期刊
FRONTIERS IN ENDOCRINOLOGY
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2023.1243992
关键词
periodontitis; tooth loss; diabetes; coronary atherosclerosis; CAC scores
The aim of this study was to investigate the association between periodontitis and tooth loss with the extent of diabetic coronary atherosclerosis. The results showed that both tooth loss and clinical attachment loss (CAL) were significantly higher in patients with moderate-to-severe coronary atherosclerosis. Salivary inflammatory factors and oral bacteremia may serve as new biomarkers for moderate-to-severe coronary atherosclerosis.
AimThe objective was to investigate the association of periodontitis and tooth loss with extent of diabetic coronary atherosclerosis.Materials and methods272 patients who were hospitalized at Shanghai East hospital and underwent a coronary artery calcium (CAC) CT scan were enrolled in this study. Individuals were grouped based on their CAC scores into a normal-to-mild coronary atherosclerosis (AS) group (0 <= score <= 100, n=184) and a moderate-to-severe group (score >= 101, n=88). Periodontitis parameters and number of missing teeth were evaluated for every patient. The severity of periodontitis was categorized as mild, moderate, or severe. The taxonomic composition of the microbiota was determined using full-length 16S ribosomal RNA gene sequencing. Salivary inflammatory factors were tested by ELISA.ResultsClinical attachment loss (CAL) (P =0.05) and the number of teeth lost (P = 0.016) were significantly higher in the moderate-to-severe coronary AS group, with these differences being more obvious in younger patients and patients with short-duration diabetes. Multivariate logistic regression analysis revealed that CAL (OR = 1.231, 95% CI = 1.066-1.214, P = 0.047) and having 10-19 missing teeth (OR = 1.604, 95% CI = 1.393-6.555, P = 0.05) were strongly associated with the presence of moderate-to-severe coronary AS. Salivary IL-6 and TNF-alpha levels, as well as levels of Porphyromonas gingivalis and Neisseria mucosa, were significantly elevated in the moderate-to-severe coronary AS group.ConclusionIt was found that both tooth loss and CAL were related to the extent of diabetic coronary AS. Saliva inflammatory factors and oral bacteremia may be new biomarkers for moderate-to-severe coronary AS.
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