Polycomb repressor complex: Its function in human cancer and therapeutic target strategy

The Polycomb Repressor Complex (PRC) plays a pivotal role in gene regulation during development and disease, with dysregulation contributing significantly to various human cancers. The intricate interplay between PRC and cellular signaling pathways sheds light on cancer complexity. PRC presents promising therapeutic opportunities, with inhibitors undergoing rigorous evaluation in preclinical and clinical studies. In this review, we emphasize the critical role of PRC complex in gene regulation, particularly PcG proteins mediated chromatin compaction through phase separation. We also highlight the pathological implications of PRC complex dysregulation in various tumors, elucidating underlying mechanisms driving cancer progression. The burgeoning field of thera-peutic strategies targeting PRC complexes, notably EZH2 inhibitors, has advanced significantly. However, we explore the need for combination therapies to enhance PRC targeted treatments efficacy, providing a glimpse into the future of cancer therapeutics.

Automated summary

The Polycomb Repressor Complex (PRC) plays a crucial role in gene regulation and its interaction with cellular signaling pathways sheds light on the complexity of cancer. Dysregulation of the PRC complex is significant in various tumors and understanding the underlying mechanisms driving cancer progression is important. The development of therapeutic strategies targeting PRC complexes, particularly EZH2 inhibitors, has made significant advancements and combination therapies may enhance targeted treatments efficacy.