in the senior population. Comparisons with healthy European adults showed significantly lower selenium and SELENOP concentrations in the patients upon hospital admission. Associations with specific comorbidities like cancer, diabetes, and chronic cardiac disease were noted, emphasizing the importance of trace element assessment for patient stratification and clinical care.

NUTRIENTS (2021)

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Article Biochemistry & Molecular Biology

Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study

Kamil Demircan et al.

Summary: Selenium is essential for the synthesis of redox active proteins and its serum status biomarkers SELENOP and GPx3 are associated with overall survival and recurrence in patients with primary invasive breast cancer. An analysis of 1996 patients showed an inverse correlation between these biomarkers and mortality, with the highest quintile associated with significantly lower hazard ratios. Triple deficiency in selenium status biomarkers was linked to the highest mortality risk, and predicting mortality based on these biomarkers outperformed traditional tumour characteristics.

REDOX BIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Selenium and outcome in heart failure

Nils Bomer et al.

EUROPEAN JOURNAL OF HEART FAILURE (2020)

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Review Immunology

Selenium and selenoproteins: it's role in regulation of inflammation

Sneha Hariharan et al.

INFLAMMOPHARMACOLOGY (2020)

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Review Oncology

Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer

Caroline Chang et al.

CANCERS (2020)

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Article Nutrition & Dietetics

Selenium Deficiency Is Associated with Mortality Risk from COVID-19

Arash Moghaddam et al.

NUTRIENTS (2020)

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Article Immunology

The Effect of Intravenous Selenium on Oxidative Stress in Critically Ill Patients with Acute Respiratory Distress Syndrome

Ata Mahmoodpoor et al.

IMMUNOLOGICAL INVESTIGATIONS (2019)

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Review Urology & Nephrology

Obesity, kidney dysfunction and hypertension: mechanistic links

John E. Hall et al.

NATURE REVIEWS NEPHROLOGY (2019)

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Article Respiratory System

Treatable traits in acute exacerbations of chronic airway diseases

Vanessa M. McDonald et al.

CHRONIC RESPIRATORY DISEASE (2019)

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Review Nutrition & Dietetics

Selenium, Selenoproteins, and Immunity

Joseph C. Avery et al.

NUTRIENTS (2018)

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Review Urology & Nephrology

The impact of insulin resistance on the kidney and vasculature

Ferruh Artunc et al.

NATURE REVIEWS NEPHROLOGY (2016)

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Review Biochemistry & Molecular Biology

Revised reference values for selenium intake

A. P. Kipp et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2015)

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Review Nutrition & Dietetics

Pharmaconutrition With Selenium in Critically Ill Patients: What Do We Know?

William Manzanares et al.

NUTRITION IN CLINICAL PRACTICE (2015)

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Article Critical Care Medicine

Selenium supplementation in critically ill patients: A systematic review and meta-analysis

Francesco Landucci et al.

JOURNAL OF CRITICAL CARE (2014)

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Article Multidisciplinary Sciences

The Importance of Intraoperative Selenium Blood Levels on Organ Dysfunction in Patients Undergoing Off-Pump Cardiac Surgery: A Randomised Controlled Trial

Ana Stevanovic et al.

PLOS ONE (2014)

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Article Medicine, Research & Experimental

SodiUm SeleniTe Adminstration IN Cardiac Surgery (SUSTAIN CSX-trial): study design of an international multicenter randomized double-blinded controlled trial of high dose sodium-selenite administration in high-risk cardiac surgical patients

Christian Stoppe et al.

TRIALS (2014)

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Review Endocrinology & Metabolism

Update on antioxidant micronutrients in the critically ill

William Manzanares et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2013)

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Article Nutrition & Dietetics

Selenium blood concentrations in patients undergoing elective cardiac surgery and receiving perioperative sodium selenite

Christian Stoppe et al.

NUTRITION (2013)

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Article Anesthesiology

Lower whole blood selenium level is associated with higher operative risk and mortality following cardiac surgery

Gyoergy Koszta et al.

JOURNAL OF ANESTHESIA (2012)

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Review Medicine, General & Internal

Selenium and human health

Margaret P. Rayman

LANCET (2012)

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Article Critical Care Medicine

The intraoperative decrease of selenium is associated with the postoperative development of multiorgan dysfunction in cardiac surgical patients

Christian Stoppe et al.

CRITICAL CARE MEDICINE (2011)

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Article Nutrition & Dietetics

Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial

Rachel Hurst et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2010)

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Article Biochemistry & Molecular Biology

Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain

Jazmin Chiu-Ugalde et al.

BIOCHEMICAL JOURNAL (2010)

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Article Cardiac & Cardiovascular Systems

Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: A randomised trial

Jee-Yoong Leong et al.

HEART LUNG AND CIRCULATION (2010)

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Article Critical Care Medicine

Serum selenium and glutathione peroxidase-3 activity: biomarkers of systemic inflammation in the critically ill?

William Manzanares et al.

INTENSIVE CARE MEDICINE (2009)

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Article Biochemistry & Molecular Biology

Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells

Gary E. Olson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Critical Care Medicine

Selenium in Intensive Care (SIC):: Results of a prospective. randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock

Matthias W. A. Angstwurm et al.

CRITICAL CARE MEDICINE (2007)

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Review Nutrition & Dietetics

Assessment of requirements for selenium and adequacy of selenium status: a review

CD Thomson

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2004)

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Article Biochemistry & Molecular Biology

Determinants of human plasma glutathione peroxidase (GPx-3) expression

C Bierl et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Article Critical Care Medicine

Possible role of increased oxidant stress in multiple organ failure after systemic inflammatory response syndrome

T Motoyama et al.

CRITICAL CARE MEDICINE (2003)

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Article Biochemistry & Molecular Biology

Selenium supplementation acting through the induction of thioredoxin reductase and glutathione peroxidase protects the human endothelial cell line EAhy926 from damage by lipid hydroperoxides

MH Lewin et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2002)

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Article Critical Care Medicine

Antioxidant and antiprotease status in peripheral blood and BAL fluid after cardiopulmonary bypass

OM Frass et al.

CHEST (2001)

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Identifying a target group for selenium supplementation in high-risk cardiac surgery: a secondary analysis of the SUSTAIN CSX trial

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