期刊
EXPERT REVIEW OF RESPIRATORY MEDICINE
卷 -, 期 -, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17476348.2023.2283135
关键词
Nontuberculous mycobacteria; pulmonary disease; epidemiology; antibiotic resistance; diagnostics; Mycobacterium avium complex; Mycobacterium abscessus complex
This paper provides a comprehensive analysis of NTM infections, covering microbiology, environmental sources and transmission pathways, risk factors, epidemiology, clinical manifestations, diagnostic approaches, treatment recommendations, drugs under development, and management challenges.
Introduction: Nontuberculous mycobacteria (NTM) are a diverse group of mycobacterial species that are ubiquitous in the environment. They are opportunistic pathogens that can cause a range of diseases, especially in individuals with underlying structural lung disease or compromised immune systems.Areas covered: This paper provides an in-depth analysis of NTM infections, including microbiology, environmental sources and transmission pathways, risk factors for disease, epidemiology, clinical manifestations and diagnostic approaches, guideline-based treatment recommendations, drugs under development, and management challenges.Expert opinion: Future approaches to the management of NTM pulmonary disease will require therapies that are well tolerated, can be taken for a shorter time period and perhaps less frequently, have few drug-drug interactions, and are active against the various strains of pathogens. As the numbers of infections increase, such therapies will be welcomed by clinicians and patients.
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